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Behavioral Neuroscience

Touch Panel

2020

β-lactolin, a whey-derived glycine―threonine―tryptophan―tyrosine lactotetrapeptide, improves prefrontal cortex-associated reversal learning in mice.
Ayabe, T., Ohya, R., & Ano, Y.
(2020). Bioscience, biotechnology, and biochemistry, 84(5), 1039-1046.

2019

Hop-Derived Iso-α-Acids in Beer Improve Visual Discrimination and Reversal Learning in Mice as Assessed by a Touch Panel Operant System.
Ayabe, T., Ohya, R., & Ano, Y.
(2019). Frontiers in Behavioral Neuroscience, 13, 67.

TaskForcer

2023

Working memory-based and-free reward prediction in a dual dopamine system in the basal ganglia.
Yoshizawa, T., Miyamura, Y., Ochi, Y., Hira, R., Funahashi, M., Sakai, Y., … & Isomura, Y.
(2023). bioRxiv, 2023-03.

2020

A spike analysis method for characterizing neurons based on phase locking and scaling to the interval between two behavioral events.
Kawabata, M., Soma, S., Saiki-Ishikawa, A., Nonomura, S., Yoshida, J., Ríos, A. A., … & Isomura, Y.
(2020). Journal of Neurophysiology.

Differential effects of dopamine D1‐like and D2‐like receptor agonists on water drinking behaviour under thirsty conditions in mice with reduced dopamine secretion.
Kao, K. C., & Hisatsune, T.
(2020). European Journal of Neuroscience, 51(2), 584-597.

2019

Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.
Soma, S., Yoshida, J., Kato, S., Takahashi, Y., Nonomura, S., Sugimura, Y. K., … & Sakai, Y.
(2019). Journal of Neuroscience, 39(3), 485-502.

Ventral striatum links motivational and motor networks during operant-conditioned movement in rats.
Hori, Y., Ihara, N., Sugai, C., Ogura, J., Honda, M., Kato, K., … & Hanakawa, T.
(2019). Neuroimage, 184, 943-953.

2018

Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition.
Yoshida, J., Saiki, A., Soma, S., Yamanaka, K., Nonomura, S., Ríos, A., … & Isomura, Y.
(2018). Neuroscience, 388, 297-316.

In vivo spiking dynamics of intra-and extratelencephalic projection neurons in rat motor cortex.
Saiki, A., Sakai, Y., Fukabori, R., Soma, S., Yoshida, J., Kawabata, M., … & Isomura, Y.
(2018). Cerebral Cortex, 28(3), 1024-1038.

Learning task-related activities from independent local-field-potential components across motor cortex layers.
Martín-Vázquez, G., Asabuki, T., Isomura, Y., & Fukai, T.
(2018). Frontiers in neuroscience, 12, 429.

Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways.
Nonomura, S., Nishizawa, K., Sakai, Y., Kawaguchi, Y., Kato, S., Uchigashima, M., … & Sano, H.
(2018). Neuron, 99(6), 1302-1314.

Super-wide-field two-photon imaging with a micro-optical device moving in post-objective space.
Terada, S. I., Kobayashi, K., Ohkura, M., Nakai, J., & Matsuzaki, M.
(2018). Nature communications, 9(1), 1-14.

Thalamocortical axonal activity in motor cortex exhibits layer-specific dynamics during motor learning.
Tanaka, Y. H., Tanaka, Y. R., Kondo, M., Terada, S. I., Kawaguchi, Y., & Matsuzaki, M.
(2018). Neuron, 100(1), 244-258.

Quantitative study of the somatosensory sensitization underlying cross-modal plasticity.
Abe, K., & Yawo, H.
(2018). PloS one, 13(12).

2017

Continuous membrane potential fluctuations in motor cortex and striatum neurons during voluntary forelimb movements and pauses.
Nonomura, S., Fujiwara-Tsukamoto, Y., Kajihara, T., Fujiyama, F., & Isomura, Y.
(2017). Neuroscience research, 120, 53-59.

Distinct laterality in forelimb-movement representations of rat primary and secondary motor cortical neurons with intratelencephalic and pyramidal tract projections.
Soma, S., Saiki, A., Yoshida, J., Ríos, A., Kawabata, M., Sakai, Y., & Isomura, Y.
(2017). Journal of Neuroscience, 37(45), 10904-10916.

Large‐scale analysis reveals populational contributions of cortical spike rate and synchrony to behavioural functions.
Kimura, R., Saiki, A., Fujiwara‐Tsukamoto, Y., Sakai, Y., & Isomura, Y.
(2017). The Journal of physiology, 595(1), 385-413.

Medial frontal circuit dynamics represents probabilistic choices for unfamiliar sensory experience.
Handa, T., Takekawa, T., Harukuni, R., Isomura, Y., & Fukai, T.
(2017). Cerebral Cortex, 27(7), 3818-3831.

Phase-dependent activity of neurons in the rostral part of the thalamic reticular nucleus with saccharin intake in a cue-guided lever-manipulation task.
oki, R., Kato, R., Fujita, S., Shimada, J., Koshikawa, N., & Kobayashi, M.
(2017). Brain research, 1658, 42-50.

Temporal and rate coding for discrete event sequences in the hippocampus.
Terada, S., Sakurai, Y., Nakahara, H., & Fujisawa, S.
(2017). Neuron, 94(6), 1248-1262.

2016

Spike timing rigidity is maintained in bursting neurons under pentobarbital-induced anesthetic conditions.
Kato, R., Yamanaka, M., Yokota, E., Koshikawa, N., & Kobayashi, M.
(2016). Frontiers in neural circuits, 10, 86.

2015

Distinct functional modules for discrete and rhythmic forelimb movements in the mouse motor cortex.
Hira, R., Terada, S. I., Kondo, M., & Matsuzaki, M.
(2015). Journal of Neuroscience, 35(39), 13311-13322.

2014

Different modulation of common motor information in rat primary and secondary motor cortices.
Saiki, A., Kimura, R., Samura, T., Fujiwara-Tsukamoto, Y., Sakai, Y., & Isomura, Y.
(2014). PloS one, 9(6).

Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning.
Hira, R., Ohkubo, F., Masamizu, Y., Ohkura, M., Nakai, J., Okada, T., & Matsuzaki, M.
(2014). Nature communications, 5(1), 1-12.

Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task.
Masamizu, Y., Tanaka, Y. R., Tanaka, Y. H., Hira, R., Ohkubo, F., Kitamura, K., … & Matsuzaki, M.
(2014). Nature neuroscience, 17(7), 987-994.

2013

Reward-modulated motor information in identified striatum neurons.
Isomura, Y., Takekawa, T., Harukuni, R., Handa, T., Aizawa, H., Takada, M., & Fukai, T.
(2013). Journal of Neuroscience, 33(25), 10209-10220.

Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement.
Hira, R., Ohkubo, F., Ozawa, K., Isomura, Y., Kitamura, K., Kano, M., … & Matsuzaki, M.
(2013). Journal of Neuroscience, 33(4), 1377-1390.

2012

Reinforcing operandum: rapid and reliable learning of skilled forelimb movements by head-fixed rodents.
Kimura, R., Saiki, A., Fujiwara-Tsukamoto, Y., Ohkubo, F., Kitamura, K., Matsuzaki, M., … & Isomura, Y.
(2012). Journal of neurophysiology, 108(6), 1781-1792.

2009

Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements.
Isomura, Y., Harukuni, R., Takekawa, T., Aizawa, H., & Fukai, T.
(2009). Nature neuroscience, 12(12), 1586.

Self Head-Restraining Platform

2017

An automated platform for high-throughput mouse behavior and physiology with voluntary head-fixation.
Aoki, R., Tsubota, T., Goya, Y., & Benucci, A.
(2017). A Nature communications, 8(1), 1-9.

Free Maze

2020

The Reconfigurable Maze Provides Flexible, Scalable, Reproducible, and Repeatable Tests.
Hoshino, S., Takahashi, R., Mieno, K., Tamatsu, Y., Azechi, H., Ide, K., & Takahashi, S.
(2020). Iscience, 23(1), 100787.

T-Maze

2023

Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.
Shoji, H., Ikeda, K., & Miyakawa, T.
(2023). Molecular Brain, 16(1), 1-24.

Inflammatory Skin Disease Causes Anxiety Symptoms Leading to an Irreversible Course.
Iida, S., Shoji, H., Kawakita, F., Nakanishi, T., Matsushima, Y., Kondo, M., … & Yamanaka, K.
(2023). International Journal of Molecular Sciences, 24(6), 5942.

ILF3 prion-like domain regulates gene expression and fear memory under chronic stress.
Yamashita, A., Shichino, Y., Fujii, K., Koshidaka, Y., Adachi, M., Sasagawa, E., … & Shiina, N.
(2023). Iscience.

PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain.
Kurihara, Y., Mitsunari, K., Mukae, N., Shoji, H., Miyakawa, T., & Shirane, M.
(2023). Molecular Brain, 16(1), 1-18.

2020

The hippocampus encodes delay and value information during delay-discounting decision making.
Masuda, A., Sano, C., Zhang, Q., Goto, H., McHugh, T. J., Fujisawa, S., & Itohara, S.
(2020). Elife, 9, e52466.

2018

An automated T-maze based apparatus and protocol for analyzing delay-and effort-based decision making in free moving rodents.
Zhang, Q., Kobayashi, Y., Goto, H., & Itohara, S.
(2018). JoVE (Journal of Visualized Experiments), (138), e57895.

2015

Exposure to social defeat stress in adolescence improves the working memory and anxiety-like behavior of adult female rats with intrauterine growth restriction, independently of hippocampal neurogenesis.
Furuta, M., Ninomiya-Baba, M., Chiba, S., Funabashi, T., Akema, T., & Kunugi, H.
(2015). Hormones and behavior, 70, 30-37.

2014

Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes.
Fujioka, R., Nii, T., Iwaki, A., Shibata, A., Ito, I., Kitaichi, K., … & Fukumaki, Y.
(2014). Molecular brain, 7(1), 31.

2013

Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice.
Ohira, K., Kobayashi, K., Toyama, K., Nakamura, H. K., Shoji, H., Takao, K., … & Takahashi, M.
(2013). Molecular brain, 6(1), 12.

2012

T-maze forced alternation and left-right discrimination tasks for assessing working and reference memory in mice.
Shoji, H., Hagihara, H., Takao, K., Hattori, S., & Miyakawa, T.
(2012). JoVE (Journal of Visualized Experiments), (60), e3300.

2008

Effects of intrahippocampal cannabinoid receptor agonist and antagonist on radial maze and T-maze delayed alternation performance in rats.
Suenaga, T., Kaku, M., & Ichitani, Y.
(2008). Pharmacology Biochemistry and Behavior, 91(1), 91-96.

Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia.
Takao, K., Toyama, K., Nakanishi, K., Hattori, S., Takamura, H., Takeda, M., … & Hashimoto, R.
(2008). Molecular brain, 1(1), 11.

Drinko Measurer

2023

Serotonin regulation of intermittent and continuous alcohol drinking in male and female C57BL/6J mice with systemic SB242084 and buspirone.
Ko, Y. E., & Hwa, L. S.
(2023). Alcohol and Alcoholism, agad019.

2021

Alcohol consumption preferentially activates a subset of pro-opiomelanocortin (POMC) producing neurons targeting the amygdala.
Leyrer-Jackson, J. M., Hood, L. E., & Olive, M. F.
(2021). Neuropharmacology, 108674.

2012

Poliovirus trafficking toward central nervous system via human poliovirus receptor-dependent and-independent pathway.
Ohka, S., Nihei, C. I., Yamazaki, M., & Nomoto, A.
(2012). Frontiers in microbiology, 3, 147.

2011

B6-MSM consomic mouse strains reveal multiple loci for genetic variation in sucrose octaacetate aversion.
Ishii, A., Koide, T., Takahashi, A., Shiroishi, T., Hettinger, T. P., Frank, M. E., … & Blizard, D. A.
(2011). Behavior genetics, 41(5), 716.

2007

Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor.
Ohka, S., Igarashi, H., Nagata, N., Sakai, M., Koike, S., Nochi, T., … & Nomoto, A.
(2007). Journal of virology, 81(15), 7902-7912.

2002

Genetic diversity underlying capsaicin intake in the Mishima battery of mouse strains.
Furuse, T., Blizard, D. A., Moriwaki, K., Miura, Y., Yagasaki, K., Shiroishi, T., & Koide, T.
(2002). Brain research bulletin, 57(1), 49-55.

Three-Chamber Social Interaction

2020

Awake functional MRI detects neural circuit dysfunction in a mouse model of autism.
Tsurugizawa, T., Tamada, K., Ono, N., Karakawa, S., Kodama, Y., Debacker, C., … & Takumi, T.
(2020). Science Advances, 6(6), eaav4520.

Wire Hang Test

2023

Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.
Shoji, H., Ikeda, K., & Miyakawa, T.
(2023). Molecular Brain, 16(1), 1-24.

2022

Chronic Inhibition of Aggressive Behavior Induces Behavioral Change in Mice.
Ueno, H., Takahashi, Y., Murakami, S., Wani, K., Miyazaki, T., Matsumoto, Y., … & Ishihara, T.
(2022). Behavioural Neurology, 2022.

The prevention of home-cage grid climbing affects muscle strength in mice.
Ueno, H., Takahashi, Y., Murakami, S., Wani, K., Miyazaki, T., Matsumoto, Y., … & Ishihara, T.
(2022). Scientific Reports, 12(1), 1-14.

Other

2023

Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.
Shoji, H., Ikeda, K., & Miyakawa, T.
(2023). Molecular Brain, 16(1), 1-24.

2022

Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.
Nagashima, T., Tohyama, S., Mikami, K., Nagase, M., Morishima, M., Kasai, A., … & Watabe, A. M.
(2022). Nature Communications, 13(1), 1-17.

Curcumin improves D-galactose and normal-aging associated memory impairment in mice: In vivo and in silico-based studies.
Rahman, M. A., Shuvo, A. A., Bepari, A. K., Hasan Apu, M., Shill, M. C., Hossain, M., … & Reza, H. M.
(2022).Plos one, 17(6), e0270123.

Hippocampal 7a-Hydroxylated Neurosteroids Are Raised by Training and Bolster Remote Spatial Memory with Increase of the Spine Densities.
Maehata, K., Shimizu, K., Ikeno, T., Pan, Y., Takao, T., & Fukada, Y.
(2022). iScience 23, 101559

Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum.
Komatsu, A., Iida, I., Nasu, Y., Ito, G., Harada, F., Kishikawa, S., … & Terunuma, M.
(2022). Journal of Biological Chemistry, 101933.

Loss of calsyntenin paralogs disrupts interneuron stability and mouse behavior.
Mori, K., Koebis, M., Nakao, K., Kobayashi, S., Kiyama, Y., Watanabe, M., … & Aiba, A.
(2022). Molecular Brain, 15(1), 1-16.

2021

Human Cerebral Organoid Implantation Alleviated the Neurological Deficits of Traumatic Brain Injury in Mice.
Bao, Z., Fang, K., Miao, Z., Li, C., Yang, C., Yu, Q., … & Ji, J.
(2021). Oxidative Medicine and Cellular Longevity, 2021.

Low-intensity pulsed ultrasound therapy promotes recovery from stroke by enhancing angio-neurogenesis in mice in vivo.
Ichijo, S., Shindo, T., Eguchi, K., Monma, Y., Nakata, T., Morisue, Y., … & Shimokawa, H.
(2021). Scientific Reports, 11(1), 1-11.

Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test.
Shoji, H., & Miyakawa, T.
(2021). Molecular Brain, 14(1), 1-12.

“Anti-Stress Composition.”
Kobayashi, Y., Maehata, H., Kuhara, T., & Toyoda, A.
(2021). U.S. Patent Application No. 16/982,888.

Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease.
Yuichi, H., Shinya, K., Mikiro, N., Koichi, O., Yuka, T., & Masaaki, M.
(2021). Translational Psychiatry, 11(1).

2020

Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice.
Nakajima, K., Miranda, A., Craig, D. W., Shekhtman, T., Kmoch, S., Bleyer, A., … & Kelsoe, J. R.
(2020). Translational Psychiatry, 10(1), 1-13.

Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning.
Shirane, M., Shoji, H., Hashimoto, Y., Katagiri, H., Kobayashi, S., Manabe, T., … & Nakayama, K. I.
(2020). Molecular Brain, 13(1), 1-18.

Vasopressin escape and memory impairment in a model of chronic syndrome of inappropriate secretion of antidiuretic hormone in mice.
Kawakami, T., Fujisawa, H., Nakayama, S., Yoshino, Y., Hattori, S., Seino, Y., … & Sugimura, Y.
(2020). Endocrine Journal, EJ20-0289.

Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA B receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice.
Arima-Yoshida, F., Raveau, M., Shimohata, A., Amano, K., Fukushima, A., Watanave, M., … & Mataga, N.
(2020). Scientific Reports, 10(1), 1-15.

Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model.
Abe, Y., Ikegawa, N., Yoshida, K., Muramatsu, K., Hattori, S., Kawai, K., … & Yamamoto, T.
(2020). Acta Neuropathologica Communications, 8(1), 1-15.

Effects of dietary intake of heat-inactivated Lactobacillus gasseri CP2305 on stress-induced behavioral and molecular changes in a subchronic and mild social defeat stress mouse model.
TOYODA, A., KAWASE, T., & TSUKAHARA, T.
(2020). Biomedical Research, 41(2), 101-111.

Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.
Takeuchi, H., Imamura, K., Ji, B., Tsukita, K., Enami, T., Takao, K., … & Inoue, M.
(2020). npj Vaccines, 5(1), 1-11.

Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances.
Matsuda, Y., Ozawa, N., Shinozaki, T., Wakabayashi, K. I., Suzuki, K., Kawano, Y., … & Tatebayashi, Y.
(2020). bioRxiv.

2019

TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility.
Andoh, C., Nishitani, N., Hashimoto, E., Nagai, Y., Takao, K., Miyakawa, T., … & Kaneko, S.
(2019). Brain research, 1704, 68-77.

The role of CaMKII-Tiam1 complex on learning and memory.
Kojima, H., Rosendale, M., Sugiyama, Y., Hayashi, M., Horiguchi, Y., Yoshihara, T., … & Hayashi, Y.
(2019). Neurobiology of learning and memory, 166, 107070.

Effects of chronic fentanyl administration on behavioral characteristics of mice.
Fujii, K., Koshidaka, Y., Adachi, M., & Takao, K.
(2019). Neuropsychopharmacology reports, 39(1), 17-35.

