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Behavioral Neuroscience
Touch Panel
2020
β-lactolin, a whey-derived glycine―threonine―tryptophan―tyrosine lactotetrapeptide, improves prefrontal cortex-associated reversal learning in mice.
Ayabe, T., Ohya, R., & Ano, Y.
(2020). Bioscience, biotechnology, and biochemistry, 84(5), 1039-1046.
2019
Hop-Derived Iso-α-Acids in Beer Improve Visual Discrimination and Reversal Learning in Mice as Assessed by a Touch Panel Operant System.
Ayabe, T., Ohya, R., & Ano, Y.
(2019). Frontiers in Behavioral Neuroscience, 13, 67.
TaskForcer
2023
Working memory-based and-free reward prediction in a dual dopamine system in the basal ganglia.
Yoshizawa, T., Miyamura, Y., Ochi, Y., Hira, R., Funahashi, M., Sakai, Y., … & Isomura, Y.
(2023). bioRxiv, 2023-03.
2020
A spike analysis method for characterizing neurons based on phase locking and scaling to the interval between two behavioral events.
Kawabata, M., Soma, S., Saiki-Ishikawa, A., Nonomura, S., Yoshida, J., Ríos, A. A., … & Isomura, Y.
(2020). Journal of Neurophysiology.
Differential effects of dopamine D1‐like and D2‐like receptor agonists on water drinking behaviour under thirsty conditions in mice with reduced dopamine secretion.
Kao, K. C., & Hisatsune, T.
(2020). European Journal of Neuroscience, 51(2), 584-597.
2019
Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.
Soma, S., Yoshida, J., Kato, S., Takahashi, Y., Nonomura, S., Sugimura, Y. K., … & Sakai, Y.
(2019). Journal of Neuroscience, 39(3), 485-502.
Ventral striatum links motivational and motor networks during operant-conditioned movement in rats.
Hori, Y., Ihara, N., Sugai, C., Ogura, J., Honda, M., Kato, K., … & Hanakawa, T.
(2019). Neuroimage, 184, 943-953.
2018
Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition.
Yoshida, J., Saiki, A., Soma, S., Yamanaka, K., Nonomura, S., Ríos, A., … & Isomura, Y.
(2018). Neuroscience, 388, 297-316.
In vivo spiking dynamics of intra-and extratelencephalic projection neurons in rat motor cortex.
Saiki, A., Sakai, Y., Fukabori, R., Soma, S., Yoshida, J., Kawabata, M., … & Isomura, Y.
(2018). Cerebral Cortex, 28(3), 1024-1038.
Learning task-related activities from independent local-field-potential components across motor cortex layers.
Martín-Vázquez, G., Asabuki, T., Isomura, Y., & Fukai, T.
(2018). Frontiers in neuroscience, 12, 429.
Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways.
Nonomura, S., Nishizawa, K., Sakai, Y., Kawaguchi, Y., Kato, S., Uchigashima, M., … & Sano, H.
(2018). Neuron, 99(6), 1302-1314.
Super-wide-field two-photon imaging with a micro-optical device moving in post-objective space.
Terada, S. I., Kobayashi, K., Ohkura, M., Nakai, J., & Matsuzaki, M.
(2018). Nature communications, 9(1), 1-14.
Thalamocortical axonal activity in motor cortex exhibits layer-specific dynamics during motor learning.
Tanaka, Y. H., Tanaka, Y. R., Kondo, M., Terada, S. I., Kawaguchi, Y., & Matsuzaki, M.
(2018). Neuron, 100(1), 244-258.
Quantitative study of the somatosensory sensitization underlying cross-modal plasticity.
Abe, K., & Yawo, H.
(2018). PloS one, 13(12).
2017
Continuous membrane potential fluctuations in motor cortex and striatum neurons during voluntary forelimb movements and pauses.
Nonomura, S., Fujiwara-Tsukamoto, Y., Kajihara, T., Fujiyama, F., & Isomura, Y.
(2017). Neuroscience research, 120, 53-59.
Distinct laterality in forelimb-movement representations of rat primary and secondary motor cortical neurons with intratelencephalic and pyramidal tract projections.
Soma, S., Saiki, A., Yoshida, J., Ríos, A., Kawabata, M., Sakai, Y., & Isomura, Y.
(2017). Journal of Neuroscience, 37(45), 10904-10916.
Large‐scale analysis reveals populational contributions of cortical spike rate and synchrony to behavioural functions.
