HPLC-ECD, HTEC-600
Start detecting neurotransmitters immediately
upon delivery with no prior knowledge
of liquid chromatography
Most researcher’s first approach to neurotransmitter analysis can leave them feeling unsure where to start and overwhelmed. As a company founded and operated by scientific minds, we get it.
That is why we developed the HTEC-600, an HPLC-ECD (High Performance Liquid Chromatography – Electrochemical Detection). The HTEC-600 offers pre-configured applications and protocols so your journey into neurotransmitter analysis is clear from start to finish.
All-in-One Turnkey HPLC-ECD
Avoid the potential confusion caused that comes from individually configuring the multiple components required for neurotransmitter analysis. The HTEC-600 combines all of the key components required for hyper sensitive neurotransmitter analysis into one easily configurable system so you can get started immediately from the moment it arrives in your lab.
” The [HTEC] has been fantastic, it’s run beautifully, and it’s super easy to use.
I like that all of my settings can be controlled right here on the screen, instead of having to make method files within the software and uploading them to the system – that’s just too much work. “
Sarah Ryan
Augusta University
Anatomy of the HPLC-ECD, HTEC-600
Electrochemical Detector
Amperometic Design with inexpensive and interchangeable working electrodes
Online Solvent Degasser
For Enhanced Pump Reliability
Pulse Quenching Pump
Computer controlled and no pulse damper is required
Ultra-high Sensitivity with Ultra-low Requirements
Allow our specialists to do the hard work for you. Follow our pre-configured protocols and applications designed to provide you with a step-by-step guide to achieving the ideal conditions required to obtain the highest quality analysis of your sample type.
How to Get Started
Introducing our 3 step plan to make sure your journey into neurotransmitter analysis is clear from start to finish.
- Step 1 - Download an Application Note
- Step 2 - Speak With our Specialists
- Step 3 - Bring an HPLC-ECD to Your Lab!
Step 2
Find the optimal conditions for your sample type with the help of our neurotransmitter analysis specialists!
We will contact you shortly after downloading the application note in Step 1.
Can’t wait?
Call us now at 888-680-7775
Step 3
Begin neurotransmitter analysis with a clear direction and understanding of the process!
HPLC-ECD, HTEC-600 Specifications
HTEC-600 Specifications
| Detector | |
| Detection Methods | Amperometric Electrochemical Detector |
| Applied voltage | 0 – ±2,000ｍV, 1mV increment |
| Working Electrode Methods | Thin Layer Method |
| Working Electrode Size | Graphite (Standard), Pure Graphite, Grassy Carbon, Platinum, Gold, Silver |
| Working Electrode Gasket | Composed by TFE, Thickness 25 µm or 50 µm |
| Reference Electrode | Silver / Silver Chloride (Lithium Chloride Enclosed Type) |
| Auxiliary Electrode | SUS316 |
| Wetting Part Material | PEEK, SUS316 |
| Recorder Output Signal | ±10 V Analog (0.1 nA = 1 mV) |
| Time Constant | 1.0 sec, 1.5 sec, 3.0 sec |
| Signal Input |
Signal In: Detect more than 300 msec, a contact signal M. Injector Signal In: Detect 300 sec switching from open/close signal |
| External Device Control Signal |
0 sec: Output contact signal for1 sec at the same time as signal input. 3 sec: Output contact signal for 1 sec at 3 sec from signal input. 6 sec: Output contact signal for 1 sec at 6 sec from signal input. |
| Liquid Feeding Pump | |
| Liquid Delivery System | Tandem Two Pistons |
| Replacement Volume Per Stroke | 80 µL |
| Piston Material | Sapphire |
| Setting Flow Rate Range | 1 – 3000 µL/min |
| Stable Flow Rate Range | 100 – 2000 µL/min |
| Wetting Part Material | PEEK, Sapphire, Ruby, PTFE, PCTFE |
| Maximum Pressure | 20 MPa |
| Pulsating Reduction Mechanism | Automatic Pulsation Control |
| Degasser | |
| Methods | Continuous Vacuum Membrane Permeation Type |
| Number of Channels | 2 Channels |
| Internal Capacity |
Upper: Around 300 µL/channel Bottom: Around 7.5 mL/channel |
| Constant Temperature Bath | |
| Methods | Heating/Cooling with peltier element w/ air circulation |
| Setting Temp Range | 15 – 50 °C (1 °C increment) |
| Temp Control Accuracy | ± 0.1 °C |
| Unit Size | |
| Dimension | 290 (W) x 380 (D) x 435 (H) mm (Excluding protrusions) |
| Weight | 23.2 kg |
| Power Supply | AC 100 – 240 V 50/60 Hz 300 VA |
“I love the [HPLC-ECD HTEC] system, it runs super fast and it’s so quiet.”
Video Resources
HPLC-ECD HTEC User Publications
Differing Patterns of Diurnal Variation and Impact of Antacids on Levodopa Pharmacokinetics in Patients with Parkinson’s Disease.
NAGAI, M., TADA, S., YAMANISHI, Y., MIYAUE, N., & ANDO, R.
(2023). Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 54(1), 3-8.
Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys.
Hori, Y., Mimura, K., Nagai, Y., Hori, Y., Kumata, K., Zhang, M. R., … & Minamimoto, T.
(2023). bioRxiv, 2023-02.
Broad Serotonergic Actions of Vortioxetine as a Promising Avenue for the Treatment of L-DOPA-Induced Dyskinesia.
Budrow, C., Elder, K., Coyle, M., Centner, A., Lipari, N., Cohen, S., … & Bishop, C.
(2023). Cells, 12(6), 837.
Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State.
Sinenko, S. A., Kuzmin, A. A., Skvortsova, E. V., Ponomartsev, S. V., Efimova, E. V., Bader, M., … & Tomilin, A. N.
(2023). International Journal of Molecular Sciences, 24(5), 4862.
Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain.
Fukuyama, K., Motomura, E., & Okada, M.
(2023). Schizophrenia, 9(1), 8.
Recent Blog Articles
Simultaneous Analysis of Glutamate and GABA for Neuroscience Applications
In this video, we’ll show you how to detect and analyze Glutamate and GABA in brain tissue or microdialysis samples in just 12 minutes.
Fast analysis of acetylcholine for neuroscience applications
We show you how to detect and analyze acetylcholine in brain microdialysis samples in 18 minutes, with minimal or no need to add an acetylcholine esterase inhibitor or AEI.
Benefits of using HPLC-ECD for Neurotransmitter Detection
For qualitative and quantitative analysis of neurotransmitters, we recommend high-performance liquid chromatography detected with an electrochemical detector, known as HPLC-ECD.
Let’s Get Started!
Ask about our loaner program of the HTEC.