2017

Deficiency in EP4 Receptor–Associated Protein Ameliorates Abnormal Anxiety-Like Behavior and Brain Inflammation in a Mouse Model of Alzheimer Disease.
Fujikawa, R., Higuchi, S., Nakatsuji, M., Yasui, M., Ikedo, T., Nagata, M., … & Minami, M.
(2017). The American journal of pathology, 187(8), 1848-1854.

Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice.
Fujikawa, R., Higuchi, S., Ikedo, T., Nagata, M., Hayashi, K., Yang, T., … & Minami, M.
(2017). Biochemical and biophysical research communications, 486(2), 584-588.

2016

Behavioral alterations following blood-brain barrier disruption stimulated by focused ultrasound.
Yang, F. Y., Huang, S. F., & Cheng, I. H. J.
(2016). Oncotarget, 7(19), 27916.

2014

IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours.
Yasumura, M., Yoshida, T., Yamazaki, M., Abe, M., Natsume, R., Kanno, K., … & Miyakawa, T.
(2014). Scientific reports, 4, 6613.

2012

Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and-L100P mutant mice.
Shoji, H., Toyama, K., Takamiya, Y., Wakana, S., Gondo, Y., & Miyakawa, T.
(2012). BMC research notes, 5(1), 108.

2013

2011

Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice.
Yao, I., Takao, K., Miyakawa, T., Ito, S., & Setou, M.
(2011). PLoS One, 6(2).

2010

Behavioral profiles of three C57BL/6 substrains.
Matsuo, N., Takao, K., Nakanishi, K., Yamasaki, N., Tanda, K., & Miyakawa, T.
(2010). Frontiers in behavioral neuroscience, 4, 29.

2008

Microdialysis

Microdialysis Probes, Instruments and Accessories

2023

In situ continuous Dopa supply by responsive artificial enzyme for the treatment of Parkinson’s disease.
Fang, X., Yuan, M., Zhao, F., Yu, A., Lin, Q., Li, S., … & Yang, H.
(2023). Nature Communications, 14(1), 1-14.

5-HT1B receptors in the basolateral amygdaloid nucleus regulate anxiety-like behaviors through AC-PKA signal pathway in a rat model of Parkinson’s disease.
Tang, G., Guo, Y., Zhang, L., Wang, T., Li, R., Yang, J., … & Liu, J.
(2023). Behavioural Brain Research, 114488.

Mesolimbic dopamine release precedes actively sought aversive stimuli in mice.
Yawata, Y., Shikano, Y., Ogasawara, J., Makino, K., Kashima, T., Ihara, K., … & Ikegaya, Y.
(2023). Nature Communications, 14(1), 2433.

Acute and chronic actions of methylphenidate mediated through the L-DOPA receptor GPR143.
Uchimura, H., Kanai, K., Arai, M., Inoue, M., Hishimoto, A., Masukawa, D., & Goshima, Y.
(2023). Journal of Pharmacological Sciences.

Toxicity manifestations and sex differences due to MARTA olanzapine.
Hattori-Usami, N., Kaizaki-Mitsumoto, A., Ashino, T., Yamamoto, M., & Numazawa, S.
(2023). The Journal of Toxicological Sciences, 48(4), 191-202.

Rat model of attention-deficit hyperactivity disorder exhibits delayed recovery from acute incisional pain due to impaired descending noradrenergic inhibition.
Suto, T., Kato, D., Koibuchi, I., Arai, Y., Ohta, J., Hiroki, T., … & Saito, S.
(2023). Scientific Reports, 13(1), 5526.

A Candidate Gliotransmitter, L-β-Aminoisobutyrate, Contributes to Weight Gain and Metabolic Complication Induced by Atypical Antipsychotics
Fukuyama, K., Motomura, E., & Okada, M.
(2023). . Nutrients, 15(7), 1621.

Changes in Acupuncture-Induced Specific Acupoint Neurotransmitters are Possibly Related to Their Physiological Functions in Rats.
Nguyen, H. T. M., Lee, D. Y., Liu, C. H., & Hsieh, C. L.
(2023). Evidence-Based Complementary and Alternative Medicine, 2023.

Electrochemical activities of Fe2O3-modified microelectrode for dopamine detection using fast-scan cyclic voltammetry.
Sato, N., Ohta, Y., Haruta, M., Takehara, H., Tashiro, H., Sasagawa, K., … & Ohta, J.
(2023). AIP Advances, 13(2), 025026.

Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain.
Fukuyama, K., Motomura, E., & Okada, M.
(2023). Schizophrenia, 9(1), 8.

Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice.
Tanaka, K., Kondo, T., Narita, M., Muta, T., Yoshida, S., Sato, D., … & Narita, M.
(2023). Molecular Brain, 16(1), 1-11.

Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus.
Yoshida, S., Hamada, Y., Narita, M., Sato, D., Tanaka, K., Mori, T., … & Narita, M.
(2023). Molecular Brain, 16(1), 1-11.

Highly selective transgene expression through the flip-excision switch system by using a unilateral spacer sequence.
Matsushita, N., Kato, S., Nishizawa, K., Sugawara, M., Takeuchi, K., Miyasaka, Y., … & Kobayashi, K.
(2023). Cell Reports Methods, 100393.

Modulation of trigeminal neuropathic pain by optogenetic inhibition of posterior hypothalamus in CCI-ION rat.
Islam, J., Kc, E., So, K. H., Kim, S., Kim, H. K., Park, Y. Y., & Park, Y. S.
(2023). Scientific Reports, 13(1), 1-14.

Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle.
Natsubori, A., Hirai, S., Kwon, S., Ono, D., Deng, F., Wan, J., … & Honda, M.
(2023). iScience, 105830.

Altered Pharmacological Efficacy of Phenobarbital with the Treatment of 7, 8-Dihydroxyflavone, an Agonist of Tropomyosin Receptor Kinase B, in Rats.
Suzuki, K., Matsumoto, K., Takenaka, M., & Aiba, T.
(2023). Biological and Pharmaceutical Bulletin, 46(1), 86-94.

2022

Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion.
Kawai, H., Bouchekioua, Y., Nishitani, N., Niitani, K., Izumi, S., Morishita, H., … & Kaneko, S.
(2022). Nature Communications, 13(1), 1-22.

Kamishoyosan Alleviates Anxiety-like Behavior in a Premenstrual Syndrome Rat Model.
Iba-Tanaka, H., Watanabe, T., Harada, K., Kubota, K., Katsurabayashi, S., & Iwasaki, K.
(2022). Evidence-Based Complementary and Alternative Medicine, 2022.

Pro-cognitive effects of the GlyT1 inhibitor Bitopertin in rodents.
Deiana, S., Hauber, W., Munster, A., Sommer, S., Ferger, B., Marti, A., … & Rosenbrock, H.
(2022). European Journal of Pharmacology, 175306.

Rubiscolin‑6 rapidly suppresses the postprandial motility of the gastric antrum and subsequently increases food intake via δ‑opioid receptors in mice.
Ataka, K., Asakawa, A., & Kato, I.
(2022). Molecular Medicine Reports, 26(5), 1-6.

Differential pharmacological and sex-specific effects of antimuscarinic agents at the hypoglossal motor nucleus in vivo in rats.
Niakani, S., Liu, H., Liu, W. Y., & Horner, R. L.
(2022). Scientific Reports, 12(1), 1-25.

High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain.
Hisaoka-Nakashima, K., Ohata, K., Yoshimoto, N., Tokuda, S., Yoshii, N., Nakamura, Y., … & Morioka, N.
(2022). Experimental Neurology, 114146.

TMEM16A blockers T16Ainh‐A01 and benzbromarone do not modulate the regulation of sweating and cutaneous vasodilatation in humans in vivo.
Fujii, N., Amano, T., Kenny, G. P., Mündel, T., Lei, T. H., Honda, Y., … & Nishiyasu, T.
(2022). Experimental Physiology.

Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy.
Hashimoto, Y., Kuniishi, H., Sakai, K., Fukushima, Y., Du, X., Yamashiro, K., … & Aoki, Y.
(2022). Progress in Neurobiology, 102288.

Effects of Lisdexamfetamine, a Prodrug of D-Amphetamine, on Locomotion, Spatial Cognitive Processing and Neurochemical Profiles in Rats: A Comparison With Immediate-Release Amphetamine.
Jian-Min, C., Zhi-Yuan, W., Shi-Xuan, W., Rui, S., Ning, W., & Jin, L.
(2022). Frontiers in Psychiatry, 13.

Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia.
Hasegawa, T., Chiken, S., Kobayashi, K., & Nambu, A.
(2022). Nature Communications, 13(1), 1-15.

Depolarization time and extracellular glutamate levels aggravate ultra-early brain injury after subarachnoid hemorrhage.
Murai, S., Hishikawa, T., Takeda, Y., Okura, Y., Fushimi, M., Kawase, H., … & Date, I.
(2022). Research Square In Review Scientific Reports

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.
Niu, M., Kasai, A., Tanuma, M., Seiriki, K., Igarashi, H., Kuwaki, T., … & Hashimoto, H.
(2022). Science Advances, 8(11), eabi6375.

Toxicokinetic evaluation during intoxication of psychotropic drugs using brain microdialysis in mice.
Inoue, Y., Kaizaki-Mitsumoto, A., & Numazawa, S.
(2022). The Journal of Toxicological Sciences, 47(3), 99-108.

Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice.
Kawaminami, A., Yamada, D., Yanagisawa, S., Shirakata, M., Iio, K., Nagase, H., & Saitoh, A.
(2022). Frontiers in Behavioral Neuroscience.

Glucose infusion suppresses acute restraint stress-induced peripheral and central sympathetic responses in rats.
Yamaguchi, N., Kakinuma, Y., Yakura, T., Naito, M., & Okada, S.
(2022). Autonomic Neuroscience, 102957.

The efficacy of duloxetine depends on spinal cholinergic plasticity in neuropathic pain model rats.
Kato, D., Suto, T., Obata, H., & Saito, S.
(2022). IBRO Neuroscience Reports.

Phasic firing of dopaminergic neurons in the ventral tegmental area triggers peripheral immune responses.
Kayama, T., Ikegaya, Y., & Sasaki, T.
(2022). Scientific Reports, 12(1), 1-9.

Investigating the Influence of GABA Neurons on Dopamine Neurons in the Ventral Tegmental Area Using Optogenetic Techniques.
Ohta, Y., Murakami, T. E., Kawahara, M., Haruta, M., Takehara, H., Tashiro, H., … & Akay, Y. M.
(2022). International Journal of Molecular Sciences, 23(3), 1114.

Oral acetaminophen-induced spinal 5-hydroxytriyptamine release produces analgesic effects in the rat formalin test.
Nakamura, S., Nonaka, T., Komatsu, S., Yamada, T., & Yamamoto, T.
(2022). Biomedicine & Pharmacotherapy, 146, 112578.

Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson’s disease.
Sato, F., Nakamura, Y., Ma, S., Kochi, T., Hisaoka-Nakashima, K., Wang, D., … & Morioka, N.
(2022). Biomedicine & Pharmacotherapy, 145, 112479.

2021

Optogenetic stimulus-triggered acquisition of seizure resistance
Shimoda, Y., Beppu, K., Ikoma, Y., Morizawa, Y. M., Zuguchi, S., Hino, U., … & Matsui, K.
(2021). . Neurobiology of Disease, 105602.

The abuse potential of prolintane in rodents: Behavioral pharmacology approaches.
Lee, W., Lee, J. W., Kim, J. M., Hong, Y. K., Kim, M. S., Choi, S. O., & Kang, M. S.
(2021). Neuropharmacology, 108917.

Characterization and Relative Efficacy of Muscarinic Receptor Antagonism at the Hypoglossal Motor Nucleus to Block Inhibition of Tongue Motor Activity.
Niakani, S.
(2021). (Doctoral dissertation)

Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine.
Hashimoto, K., Yamawaki, Y., Yamaoka, K., Yoshida, T., Okada, K., Tan, W., … & Yamawaki, S.
(2021). Brain Communications.

Isoproterenol injected into the basolateral amygdala rescues amyloid β1-42-induced conditioned fear memory deficit via reducing intracellular Zn2+ toxicity.
Ishikawa, Y., Itoh, R., Tsujimoto, R., Tamano, H., & Takeda, A.
(2021). Neuroscience Letters, 136353.

Reduction of acetylcholine in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
Kondo-Takuma, Y., Mizuno, M., Tsuda, Y., Madokoro, Y., Suzuki, K., Sato, T., … & Matsukawa, N.
(2021). Scientific Reports, 11(1), 1-9.

Effect of P-glycoprotein Inhibition on the Penetration of Ceftriaxone Across the Blood–Brain Barrier.
Shan, Y., Cen, Y., Zhang, Y., Tan, R., Zhao, J., Nie, Z., … & Yu, S.
(2021). Neurochemical Research, 1-10.

Pharmacogenetic excitation of the median raphe region affects social and depressive-like behavior and core body temperature in male mice.
Fazekas, C. L., Bellardie, M., Török, B., Sipos, E., Tóth, B., Baranyi, M., … & Zelena, D.
(2021). Life Sciences, 120037.

Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats.
WAKABAYASHI, Y., OKAMURA, H., & YAMAMURA, T.
(2021). Journal of Reproduction and Development.

Participation of the descending noradrenergic inhibitory system in the anti-hyperalgesic effect of acetaminophen in a rat model of inflammation.
Juri, T., Fujimoto, Y., Suehiro, K., Nishikawa, K., & Mori, T.
(2021). Life Sciences, 120030.

Paraquat-induced intracellular Zn2+ dysregulation causes dopaminergic degeneration in the substantia nigra, but not in the striatum.Tamura, H., Nishio, R., Saeki, N., Katahira, M., Morioka, H., Tamano, H., & Takeda, A.
2021). Research Square

Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss.
Zhu, Y., Wang, R., Fan, Z., Luo, D., Cai, G., Li, X., … & Wu, S.
(2021). Research Square.

FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice.
Sadamura, Y., Thapa, S., Mizunuma, R., Kambe, Y., Hirasawa, A., Nakamoto, K., … & Kurihara, T.
(2021). Front. Pharmacol. 12: 699026. doi: 10.3389/fphar. 2021.699026. Frontiers in Pharmacology| www. frontiersin. org, 12.

Methods for Intratumoral Microdialysis Probe Targeting and Validation in Murine Brain Tumor Models.
Rajani, K., Olson, I., Jacobs, J. J., Riviere-cazaux, C., Burns, K., Carlstrom, L., … & Burns, T. C.
(2021). Journal of Neuroscience Methods, 109321.

Specific gene expression in unmyelinated dorsal root ganglion neurons in nonhuman primates by intra-nerve injection of adeno-associated virus 6 vector.
Kudo, M., Wupuer, S., Fujiwara, M., Saito, Y., Kubota, S., Inoue, K. I., … & Seki, K.
(2021). Molecular Therapy-Methods & Clinical Development.

Regulation of maternal care by corticotropin-releasing factor receptors in the dorsal raphe nucleus in mice.
Kijima, T., Muroi, Y., & Ishii, T.
(2021). Behavioral Neuroscience, 135(3), 359.

Preventive effect of Ninjin-yoei-to, a Kampo medicine, on amyloid β1-42-induced neurodegeneration via intracellular Zn2+ toxicity in the dentate gyrus.
TAMANO, H., TOKORO, H., MURAKAMI, D., FURUHATA, R., NAKAJIMA, S., SAEKI, N., … & TAKEDA, A.
(2021). Experimental Animals, 21-0044.

Intracellular Hydrogen Peroxide Produced by 6-Hydroxydopamine is a Trigger for Nigral Dopaminergic Degeneration Via Rapid Influx of Extracellular Zn2+.
Nishio, R., Morioka, H., Takeuchi, A., Saeki, N., Furuhata, R., Chinenn, T., … & Takeda, A.
(2021).

Deep Brain Stimulation Using Animal Models of Parkinson’s Disease. In Experimental Models of Parkinson’s Disease (pp. 151-160).
Nakajima, A., & Shimo, Y.
(2021). Humana, New York, NY.

Astrocytes in the rostral ventromedial medulla contribute to the maintenance of orofacial hyperalgesia induced by late removal of dental occlusal interference.
Mo, S. Y., Bai, S. S., Xu, X. X., Liu, Y., Fu, K. Y., Sessle, B. J., … & Xie, Q. F.
(2021). Journal of Oral Rehabilitation.

Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model.
Elina, K. C., Oh, B. H., Islam, J., Kim, S., & Park, Y. S.
(2021). The Journal of Headache and Pain, 22(1), 1-14.

Lesions of the lateral habenula produce anxiolytic effects in a rat model of Parkinson’s disease.
Du, C. X., Guo, Y., & Liu, J.
(2021). Neurological Research, 1-8.

A Novel Chronic Dural Port Platform for Continuous Collection of Large Volumes of Cerebrospinal Fluid and Intrathecal Drug Delivery in Free-Moving Mice.
Nakajima, T., Takeda, S., Ito, Y., Oyama, A., Takami, Y., Takeya, Y., … & Morishita, R.
(2021).

β-adrenergic Receptor Activity in the Hippocampal Dentate Gyrus Participates in Spatial Learning and Memory Impairment in Sleep-deprived Rats.
Lu, H. J.
(2021). Experimental Neurobiology, 30(2), 144-154.

Period1 gene expression in the olfactory bulb and liver of freely moving streptozotocin-treated diabetic mouse.
Kanou, H., Nagasawa, K., Ishii, Y., Chishima, A., Hayashi, J., Haga, S., … & Hamada, T.
(2021). Biochemical and Biophysical Research Communications, 560, 14-20.

Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment.
Toriumi, K., Miyashita, M., Suzuki, K., Yamasaki, N., Yasumura, M., Horiuchi, Y., … & Arai, M.
(2021). Translational Psychiatry, 11(1), 1-11.

Effects of Inhaled Linalool on Anxiety Related Behaviors and Frontal Cortical Serotonin Levels in Mice.
KAWAGUCHI, T., GOTOH, L., TAGUCHI, M., OGUSHI, Y., HATANAKA, A., IIDA, H., & KAWASAKI, H.
(2021). Med. Bull. Fukuoka Univ: 48 (1), 31-38

Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia.
Sotoyama, H., Namba, H., Kobayashi, Y., Hasegawa, T., Watanabe, D., Nakatsukasa, E., … & Nawa, H.
(2021). Translational Psychiatry, 11(1), 1-11.