Kimura, R., Saiki, A., Fujiwara‐Tsukamoto, Y., Sakai, Y., & Isomura, Y.
(2017). The Journal of physiology, 595(1), 385-413.
Medial frontal circuit dynamics represents probabilistic choices for unfamiliar sensory experience.
Handa, T., Takekawa, T., Harukuni, R., Isomura, Y., & Fukai, T.
(2017). Cerebral Cortex, 27(7), 3818-3831.
Phase-dependent activity of neurons in the rostral part of the thalamic reticular nucleus with saccharin intake in a cue-guided lever-manipulation task.
oki, R., Kato, R., Fujita, S., Shimada, J., Koshikawa, N., & Kobayashi, M.
(2017). Brain research, 1658, 42-50.
Temporal and rate coding for discrete event sequences in the hippocampus.
Terada, S., Sakurai, Y., Nakahara, H., & Fujisawa, S.
(2017). Neuron, 94(6), 1248-1262.
2016
Spike timing rigidity is maintained in bursting neurons under pentobarbital-induced anesthetic conditions.
Kato, R., Yamanaka, M., Yokota, E., Koshikawa, N., & Kobayashi, M.
(2016). Frontiers in neural circuits, 10, 86.
2015
Distinct functional modules for discrete and rhythmic forelimb movements in the mouse motor cortex.
Hira, R., Terada, S. I., Kondo, M., & Matsuzaki, M.
(2015). Journal of Neuroscience, 35(39), 13311-13322.
2014
Different modulation of common motor information in rat primary and secondary motor cortices.
Saiki, A., Kimura, R., Samura, T., Fujiwara-Tsukamoto, Y., Sakai, Y., & Isomura, Y.
(2014). PloS one, 9(6).
Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning.
Hira, R., Ohkubo, F., Masamizu, Y., Ohkura, M., Nakai, J., Okada, T., & Matsuzaki, M.
(2014). Nature communications, 5(1), 1-12.
Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task.
Masamizu, Y., Tanaka, Y. R., Tanaka, Y. H., Hira, R., Ohkubo, F., Kitamura, K., … & Matsuzaki, M.
(2014). Nature neuroscience, 17(7), 987-994.
2013
Reward-modulated motor information in identified striatum neurons.
Isomura, Y., Takekawa, T., Harukuni, R., Handa, T., Aizawa, H., Takada, M., & Fukai, T.
(2013). Journal of Neuroscience, 33(25), 10209-10220.
Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement.
Hira, R., Ohkubo, F., Ozawa, K., Isomura, Y., Kitamura, K., Kano, M., … & Matsuzaki, M.
(2013). Journal of Neuroscience, 33(4), 1377-1390.
2012
Reinforcing operandum: rapid and reliable learning of skilled forelimb movements by head-fixed rodents.
Kimura, R., Saiki, A., Fujiwara-Tsukamoto, Y., Ohkubo, F., Kitamura, K., Matsuzaki, M., … & Isomura, Y.
(2012). Journal of neurophysiology, 108(6), 1781-1792.
2009
Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements.
Isomura, Y., Harukuni, R., Takekawa, T., Aizawa, H., & Fukai, T.
(2009). Nature neuroscience, 12(12), 1586.
Self Head-Restraining Platform
2017
An automated platform for high-throughput mouse behavior and physiology with voluntary head-fixation.
Aoki, R., Tsubota, T., Goya, Y., & Benucci, A.
(2017). A Nature communications, 8(1), 1-9.
Free Maze
2020
The Reconfigurable Maze Provides Flexible, Scalable, Reproducible, and Repeatable Tests.
Hoshino, S., Takahashi, R., Mieno, K., Tamatsu, Y., Azechi, H., Ide, K., & Takahashi, S.
(2020). Iscience, 23(1), 100787.
T-Maze
2023
Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.
Shoji, H., Ikeda, K., & Miyakawa, T.
(2023). Molecular Brain, 16(1), 1-24.
Inflammatory Skin Disease Causes Anxiety Symptoms Leading to an Irreversible Course.
Iida, S., Shoji, H., Kawakita, F., Nakanishi, T., Matsushima, Y., Kondo, M., … & Yamanaka, K.
(2023). International Journal of Molecular Sciences, 24(6), 5942.
ILF3 prion-like domain regulates gene expression and fear memory under chronic stress.
Yamashita, A., Shichino, Y., Fujii, K., Koshidaka, Y., Adachi, M., Sasagawa, E., … & Shiina, N.
(2023). Iscience.
PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain.
