Confidently Bring an All-In-One Electrochemical Detection System to Your Lab

Ultra-High Sensitivity Electrochemical Detection

Trust in the sensitivity of electrochemical detection. Rely on our pre-configured applications and system to easily ensure 160 attomole sensitivity for dopamine and serotonin, and 5 fmol for acetylcholine.


Turn Key System

Get started with high-throughput electrochemical detection right away with the all-in-one HPLC-ECD system. Confidently trust in our prepared neuroscience-specific analytical applications to get you the results you deserve. Simply choose the method and follow the detailed protocol.

Worry-free Maintenance

Avoid the concern normally associated with system maintenance. The simple compact design of the HTEC-600 (HPLC-ECD) allows for easy maintenance. 

15 min Analysis

Obtain highly sensitive analysis of norepinephrine, dopamine & serotonin in microdialysis samples in 15 minutes.

To ensure you maintain the high sensitivity you deserve, we will be here every step of the way to make sure your system is always fully functional.

Superior Customer Support

Learning a new system can be stressful. We get it. That is why we make sure you gain the support you need. A trained specialist will work with you directly from the beginning to make sure your experience is smooth and stress-free.

Fast and Ultra-Sensitive Method for Analyzing Dopamine and Serotonin

In this application note, we introduce a fast and ultra-sensitive method for analyzing dopamine and serotonin levels with improved throughput and resolution time.

Dopamine and Serotonin Analysis in 5 min


HTEC-600 Specifications
Detection Methods Amperometric Electrochemical Detector
Applied voltage 0 – ±2,000mV, 1mV increment
Working Electrode Methods Thin Layer Method
Working Electrode Size Graphite (Standard), Pure Graphite, Grassy Carbon, Platinum, Gold, Silver
Working Electrode Gasket Composed by TFE, Thickness 25 µm or 50 µm
Reference Electrode Silver / Silver Chloride (Lithium Chloride Enclosed Type)
Auxiliary Electrode SUS316
Wetting Part Material PEEK, SUS316
Recorder Output Signal ±10 V Analog (0.1 nA = 1 mV)
Time Constant 1.0 sec, 1.5 sec, 3.0 sec
Signal Input

Signal In: Detect more than 300 msec, a contact signal

M. Injector Signal In:  Detect 300 sec  switching from open/close signal

External Device Control Signal

0 sec: Output contact signal for1 sec  at the same time as signal input.

3 sec: Output contact signal for 1 sec at 3 sec from signal input.

6 sec: Output contact signal for 1 sec at 6 sec from signal input.

Liquid Feeding Pump
Liquid Delivery System Tandem Two Pistons
Replacement Volume Per Stroke 80 µL
Piston Material Sapphire
Setting Flow Rate Range 1 – 3000 µL/min
Stable Flow Rate Range 100 – 2000 µL/min
Wetting Part Material PEEK, Sapphire, Ruby, PTFE, PCTFE
Maximum Pressure 20 MPa
Pulsating Reduction Mechanism Automatic Pulsation Control
Methods Continuous Vacuum Membrane Permeation Type
Number of Channels 2 Channels
Internal Capacity

Upper: Around 300 µL/channel

Bottom: Around 7.5 mL/channel

Constant Temperature Bath
Methods Heating/Cooling with peltier element w/ air circulation
Setting Temp Range 15 – 50 °C (1 °C increment)
Temp Control Accuracy ± 0.1 °C
Unit Size
Dimension 290 (W) x 380 (D) x 435 (H) mm (Excluding protrusions)
Weight 23.2 kg
Power Supply AC 100 – 240 V 50/60 Hz 300 VA

Anatomy of the HTEC-600


Eicom’s Innovative Cell Design

  • Ultrasensitive, 30 fg of dopamine
  • Graphite electrode often ready to use for < 30 mins after start-up
  • No tools to access the working electrode
  • Easy to clean or change the working electrode

The key to the sensitivity is the cell design. Eicom relies on a spring-loaded mechanism that always maintains the proper pressure. This structure allows the detector to quickly stabilize after the cell is opened and closed. Another benefit is that the working electrode can easily be accessed with no tools. In this way, the electrode can easily be wiped clean and reinstalled to ensure maximum sensitivity.

Video Resources

Benefits using HPLC-ECD for neurotransmitter detection

The [HTEC] has been fantastic, it’s run beautifully, and it’s super easy to use.

I like that all of my settings can be controlled right here on the screen, instead of having to make method files within the software and uploading them to the system – that’s just too much work.

Sarah Ryan

Augusta University

HTEC User Publications

Differing Patterns of Diurnal Variation and Impact of Antacids on Levodopa Pharmacokinetics in Patients with Parkinson’s Disease.
(2023).  Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics54(1), 3-8.

Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys.
Hori, Y., Mimura, K., Nagai, Y., Hori, Y., Kumata, K., Zhang, M. R., … & Minamimoto, T.
(2023).  bioRxiv, 2023-02.

Broad Serotonergic Actions of Vortioxetine as a Promising Avenue for the Treatment of L-DOPA-Induced Dyskinesia.
Budrow, C., Elder, K., Coyle, M., Centner, A., Lipari, N., Cohen, S., … & Bishop, C.
(2023).  Cells12(6), 837.

Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State.
Sinenko, S. A., Kuzmin, A. A., Skvortsova, E. V., Ponomartsev, S. V., Efimova, E. V., Bader, M., … & Tomilin, A. N.
(2023).  International Journal of Molecular Sciences24(5), 4862.

Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain.
Fukuyama, K., Motomura, E., & Okada, M.
(2023).  Schizophrenia9(1), 8.

Let’s Get Started!

NEW!! Ask about our loaner program of the HTEC.