In Vivo Monitoring of Acetylcholine Release from Nerve Endings in Salivary Gland.
Yoshikawa, M., & Kawaguchi, M.
(2021). Biology, 10(5), 351

Striatal TRPV1 activation by acetaminophen ameliorates dopamine D 2 receptor antagonists-induced orofacial dyskinesia.
Nagaoka, K., Nagashima, T., Asaoka, N., Yamamoto, H., Toda, C., Kayanuma, G., … & Kaneko, S.
(2021). JCI insight.

Monitoring Neuronal Dynamics in the Ventral Tegmental Area Using an Implantable Microimaging Device With Microdialysis System.
Sunaga, Y., Ohta, Y., Murakami, T. E., Akay, Y. M., Ohta, J., & Akay, M.
(2021). IEEE Access, 9, 55871-55878.

Ferulic acid alleviates abnormal behaviors in isolation-reared mice via 5-HT 1A receptor partial agonist activity.
Araki, R., Yasubuchi, A., Ikegaya, M., Hojo, C., Tachioka, H., Kawai, K., … & Yabe, T.
(2021). Psychopharmacology, 1-8.

Dehydroeffusol Pprevents Amyloid β 1-42-mediated Hippocampal Neurodegeneration via Reducing Intracellular Zn 2+ Toxicity.
Tamano, H., Takiguchi, M., Saeki, N., Katahira, M., Shioya, A., Tanaka, Y., … & Takeda, A.
(2021). Molecular Neurobiology, 1-11.

Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target.
Okada, T., Kato, D., Nomura, Y., Obata, N., Quan, X., Morinaga, A., … & Wake, H.
(2021). Science Advances, 7(12), eabd8261.

Mitochondrial toxins potentiate hydroxyl radical production in rat striatum during carbon monoxide poisoning.
Kuriiwa, F., Kobayashi, M., Mizukami, H., & Hara, S.
(2021). Journal of Pharmacological Sciences.

Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression.
Kinoshita, C., Kikuchi-Utsumi, K., Aoyama, K., Suzuki, R., Okamoto, Y., Matsumura, N., … & Nakaki, T.
(2021). Communications Biology, 4(1), 1-12.

Dual actions of 5‐MeO‐DIPT at the serotonin transporter and serotonin 5‐HT1A receptor in the mouse striatum and prefrontal cortex.
Hagino, Y., Hall, F. S., Uhl, G. R., Sora, I., & Ikeda, K.
(2021). Neuropsychopharmacology Reports.

Effects of Subchronic Administrations of Vortioxetine, Lurasidone, and Escitalopram on Thalamocortical Glutamatergic Transmission Associated with Serotonin 5-HT7 Receptor.
Okada, M., Matsumoto, R., Yamamoto, Y., & Fukuyama, K.
(2021). International Journal of Molecular Sciences, 22(3), 1351.

Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis.
Chang, H. Y., Wu, S., Li, Y., Zhang, W., Burrell, M., Webster, C. I., & Shah, D. K.
(2021, January). In mAbs (Vol. 13, No. 1, p. 1874121). Taylor & Francis.

Antagonism for NPY signaling reverses cognitive behavior defects induced by activity-based anorexia in mice.
Rokot, N. T., Ataka, K., Iwai, H., Suzuki, H., Tachibe, H., Kairupan, T. S., … & Asakawa, A.
(2021). Psychoneuroendocrinology, 105133.

Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors.
Matsuo, T., Isosaka, T., Tang, L., Soga, T., Kobayakawa, R., & Kobayakawa, K.
(2021). Communications Biology, 4(1), 1-17.

Toxicokinetic characteristics and effects of diphenylarsinic acid on dopamine in the striatum of free-moving mice.
Umezu, T., & Shibata, Y.
(2021). NeuroToxicology.

Age-related vulnerability to nigral dopaminergic degeneration in rats via Zn2+-permeable GluR2-lacking AMPA receptor activation.
Nakajima, S., Saeki, N., Tamano, H., Nishio, R., Katahira, M., Takeuchi, A., & Takeda, A.
(2021). NeuroToxicology.

A potential defense mechanism against amyloid deposition in cerebellum.
Shahnur, A., Nakano, M., Ishihara, S., Kakuda, N., Miyasaka, T., Uchiyama, H., … & Nishimura, M.
(2021). Biochemical and Biophysical Research Communications, 535, 25-32.

2020

Role of Oral Sensory and Serotonergic Neurons in Dopamine-induced Tongue Movement in Rat.
HARADA, T., IIDA, S., INADA, Y., TANAKA, S., HAMADA, Y., & KOGO, M.
(2020). Nano Biomedicine, 12(2), 53-60.

A potential defense mechanism against amyloid deposition in cerebellum.
Shahnur, A., Nakano, M., Ishihara, S., Kakuda, N., Miyasaka, T., Uchiyama, H., … & Nishimura, M. Biochemical and Biophysical Research Communications, 535, 25-32.

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques.
Hashimoto, T., Fujii, D., Naka, Y., Kashiwagi-Hakozaki, M., Matsuo, Y., Matsuura, Y., … & Iwatsubo, T.
(2020). Acta Neuropathologica Communications, 8(1), 1-18.

Increased penetration of diphenhydramine in brain via proton-coupled organic cation antiporter in rats with lipopolysaccharide-induced inflammation.
Kawase, A., Chuma, T., Irie, K., Kazaoka, A., Kakuno, A., Matsuda, N., … & Iwaki, M.
(2020). Brain, Behavior, & Immunity-Health, 100188.

Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway.
Lin, Y. H., Yamahashi, Y., Kuroda, K., Faruk, M. O., Zhang, X., Yamada, K., … & Kaibuchi, K.
(2020). Neurochemistry International, 104935.

Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction.
Kellis, D. M., Kaigler, K. F., Witherspoon, E., Fadel, J. R., & Wilson, M. A.
(2020). Neurobiology of Stress, 100279.

G-protein Signaling Regulating Opioid-induced Respiratory Rate Depression (Doctoral dissertation).
Danaf, J. (2020).

Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards.
Miyazaki, K., Miyazaki, K. W., Sivori, G., Yamanaka, A., Tanaka, K. F., & Doya, K.
(2020). Science Advances, 6(48), eabc7246.

Gαq protein signaling in the bed nucleus of the stria terminalis regulate the lipopolysaccharide-induced despair-like behavior in mice.
Fukuwada, N., Kanno, M., Yoshida, S., & Seki, K.
(2020). AIMS Neuroscience, 7(4): 438–458.

Simultaneous blood and brain microdialysis in a free-moving mouse to test blood-brain barrier permeability of chemicals.
Umezu, T., Sano, T., Hayashi, J., & Shibata, Y.
(2020). Toxicology Reports.

Mice Carrying a Schizophrenia-associated Mutation of the Arhgap10 Gene Are Vulnerable to the Effects of Methamphetamine Treatment on Cognitive Function: Association With Morphological Abnormalities in Striatal Neurons.
Hada, K., Wulaer, B., Nagai, T., Itoh, N., Sawahata, M., Sobue, A., … & Ozaki, N.
(2020).

Glutathione Peroxidase-1 Knockout Facilitates Memory Impairment Induced by β-Amyloid (1–42) in Mice via Inhibition of PKC βII-Mediated ERK Signaling; Application with Glutathione Peroxidase-1 Gene-Encoded Adenovirus Vector.
Shin, E. J., Chung, Y. H., Sharma, N., Nguyen, B. T., Lee, S. H., Kang, S. W., … & Kim, H. C.
(2020). Neurochemical Research, 1-12.

α2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline.
Kawashita, E., Ishihara, K., Miyaji, H., Tanishima, Y., Kiriyama, A., Matsuo, O., & Akiba, S.
(2020). Molecular Brain, 13(1), 1-14.

Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice.
Kawaguchi, C., Shintani, N., Hayata-Takano, A., Hatanaka, M., Kuromi, A., Nakamura, R., … & Sugimoto, Y.
(2020). Communications Biology, 3(1), 1-13.

Dissecting the tectal output channels for orienting and defense responses.
Isa, K., Sooksawate, T., Kobayashi, K., Kobayashi, K., Redgrave, P., & Isa, T.
(2020). eNeuro.

Noradrenaline enhances the excitatory effects of dopamine on medial prefrontal cortex pyramidal neurons in rats.
Shinohara, F., Arakaki, S., Amano, T., Minami, M., & Kaneda, K.
(2020). Neuropsychopharmacology Reports.

Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure.
Yamaguchi, T., Sumida, T. S., Nomura, S., Satoh, M., Higo, T., Ito, M., … & Yoshimi, K.
(2020). Nature Communications, 11(1), 1-8.

Effects of the Endocannabinoid Anandamide on the Efficiency of Noradrenergic Neurotransmission in the Amygdaloid Body in Acute Stress in Mice.
Anderzhanova, E. E., Kudrin, V. S., & Wotjak, S. T.
(2020). Neuroscience and Behavioral Physiology, 1-6.

Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice.
Sakayori, N., Katakura, M., Hamazaki, K., Higuchi, O., Fujii, K., Fukabori, R., … & Arita, M.
(2020). Communications Biology, 3(1), 1-13.

Immobility-reducing Effects of Ketamine during the Forced Swim Test on 5-HT1A Receptor Activity in the Medial Prefrontal Cortex in an Intractable Depression Model.
Takahashi, K., Kitamura, Y., Ushio, S., & Sendo, T.
(2020). Acta Medica Okayama, 74(4), 301-306.

Absence of methamphetamine‐induced conditioned place preference in weaver mutant mice.
Ikekubo, Y., Ide, S., Hagino, Y., & Ikeda, K.
(2020). Neuropsychopharmacology Reports.

Modulation of TASK-1/3 Channels at the Hypoglossal Motoneuron Pool and Effects on Tongue Motor Output and Responses to Excitatory Inputs In-Vivo: Implications for Strategies for Obstructive Sleep Apnea Pharmacotherapy.
Gurges, P., Liu, H., & Horner, R. L.
(2020). Sleep.

Enhancement of the rewarding effects of 3, 4-methylenedioxymethamphetamine in orexin knockout mice.
Mori, T., Uzawa, N., Masukawa, D., Hirayama, S., Iwase, Y., Hokazono, M., … & Suzuki, T.
(2020). Behavioural Brain Research, 112802.

Effects of adipokine administration to the hypothalamic preoptic area on body temperature in rats.
Tsushima, H., & Yamada, K.
(2020). Journal of Pharmacological Sciences.

Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer’s disease model by increasing the expression of microRNA-146a in hippocampus.
Nakano, M., Kubota, K., Kobayashi, E., Chikenji, T. S., Saito, Y., Konari, N., & Fujimiya, M.
(2020). Scientific Reports, 10(1), 1-15.

Astrocytic histone deacetylase 2 facilitates delayed depression and memory impairment after subarachnoid hemorrhage by negatively regulating glutamate transporter-1.
Tao, K., Cai, Q., Zhang, X., Zhu, L., Liu, Z., Li, F., … & Feng, D.
(2020). Annals of Translational Medicine, 8(11).

Interaction between Mesocortical and Mesothalamic Catecholaminergic Transmissions Associated with NMDA Receptor in the Locus Coeruleus.
Okada, M., & Fukuyama, K.
(2020). Biomolecules, 10(7), 990.

Opposing Ventral Striatal Medium Spiny Neuron Activities Shaped by Striatal Parvalbumin-Expressing Interneurons during Goal-Directed Behaviors.
Yoshida, K., Tsutsui-Kimura, I., Kono, A., Yamanaka, A., Kobayashi, K., Watanabe, M., … & Tanaka, K. F.
(2020). Cell Reports, 31(13), 107829.

Dopaminergic loss of cyclin-dependent kinase-like 5 recapitulates methylphenidate-remediable hyperlocomotion in mouse model of CDKL5 deficiency disorder.
Jhang, C. L., Lee, H. Y., Chen, J., & Liao, W.
(2020). Human Molecular Genetics.

GABA storage and release in the medial globus pallidus in L-DOPA-induced dyskinesia priming.
Nishijima, H., Mori, F., Arai, A., Zhu, G., Wakabayashi, K., Okada, M., … & Tomiyama, M.
(2020). Neurobiology of Disease, 104979.

The antagonistic activity profile of naloxone in μ-opioid receptor agonist-induced psychological dependence.
Nakamura, A., Yasufuku, K., Shimada, S., Aritomi, H., Furue, Y., Chiba, H., … & Shimada, T.
(2020). Neuroscience Letters, 135177.

Okamoto, K., Kawamura, S., Tagawa, M., Mizuta, T., Zahid, H. M., & Nabika, T. Production of an antihypertensive peptide from milk by the brown rot fungus Neolentinus lepideus.
(2020). Eur Food Res Technol

Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels.
Fukuyama, K., Ueda, Y., & Okada, M.
(2020). Pharmaceuticals, 13(6), 117.

Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors.
Nakamura, Y., Fukushige, R., Watanabe, K., Kishida, Y., Hisaoka-Nakashima, K., Nakata, Y., & Morioka, N.
(2020). Behavioural Brain Research, 112714.

Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord.
Chae, J. W., Kang, D. H., Li, Y., Kim, S. H., Lee, H. G., Choi, J. I., … & Kim, W. M.
(2020). Neuroscience Letters, 135057.

Upregulated and Hyperactivated Thalamic Connexin 43 Plays Important Roles in Pathomechanisms of Cognitive Impairment and Seizure of Autosomal Dominant Sleep-Related Hypermotor Epilepsy with S284L-Mutant α4 Subunit of Nicotinic ACh Receptor.
Fukuyama, K., Fukuzawa, M., & Okada, M.
(2020). Pharmaceuticals, 13(5), 99.

Stress induces insertion of calcium-permeable AMPA receptors in the OFC–BLA synapse and modulates emotional behaviours in mice.
Kuniishi, H., Yamada, D., Wada, K., Yamada, M., & Sekiguchi, M.
(2020). Translational Psychiatry, 10(1), 1-11.

Pathomechanism of nocturnal paroxysmal dystonia in autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant α4 subunit of nicotinic ACh receptor.
Fukuyama, K., Fukuzawa, M., Shiroyama, T., & Okada, M.
(2020). Biomedicine & Pharmacotherapy, 126, 110070.

Hispidulin attenuates the social withdrawal in isolated disrupted‐in‐schizophrenia‐1 mutant and chronic phencyclidine‐treated mice.
Mouri, A., Lee, H. J., Mamiya, T., Aoyama, Y., Matsumoto, Y., Kubota, H., … & Nabeshima, T.
(2020). British Journal of Pharmacology.

Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain.
Tanuma, M., Kasai, A., Bando, K., Kotoku, N., Harada, K., Minoshima, M., … & Seiriki, K.
(2020). JCI insight.

LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP.
Tan, Y., Xu, Y., Cheng, C., Zheng, C., Zeng, W., Wang, J., … & Nie, S.
(2020). Frontiers in Pharmacology, 11, 183.

Thromboxane A2 in the paraventricular hypothalamic nucleus mediates glucoprivation-induced adrenomedullary outflow.
Tachi, M., Yamaguchi, N., & Okada, S.
(2020). European Journal of Pharmacology, 173034.

“SIALYLATION-INCREASING THERAPIES FOR DISEASES ASSOCIATED WITH OXIDATIVE STRESS.”
Huizing, M., Malicdan, M. C., & Carrillo, N.
(2020). U.S. Patent Application No. 16/655,004.

Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning.
Hara, S., Kobayashi, M., Kuriiwa, F., Mizukami, H., & Mukai, T.
(2020). Scientific Reports, 10(1), 1-10.

Microglial depletion under thalamic hemorrhage ameliorates mechanical allodynia and suppresses aberrant axonal sprouting.
Hiraga, S. I., Itokazu, T., Hoshiko, M., Takaya, H., Nishibe, M., & Yamashita, T.
(2020). JCI Insight, 5(3).

Kv7. 2 subunit-containing M-type potassium channels in the lateral habenula are involved in the regulation of working memory in parkinsonian rats.
Bian, G., Liu, J., Guo, Y., Yang, Y., Li, L., Qiao, H., … & Zhang, Q.
(2020). Neuropharmacology, 108012.

The Intravitreal Injection of Lanosterol Nanoparticles Rescues Lens Structure Collapse at an Early Stage in Shumiya Cataract Rats.
Nagai, N., Fukuoka, Y., Sato, K., Otake, H., Taga, A., Oka, M., … & Yamamoto, N.
(2020). International Journal of Molecular Sciences, 21(3), 1048.

Radiation Induced Metabolic Alterations Associate with Tumor Aggressiveness and Poor Outcome in Glioblastoma.
Gupta, K., Vuckovic, I., Zhang, S., Xiong, Y., Carlson, B. L., Jacobs, J., … & Burns, T.
(2020). bioRxiv.

An ultra-stable cytoplasmic antibody engineered for in vivo applications.
Kabayama, H., Takeuchi, M., Tokushige, N., Muramatsu, S. I., Kabayama, M., Fukuda, M., … & Mikoshiba, K.
(2020). Nature Communications, 11(1), 1-20.

Activation of mGluR5 and NMDA Receptor Pathways in the Rostral Ventrolateral Medulla as a Central Mechanism for Methamphetamine-Induced Pressor Effect in Rats.
Lai, C. C., Fang, C., Kuo, C. Y., Wu, Y. W., & Lin, H. H.
(2020). Biomolecules, 10(1), 149.

Pathogenesis and pathophysiology of autosomal dominant sleep‐related hypermotor epilepsy with S284L‐mutant α4 subunit of nicotinic ACh receptor.
Fukuyama, K., Fukuzawa, M., Shiroyama, T., & Okada, M.
(2020). British Journal of Pharmacology.

2019

Optimization and validation of online column-switching assisted HPLC-spectrometric method for quantification of dansylated endocannabinoids and neurotransmitters in animal models of brain diseases.
Baranyi, M., & Sperlagh, B.
(2019). Open J Anal Bioanal Chem, 3(1), 083-093.

Sex Differences in the Behavioral and Neuromolecular Effects of the Rapid-Acting Antidepressant Drug Ketamine in Mice
Thelen, C.
(2019). (Doctoral dissertation, University of Dayton).

5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism.
Ago, Y., Tanabe, W., Higuchi, M., Tsukada, S., Tanaka, T., Yamaguchi, T., … & Nakazawa, T.
(2019). International Journal of Neuropsychopharmacology, 22(10), 665-674.