Kurihara, Y., Mitsunari, K., Mukae, N., Shoji, H., Miyakawa, T., & Shirane, M.
(2023). Molecular Brain, 16(1), 1-18.
2020
The hippocampus encodes delay and value information during delay-discounting decision making.
Masuda, A., Sano, C., Zhang, Q., Goto, H., McHugh, T. J., Fujisawa, S., & Itohara, S.
(2020). Elife, 9, e52466.
2018
An automated T-maze based apparatus and protocol for analyzing delay-and effort-based decision making in free moving rodents.
Zhang, Q., Kobayashi, Y., Goto, H., & Itohara, S.
(2018). JoVE (Journal of Visualized Experiments), (138), e57895.
2015
Exposure to social defeat stress in adolescence improves the working memory and anxiety-like behavior of adult female rats with intrauterine growth restriction, independently of hippocampal neurogenesis.
Furuta, M., Ninomiya-Baba, M., Chiba, S., Funabashi, T., Akema, T., & Kunugi, H.
(2015). Hormones and behavior, 70, 30-37.
2014
Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes.
Fujioka, R., Nii, T., Iwaki, A., Shibata, A., Ito, I., Kitaichi, K., … & Fukumaki, Y.
(2014). Molecular brain, 7(1), 31.
2013
Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice.
Ohira, K., Kobayashi, K., Toyama, K., Nakamura, H. K., Shoji, H., Takao, K., … & Takahashi, M.
(2013). Molecular brain, 6(1), 12.
2012
T-maze forced alternation and left-right discrimination tasks for assessing working and reference memory in mice.
Shoji, H., Hagihara, H., Takao, K., Hattori, S., & Miyakawa, T.
(2012). JoVE (Journal of Visualized Experiments), (60), e3300.
2008
Effects of intrahippocampal cannabinoid receptor agonist and antagonist on radial maze and T-maze delayed alternation performance in rats.
Suenaga, T., Kaku, M., & Ichitani, Y.
(2008). Pharmacology Biochemistry and Behavior, 91(1), 91-96.
Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia.
Takao, K., Toyama, K., Nakanishi, K., Hattori, S., Takamura, H., Takeda, M., … & Hashimoto, R.
(2008). Molecular brain, 1(1), 11.
Drinko Measurer
2023
Serotonin regulation of intermittent and continuous alcohol drinking in male and female C57BL/6J mice with systemic SB242084 and buspirone.
Ko, Y. E., & Hwa, L. S.
(2023). Alcohol and Alcoholism, agad019.
2021
Alcohol consumption preferentially activates a subset of pro-opiomelanocortin (POMC) producing neurons targeting the amygdala.
Leyrer-Jackson, J. M., Hood, L. E., & Olive, M. F.
(2021). Neuropharmacology, 108674.
2012
Poliovirus trafficking toward central nervous system via human poliovirus receptor-dependent and-independent pathway.
Ohka, S., Nihei, C. I., Yamazaki, M., & Nomoto, A.
(2012). Frontiers in microbiology, 3, 147.
2011
B6-MSM consomic mouse strains reveal multiple loci for genetic variation in sucrose octaacetate aversion.
Ishii, A., Koide, T., Takahashi, A., Shiroishi, T., Hettinger, T. P., Frank, M. E., … & Blizard, D. A.
(2011). Behavior genetics, 41(5), 716.
2007
Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor.
Ohka, S., Igarashi, H., Nagata, N., Sakai, M., Koike, S., Nochi, T., … & Nomoto, A.
(2007). Journal of virology, 81(15), 7902-7912.
2002
Genetic diversity underlying capsaicin intake in the Mishima battery of mouse strains.
Furuse, T., Blizard, D. A., Moriwaki, K., Miura, Y., Yagasaki, K., Shiroishi, T., & Koide, T.
(2002). Brain research bulletin, 57(1), 49-55.
Three-Chamber Social Interaction
2020
Awake functional MRI detects neural circuit dysfunction in a mouse model of autism.
Tsurugizawa, T., Tamada, K., Ono, N., Karakawa, S., Kodama, Y., Debacker, C., … & Takumi, T.
(2020). Science Advances, 6(6), eaav4520.
Wire Hang Test
2023
Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.
Shoji, H., Ikeda, K., & Miyakawa, T.
(2023). Molecular Brain, 16(1), 1-24.
ILF3 prion-like domain regulates gene expression and fear memory under chronic stress.
Yamashita, A., Shichino, Y., Fujii, K., Koshidaka, Y., Adachi, M., Sasagawa, E., … & Shiina, N.
(2023). Iscience.
PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain.
Kurihara, Y., Mitsunari, K., Mukae, N., Shoji, H., Miyakawa, T., & Shirane, M.
(2023). Molecular Brain, 16(1), 1-18.
2022
Chronic Inhibition of Aggressive Behavior Induces Behavioral Change in Mice.
Ueno, H., Takahashi, Y., Murakami, S., Wani, K., Miyazaki, T., Matsumoto, Y., … & Ishihara, T.
(2022). Behavioural Neurology, 2022.
The prevention of home-cage grid climbing affects muscle strength in mice.
Ueno, H., Takahashi, Y., Murakami, S., Wani, K., Miyazaki, T., Matsumoto, Y., … & Ishihara, T.
(2022). Scientific Reports, 12(1), 1-14.
Other
2023
Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.
Shoji, H., Ikeda, K., & Miyakawa, T.
(2023). Molecular Brain, 16(1), 1-24.
Inflammatory Skin Disease Causes Anxiety Symptoms Leading to an Irreversible Course.
Iida, S., Shoji, H., Kawakita, F., Nakanishi, T., Matsushima, Y., Kondo, M., … & Yamanaka, K.
(2023). International Journal of Molecular Sciences, 24(6), 5942.
ILF3 prion-like domain regulates gene expression and fear memory under chronic stress.
Yamashita, A., Shichino, Y., Fujii, K., Koshidaka, Y., Adachi, M., Sasagawa, E., … & Shiina, N.
(2023). Iscience.
PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain.
Kurihara, Y., Mitsunari, K., Mukae, N., Shoji, H., Miyakawa, T., & Shirane, M.
(2023). Molecular Brain, 16(1), 1-18.
2022
Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.
Nagashima, T., Tohyama, S., Mikami, K., Nagase, M., Morishima, M., Kasai, A., … & Watabe, A. M.
(2022). Nature Communications, 13(1), 1-17.
Curcumin improves D-galactose and normal-aging associated memory impairment in mice: In vivo and in silico-based studies.
Rahman, M. A., Shuvo, A. A., Bepari, A. K., Hasan Apu, M., Shill, M. C., Hossain, M., … & Reza, H. M.
(2022).Plos one, 17(6), e0270123.
Hippocampal 7a-Hydroxylated Neurosteroids Are Raised by Training and Bolster Remote Spatial Memory with Increase of the Spine Densities.
Maehata, K., Shimizu, K., Ikeno, T., Pan, Y., Takao, T., & Fukada, Y.
(2022). iScience 23, 101559
Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum.
Komatsu, A., Iida, I., Nasu, Y., Ito, G., Harada, F., Kishikawa, S., … & Terunuma, M.
(2022). Journal of Biological Chemistry, 101933.
Loss of calsyntenin paralogs disrupts interneuron stability and mouse behavior.
Mori, K., Koebis, M., Nakao, K., Kobayashi, S., Kiyama, Y., Watanabe, M., … & Aiba, A.
(2022). Molecular Brain, 15(1), 1-16.
2021
Human Cerebral Organoid Implantation Alleviated the Neurological Deficits of Traumatic Brain Injury in Mice.
Bao, Z., Fang, K., Miao, Z., Li, C., Yang, C., Yu, Q., … & Ji, J.
(2021). Oxidative Medicine and Cellular Longevity, 2021.
Low-intensity pulsed ultrasound therapy promotes recovery from stroke by enhancing angio-neurogenesis in mice in vivo.
Ichijo, S., Shindo, T., Eguchi, K., Monma, Y., Nakata, T., Morisue, Y., … & Shimokawa, H.
(2021). Scientific Reports, 11(1), 1-11.
Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test.
Shoji, H., & Miyakawa, T.
(2021). Molecular Brain, 14(1), 1-12.
“Anti-Stress Composition.”
Kobayashi, Y., Maehata, H., Kuhara, T., & Toyoda, A.
(2021). U.S. Patent Application No. 16/982,888.
Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease.
Yuichi, H., Shinya, K., Mikiro, N., Koichi, O., Yuka, T., & Masaaki, M.
(2021). Translational Psychiatry, 11(1).
2020
Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice.
Nakajima, K., Miranda, A., Craig, D. W., Shekhtman, T., Kmoch, S., Bleyer, A., … & Kelsoe, J. R.
(2020). Translational Psychiatry, 10(1), 1-13.
Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning.