Effects of Edaravone on Nitric Oxide, Hydroxyl Radicals and Neuronal Nitric Oxide Synthase During Cerebral Ischemia and Reperfusion in Mice.
Kawasaki, H., Ito, Y., Kitabayashi, C., Tanaka, A., Nishioka, R., Yamazato, M., … & Yamamoto, T.
(2019). Journal of Stroke and Cerebrovascular Diseases, 104531.

To be or not to be pink(1): contradictory findings in an animal model for Parkinson’s disease.
de Haas, R., Heltzel, L. C., Tax, D., van den Broek, P., Steenbreker, H., Verheij, M. M., … & Smeitink, J. A.
(2019). Brain communications, 1(1), fcz016.

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.
Haruwaka, K., Ikegami, A., Tachibana, Y., Ohno, N., Konishi, H., Hashimoto, A., … & Moorhouse, A. J.
(2019). Nature Communications, 10(1), 1-17.

Preferential Neurodegeneration in the Dentate Gyrus by Amyloid β 1–42-Induced Intracellular Zn 2+ Dysregulation and Its Defense Strategy.
Tamano, H., Takiguchi, M., Tanaka, Y., Murakami, T., Adlard, P. A., Bush, A. I., & Takeda, A.
(2019). Molecular Neurobiology, 1-14.

Neurogranin Regulates Alcohol Sensitivity Through AKT Pathway in the Nucleus Accumbens.
Nam, H. W., Grant, C., Jorgensen, A., Heppelmann, C. J., Trutschl, M., & Cvek, U.
(2019). Proteomics.

Studies of blood–brain barrier permeability of gastrodigenin in vitro and in vivo.
Mi, Y., Mao, Y., Cheng, H., Ke, G., Liu, M., Fang, C., & Wang, Q.
(2019). Fitoterapia, 104447.

Involvement of glutamatergic mechanisms in the median preoptic nucleus in the dipsogenic response induced by angiotensinergic activation of the subfornical organ in rats.
Ushigome, A., Momoi, K., Takahashi, M., & Tanaka, J. (2019).
Experimental Brain Research, 1-8.

Anxiety during alcohol withdrawal involves 5-HT2C receptors and M-channels in the lateral habenula.
Fu, R., Mei, Q., Shiwalkar, N., Zuo, W., Zhang, H., Gregor, D., … & Ye, J. H.
(2020). Neuropharmacology, 163, 107863.

Pharmacological Discrimination of Effects of MK801 on Thalamocortical, Mesothalamic, and Mesocortical Transmissions.
Okada, M., Fukuyama, K., Nakano, T., & Ueda, Y.
(2019). Biomolecules, 9(11), 746.

Characterization of striatal phenotypes in heterozygous Disc1 mutant mice, a model of haploinsufficiency.
Baskaran, R., Lai, C. C., Li, W. Y., Tuan, L. H., Wang, C. C., Lee, L. J. H., … & Lee, L. J.
(2019). Journal of Comparative Neurology.

Neural Circuitry of Upper Airway Respiratory Plasticity: Identifying the Neural Circuitry Underlying Long-term Facilitation of Inspiratory Genioglossus Motor Output
Lui, S. K. C. (2019). (Doctoral dissertation).

Central Transient Receptor Potential Vanilloid 4 Contributes to Systemic Water Homeostasis through Urinary Excretion.
Tsushima, H., & Mori-Kawabe, M.
(2019). Biological and Pharmaceutical Bulletin, 42(11), 1877-1882.

TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice.
Yukitake, H., Fujimoto, T., Ishikawa, T., Suzuki, A., Shimizu, Y., Rikimaru, K., … & Kimura, H.
(2019). Pharmacology Biochemistry and Behavior, 172794.

GABAergic function in the lateral hypothalamus regulates feeding behavior: Possible mediation via orexin. Yonemochi, N., Ardianto, C., Ueda, D., Kamei, J., & Ikeda, H.
(2019). Neuropsychopharmacology Reports.

Rapid alterations in neuroimmune gene expression after acute ethanol: Timecourse, sex differences and sensitivity to cranial surgery.
Gano, A., Mondello, J. E., Doremus-Fitzwater, T. L., & Deak, T.
(2019). Journal of Neuroimmunology, 577083.

Neuropeptide W, an Endogenous Ligand for Gpr7, Injected Into Rvm, Lc and Pag Increased Spinal 5ht and Dopamine.
Yamamoto, T., Nakamura, S., Yoshida, K., Nonaka, T., & Ikuta, Y.
(2019). American Society of Anesthesiologists.

The Lacto-Tetrapeptide Gly–Thr–Trp–Tyr, β-Lactolin, Improves Spatial Memory Functions via Dopamine Release and D1 Receptor Activation in the Hippocampus.
Ayabe, T., Ano, Y., Ohya, R., Kitaoka, S., & Furuyashiki, T.
(2019). Nutrients, 11(10), 2469.

Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus.
Okada, M., Fukuyama, K., Okubo, R., Shiroyama, T., & Ueda, Y.
(2019). Pharmaceuticals, 12(4), 149.

Quantification of Prostaglandin E2 Concentration in Interstitial Fluid from the Hypothalamic Region of Free-moving Mice.
Nakamura, Y., Sakaguchi, T., Tamai, I., & Nakanishi, T.
(2019). Bio-protocol 9(15): e3324. DOI:10.21769/BioProtoc.3324

Pharmacokinetic comparative study of tetramethylpyrazine and ferulic acid and their compatibility with different concentration of gastrodin and gastrodigenin on blood–stasis migraine model by blood–brain microdialysis method.
Mi, Y., Guo, S., Cheng, H., Liu, M., Wei, P., Wang, M., … & Ke, G.
(2019). Journal of Pharmaceutical and Biomedical Analysis, 112885.

Prostaglandin E2 receptor EP3 subtype in the paraventricular hypothalamic nucleus mediates corticotropin-releasing factor-induced elevation of plasma noradrenaline levels in rats.
Yamaguchi, N., Mimura, K., & Okada, S.
(2019). European Journal of Pharmacology, 172693.

TAK-915, a Phosphodiesterase 2A Inhibitor, Ameliorates the Cognitive Impairment Associated with Aging in Rodent Models.
Nakashima, M., Suzuki, N., Shiraishi, E., & Iwashita, H.
(2019). Behavioural brain research, 112192.

Dopaminergic mechanisms in the lateral hypothalamus regulate feeding behavior in association with neuropeptides.
Yonemochi, N., Ardianto, C., Yang, L., Yamamoto, S., Ueda, D., Kamei, J., … & Ikeda, H.
(2019). Biochemical and Biophysical Research Communications.

Vulnerability to depressive behavior induced by overexpression of striatal Shati/Nat8l via the serotonergic neuronal pathway in mice.
Uno, K., Miyanishi, H., Sodeyama, K., Fujiwara, T., Miyazaki, T., Muramatsu, S. I., & Nitta, A.
(2019). Behavioural Brain Research, 112227.

Tonic suppression of the mesolimbic dopaminergic system by enhanced corticotropin-releasing factor signaling within the bed nucleus of the stria terminalis in chronic pain model rats.
Takahashi, D., Asaoka, Y., Kimura, K., Hara, R., Arakaki, S., Sakasai, K., … & Minami, M.
(2019). Journal of Neuroscience, 3047-18.

Differential effects of dopamine D1‐like and D2‐like receptor agonists on water drinking behavior under thirsty conditions in mice with reduced dopamine secretion.
Kao, K. C., & Hisatsune, T.
(2019). European Journal of Neuroscience.

Optogenetic recruitment of spinal reflex pathways from large‐diameter primary afferents in non‐transgenic rats transduced with AAV9/Channelrhodopsin 2.
Kubota, S., Sidikejiang, W., Kudo, M., Inoue, K. I., Umeda, T., Takada, M., & Seki, K.
(2019). The Journal of Physiology.

Dynamic interaction between cortico-brainstem pathways during training-induced recovery in stroke model rats.
Ishida, A., Kobayashi, K., Ueda, Y., Shimizu, T., Tajiri, N., Isa, T., & Hida, H.
(2019). Journal of Neuroscience, 0649-19.

Dopamine D2L Receptor Deficiency Causes Stress Vulnerability through 5-HT1A Receptor Dysfunction in Serotonergic Neurons.
Shioda, N., Imai, Y., Yabuki, Y., Sugimoto, W., Yamaguchi, K., Wang, Y., … & Fukunaga, K.
(2019). Journal of Neuroscience, 0079-19.

Lurasidone inhibits NMDA/glutamate antagonist‐induced functional abnormality of thalamocortical glutamatergic transmission via 5‐HT7 receptor blockade.
Okada, M., Fukuyama, K., & Ueda, Y.
(2019) British Journal of Pharmacology.

NDRG2 Protects the Brain from Excitotoxicity by Facilitating Interstitial Glutamate Uptake.
Yin, A., Guo, H., Tao, L., Cai, G., Wang, Y., Yao, L., … & Zhang, J.
(2019). Translational Stroke Research, 1-14.

Type 1 equilibrative nucleoside transporter (ENT1) regulates sex‐specific ethanol drinking during disruption of circadian rhythms.
Jia, Y. F., Vadnie, C. A., Ho, A. M. C., Peyton, L., Veldic, M., Wininger, K., … & Choi, D. S.
(2019). Addiction biology, e12801.

Different roles of distinct serotonergic pathways in anxiety-like behavior, antidepressant-like, and anti-impulsive effects.
Ohmura, Y., Tsutsui-Kimura, I., Sasamori, H., Nebuka, M., Nishitani, N., Tanaka, K. F., … & Yoshioka, M.
(2019). Neuropharmacology, 107703.

Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration.
Uchida, M., Hida, H., Mori, K., Yoshimi, A., Kitagaki, S., Yamada, K., … & Noda, Y. (2019).
European Neuropsychopharmacology.

Diverse mechanisms lead to common dysfunction of striatal cholinergic interneurons in distinct genetic mouse models of dystonia.
Jaunarajs, K. L. E., Scarduzio, M., Ehrlich, M. E., McMahon, L. L., & Standaert, D. G.
(2019). Journal of Neuroscience, 0407-19.

The basolateral nucleus of the amygdala executes the parallel processes of avoidance and palatability in the retrieval of conditioned taste aversion in male rats.
Inui, T., Sugishita, T., Inui-Yamamoto, C., Yasoshima, Y., & Shimura, T.
(2019) eNeuro, ENEURO-0004.

Mechanical allodynia induced by optogenetic sensory nerve excitation activates dopamine signaling and metabolism in medial nucleus accumbens.
Sugiyama, E., Kondo, T., Kuzumaki, N., Honda, K., Yamanaka, A., Narita, M., … & Sugiura, Y.
(2019) Neurochemistry International, 104494.

Clozapine Normalizes a Glutamatergic Transmission Abnormality Induced by an Impaired NMDA Receptor in the Thalamocortical Pathway via the Activation of a Group III Metabotropic Glutamate Receptor.
Fukuyama, K., Kato, R., Murata, M., Shiroyama, T., & Okada, M.
(2019) Biomolecules, 9(6), 234.

Mild hypothermia causes a shift in the alternative splicing of cold-inducible RNA-binding protein transcripts in Syrian hamsters.
Horii, Y., Shimaoka, H., Horii, K., Shiina, T., & Shimizu, Y.
(2019). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.

Development of an in vivo retrodialysis calibration method using stable isotope labeling to monitor metabolic pathways in the tumor microenvironment via microdialysis.
Bartlett, D. W., Wu, A., Li, X., Kraus, M., Wang, H., & Kindt, E.
(2019). Journal of Pharmaceutical Sciences.

Paraquat as an Environmental Risk Factor in Parkinson’s Disease Accelerates Age-Related Degeneration Via Rapid Influx of Extracellular Zn 2+ into Nigral Dopaminergic Neurons.
Tamano, H., Nishio, R., Morioka, H., Furuhata, R., Komata, Y., & Takeda, A.
(2019). Molecular Neurobiology, 1-11.

Chemiluminescent Sensor for Hydrogen Sulfide in Rat Brain Microdialysis based on Target-Induced Horseradish Peroxidase Deactivation.
Fang, Z., Yue, G., Wang, J., Luo, F., Guo, L., Qiu, B., & Lin, Z.
(2019). Analytical Methods.

Amantadine Combines Astroglial System Xc− Activation with Glutamate/NMDA Receptor Inhibition.
Nakano, T., Hasegawa, T., Suzuki, D., Motomura, E., & Okada, M.
(2019). Biomolecules, 9(5), 191.

Hyperreflexia induced by XLR-11 smoke is caused by the pyrolytic degradant.
Hataoka, K., Kaizaki-Mitsumoto, A., Takebayashi-Ohsawa, M., Hattori, N., Funada, M., & Numazawa, S.
(2019). Forensic Toxicology, 1-12.

The Integration of Goal-Directed Signals onto Spatial Maps of Hippocampal Place Cells.
Aoki, Y., Igata, H., Ikegaya, Y., & Sasaki, T.
(2019). Cell Reports, 27(5), 1516-1527.

Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants.
Pogorelov, V. M., Kao, H. T., Augustine, G. J., & Wetsel, W. C.
(2019). International Journal of Neuropsychopharmacology.

Impaired cortico-striatal excitatory transmission triggers epilepsy.
Miyamoto, H., Tatsukawa, T., Shimohata, A., Yamagata, T., Suzuki, T., Amano, K., … & Hensch, T. K.
(2019). Nature Communications, 10(1), 1917.

Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior.
Yoshida, K., Drew, M. R., Mimura, M., & Tanaka, K. F.
(2019) Nature neuroscience, 1.

Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice.
Suzuki, H., Ataka, K., Asakawa, A., Cheng, K. C., Ushikai, M., Iwai, H., … & Yokoyama, Y.
(2019) Scientific Reports, 9(1), 6011.

A Simple and Efficient Microfluidic System for Reverse Chemical Synthesis (5′-3′) of a Short-Chain Oligonucleotide Without Inert Atmosphere.
Bhardwaj, R., Tue, P. T., Biyani, M., & Takamura, Y.
(2019) Applied Sciences, 9(7), 1357.

Inhibitory effects of Shati/Nat8l overexpression in the medial prefrontal cortex on methamphetamine‐induced conditioned place preference in mice.
Haddar, M., Uno, K., Azuma, K., Muramatsu, S. I., & Nitta, A.
(2019) Addiction Biology.

DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5.
Kondo, N., Tohnai, G., Sahashi, K., Iida, M., Kataoka, M., Nakatsuji, H., … & Shinjo, K.
(2019) EMBO Molecular Medicine, e8547.

Neonatal estrogen causes irreversible male infertility via specific suppressive action on hypothalamic Kiss1 neurons.
Minabe, S., Sato, M., Inoue, N., Watanabe, Y., Magata, F., Matsuda, F., … & Tsukamura, H.
(2019) Endocrinology.

Striatal Pre-and Postsynaptic Profile of Adenosine A. sub. 2A Receptor Antagonists.
Orru, M., Bakesová, J., Brugarolas, M., Quiroz, C., Beaumont, V., Goldberg, S. R., … & Canela, E. I.
(2019) PLoS ONE, vol. 6, no. 1, 2011, p. e16088.

Recurrent Glucose Deprivation Leads to the Preferential Use of Lactate by Neurons in the Ventromedial Hypothalamus.
Shah, M., Addison, A., Wang, P., Zhu, W., & Chan, O.
(2019) American Journal of Physiology-Endocrinology and Metabolism.

Effects of the synthetic cannabinoid 5F-AMB on anxiety and recognition memory in mice.
Ito, S., Deyama, S., Domoto, M., Zhang, T., Sasase, H., Fukao, A., … & Kaneda, K.
(2019) Psychopharmacology, 1-8.

Central neuropeptide-S treatment improves neurofunctions of 6-OHDA-induced Parkinsonian rats.
Bülbül, M., Sinen, O., Özkan, A., Aslan, M. A., & Ağar, A.
(2019) Experimental Neurology.

In Vivo Study on Mechanism Underlying Increased Pharmacological Effects of Phenobarbital in Rats with Glycerol-Induced Acute Renal Failure.
Okada, A., Suzuki, K., Hara, K., Kojina, M., & Aiba, T.
(2019) Biological and Pharmaceutical Bulletin, 42(3), 501-506.

Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight.
Bannai, T., Mano, T., Chen, X., Ohtomo, G., Ohtomo, R., Tsuchida, T., … & Tsuji, S.
(2019) Scientific Reports, 9(1), 2827.

Effects of Acute and Sub-chronic Administrations of Guanfacine on Catecholaminergic Transmissions in the Orbitofrontal Cortex.
Okada, M., Fukuyama, K., Kawano, Y., Shiroyama, T., Suzuki, D., & Ueda, Y.
(2019) Neuropharmacology.

Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis.
Bai, F., Ma, Y., Guo, H., Li, Y., Xu, F., Zhang, M., … & Xiong, L.
(2019) Evidence-Based Complementary and Alternative Medicine, 2019.

Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus.
Sakayori, N., Kato, S., Sugawara, M., Setogawa, S., Fukushima, H., Ishikawa, R., … & Kobayashi, K.
(2019) Molecular Brain, 12(1), 13.

Evaluation of Dissolution Profile between Original and Generic Products of Zolpidem Tartrate by Microdialysis-HPLC.
Inaba, K., Oie, T., Otake, H., Kotake, T., & Nagai, N.
(2019) Chemical and Pharmaceutical Bulletin, 67(2), 120-124.

GABAB receptors in the hypothalamic paraventricular nucleus mediate β-adrenoceptor-induced elevations of plasma noradrenaline in rats.
Yamaguchi, N., Mimura, K., & Okada, S.
(2019) European Journal of Pharmacology.

Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice.
Zhou, X., Oishi, Y., Cherasse, Y., Korkutata, M., Fujii, S., Lee, C. Y., & Lazarus, M.
(2019) Neurochemistry International.

Assessment of extracellular cytokines in the hippocampus of the awake behaving rat using large‐molecule microdialysis combined with multiplex arrays after acute and chronic ethanol exposure.
Gano, A., Vore, A. S., Sammakia, M., & Deak, T.
(2019) Alcoholism: Clinical and Experimental Research.

Effect of Yokukansan on Nitric Oxide Production and Hydroxyl Radical Metabolism During Cerebral Ischemia and Reperfusion in Mice.
Kitabayashi, C., Ito, Y., Kawasaki, H., Tanaka, A., Nishioka, R., Yamazato, M., … & Yamamoto, T.
(2019) Journal of Stroke and Cerebrovascular Diseases.