Shirane, M., Shoji, H., Hashimoto, Y., Katagiri, H., Kobayashi, S., Manabe, T., … & Nakayama, K. I.
(2020). Molecular Brain, 13(1), 1-18.
Vasopressin escape and memory impairment in a model of chronic syndrome of inappropriate secretion of antidiuretic hormone in mice.
Kawakami, T., Fujisawa, H., Nakayama, S., Yoshino, Y., Hattori, S., Seino, Y., … & Sugimura, Y.
(2020). Endocrine Journal, EJ20-0289.
Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA B receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice.
Arima-Yoshida, F., Raveau, M., Shimohata, A., Amano, K., Fukushima, A., Watanave, M., … & Mataga, N.
(2020). Scientific Reports, 10(1), 1-15.
Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model.
Abe, Y., Ikegawa, N., Yoshida, K., Muramatsu, K., Hattori, S., Kawai, K., … & Yamamoto, T.
(2020). Acta Neuropathologica Communications, 8(1), 1-15.
Effects of dietary intake of heat-inactivated Lactobacillus gasseri CP2305 on stress-induced behavioral and molecular changes in a subchronic and mild social defeat stress mouse model.
TOYODA, A., KAWASE, T., & TSUKAHARA, T.
(2020). Biomedical Research, 41(2), 101-111.
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.
Takeuchi, H., Imamura, K., Ji, B., Tsukita, K., Enami, T., Takao, K., … & Inoue, M.
(2020). npj Vaccines, 5(1), 1-11.
Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances.
Matsuda, Y., Ozawa, N., Shinozaki, T., Wakabayashi, K. I., Suzuki, K., Kawano, Y., … & Tatebayashi, Y.
(2020). bioRxiv.
2019
TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility.
Andoh, C., Nishitani, N., Hashimoto, E., Nagai, Y., Takao, K., Miyakawa, T., … & Kaneko, S.
(2019). Brain research, 1704, 68-77.
The role of CaMKII-Tiam1 complex on learning and memory.
Kojima, H., Rosendale, M., Sugiyama, Y., Hayashi, M., Horiguchi, Y., Yoshihara, T., … & Hayashi, Y.
(2019). Neurobiology of learning and memory, 166, 107070.
Effects of chronic fentanyl administration on behavioral characteristics of mice.
Fujii, K., Koshidaka, Y., Adachi, M., & Takao, K.
(2019). Neuropsychopharmacology reports, 39(1), 17-35.
2017
Deficiency in EP4 Receptor–Associated Protein Ameliorates Abnormal Anxiety-Like Behavior and Brain Inflammation in a Mouse Model of Alzheimer Disease.
Fujikawa, R., Higuchi, S., Nakatsuji, M., Yasui, M., Ikedo, T., Nagata, M., … & Minami, M.
(2017). The American journal of pathology, 187(8), 1848-1854.
Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice.
Fujikawa, R., Higuchi, S., Ikedo, T., Nagata, M., Hayashi, K., Yang, T., … & Minami, M.
(2017). Biochemical and biophysical research communications, 486(2), 584-588.
2016
Behavioral alterations following blood-brain barrier disruption stimulated by focused ultrasound.
Yang, F. Y., Huang, S. F., & Cheng, I. H. J.
(2016). Oncotarget, 7(19), 27916.
2014
IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours.
Yasumura, M., Yoshida, T., Yamazaki, M., Abe, M., Natsume, R., Kanno, K., … & Miyakawa, T.
(2014). Scientific reports, 4, 6613.
2012
Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and-L100P mutant mice.
Shoji, H., Toyama, K., Takamiya, Y., Wakana, S., Gondo, Y., & Miyakawa, T.
(2012). BMC research notes, 5(1), 108.
2013
Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice.
Ohira, K., Kobayashi, K., Toyama, K., Nakamura, H. K., Shoji, H., Takao, K., … & Takahashi, M.
(2013). Molecular brain, 6(1), 12.
2011
Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice.
Yao, I., Takao, K., Miyakawa, T., Ito, S., & Setou, M.
(2011). PLoS One, 6(2).
2010
Behavioral profiles of three C57BL/6 substrains.
Matsuo, N., Takao, K., Nakanishi, K., Yamasaki, N., Tanda, K., & Miyakawa, T.
(2010). Frontiers in behavioral neuroscience, 4, 29.
2008
Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia.
Takao, K., Toyama, K., Nakanishi, K., Hattori, S., Takamura, H., Takeda, M., … & Hashimoto, R.
(2008). Molecular brain, 1(1), 11.