Proteomic analysis and ATP assay reveal a positive effect of artificial cerebral spinal fluid perfusion following microdialysis sampling on repair of probe-induced brain damage.
Ohyama, K., Ikeshita, Y., Fuchigami, Y., Kawakami, S., Nakashima, M. N., & Nakashima, M.
(2019) Journal of Neuroscience Methods.

Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc−.
Okada, M., Fukuyama, K., Kawano, Y., Shiroyama, T., & Ueda, Y.
(2019) Pharmacology Research & Perspectives, 7(1), e00457.

Iso-α-acids, the bitter components of beer, improve hippocampus-dependent memory through vagus nerve activation.
Ano, Y., Hoshi, A., Ayabe, T., Ohya, R., Uchida, S., Yamada, K., … & Furuyashiki, T.
(2019). The FASEB Journal, fj-201801868RR.

Brain Microdialysis Study of Vancomycin in the Cerebrospinal Fluid After Intracerebroventricular Administration in Mice.
Miura, Y., Fuchigami, Y., Nomura, S., Nishimura, K., Hagimori, M., & Kawakami, S.
(2019) AAPS PharmSciTech, 20(1), 5.

Theanine attenuates memory impairments induced by klotho gene depletion in mice.
Nguyen, B. T., Sharma, N., Shin, E. J., Jeong, J. H., Lee, S. H., Jang, C. G., … & Kim, H. C.
(2018) Food & Function.

2018

“Soluble high molecular weight (hmw) tau species and applications thereof.”
Hyman, B., & Takeda, S.
(2018) U.S. Patent Application No. 16/010,883.

T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.
Wang, S., Yabuki, Y., Matsuo, K., Xu, J., Izumi, H., Sakimura, K., … & Fukunaga, K.
(2018) PLOS ONE, 13(12), e0206986.

Somatostatin-somatostatin receptor 2 signaling mediates LH pulse suppression in lactating rats.
Sugimoto, A., Tsuchida, H., Ieda, N., Ikegami, K., Inoue, N., Uenoyama, Y., & Tsukamura, H.
(2018) Endocrinology.

Tropomyosin receptor kinase B receptor activation in the locus coeruleus restores impairment of endogenous analgesia at a late stage following nerve injury in rats.
Suto, T., Kato, D., Obata, H., & Saito, S.
(2018) The Journal of Pain.

Dopamine in the hippocampal dentate gyrus modulates spatial learning via D1-like receptors.
Wang, F., Wan, P., Wang, W., Xiao, B., Jin, H., & Jin, Q.
(2018) Brain research bulletin.

Propranolol prevents cerebral blood flow changes and pain-related behaviors in migraine model mice.
Kurauchi, Y., Haruta, M., Tanaka, R., Sasagawa, K., Ohta, J., Hisatsune, A., … & Katsuki, H.
(2018) Biochemical and Biophysical Research Communications.

Noradrenaline reuptake inhibition increases control of impulsive action by activating D1-like receptors in the infralimbic cortex.
Sasamori, H., Ohmura, Y., Yoshida, T., & Yoshioka, M.
(2018) European Journal of Pharmacology.

Amyloid β 1–42-Induced Rapid Zn 2+ Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia.
Tamano, H., Suzuki, H., Murakami, T., Fujii, H., Adlard, P. A., Bush, A. I., & Takeda, A.
(2018) Molecular Neurobiology, 1-10.

In vivo neurochemical evidence that stimulation of accumbal GABAA and GABAB receptors each reduce acetylcholine efflux without affecting dopamine efflux in the nucleus accumbens of freely moving rats.
Aono, Y., Watanabe, Y., Ishikawa, M., Kuboyama, N., Waddington, J. L., & Saigusa, T.
(2018) Synapse.

Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission.
Fukuyama, K., Hasegawa, T., & Okada, M.
(2018) International Journal of Molecular Sciences, 19(11), 3645.

Pharmacological characterization of (3-(benzo [d][1, 3] dioxol-4-yloxy).
Xu, X., Wei, Y., Guo, Q., Zhao, S., Liu, Z., Xiao, T., … & Wang, K.
(2018) Neuropsychopharmacology, 25, 871-880.

Astrocyte‐neuron lactate shuttle sensitizes nociceptive transmission in the spinal cord.
Miyamoto, K., Ishikura, K. I., Kume, K., & Ohsawa, M.
(2018) Glia.

Enhanced AMPA receptor-mediated excitatory transmission in the rodent rostromedial tegmental nucleus following lesion of the nigrostriatal pathway.
Chang, Y., Du, C., Han, L., Lv, S., Zhang, J., Bian, G., … & Liu, J.
(2018) Neurochemistry International.

E rythropoietin reduces nerve demyelination, neuropathic pain behavior and microglial MAPK s activation through erythropoietin receptors on S chwann cells in a rat model of peripheral neuropathy.
Huang, C. T., Chen, S. H., Lin, S. C., Chen, W. T., Lue, J. H., & Tsai, Y. J
(2018) Glia.

Blockade of Rapid Influx of Extracellular Zn 2+ into Nigral Dopaminergic Neurons Overcomes Paraquat-Induced Parkinson’s Disease in Rats.
Tamano, H., Morioka, H., Nishio, R., Takeuchi, A., & Takeda, A.
(2018) Molecular Neurobiology, 1-10.

Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve.
Ayabe, T., Ohya, R., Taniguchi, Y., Shindo, K., Kondo, K., & Ano, Y.
(2018) Scientific Reports, 8(1), 15372.

In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes.
Yamada, K.
(2018). JoVE (Journal of Visualized Experiments), (139), e57869-e57869.

A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice.
Saitoh, A., Soda, A., Kayashima, S., Yoshizawa, K., Oka, J. I., Nagase, H., & Yamada, M.
(2018). Journal of Pharmacological Sciences.

An enzyme-modified capillary as a platform for simultaneous fluorometric detection of D-glucose and L-lactate.
Shoji, A., Takahashi, Y., Osato, S., & Sugawara, M.
(2018). Journal of Pharmaceutical and Biomedical Analysis.

Pregabalin increases food intake through dopaminergic systems in the hypothalamus.
Ikeda, H., Yonemochi, N., Ardianto, C., Yang, L., & Kamei, J.
(2018). Brain Research.

“SIALYLATION-INCREASING THERAPIES FOR DISEASES ASSOCIATED WITH OXIDATIVE STRESS.”
Huizing, M., Malicdan, M. C., & Carrillo, N.
(2018). U.S. Patent Application No. 15/553,561.

Mesolimbic Dopamine, Its Receptors and Social Learning
Matta, R.
(2018) (Doctoral dissertation, NOVA Science Publishers).

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia.
Sobue, A., Kushima, I., Nagai, T., Shan, W., Kohno, T., Aleksic, B., … & Yamamoto, M.
(2018) Scientific Reports, 8(1), 13046.

Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity.
Lui, S., Torontali, Z., Tadjalli, A., & Peever, J.
(2018) Scientific Reports, 8(1), 12709.

A Smart and Sensitive Sensing Platform to Monitor the Extracellular of Hydrogen Peroxide in Rat Brain Microdialysate under Pathological Process based on Mesoporous Silica Nanoparticles.
Xu, G., Xie, Q., Chen, Z., Luo, F., Qiu, B., Guo, L., & Lin, Z.
(2018) Analytical Methods.

“METHODS OF TREATING PATIENTS SUFFERING FROM MOVEMENT DISORDERS.”
Kase, H., Mori, A., Waki, Y., Ohsawa, Y., Karasawa, A., & Kuwana, Y.
(2018) U.S. Patent Application No. 15/908,974.

“ANTI-SEMAPHORIN 3A ANTIBODY AND TREATMENT OF ALZHEIMER’S DISEASE AND INFLAMMATORY IMMUNE DISEASES USING SAME.”
Goshima, Y., Nakamura, F., Yamashita, N., Seo, H., Hashimoto, S., Murakami, K., … & Sasakura, Y.
(2018) U.S. Patent Application No. 15/847,740.

Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.

Stimulation of accumbal GABAB receptors inhibits delta1-and delta2-opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats.
Watanabe, Y., Aono, Y., Komiya, M., Waddington, J. L., & Saigusa, T.
(2018) European Journal of Pharmacology.

Translocator protein 18kDa antagonist ameliorates stress‐induced stool abnormality and abdominal pain in rodent stress models.
Kawahara, Y., Mitsui, K., Niwa, T., Morimoto, N., Kawaharada, S., & Katsumata, S.
(2018) Neurogastroenterology & Motility, e13425.

Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies.
Wang, J., Jin, W. S., Bu, X. L., Zeng, F., Huang, Z. L., Li, W. W., … & Zhu, J.
(2018) Acta Neuropathologica, 1-12.

Surgical Reinforcement Alters Collagen Alignment and Turnover in Healing Myocardial Infarcts.
Caggiano, L. R., Lee, J. J., & Holmes, J. W.
(2018) American Journal of Physiology-Heart and Circulatory Physiology.

Central apelin administration and restraint stress induce hypothalamic cholecystokinin release through APJ receptor.
Bülbül, M., Sinen, O., Abueid, L., Akkoyunlu, G., & Özsoy, Ö.
(2018) Journal of neuroendocrinology, e12635.

Acetaldehyde administration induces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice.
Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., … & Kinoshita, H.
(2018) Neuroscience Letters.

Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex.
Saiki, M., Matsui, T., Soya, M., Kashibe, T., Shima, T., Shimizu, T., … & Soya, H.
(2018) Scientific reports, 8(1), 10469.

Escitalopram Attenuates Fear Stress-Induced Increase in Amygdalar Dopamine Following Methamphetamine-induced Sensitisation: Implications of Fine-Tuning Action of Selective Serotonin Reuptake Inhibitors on Emotional Processing.
Muraoka, H., Oshibuchi, H., Kawano, M., Kawano, T., Tsutsumi, T., Yamada, M., … & Inada, K.
(2018) European Journal of Pharmacology.

Female Japanese quail visually differentiate testosterone-dependent male attractiveness for mating preferences.
Hiyama, G., Mizushima, S., Matsuzaki, M., Tobari, Y., Choi, J. H., Ono, T., … & Sugita, S.
(2018) Scientific Reports, 8(1), 10012.

A voxel-based analysis of neurobiological mechanisms in placebo analgesia in rats.
Zeng, Y., Hu, D., Yang, W., Hayashinaka, E., Wada, Y., Watanabe, Y., … & Cui, Y.
(2018) NeuroImage.

Rapid Intracellular Zn 2+ Dysregulation via Membrane Corticosteroid Receptor Activation Affects In Vivo CA1 LTP.
Suzuki, M., Sato, Y., Tamura, K., Tamano, H., & Takeda, A.
(2018) Molecular Neurobiology, 1-10.

Diazepam suppresses the stress-induced dopaminergic release in the amygdala of methamphetamine-sensitized rat.
Kawano, T., Oshibuchi, H., Kawano, M., Muraoka, H., Tsutsumi, T., Yamada, M., … & Inada, K.
(2018) European Journal of Pharmacology.

Involvement of NMDA receptors, nitric oxide and GABA in rostral ventrolateral medulla in acute ethanol‐induced cardiovascular responses in rats.
Lo, H., Lin, H. H., Chen, J. K., Situmorang, J. H., & Lai, C. C.
(2018) Alcoholism: Clinical and Experimental Research.

A single episode of binge alcohol drinking causes sleep disturbance, disrupts sleep homeostasis and downregulates equilibrative nucleoside transporter 1.
Sharma, R., Sahota, P., & Thakkar, M. M.
(2018) Journal of Neurochemistry.

Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer’s disease models.
Higaki, S., Muramatsu, M., Matsuda, A., Matsumoto, K., Satoh, J. I., Michikawa, M., & Niida, S.
(2018) PLOS ONE, 13(5), e0196929.

Extracellular Zn 2+ Influx into Nigral Dopaminergic Neurons Plays a Key Role for Pathogenesis of 6-Hydroxydopamine-Induced Parkinson’s Disease in Rats.
Tamano, H., Nishio, R., Morioka, H., & Takeda, A.
(2018) Molecular neurobiology, 1-9.

Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo
Yuan, X., Fei, F., Sun, H., Xiao, C., Zhao, X., Zhang, Y., & Zheng, X.
(2018) International journal of nanomedicine, 13, 2265.

Fear memory consolidation in sleep requires protein kinase A.
Cho, J., Sypniewski, K. A., Arai, S., Yamada, K., Ogawa, S., & Pavlides, C.
(2018) Learning & Memory, 25(5), 241-246.

Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity.
Kehr, J., Yoshitake, T., Ichinose, F., Yoshitake, S., Kiss, B., Gyertyán, I., & Adham, N.
(2018) Psychopharmacology, 1-15.

Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity.
Hayashida, K. I., Kimuram, M., & Eisenach, J. C.
(2018) Neuroscience Letters.

Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Igarashi, H., Ikeda, K., Onimaru, H., Kaneko, R., Koizumi, K., Beppu, K., … & Kobayashi, K.
(2018) Scientific Reports, 8(1), 5435.

Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with b-amyloid in rats.
Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences, 30, 1e6.

Age-related and function-dependent regional alterations of free L-and D-aspartate in postembryonic chick brain.
Zachar, G., Jakó, T., Vincze, I., Wagner, Z., Tábi, T., Bálint, E., … & Csillag, A.
(2018) Acta Biologica Hungarica, 69(1), 1-15.

Functional mechanism of ASP5736, a selective serotonin 5-HT 5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia.
Yamazaki, M., Yamamoto, N., Yarimizu, J., Okabe, M., Moriyama, A., Furutani, M., … & Harada, K.
(2018) European Neuropsychopharmacology.

Insular cortex inactivation generalizes fear-induced underestimation of interval timing in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.

Effects of mild perinatal hypothyroidism on cognitive function of adult male offspring.
Amano, I., Takatsuru, Y., Khairinisa, M. A., Kokubo, M., Haijima, A., & Koibuchi, N.
(2018) Endocrinology.

Effects of pregabalin and duloxetine on neurotransmitters in the dorsal horn of the spinal cord in a rat model of fibromyalgia.
Kiso, T., Moriyama, A., Furutani, M., Matsuda, R., & Funatsu, Y.
(2018) European Journal of Pharmacology.

Mass Spectrometric Analysis of Neurologically-Relevant Molecules.
Smith, C. L.
(2018) Doctoral dissertation, The University of Arizona.

Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition.
Wang, X., Ma, S., Wu, H., Shen, X., Xu, S., Guo, X., … & Wang, F.
(2018) Experimental & Molecular Medicine, 50(2), e445.

Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with β-amyloid in rats.
Egashira, N., Akiyoshi, Y., Iba, H., Arai, T., Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences.

Effects of Memantine on Nitric Oxide Production and Hydroxyl Radical Metabolism during Cerebral Ischemia and Reperfusion in Mice.
Tanaka, A., Ito, Y., Kawasaki, H., Kitabayashi, C., Nishioka, R., Yamazato, M., … & Yamamoto, T.
(2018) Journal of Stroke and Cerebrovascular Diseases.

Determination of the Target Temperature Required to Block Increases in Extracellular Glutamate Levels During Intraischemic Hypothermia.
Sato, S., Takeda, Y., Mizoue, R., Kawase, H., Fushimi, M., Shimizu, T., & Morimatsu, H.
(2018) Therapeutic Hypothermia and Temperature Management.

[EXPRESS] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer.
Watanabe, M., Narita, M., Hamada, Y., Yamashita, A., Tamura, H., Ikegami, D., … & Muto, A.
(2018) Molecular Pain, 1744806918756406.

Ketamine-induced prefrontal serotonin release is mediated by cholinergic neurons in the pedunculopontine tegmental nucleus.
Kinoshita, H., Nishitani, N., Nagai, Y., Andoh, C., Asaoka, N., Kawai, H., … & Kaneko, S.
(2018) International Journal of Neuropsychopharmacology.

Delayed administration of BQ788, an ETB antagonist, after experimental traumatic brain injury promotes recovery of blood–brain barrier function and reduction of cerebral edema in mice.
Michinaga, S., Kimura, A., Hatanaka, S., Minami, S., Asano, A., Ikushima, Y., … & Koyama, Y.
(2018) Journal of Neurotrauma, (ja)

[EXPRESS] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: analysis using a microdialysis/mass spectrometry integrated system.
Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., … & Narita, M.
(2018) Molecular Pain, 1744806918754934.

2017

“CNS hormonal and nutritional regulation of glucose and energy homeostasis.”
Abraham, M.
(2017) Doctoral dissertation

PKCδ-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity.
Dang, D. K., Shin, E. J., Kim, D. J., Tran, H. Q., Jeong, J. H., Jang, C. G., … & Kim, H. C.
(2017) Free Radical Biology and Medicine.

The Japanese Angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia.
Nogami-Hara, A., Nagao, M., Takasaki, K., Egashira, N., Fujikawa, R., Kubota, K., … & Iwasaki, K.
(2017) Journal of Ethnopharmacology.

δ-Subunit Containing GABA A Receptors Modulate Respiratory Networks.
Montandon, G., Wu, H., Liu, H., Vu, M. T., Orser, B. A., & Horner, R. L.
(2017) Scientific Reports, 7(1), 18105.

Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice.
Park, S. H., Eber, M. R., Tsuzuki, S., Booker, M. E., Sunil, A. G., Widner, D. B., … & Shiozawa, Y.
(2017) Scientific reports, 7(1), 17428.

Region‐specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice.
Sugimoto, J., Tanaka, M., Sugiyama, K., Ito, Y., Aizawa, H., Soma, M., … & Tanaka, K.
(2017) Glia.

Post-reexposure administration of riluzole attenuates the reconsolidation of conditioned fear memory in rats.
Akagi, K., Yamada, M., Saitoh, A., Oka, J. I., & Yamada, M
(2017) Neuropharmacology.

Hydroxyl radical production via NADPH oxidase in rat striatum due to carbon monoxide poisoning.
Hara, S., Kobayashi, M., Kuriiwa, F., Ikematsu, K., & Mizukami, H.
(2017) Toxicology.

Overexpression of transmembrane protein 168 in the mouse nucleus accumbens induces anxiety and sensorimotor gating deficit.
Fu, K., Miyamoto, Y., Sumi, K., Saika, E., Muramatsu, S. I., Uno, K., & Nitta, A.
(2017) PLoS One, 12(12), e0189006.

“METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS.”
Davidson, Beverly L., Bradley T. Hyman, and Eloise Hudry.
(2017) Patent 20,170,336,395, issued November 23, 2017.

Smaller effect of propofol than sevoflurane anesthesia on dopamine turnover induced by methamphetamine and nomifensine in the rat striatum: an in vivo microdialysis study.
TAHARABARU, S., SATOMOTO, M., TAMURA, T., & ADACHI, Y. U.
(2017) Experimental Animals, 17-0092.

Histamine N-methyltransferase regulates aggression and the sleep-wake cycle.
Kárpáti, A., Mogi, A., Yanai, A., Naganuma, F., Yanai, K., Okamura, N., … & Iida, T.
(2017) Scientific Reports, 7(1), 1.

β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system.
Ohara, K., Fukuda, T., Ishida, Y., Takahashi, C., Ohya, R., Katayama, M., … & Nagai, K.
(2017) Scientific Reports, 7(1), 15785.

Syntaxin1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.
Fujiwara, T., Kofuji, T., Mishima, T., & Akagawa, K.
(2017) European Journal of Neuroscience.

Moderate intensity, exercise-induced catecholamine release in the preoptic area and anterior hypothalamus in rats is enhanced in a warm environment.
Zheng, X., Takatsu, S., Ishikawa, R., & Hasegawa, H.
(2017) Journal of Thermal Biology.

Changes in thermoregulation and monoamine release in freely moving rats during cold exposure and inhibition of the ventromedial, dorsomedial, or posterior hypothalamus.
Ishiwata, T., & Greenwood, B. N.
(2017) Journal of Comparative Physiology B, 1-11.

Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23.
Deyama, S., Shimoda, K., Suzuki, H., Ishikawa, Y., Ishimura, K., Fukuda, H., … & Shuto, S.
(2017) Psychopharmacology, 1-8.

The Role of Cholecystokinin in Peripheral Taste Signaling in Mice.
Yoshida, R., Shin, M., Yasumatsu, K., Takai, S., Inoue, M., Shigemura, N., … & Ninomiya, Y.
(2017) Frontiers in Physiology, 8, 866.

Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior.
Li, Y., Yin, A., Sun, X., Zhang, M., Zhang, J., Wang, P., … & Wang, H.
(2017) The Journal of Clinical Investigation, 127(12)

Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice.
Gölöncsér, F., Baranyi, M., Balázsfi, D., Demeter, K., Haller, J., Freund, T. F., … & Sperlágh, B.
(2017) Frontiers in Molecular Neuroscience, 10, 325.

Involvement of neuronal and glial activities in control of the extracellular d-serine concentrations by the AMPA glutamate receptor in the mouse medial prefrontal cortex.
Ishiwata, S., Umino, A., & Nishikawa, T.
(2017) Neurochemistry International.

Subthalamic Nucleus and Globus Pallidus Interna Influence Firing of Tonically Active Neurons in the Primate Striatum through Different Mechanisms.
Nakajima, A., Shimo, Y., Uka, T., & Hattori, N.
(2017) European Journal of Neuroscience, 10.1111/ejn.13726.

The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain.
Du, J., Fang, J., Wen, C., Shao, X., Liang, Y., & Fang, J.
(2017) Neural Plasticity, 2017.

Stimulation of accumbal GABA A receptors inhibits delta2-, but not delta1-, opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats.
Aono, Y., Kiguchi, Y., Watanabe, Y., Waddington, J. L., & Saigusa, T.
(2017) European Journal of Pharmacology.

Striatal N-acetylaspartate synthetase Shati/Nat8l regulates depression-like behaviors via mGluR3-mediated serotonergic suppression in mice.
Miyamoto, Y., Iegaki, N., Fu, K., Ishikawa, Y., Sumi, K., Azuma, S., … & Nitta, A.
(2017) International Journal of Neuropsychopharmacology.

The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice.
Saitoh, A., Suzuki, S., Soda, A., Ohashi, M., Yamada, M., Oka, J. I., … & Yamada, M.
(2017) Behavioural Brain Research.

Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug.
Yamamoto, S., Ushio, S., Egashira, N., Kawashiri, T., Mitsuyasu, S., Higuchi, H., … & Masuda, S.
(2017) Scientific Reports, 7.

Perfusion with carbon monoxide does not affect extracellular glutamate in dialysates of the hippocampus of freely moving mice.
Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Miki, T., & Kinoshita, H.
(2017) Drug and Chemical Toxicology, 1-3.

Ginsenoside Re Protects Trimethyltin-Induced Neurotoxicity via Activation of IL-6-Mediated Phosphoinositol 3-Kinase/Akt Signaling in Mice.
Tu, T. H. T., Sharma, N., Shin, E. J., Tran, H. Q., Lee, Y. J., Jeong, J. H., … & Ko, S. K.
(2017) Neurochemical Research, 1-15.

Alpha-PVP induces the rewarding effect via activating dopaminergic neuron.
Hataoka, K., Kaizaki-Mitsumoto, A., & Numazawa, S.
(2017) The Journal of Toxicological Sciences, 42(5), 539-543

Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway.
Shimizu, S., Sogabe, S., Yanagisako, R., Inada, A., Yamanaka, M., Iha, H. A., & Ohno, Y.
(2017) International journal of molecular sciences, 18(7), 1416.

Characterization of CRF 1 receptor antagonists with differential peripheral vs central actions in CRF challenge in rats.
Tanaka, M., Tomimatsu, Y., Sakimura, K., Ootani, Y., Sako, Y., Kojima, T., … & Hirai, K
(2017) Peptides.

Evidence for Tonic Control by the GABAA Receptor of Extracellular D-Serine Concentrations in the Medial Prefrontal Cortex of Rodents.
Umino, A., Ishiwata, S., Iwama, H., & Nishikawa, T.
(2017) Frontiers in Molecular Neuroscience, 10, 240

The effect of electroacupuncture on PKMzeta in the ACC in regulating.
Du, J., Fang, J., Wen, C., Shao, X., Liang, Y., & Fang, J.
(2017)

A novel LRP1-binding peptide L57 that crosses the blood brain barrier.
Sakamoto, K., Shinohara, T., Adachi, Y., Asami, T., & Ohtaki, T.
(2017) Biochemistry and Biophysics Reports.

Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice.
Hara, Y., Ago, Y., Taruta, A., Hasebe, S., Kawase, H., Tanabe, W., … & Takuma, K.
(2017) Psychopharmacology, 1-12.

Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the.
Matsunami, S., Ogura, Y., Amita, H., Izumi, T., Yoshioka, M., & Matsushima, T.
(2017) Behavioural Brain Research, 233(2), 577-586.

Role of microglia in mechanical allodynia in the anterior cingulate cortex.
Miyamoto, K., Kume, K., & Ohsawa, M.
(2017) Journal of Pharmacological Sciences.

Rapid and sustained antidepressant effects of resolvin D1 and D2 in a chronic unpredictable stress model.
Ishikawa, Y., Deyama, S., Shimoda, K., Yoshikawa, K., Ide, S., Satoh, M., & Minami, M.
(2017) Behavioural Brain Research.

Involvement of serotonin in the ventral tegmental area in thermoregulation of freely moving rats.
Ishiwata, T., Hasegawa, H., & Greenwood, B. N
(2017) Neuroscience Letters.

Induction of hibernation-like hypothermia by central activation of the A1 adenosine receptor in a non-hibernator, the rat.
Shimaoka, H., Kawaguchi, T., Morikawa, K., Sano, Y., Naitou, K., Nakamori, H., … & Shimizu, Y.
(2017) Journal of Physiological Sciences, 1-6

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation.
Shinozaki, Y., Shibata, K., Yoshida, K., Shigetomi, E., Gachet, C., Ikenaka, K., … & Koizumi, S.
(2017) Cell Reports, 19(6), 1151-1164.

Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential.
Sandweiss, A. J., McIntosh, M. I., Moutal, A., Davidson-Knapp, R., Hu, J., Giri, A. K., … & Vanderah, T. W.
(2017) Molecular Psychiatry.

The involvement of brain-derived neurotrophic factor in 3, 4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization.
Mouri, A., Noda, Y., Niwa, M., Matsumoto, Y., Mamiya, T., Nitta, A., … & Nabeshima, T.
(2017) Behavioural Brain Research.

A novel 5HT3 receptor–IGF1 mechanism distinct from SSRI-induced antidepressant effects.
Kondo, M., Koyama, Y., Nakamura, Y., & Shimada, S.
(2017) Molecular Psychiatry.

Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption.
Sharma, R., Sahota, P., & Thakkar, M. M.
(2017) Journal of Neurochemistry.

A novel device for continuous long-term electroencephalogram recording and drug administration in mice with a nice, powerful and sophisticated wired system.
Watanabe, S., Saito, M., Soma, M., Miyaoka, H., & Takahashi, M.
(2017) Journal of Neuroscience Methods.

Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: differential responses to drug treatment.
Minami, S., Satoyoshi, H., Ide, S., Inoue, T., Yoshioka, M., & Minami, M.
(2017) Neuroscience Letters.

Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
Chen, M., Hoshino, H., Saito, S., Yang, Y., & Obata, H.
(2017) Neuroscience Letters.

Involvement of intracellular Zn2+ signaling in LTP at perforant pathway‐CA1 pyramidal cell synapse.
Tamano, H., Nishio, R., & Takeda, A.
(2017) Hippocampus.

Prenatal nicotine exposure decreases the release of dopamine in the medial frontal cortex and induces atomoxetine-responsive neurobehavioral deficits in mice.
Alkam, T., Mamiya, T., Kimura, N., Yoshida, A., Kihara, D., Tsunoda, Y., … & Nabeshima, T.
(2017) Psychopharmacology, 1-17.

Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Shimohata, A., Ishihara, K., Hattori, S., Miyamoto, H., Morishita, H., Ornthanalai, G., … & Sago, H.
(2017) Experimental Neurology.

Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer’s disease rat model.
Moriyama, H., Watanabe, T., Takasaki, K., Nagao, M., Kubota, K., Katsurabayashi, S., … & Iwasaki, K.
(2017) Traditional & Kampo Medicine.

Activation of the NMDA receptor–neuronal nitric oxide synthase pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain.
Deyama, S., Sugano, Y., Mori, S., Amano, T., Yoshioka, M., Kaneda, K., & Minami, M.
(2017) Neuropharmacology.

A positive feedback loop between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage in human lens epithelial cells.
Nagai, N., Ito, Y., Shibata, T., Kubo, E., & Sasaki, H.
(2017) Toxicology.

In vitro and in vivo physiology of low nanomolar concentrations of Zn2+ in artificial cerebrospinal fluid.
Tamano, H., Nishio, R., Shakushi, Y., Sasaki, M., Osawa, M., & Takeda, A.
(2017) Scientific Reports, 7, 42897.

Differential requirements of hippocampal de novo protein and mRNA synthesis in two long-term spatial memory tests: Spontaneous place recognition and delay-interposed radial maze performance in rats.
Ozawa, T., Yamada, K., & Ichitani, Y.
(2017) PloS one, 12(2), e0171629.

Maintained LTP and Memory Are Lost by Zn2+ Influx into Dentate Granule Cells, but Not Ca2+ Influx.
Takeda, A., Tamano, H., Hisatsune, M., Murakami, T., Nakada, H., & Fujii, H.
(2017) Molecular Neurobiology, 1-11.

Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity.
Natsubori, A., Tsustui-Kimura, I., Nishida, H., Bouchekioua, Y., Sekiya, H., Uchigashima, M., … & Tanaka, K. F.
(2017) Journal of Neuroscience, 3377-16.

Oral administration of methylphenidate (Ritalin) differentially affects dopamine release between the prefrontal cortex and striatum-a microdialysis study in the monkey.
Kodama, T., Kojima, T., Honda, Y., Hosokawa, T., Tsutsui, K. I., & Watanabe, M.
(2017) Journal of Neuroscience, 2155-16.

Blockade of intracellular Zn 2+ signaling in the basolateral amygdala affects object recognition memory via attenuation of dentate gyrus LTP.
Fujise, Y., Kubota, M., Suzuki, M., Tamano, H., & Takeda, A.
(2017) Neurochemistry International.

Involvement of lateral habenula α1 subunit-containing GABA A receptor-mediated inhibitory transmission in the regulation of depression-related behaviors in experimental Parkinson’s disease.
Wang, T., Zhang, L., Zhang, Q. J., Wang, Y., Du, C. X., Sun, Y. N., … & Liu, J.
(2017) Neuropharmacology.

Pharmacological properties of SAK3, a novel T-type voltage-gated Ca 2+ channel enhancer.
Yabuki, Y., Matsuo, K., Izumi, H., Haga, H., Yoshida, T., Wakamori, M., … & Fukunaga, K.
(2017) Neuropharmacology.

Basic Study Correlation between colonic secretion and colonic motility in rats: Role of ghrelin
Huang, H. H., Chen, C. Y., Ting, C. H., Syu, Y. F., & Chang, S. C.
(2017) Name of Journal: World Journal of Gastroenterology ESPS Manuscript NO: 28232 Manuscript Type: ORIGINAL ARTICLE

Glutamatergic modulation of noradrenaline release in the rat median preoptic area.
Takahashi, M., Hayashi, Y., & Tanaka, J.
(2017) Brain Research Bulletin.

2016

The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain.
Do Yun Kim, J. W. C., Lim, C. H., Heo, B. H., Park, K. S., Lee, H. G., Choi, J. I., … & Kim, W. M.
(2016). The Korean journal of pain, 29(3), 164.

Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice.
Tanaka, T., Ago, Y., Umehara, C., Imoto, E., Hasebe, S., Hashimoto, H., … & Matsuda, T.
(2016) International Journal of Neuropsychopharmacology, pyw115.

Exploring the mechanism by which accumbal deep brain stimulation attenuates morphine-induced reinstatement through manganese-enhanced MRI and pharmacological intervention.
Zhang, L., Cui, Y., Wang, Y. C., Yin, H., Zheng, J. M., Huang, L., … & Li, J.
(2016) Experimental Neurology.

Controlling the length of short electrospun polymer nanofibers via the addition of micro-spherical silica particles.
Yabuki, A., Motonobu, E., & Fathona, I. W.
Journal of Materials Science, 1-9.

Correlation between colonic secretion and colonic motility in rats: Role of ghrelin.
Huang, H. H., Ting, C. H., Syu, Y. F., Chang, S. C., & Chen, C. Y.
(2016) World J Gastroenterol, 22(46), 10140-10147.

Betaine attenuates memory impairment after water-immersion restraint stress and is regulated by the GABAergic neuronal system in the hippocampus.
Kunisawa, K., Kido, K., Nakashima, N., Matsukura, T., Nabeshima, T., & Hiramatsu, M.
(2016) European Journal of Pharmacology.

Noradrenaline receptor mechanisms modulate the angiotensin II-induced water intake in the subfornical organ in rats.
Takahashi, M., & Tanaka, J.
(2016) Experimental Brain Research, 1-7.

Induction of antinociceptive tolerance to the chronic intrathecal administration of apelin-13 in rat.
Abbasloo, E., Najafipour, H., & Esmaeili-Mahani, S.
(2016) Neuropeptides, 60, 7-12.

Opposite effects of central oxytocin and arginine vasopressin on changes in gastric motor function induced by chronic stress.
Bülbül, M., Sinen, O., Gemici, B., & İzgüt-Uysal, V. N.
(2016) Peptides, 87, 1-11.

Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.
Yue, J. T., Abraham, M. A., Bauer, P. V., LaPierre, M. P., Wang, P., Duca, F. A., … & Lam, T. K.
(2016) Nature Communications, 7, 13501

Neuropeptide EI-induced paradoxical sleep in rats.
Fujimoto, M., Fukuda, S., Sakamoto, H., Takata, J., & Sawamura, S.
(2016) Peptides.

Activation of mu-opioid receptors in the ventral pallidum decreases the negative hedonic evaluation of a conditioned aversive taste in rats.
Inui, T., & Shimura, T.
(2016) Behavioural Brain Research.

Opposite Effects of Central Oxytocin and Arginine Vasopressin on Changes in Gastric Motor Function Induced by Chronic Stress.
Bülbül, M., Sinen, O., Gemici, B., & İzgüt-Uysal, V. N.
(2016) Peptides.

Effect of p22phox depletion on sympathetic regulation of blood pressure in SHRSP: evaluation in a new congenic strain.
Zahid, H. M., Ferdaus, M. Z., Ohara, H., Isomura, M., & Nabika, T.
(2016) Scientific Reports, 6, 36739.

The role of inversely operating glutamate transporter in the paradoxical analgesia produced by glutamate transporter inhibitors.
Kim, W. M., Chae, J. W., Heo, B. H., Park, K. S., Kim, H. S., Lee, H. G., … & Yoon, M. H.
(2016) European Journal of Pharmacology

The Role of Adenosine in the Maturation of Sleep Homeostasis in Rats.
Gvilia, I., Suntsova, N., Kostin, A., Kalinchuk, A., McGinty, D., Basheer, R., & Szymusiak, R.
(2016) Journal of Neurophysiology, jn-00675

15-deoxy-Δ 12, 14-prostaglandin J 2 induced neurotoxicity via suppressing phosphoinositide 3-kinase.
Koma, H., Yamamoto, Y., Nishi, A., & Yagami, T.
(2016) Neuropharmacology.

Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropin releasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus.
Tokunaga, R., Shimoju, R., Shibata, H., & Kurosawa, M
(2016) The Journal of Physiological Sciences, 1-10.

PKCδ knockout mice are protected from para-methoxymethamphetamine-induced mitochondrial stress and associated neurotoxicity in the striatum of mice.
Shin, E. J., Dang, D. K., Tran, H. Q., Nam, Y., Jeong, J. H., Lee, Y. H., … & Nabeshima, T.
(2016) Neurochemistry International.

Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors.
Montandon, G., Liu, H., & Horner, R. L.
(2016) Scientific Reports, 6, 32707.

Mapping the influence of electrospinning parameters on the morphology transition of short and continuous nanofibers.
Fathona, I. W., & Yabuki, A.
(2016) Fibers and Polymers, 17(8), 1238-1244.

Equilibrative Nucleoside Transporter ENT1 as a Biomarker of Huntington Disease.
Guitart, X., Bonaventura, J., Rea, W., Orrú, M., Cellai, L., Dettori, I., … & Chang, C. P.
(2016) Neurobiology of Disease.

Suppressed GABAergic signaling in the zona incerta causes neuropathic pain in a thoracic hemisection spinal cord injury rat model.
Moon, H. C., Lee, Y. J., Cho, C. B., & Park, Y. S.
(2016) Neuroscience Letters.

Sex differences in abuse-related neurochemical and behavioral effects of 3, 4-methylenedioxymethamphetamine (MDMA) in rats.
Lazenka, M. F., Suyama, J. A., Bauer, C. T., Banks, M. L., & Negus, S. S.
(2016) Pharmacology Biochemistry and Behavior.

Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters.
Solis Jr, E., Suyama, J. A., Lazenka, M. F., DeFelice, L. J., Negus, S. S., Blough, B. E., & Banks, M. L.
(2016) Scientific Reports, 6, 31385.

Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion.
Umezu, T., & Shibata, Y.
(2016) Toxicology Reports, 3, 552-562.

Wake-promoting effects of ONO-4127Na, a prostaglandin DP1 receptor antagonist, in hypocretin/orexin deficient narcoleptic mice.
Sagawa, Y., Sato, M., Sakai, N., Chikahisa, S., Chiba, S., Maruyama, T., … & Nishino, S.
(2016) Neuropharmacology.

Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats.
Yang, F., Zhou, L., Wang, D., Yang, L. L., Yuan, G. R., & Huang, Q. Y.
(2016) Scientific Reports, 6, 30168.

GABAergic Modulation of Serotonin Release in the Rat Subfornical Organ Area.
Takahashi, M., Nomura, M., & Tanaka, J.
(2016) Neuroscience Letters.

Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia.
Tamano, H., Ide, K., Adlard, P. A., Bush, A. I., & Takeda, A.
(2016) The Journal of Toxicological Sciences, 41(4), 449-457.

In vivo neurochemical evidence that delta1-, delta2-and mu2-opioid receptors, but not mu1-opioid receptors, inhibit acetylcholine efflux in the nucleus accumbens of freely moving rats.
Kiguchi, Y., Aono, Y., Watanabe, Y., Yamamoto, S., Shimizu, K., Shimizu, T., … & Saigusa, T.
(2016) European Journal of Pharmacology.

Neurochemical Substrates of Asymmetrical Sleep in the Fur Seal.
Lapierre, J. L.
(2016) Doctoral dissertation, University of Toronto.

The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain.
Kim, D. Y., Chae, J. W., Lim, C. H., Heo, B. H., Park, K. S., Lee, H. G., … & Kim, W. M.
(2016) The Korean Journal of Pain, 29(3), 164-171.

Involvement of GABAA.
Ago, Y., Hasebe, S., Hiramatsu, N., Mori, K., Watabe, Y., Onaka, Y., … & Matsuda, T.
(2016) Psychopharmacology, 1-10.

Pain relief induces dopamine release in the rat nucleus accumbens during the early but not late phase of neuropathic pain.
Kato, T., Ide, S., & Minami, M.
(2016) Neuroscience Letters.

Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion.
Umezu, T., & Shibata, Y.
(2016) Toxicology Reports.

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission.
Tokudome, K., Okumura, T., Shimizu, S., Mashimo, T., Takizawa, A., Serikawa, T., … & Ohno, Y.
(2016) Scientific Reports, 6, 27420.

Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine.
Ip, J. Y., Sone, M., Nashiki, C., Pan, Q., Kitaichi, K., Yanaka, K., … & Nakagawa, S.
(2016) Scientific Reports, 6, 27204

Effects of propofol on the dopamine, metabolites and GABAA receptors in media prefrontal cortex in freely moving rats.
Wang, Y., Yu, T., Yuan, C., Yuan, J., Luo, Z., Pan, Y., … & Yu, B.
(2016) Am J Transl Res, 8(5), 2301-2308.

Motor Training Promotes Both Synaptic and Intrinsic Plasticity of Layer II/III Pyramidal Neurons in the Primary Motor Cortex.
Kida, H., Tsuda, Y., Ito, N., Yamamoto, Y., Owada, Y., Kamiya, Y., & Mitsushima, D.
(2016) Cerebral Cortex, bhw134.

Novel psychoactive benzofurans strongly increase extracellular serotonin level in mouse corpus striatum.
Fuwa, T., Suzuki, J., Tanaka, T., Inomata, A., Honda, Y., & Kodama, T.
(2016) The Journal of Toxicological Sciences, 41(3), 329-337.

“Acute and Chronic Effects of Inhalants in Intracranial Self-stimulation.”
Tracy, Matthew.
(2016)

GABA B receptors in the hippocampal dentate gyrus are involved in spatial learning and memory impairment in a rat model of vascular dementia.
Li, G., Lv, J., Wang, J., Wan, P., Li, Y., Jiang, H., & Jin, Q.
(2016) Brain Research Bulletin.

Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptors.
Miyazaki, Y., Sunaga, H., Hobo, S., Miyano, K., & Uezono, S.
(2016) Journal of Anesthesia, 1-6.

Mirtazapine exerts an anxiolytic-like effect through activation of the median raphe nucleus-dorsal hippocampal 5-HT pathway in contextual fear conditioning in rats.
An, Y., Chen, C., Inoue, T., Nakagawa, S., Kitaichi, Y., Wang, C., … & Kusumi, I.
(2016) Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Serotonin release in the subfornical organ area induced by sodium and water intake in the rat.
Takahashi, M., & Tanaka, J.
(2016) Physiology & Behavior.

Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.
Kim, S. K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., … & Bae, H.
(2016) The Journal of Clinical Investigation, 126(5).

Dopamine dynamics during emotional cognitive processing: implications of the specific actions of clozapine compared with haloperidol.
Kawano, M., Oshibuchi, H., Kawano, T., Muraoka, H., Tsutsumi, T., Yamada, M., … & Ishigooka, J.
(2016) European Journal of Pharmacology

A Clock mutation enhances light-phase responsiveness to cocaine in locomotor activity and self-administration with impulsive-like responding in mice.
Meng, H., Murakami, G., Suenaga, T., Edamura, M., Doi, M., Ishida, Y., … & Nakahara, D.
(2016) Psychopharmacology, 1-8.

Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT.
Mori, T., Uzawa, N., Iwase, Y., Masukawa, D., Rahmadi, M., Hirayama, S., … & Suzuki, T.
(2016) Psychopharmacology, 1-11

Unusual social behavior in HPC‐1/syntaxin1A knockout mice is caused by disruption of the oxytocinergic neural system.
Fujiwara, T., Sanada, M., Kofuji, T., & Akagawa, K.
(2016) Journal of Neurochemistry.

Involvement of hippocampal NMDA receptors in retrieval of spontaneous object recognition memory in rats
Iwamura, E., Yamada, K., & Ichitani, Y.
(2016) Behavioural Brain Research.

Brain Site-and Transmitter-dependent Actions of Methamphetamine, Morphine and Antipsychotics.
Mori, T., Iwase, Y., Murata, A., Iwata, N., & Suzuki, T
(2016) Behavioural Brain Research.

5‐HT (1A) receptor antagonist improves behavior performance of delirium rats through inhibiting PI3K/Akt/mTOR activation‐induced NLRP3 activity.
Qiu, Y., Huang, X., Huang, L., Tang, L., Jiang, J., Chen, L., & Li, S.
(2016) IUBMB life.

Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats.
Hazama, Y., Maekawa, T., Miki, R., Oshima, S., Egawa, Y., Morimoto, K., & Seki, T
(2016) Biological and Pharmaceutical Bulletin, 39(3), 343-352.

Non-invasive determination of glucose directly in raw fruits using a continuous flow system based on microdialysis sampling and amperometric detection at an integrated enzymatic biosensor.
Vargas, E., Ruiz, M. A., Campuzano, S., Reviejo, A. J., & Pingarrón, J. M
(2016) Analytica Chimica Acta.

Involvement of spinal glutamate in nociceptive behavior induced by intrathecal administration of hemokinin-1 in mice.
Watanabe, C., Mizoguchi, H., Bagetta, G., & Sakurada, S.
(2016) Neuroscience Letters.

Neuropeptide Y signaling in the dorsal raphe nucleus inhibits male sexual behavior in mice.
Inaba, A., Komori, Y., Muroi, Y., Kinoshita, K. I., & Ishii, T.
(2016) Neuroscience.

Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and gaba neurons.
Ardianto, C., Yonemochi, N., Yamamoto, S., Yang, L., Takenoya, F., Shioda, S., … & Kamei, J.
(2016) Neuroscience.

Opposing Roles of Cholinergic and GABAergic Activity in the Insular Cortex and Nucleus Basalis Magnocellularis during Novel Recognition and Familiar Taste Memory Retrieval.
Rodríguez-García, G., & Miranda, M. I.
(2016) The Journal of Neuroscience, 36(6), 1879-1889.

The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat.
Shahbazi-Gahrouei, D., Shiri, L., Alaei, H., & Naghdi, N.
(2016) Journal of Radiation Research, rrv093.

Differencial Activation of the Dopaminergic Systems in Rat Brain Basal Ganglia by Morphine and Methamphetamine.
Mori, T., Iwase, Y., Saeki, T., Iwata, N., Murata, A., Masukawa, D., & Suzuki, T.
(2016) Neuroscience.

Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK.
Dang, D. K., Shin, E. J., Nam, Y., Ryoo, S., Jeong, J. H., Jang, C. G., … & Kim, H. C.
(2016) Journal of Neuroinflammation, 13(1), 12.

Causal Link between the Cortico-Rubral Pathway and Functional Recovery through Forced Impaired Limb Use in Rats with Stroke.
Ishida, A., Isa, K., Umeda, T., Kobayashi, K., Kobayashi, K., Hida, H., & Isa, T.
(2016) The Journal of Neuroscience, 36(2), 455-467.

Contributions of ADP and ATP to the increase in skeletal muscle blood flow after manual acupuncture stimulation in rats.
Nagaoka, S., Shinbara, H., Okubo, M., Kawakita, T., Hino, K., & Sumiya, E.
(2016) Acupuncture in Medicine, acupmed-2015.

2015

Elucidation of the central role of long-chain fatty acids in the palatability of dietary fat by neuroscientific and animal behavioral studies.
Adachi, S.
(2015)

“METHODS AND COMPOSITIONS USING 4-AMINO-2-(2, 6-DIOXO-PIPERIDINE-3-YL)-ISOINDOLINE-1, 3-DIONE FOR TREATMENT OF CANCERS.”
LI, Y., Palmisano, M., Zhou, S., Chen, N., & James, A. J.
(2015) U.S. Patent No. 20,150,328,199. Washington, DC: U.S. Patent and Trademark Office.

Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats.
Kawaura, K., Ogata, Y., Honda, S., Soeda, F., Shirasaki, T., & Takahama, K.
(2015) Behavioural Brain Research

Ethanol and Acetaldehyde Differentially Alter Extracellular Dopamine and Serotonin in Aldh2-Knockout Mouse Dorsal Striatum: A Reverse Microdialysis Study.
Jamal, M., Ameno, K., Miki, T., Tanaka, N., Ito, A., Ono, J., … & Kinoshita, H.
(2015) NeuroToxicology.

Preventive Effect of 3, 5-dihydroxy-4-methoxybenzyl Alcohol (DHMBA) and Zinc, Components of the Pacific Oyster Crassostrea gigas, on Glutamatergic Neuron Activity in the Hippocampus.
Tamano, H., Shakushi, Y., Watanabe, M., Ohashi, K., Uematsu, C., Otsubo, T., … & Takeda, A.
(2015) The Biological Bulletin, 229(3), 282-288.

Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
Bonaventure, P., Shelton, J., Yun, S., Nepomuceno, D., Sutton, S., Aluisio, L., … & Dugovic, C.
(2015) Journal of Pharmacology and Experimental Therapeutics, jpet-115.

Improvement of Cold Injury‐Induced Mouse Brain Edema by Endothelin ETB Antagonists is Accompanied with Decreases in Matrixmetalloproteinase 9 and Vascular Endothelial Growth Factor‐A.
Michinaga, S., Seno, N., Fuka, M., Yamamoto, Y., Minami, S., Kimura, A., … & Koyama, Y.
(2015) European Journal of Neuroscience.

Oxidative stress and lipid peroxidation are upstream of amyloid pathology.
Arimon, M., Takeda, S., Post, K. L., Svirsky, S., Hyman, B. T., & Berezovska, O.
(2015) Neurobiology of Disease.

Chewing, Stress-Related Diseases, and Brain Function.
Kubo, K. Y., Chen, H., Liu, J. H., Zhou, X., & Darbin, O.
(2015) BioMed Research International, 2015.

Changes in free amino acid and monoamine concentrations in the chick brain associated with feeding behavior.
Tran, P. V., Chowdhury, V. S., Nagasawa, M., & Furuse, M.
(2015) SpringerPlus 4(1), 252.

Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex.
Ueda, S., Niwa, M., Hioki, H., Sohn, J., Kaneko, T., Sawa, A., & Sakurai, T.
(2015) Molecular Neuropsychiatry,1(2), 94-104.

Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain.
Navratilova, E., Xie, J. Y., Meske, D., Qu, C., Morimura, K., Okun, A., … & Porreca, F.
(2015) The Journal of Neuroscience,, 35(18), 7264-7271.

DSP‐1053, a novel serotonin reuptake inhibitor with 5‐HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats.
Kato, T., Matsumoto, Y., Yamamoto, M., Matsumoto, K., Baba, S., Nakamichi, K., … & Yabuuchi, K.
(2015) Pharmacology Research & Perspectives, 3(3).

2014

Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy.
Xie, J. Y., Qu, C., Patwardhan, A., Ossipov, M. H., Navratilova, E., Becerra, L., … & Porreca, F.
(2014) PAIN®, 155(8), 1659-1666.

A Food and Administration- approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer’s disease.
Hori Y, Takeda S, Cho H, Wegmann S, Shoup T, Takahashi K, Irima D, Elmaleh D, Hyman B, Hudry E.
(2014) J Biol Chem; 23 1966-78

2013

Validation of an efficient LC-microdialysis method for gemifloxacin quantitation in lung, kidney and liver of rats.
Furness, A. M., Thomas, S., & Lunte, C. E. 10 de Araújo BV, Laureano JV, Grünspan LD, Dalla Costa T, Tasso L.
(3). J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 919–920 (0), 62–66 (2013).

Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis.
Yang, H., Thompson, A. B., McIntosh, B. J., Altieri, S. C., & Andrews, A. M.
(2013). ACS chemical neuroscience, 4(5), 790-798.

Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic γ-aminobutyric acid mechanisms.
Kimura M, Hayashida K, Eisenach J, Saito S, Obata H.
(2013) Anesthesiology 118;173-80

Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry.
Navarailova E, Xie J, Okun A, Qu C, Eyde N, Ci S, Ossipov M, King T, Fields H, Porreca F.
(2013) PNAS 109; 50 2079-20713

2012

Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve insury.
Hayashida K, Kimura M, Yoshizumi M, Hobo S, Obata H, J Eisenach.
(2012) Anesthesiology 117; 389-98

Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Yoshizumi M, Parker R, Esenach J, Hayashida K.
(2012) Anesthesiology 116; 1347-53

2011

Novel microdialysis method to assess meuropeptides and large molecules in free-moiving mouse.
Takeda S, Sato N, Ikimura K, Nishino H, Rkugi H, Morishita R.
(2011) Neuroscience; 186 110-119

2009

Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
(2009) Brain Research 1260; 30-37

Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.
Yano K, Koda K, Ago Y, Kobayashi H, Kawasaki T, Takuma K, Matsuda T
(2009) British Journal of Pharmacology 156(1):173-180.

2008

Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects.
Mitsushima D, Takase K, Funabashi T, Kimura F
(2008) Endocrinology;149(2):802-811. Epub 2007 Oct 25

Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats.
Deyama S, Katayama T, Ohno A, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M
(2008) Journal of Neuroscience; 28(31):7728-7736

Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure.
Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H.
(2008) Toxicology and applied pharmacology Jan 15;226(2):192-198

2007

Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats.
Takase K, Mitsushima D, Funabashi T, Kimura F.
(2007) Brain Research 1154:105-115. Epub 2007 Apr 5

Maternal attenuation of hypothalamic paraventricular nucleus norepinephrine switches avoidance learning to preference learning in preweanling rat pups.
Shionoya K, Moriceau S, Bradstock P, Sullivan RM.
(2007) Hormones and Behavior 52(3):391-400. Epub 2007 Jun 29

2006

Ascorbic acid concentration in rabbit vitreous measured by microdialysis with HPLC-electrochemical detection before and after vitreous surgery.
Koide K, Zhang XM, Ohishi K, Usami Y, Hotta Y, Hiramitsu T
(2006) Experimental Eye Research 82(5):868-873

Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Dong HL, Fukuda S, Murata E, Zhu Z, Higuchi T
(2006) Anesthesiology 104(5):1023-1032

Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats.
Sasaki M, Obata H, Kawahara K, Saito S, Goto F
(2006) Pain 122(1-2):130-136

Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.
Dong HL, Fukuda S, Murata E, Higuchi T
(2006) Anesthesiology 104(1):122-133

Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions.
De Leonibus E, Verheij MM, Mele A, Cools A
(2006) European Journal of Neuroscience 23(5):1332-1340

Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T
(2006) Journal of Neuroscience 26(2):398-405

Epinephrine increases the extracellular lidocaine concentration in the brain: a possible mechanism for increased central nervous system toxicity.
Takahashi R, Oda Y, Tanaka K, Morishima HO, Inoue K, Asada A.
(2006) Anesthesiology 105(5):984-989

Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats.
Mitsushima D, Yamada K, Takase K, Funabashi T, Kimura F.
(2006) European Journal of Neuroscience 24(11):3245-3254

2005

Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex.Ago Y, Nakamura S, Baba A, Matsuda T
(2005) Neuropsychopharmacology 30: 43-51

Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats.
Jamal M, Ameno K, Wang W, Kumihashi M, Ameno S, Ikuo U, Shinji A, Ijiri I
(2005) Brain Research 1039(1-2):90-96

Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F
(2005) Neuroscience 136: 593-599

Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats.
Masuda J, Mitsushima D, Funabashi T, Kimura F
(2005) Neuroscience 132: 537-542

Striatal dopamine level increases in the urinary storage phase in cats: an in vivo microdialysis study.
Yamamoto T, Sakakibara R, Hashimoto K, Nakazawa K, Uchiyama T, Liu Z, Ito T, Hattori T.
(2005) Neuroscience 135: 299-303