Microdialysis
Microdialysis Probes, Instruments and Accessories
2023
In situ continuous Dopa supply by responsive artificial enzyme for the treatment of Parkinson’s disease.
Fang, X., Yuan, M., Zhao, F., Yu, A., Lin, Q., Li, S., … & Yang, H.
(2023). Nature Communications, 14(1), 1-14.
5-HT1B receptors in the basolateral amygdaloid nucleus regulate anxiety-like behaviors through AC-PKA signal pathway in a rat model of Parkinson’s disease.
Tang, G., Guo, Y., Zhang, L., Wang, T., Li, R., Yang, J., … & Liu, J.
(2023). Behavioural Brain Research, 114488.
Mesolimbic dopamine release precedes actively sought aversive stimuli in mice.
Yawata, Y., Shikano, Y., Ogasawara, J., Makino, K., Kashima, T., Ihara, K., … & Ikegaya, Y.
(2023). Nature Communications, 14(1), 2433.
Acute and chronic actions of methylphenidate mediated through the L-DOPA receptor GPR143.
Uchimura, H., Kanai, K., Arai, M., Inoue, M., Hishimoto, A., Masukawa, D., & Goshima, Y.
(2023). Journal of Pharmacological Sciences.
Toxicity manifestations and sex differences due to MARTA olanzapine.
Hattori-Usami, N., Kaizaki-Mitsumoto, A., Ashino, T., Yamamoto, M., & Numazawa, S.
(2023). The Journal of Toxicological Sciences, 48(4), 191-202.
Rat model of attention-deficit hyperactivity disorder exhibits delayed recovery from acute incisional pain due to impaired descending noradrenergic inhibition.
Suto, T., Kato, D., Koibuchi, I., Arai, Y., Ohta, J., Hiroki, T., … & Saito, S.
(2023). Scientific Reports, 13(1), 5526.
A Candidate Gliotransmitter, L-β-Aminoisobutyrate, Contributes to Weight Gain and Metabolic Complication Induced by Atypical Antipsychotics
Fukuyama, K., Motomura, E., & Okada, M.
(2023). . Nutrients, 15(7), 1621.
Changes in Acupuncture-Induced Specific Acupoint Neurotransmitters are Possibly Related to Their Physiological Functions in Rats.
Nguyen, H. T. M., Lee, D. Y., Liu, C. H., & Hsieh, C. L.
(2023). Evidence-Based Complementary and Alternative Medicine, 2023.
Electrochemical activities of Fe2O3-modified microelectrode for dopamine detection using fast-scan cyclic voltammetry.
Sato, N., Ohta, Y., Haruta, M., Takehara, H., Tashiro, H., Sasagawa, K., … & Ohta, J.
(2023). AIP Advances, 13(2), 025026.
Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain.
Fukuyama, K., Motomura, E., & Okada, M.
(2023). Schizophrenia, 9(1), 8.
Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice.
Tanaka, K., Kondo, T., Narita, M., Muta, T., Yoshida, S., Sato, D., … & Narita, M.
(2023). Molecular Brain, 16(1), 1-11.
Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus.
Yoshida, S., Hamada, Y., Narita, M., Sato, D., Tanaka, K., Mori, T., … & Narita, M.
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Highly selective transgene expression through the flip-excision switch system by using a unilateral spacer sequence.
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Modulation of trigeminal neuropathic pain by optogenetic inhibition of posterior hypothalamus in CCI-ION rat.
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Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle.
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Altered Pharmacological Efficacy of Phenobarbital with the Treatment of 7, 8-Dihydroxyflavone, an Agonist of Tropomyosin Receptor Kinase B, in Rats.
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2022
Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion.
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Kamishoyosan Alleviates Anxiety-like Behavior in a Premenstrual Syndrome Rat Model.
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Pro-cognitive effects of the GlyT1 inhibitor Bitopertin in rodents.
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Rubiscolin‑6 rapidly suppresses the postprandial motility of the gastric antrum and subsequently increases food intake via δ‑opioid receptors in mice.
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Differential pharmacological and sex-specific effects of antimuscarinic agents at the hypoglossal motor nucleus in vivo in rats.
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High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain.
Hisaoka-Nakashima, K., Ohata, K., Yoshimoto, N., Tokuda, S., Yoshii, N., Nakamura, Y., … & Morioka, N.
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TMEM16A blockers T16Ainh‐A01 and benzbromarone do not modulate the regulation of sweating and cutaneous vasodilatation in humans in vivo.
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Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy.
Hashimoto, Y., Kuniishi, H., Sakai, K., Fukushima, Y., Du, X., Yamashiro, K., … & Aoki, Y.
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Effects of Lisdexamfetamine, a Prodrug of D-Amphetamine, on Locomotion, Spatial Cognitive Processing and Neurochemical Profiles in Rats: A Comparison With Immediate-Release Amphetamine.
Jian-Min, C., Zhi-Yuan, W., Shi-Xuan, W., Rui, S., Ning, W., & Jin, L.
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Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia.
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Depolarization time and extracellular glutamate levels aggravate ultra-early brain injury after subarachnoid hemorrhage.
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Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.
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Toxicokinetic evaluation during intoxication of psychotropic drugs using brain microdialysis in mice.
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Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice.
Kawaminami, A., Yamada, D., Yanagisawa, S., Shirakata, M., Iio, K., Nagase, H., & Saitoh, A.
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Glucose infusion suppresses acute restraint stress-induced peripheral and central sympathetic responses in rats.
Yamaguchi, N., Kakinuma, Y., Yakura, T., Naito, M., & Okada, S.
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The efficacy of duloxetine depends on spinal cholinergic plasticity in neuropathic pain model rats.
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Phasic firing of dopaminergic neurons in the ventral tegmental area triggers peripheral immune responses.
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Investigating the Influence of GABA Neurons on Dopamine Neurons in the Ventral Tegmental Area Using Optogenetic Techniques.
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Oral acetaminophen-induced spinal 5-hydroxytriyptamine release produces analgesic effects in the rat formalin test.
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Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson’s disease.
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2021
Optogenetic stimulus-triggered acquisition of seizure resistance
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The abuse potential of prolintane in rodents: Behavioral pharmacology approaches.
Lee, W., Lee, J. W., Kim, J. M., Hong, Y. K., Kim, M. S., Choi, S. O., & Kang, M. S.
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Characterization and Relative Efficacy of Muscarinic Receptor Antagonism at the Hypoglossal Motor Nucleus to Block Inhibition of Tongue Motor Activity.
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Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine.
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Isoproterenol injected into the basolateral amygdala rescues amyloid β1-42-induced conditioned fear memory deficit via reducing intracellular Zn2+ toxicity.
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Reduction of acetylcholine in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
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Effect of P-glycoprotein Inhibition on the Penetration of Ceftriaxone Across the Blood–Brain Barrier.
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Pharmacogenetic excitation of the median raphe region affects social and depressive-like behavior and core body temperature in male mice.
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Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats.
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Participation of the descending noradrenergic inhibitory system in the anti-hyperalgesic effect of acetaminophen in a rat model of inflammation.
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Paraquat-induced intracellular Zn2+ dysregulation causes dopaminergic degeneration in the substantia nigra, but not in the striatum.Tamura, H., Nishio, R., Saeki, N., Katahira, M., Morioka, H., Tamano, H., & Takeda, A.
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Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss.
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FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice.
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Methods for Intratumoral Microdialysis Probe Targeting and Validation in Murine Brain Tumor Models.
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Specific gene expression in unmyelinated dorsal root ganglion neurons in nonhuman primates by intra-nerve injection of adeno-associated virus 6 vector.
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Regulation of maternal care by corticotropin-releasing factor receptors in the dorsal raphe nucleus in mice.
Kijima, T., Muroi, Y., & Ishii, T.
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Preventive effect of Ninjin-yoei-to, a Kampo medicine, on amyloid β1-42-induced neurodegeneration via intracellular Zn2+ toxicity in the dentate gyrus.
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Intracellular Hydrogen Peroxide Produced by 6-Hydroxydopamine is a Trigger for Nigral Dopaminergic Degeneration Via Rapid Influx of Extracellular Zn2+.
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Deep Brain Stimulation Using Animal Models of Parkinson’s Disease. In Experimental Models of Parkinson’s Disease (pp. 151-160).
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Astrocytes in the rostral ventromedial medulla contribute to the maintenance of orofacial hyperalgesia induced by late removal of dental occlusal interference.
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Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model.
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Lesions of the lateral habenula produce anxiolytic effects in a rat model of Parkinson’s disease.
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A Novel Chronic Dural Port Platform for Continuous Collection of Large Volumes of Cerebrospinal Fluid and Intrathecal Drug Delivery in Free-Moving Mice.
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β-adrenergic Receptor Activity in the Hippocampal Dentate Gyrus Participates in Spatial Learning and Memory Impairment in Sleep-deprived Rats.