The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.
Fusa K, Takahashi I, Watanabe S, Aono Y, Ikeda H, Saigusa T, Nagase H, Suzuki T, Koshikawa N, Cools AR
(2005) Neuroscience 130(3):745-755

Contribution of vesicular and cytosolic dopamine to the increased striatal dopamine efflux elicited by intrastriatal injection of dexamphetamine.
Watanabe S, Aono Y, Fusa K, Takada K, Saigusa T, Koshikawa N, Cools AR
(2005) Neuroscience 136(1):251-257

Effects of alpha-methyl-p-tyrosine on extracellular dopamine levels in the nucleus accumbens and the dorsal striatum of freely moving rats.
Watanabe S, Fusa K, Takada K, Aono Y, Saigusa T, Koshikawa N, Cools AR
(2005) Journal of Oral Science 47(4):185-190

Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Narita M, Kishimoto Y, Ise Y, Yajima Y, Misawa K, Suzuki T
(2005) Neuropsychopharmacology 30(1):111-118

Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M.
(2005) British Journal of Pharmacology 145(8):1035-1044

2004

Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats.
Yamato T, Misumi Y, Yamasaki S, Kino M, Aomine M
(2004) Diabetes, Nutrition & Metabolism 17: 128-136

Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.| Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, He J, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC, Nabeshima T
(2004) Journal of Neuroscience 24: 2212-2225

The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.
Nagai T, Yamada K, Yoshimura M, Ishikawa K, Miyamoto Y, Hashimoto K, Noda Y, Nitta A, Nabeshima T
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 3650-3655

Brain microdialysis study of the effects of hazardous chemicals on the central nervous system 2. Toluene exposure and cerebral acetylcholine.
Honma T, Suda M
(2004) Industrial Health 42(3):336-347

Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study.
Kino M, Yamato T, Aomine M
(2004) Neurochemistry International 44: 65-73

Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.
Okamura N, Hashimoto K, Shimizu E, Kumakiri C, Komatsu N, Iyo M
(2004) Neuropsychopharmacology 29: 544-550

Hypericum perforatum L (St John’s wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.
Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Muller WE, Ogren SO, Kehr J
(2004) British Journal of Pharmacology 142: 414-418

Determination of serotonin, noradrenaline, dopamine and their metabolites in rat brain extracts and microdialysis samples by column liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine.
Yoshitake T, Kehr J, Yoshitake S, Fujino K, Nohta H, Yamaguchi M
(2004) Journal of Chromatography B 807: 177-183

Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine.
Shioda K, Nisijima K, Yoshino T, Kato S
(2004) Progress in Neuro-Psychopharmacology & Biological Psychiatry 28: 633-640

Sexual dimorphism of GABA release in the medial preoptic area and luteinizing hormone release in gonadectomized estrogen-primed rats.
Tin-Tin-Win-Shwe, Mitsushima D, Shinohara K, Kimura F
(2004) Neuroscience 127(1):243-250

Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Shen, H. W., Hagino, Y., Kobayashi, H., Shinohara-Tanaka, K., Ikeda, K., Yamamoto, H., … & Uhl, G. R.
(2004). Neuropsychopharmacology, 29(10), 1790-1799.

2003

Activation of cholinergic and adrenergic receptors increases the concentration of extracellular adenosine in the cerebral cortex of unanesthetized rat.
Bennett HJ, White TD, Semba K
(2003) Neuroscience 117: 119-127
Effects of repetitive transcranial magnetic stimulation on behavioral and neurochemical changes in rats during an elevated plus-maze test.
Kanno M, Matsumoto M, Togashi H, Yoshioka M, Mano Y
(2003) Journal of Neurological Sciences 211: 5-14

Implication of Rho-associated kinase in the elevation of extracellular dopamine levels and its related behaviors induced by methamphetamine in rats.
Narita M, Takagi M, Aoki K, Kuzumaki N, Suzuki T
(2003) Journal of Neurochemistry 86: 273-282

Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats.
John J, Wu MF, Kodama T, Siegel JM
(2003) The Journal of Physiology 548(Pt 2): 557-562

Increase of hippocampal acetylcholine release at the onset of dark phase is suppressed in a mutant mice model of evening-type individuals.
Sei H, Sano A, Oishi K, Fujihara H, Kobayashi H, Ishida N, Morita Y
(2003) Neuroscience 117: 785-789

In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis.
Jamal M, Ameno K, Kubota T, Ameno S, Zhang X, Kumihashi M, Ijiri I
(2003) Alcohol & Alcoholism 38: 197-201

Detection of 3-methoxy-4-hydroxyphenylglycol in rabbit skeletal muscle microdialysate
Tokunaga N, Yamazaki T, Akiyama T, Mori H
(2003) Journal of Chromatography B 798: 163-166

Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouse.
Nakahara D, Nakamura M, Iigo M, Okamura H
(2003) Proceedings of the National Academy of Sciences USA (PNAS) 100: 9584-9589

Simultaneous determination of norepinephrine, serotonin, and 5-hydroxyindole-3-acetic acid in microdialysis samples from rat brain by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine.
Yoshitake T, Fujino K, Kehr J, Ishida J, Nohta H, Yamaguchi M
(2003) Analytical Biochemistry 312: 125-33

Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.
Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M
(2003) Psychopharmacology (Berl) 170: 80-88

Sex differences in the stress-induced release of acetylcholine in the hippocampus and corticosterone from the adrenal cortex in rats.
Mitsushima D, Masuda J, Kimura F.
(2003) Neuroendocrinology 78(4):234-240

Sexual dimorphism in the GABAergic control of gonadotropin release in intact rats.
Mitsushima D, Tin-Tin-Win-Shwe, Kimura F
(2003) Neuroscience Research 46(4):399-405

Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release.
Mitsushima D, Funabashi T, Shinohara K, Kimura F
(2003) Psychoneuroendocrinology 28(4):574-583

2002

Expression of angiotensin II type 1 (AT1) receptor in the rostral ventrolateral medulla in rats.
Hu, L., Zhu, D. N., Yu, Z., Wang, J. Q., Sun, Z. J., & Yao, T.
(2002) Journal of Applied Physiology, 92(5), 2153-2161.

Suppression of the morphine-induced rewarding effect in the rat with neuropathic pain: implication of the reduction in mu-opioid receptor functions in the ventral tegmental area.
Ozaki S, Narita M, Narita M, Iino M, Sugita J, Matsumura Y, Suzuki T
(2002) Journal of Neurochemistry 82: 1192-1198

Effects of brief ischaemia on myocardial acetylcholine and noradrenaline levels in anaesthetized cats.
Kawada T, Yamazaki T, Akiyama T, Mori H, Inagaki M, Shishido T, Takaki H, Sugimachi M, Sunagawa K
(2002) Autonomic Neuroscience 95: 37-42

Effects of moderate hypothermia on in situ cardiac sympathetic nerve endings.
Kitagawa H, Akiyama T, Yamazaki T
(2002) Neurochemistry International 40: 235-242

Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors
Fujino K, Yoshitake T, Inoue O, Ibii N, Kehr J, Ishida J, Nohta H, Yamaguchi M
(2002) Neuroscience Letters 320: 91-95

Role of endothelin ET(B) receptors in the renal hemodynamic and excretory responses to big endothelin-1.
Konishi F, Okada Y, Takaoka M, Gariepy CE, Yanagisawa M, Matsumura Y
(2002) European Journal of Pharmacology 451: 177-184

Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359

Relationship between oxidation of glutathione and reactive nitrogen species during the early-reperfusion phase of cerebral ischemia.
Iijima T, Sakamoto H, Okada C, Iwao Y
(2002) Neurochemical Research 27: 497-500

Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems.
Matsuda Y, Hirano H, Watanabe Y
(2002) Brain Research 937: 58-65

GABA release in the medial preoptic area of cyclic female rats.|
Mitsushima D, Shwe TT, Funabashi T, Shinohara K, Kimura F
(2002) Neuroscience 113: 109-114

Profiles of in vivo gamma-aminobutyric acid release in the medial preoptic area of intact and castrated male rats.
Tin-Tin-Win-Shwe, Mitsushima D, Kimura F
(2002) Neuroendocrinology 76(5):290-296

2001

â-Phenylethlamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D2 receptor mechanism
Kato M, Ishida K, Chuma T, Abe K, Shigenaga T, Taguchi K, Miyake T
(2001) European Journal of Pharmacology 418: 65-71

Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca²⁺ – and K⁺ -evoked serotonin release
Kawata Y, Okada M, Murakami T, Kamata A, Zhu G, Kaneko S
(2001) British Jourmal of Pharmacology 133: 557-567

Determination of serotonin in microdialysis samples from rat brain by microbore column liquid chromatography with post-column derivatization and fluorescence detection
Yoshitake T, Iizuka R, Kehr J, Nohta H, Ishida J, Yamaguchi M
(2001) Journal of Neuroscience Methods 109: 91-96

Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine.
Hatip-Al-Khatib I, Mishima K, Iwasaki K, Fujiwara M
(2001) Brain Research 902: 108-118

Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study.
Hatip-Al-khati I, Bolukbasi F, Mishima K, Egashira N, Iwasaki K, Fujiwara M
(2001) Japanese Journal of Pharmacology 87: 277-287

Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neuroscience Letters 306: 206-208

Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.
Yoshida Y, Fujiki N, Nakajima T, Ripley B, Matsumura H, Yoneda H, Mignot E, Nishino S
(2001) European Journal of Neuroscience 14: 1075-1081

Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.
Kishi T, Hirooka Y, Sakai K, Shigematsu H, Shimokawa H, Takeshita A
(2001) Hypertension 38: 896-901

Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo.
Matsuo I, Hirooka Y, Hironaga K, Eshima K, Shigematsu H, Shihara M, Sakai K, Takeshita A
The American Journal of Physiology – Regulatory, Integrative and (2001) Comparative Physiology 280: R1285-1291

Differential effects of psychological stress on activation of the 5-hydroxytryptamine- and dopamine-containing neurons in the brain of freely moving rats.
Funada M, Hara C.
(2001) Brain Research 901(1-2):247-251

Adenosine Receptor Subtypes Modulate Two Major Functional Pathways for Hippocampal Serotonin Release.
Okada M, Nutt DJ, Murakami T, Zhu G, Kamata A, Kawata Y, Kaneko S
(2001) The Journal of Neuroscience 21: 628-640

Monitering of extracellular dopamine levels in the dorsal striatum and the nucleus accumbens with 5-minute on-line microdialysis in freely movin rats.
Saigusa T, Fusa K, Okutsu H, Koshikawa N
(2001) Journal of Oral Science 43: 129-134

Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum.
Yamato H, Kannari K, Shen H, Suda T, Matsunaga M
(2001)Neuropharmacology and Neurotoxicology 12: 1123-1126

Activationof 5-HT1A but not 5-HT1B receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation.
Kannnari K, Yamato H, Shen H, Tomiyama M, Suda T, Matsunaga M
(2001) Journal of Neurochemistry 76: 1346-1353

In vivo assessment of acetylcholine-releasing function at cardiac vagal nerve terminals.
Kawada T, Yamazaki T, Akiyama T, Shishido T, Inagaki M, Uemura K, Miyamoto T, Sugimachi M, Takaki H, Sunagawa K
(2001) American Journal of Physiology – Heart and Circulatory Physiology 281: H139-H145

Effects of ketamine on in vivo cardiac sympathetic nerve endings.
Kitagawa H, Yamazaki T, Akiyama T, Mori H, Sunagawa K
(2001) Journal of Cardiovascular Pharmacology 38 (Suppl. 1): S39-S42

Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid.
Ueda Y, Doi T, Tokumaru J, Yokoyama H, Nakajima A, Mitsuyama Y, Ohya-Nishiguchi H, Kamada H, Willmore LJ
(2001) Journal of Neurochemistry 76: 892-900

Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia.
Anzawa N, Kushikata T, Ohkawa H, Yoshida H, Kubota T, Matsuki A
(2001) Canadian Journal of Anaesthesia 48: 462-465

Xenon inhalation increases norepinephrine release from the anterior and posterior hypothalamus in rats.
Yoshida H, Kushikata T, Kubota T, Hirota K, Ishihara H, Matsuki A.
(2001) Canadian Journal of Anesthesia 48:651-655

2000

Nitric oxide formation in the dog sphincter of Oddi from nitric oxide donors as measured with in vivo microdialysis.
Yamamoto I, Fujiwara M, Kuhara N, Kumano K, Yamada T, Yamamoto H, Fujiwara M
(2000) Alimentary Pharmacology & Therapeutics 14: 1095-1101

静脈麻酔薬がラット背側海馬の一酸化窒素産生に与える影響 (The Influence of Intravenous Anethetics on Nitric Oxide Production in the Rat Dorsal Hippocampus).
白石直之、大井久美子
(2000) 日本歯科麻酔学会雑誌 28: 27-35

Reserpine Pretreatment Prevents Increase in Extracellular Striatal Dopamine Following L-DOPA Administration in Rats with Nigrostriatal Denervation.
Kannari K, Tanaka H, Maeda T, Tomiyama M, Suda T, Matsunaga M
(2000) Journal of Neurochemistry 74: 263-269

Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarnic M1 receptor stimulation.
Murakami Y, Ikenoya M, Matsumoto K, Li H, Watanabe H
(2000) Behavioural Brain Research 109: 83-90

Preferable Monosodium Glutamate and Sodium Chloride Solutions do not Affect Diurnal Norepinephrine Release in the Rat Lateral Hypothalamus.
Smriga M, Torii K
(2000) Nutritional Neuroscience 3: 367-372

Presynaptic L-type Ca2+ channels on excessive dopamine release from rat caudate putamen.
Okita M, Watanabe Y, Taya K, Utsumi H, Hayashi T
(2000) Physiology & Behavior 68: 641-649

抹消組織での無麻酔・無拘束マイクロダイアリシス法
倉田知光
(2000) 日薬理誌 116: 181-187

Chronic adriamycin treatment impairs myocardial interstitial neuronal release of norepinephrine and epinephrine.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Sunagawa K
(2000) Journal of Cardiovascular Pharmacology 36 (Suppl. 2): S31-S34

Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Takaki H, Sugimachi M, Sunagawa K
(2000) Journal of Molecular and Cellular Cardiology 32: 405-414

Vasopressin regulation of noradrenaline release within the supraoptic nucleus.
Ludwig M, Onaka T, Yagi K
(2000) Journal of Neuroendocrinology 12: 477-479

The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral hippocampus in rats.
Mishima K, Iwasaki K, Tsukikawa H, Matsumoto Y, Egashira N, Abe K, Egawa T, Fujiwara M.
(2000) Japanese Journal of Pharmacology 84: 163-173

Activation of peripheral NMDA-nitric oxide cascade in formalin test.
Omote K, Kawamata T, Kawamata M, Nakayama Y, Hazama K, Namiki A.
(2000) Anesthesiology 93(1):173-178

1999

Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia.
Ohtani N, Sugano T, Ohta M
(1999) Brain Research 842: 6-14

Effect of selegiline on dopamine concentration in the striatum of a primate.
Kaseda S, Nomoto M, Iwata S
(1999) Brain Research 815: 44-50

セフジトレンピボキシルの脳内移行について
山崎由香子、今井恵子、奈良圭之輔、岩井信市、徳永　晋、小口勝司
(1999) 昭和医学会雑誌 59: 629-634

Serotonin-mediated increases in the extracellular levels of beta-endorphin in the arcuate nucleus and nucleus accumbens: a microdialysis study.
Zangen A, Nakash R, Yadid G
(1999) Journal of Neurochemistry 73: 2569-2574

1998

Enhanced glutamate release during REM sleep in the rostromedial medulla as measured by in vivo microdialysis.
Kodama T, Lai YY, Siegel JM
(1998) Brain Research 780: 178-181

Pharmacokinetics of Topical â-Adrenergic Antagonists in Rabbit Aqueous Humor Evaluated with the Microdialysis Method.
Ohtori R, Sato H, Fukuda S, Ueda T, Koide R, Kanda Y, Kiuchi Y, Oguchi K
(1998) Experimental Eye Research 66: 487-494

Liquid chromatographic determination of myocardial interstitial epinephrine.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Inagaki M, Alexander J, Sunagawa K
(1998) Journal of chromatography B 714: 375-378

Effect of the nitric oxide level in the medial preoptic area on male copulatory behavior in rats.
Sato Y, Horita H, Kurohata T, Adachi H, Tsukamoto T.
(1998) American Journal of Physiology 274(1 Pt 2):R243-R247

1997

Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats.
Murakami Y, Matsumoto K, Watanabe H
(1997) Biological & Pharmaceutical Bulletin 20: 88-90

New antioxidant mixture for long term stability of serotonin, dopamine and their metabolites in automated microbore liquid chromatography with dual electrochemical detection.
Thorré K, Pravda M, Sarre S, Ebinger G, Michotte Y
(1997) Journal of Chromatography B, 694: 297-303

High-performance liquid chromatographic determination of myocardial interstitial dihidroxyphenylglycol.
Takauchi Y, Kitagawa H, Kaeada T, Akiyama T, Yamazaki T
(1997) Journal of Chromatography B 693: 218-221

1995

Routine high-performance liquid chromatographic determination of myocardial interstitial norepinephrine.
Yamazaki T, Akiyama T, Shindo T
(1995) Journal of Chromatography B 670: 328-331

Changes of hepatic microsomal oxidative drug metabolizing enzymes in chronic renal failure (CRF) rats by partial nephrectomy.
Uchida N, Kurata N, Shimada K, Nishimura Y, Yasuda K, Hashimoto M, Uchida E, Yasuhara H.
(1995) Japanese Journal of Pharmacology 68(4):431-439

1993

Effects of repeated cerebral ischemia on extracellular amino acid concentrations measured with intracerebral microdialysis in the gerbil hippocampus.
Nakata, N., Kato, H., & Kogure, K.
(1993) Stroke, 24(3), 458-463.

Increase in serotonin levels in the dog ileum and blood by cisplatin as measured by microdialysis.
Fukui H, Yamamoto M, Ando T, Sasaki S, Sato S.
(1993) Neuropharmacology 32(10):959-968

1991

Pineal microdialysis in freely moving rats.
Azekawa T, Sano A, Sei H, Yamamoto A, Aoi K, Morita Y
(1991) Brain Research Bulletin 26(3):413-417

1990

Concurrent on-line sampling of melatonin in pineal microdialysates from conscious rat and its analysis by high-performance liquid chromatography with electrochemical detection.
Azekawa T, Sano A, Aoi K, Sei H, Morita Y
(1990) Journal of Chromatography 530(1):47-55