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Period1 gene expression in the olfactory bulb and liver of freely moving streptozotocin-treated diabetic mouse.
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Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment.
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Effects of Inhaled Linalool on Anxiety Related Behaviors and Frontal Cortical Serotonin Levels in Mice.
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Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia.
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In Vivo Monitoring of Acetylcholine Release from Nerve Endings in Salivary Gland.
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Striatal TRPV1 activation by acetaminophen ameliorates dopamine D 2 receptor antagonists-induced orofacial dyskinesia.
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Monitoring Neuronal Dynamics in the Ventral Tegmental Area Using an Implantable Microimaging Device With Microdialysis System.
Sunaga, Y., Ohta, Y., Murakami, T. E., Akay, Y. M., Ohta, J., & Akay, M.
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Ferulic acid alleviates abnormal behaviors in isolation-reared mice via 5-HT 1A receptor partial agonist activity.
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Dehydroeffusol Pprevents Amyloid β 1-42-mediated Hippocampal Neurodegeneration via Reducing Intracellular Zn 2+ Toxicity.
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Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target.
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Mitochondrial toxins potentiate hydroxyl radical production in rat striatum during carbon monoxide poisoning.
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Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression.
Kinoshita, C., Kikuchi-Utsumi, K., Aoyama, K., Suzuki, R., Okamoto, Y., Matsumura, N., … & Nakaki, T.
(2021). Communications Biology, 4(1), 1-12.
Dual actions of 5‐MeO‐DIPT at the serotonin transporter and serotonin 5‐HT1A receptor in the mouse striatum and prefrontal cortex.
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Effects of Subchronic Administrations of Vortioxetine, Lurasidone, and Escitalopram on Thalamocortical Glutamatergic Transmission Associated with Serotonin 5-HT7 Receptor.
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Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis.
Chang, H. Y., Wu, S., Li, Y., Zhang, W., Burrell, M., Webster, C. I., & Shah, D. K.
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Antagonism for NPY signaling reverses cognitive behavior defects induced by activity-based anorexia in mice.
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Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors.
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A potential defense mechanism against amyloid deposition in cerebellum.
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Role of Oral Sensory and Serotonergic Neurons in Dopamine-induced Tongue Movement in Rat.
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A potential defense mechanism against amyloid deposition in cerebellum.
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Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques.
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Increased penetration of diphenhydramine in brain via proton-coupled organic cation antiporter in rats with lipopolysaccharide-induced inflammation.
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Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway.
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Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction.
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G-protein Signaling Regulating Opioid-induced Respiratory Rate Depression (Doctoral dissertation).
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Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards.
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Gαq protein signaling in the bed nucleus of the stria terminalis regulate the lipopolysaccharide-induced despair-like behavior in mice.
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Simultaneous blood and brain microdialysis in a free-moving mouse to test blood-brain barrier permeability of chemicals.
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Mice Carrying a Schizophrenia-associated Mutation of the Arhgap10 Gene Are Vulnerable to the Effects of Methamphetamine Treatment on Cognitive Function: Association With Morphological Abnormalities in Striatal Neurons.
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Glutathione Peroxidase-1 Knockout Facilitates Memory Impairment Induced by β-Amyloid (1–42) in Mice via Inhibition of PKC βII-Mediated ERK Signaling; Application with Glutathione Peroxidase-1 Gene-Encoded Adenovirus Vector.
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α2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline.
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Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice.
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Dissecting the tectal output channels for orienting and defense responses.
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Noradrenaline enhances the excitatory effects of dopamine on medial prefrontal cortex pyramidal neurons in rats.
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Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure.
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Effects of the Endocannabinoid Anandamide on the Efficiency of Noradrenergic Neurotransmission in the Amygdaloid Body in Acute Stress in Mice.
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Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice.
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Immobility-reducing Effects of Ketamine during the Forced Swim Test on 5-HT1A Receptor Activity in the Medial Prefrontal Cortex in an Intractable Depression Model.
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Modulation of TASK-1/3 Channels at the Hypoglossal Motoneuron Pool and Effects on Tongue Motor Output and Responses to Excitatory Inputs In-Vivo: Implications for Strategies for Obstructive Sleep Apnea Pharmacotherapy.
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Enhancement of the rewarding effects of 3, 4-methylenedioxymethamphetamine in orexin knockout mice.
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Effects of adipokine administration to the hypothalamic preoptic area on body temperature in rats.
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Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer’s disease model by increasing the expression of microRNA-146a in hippocampus.
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Astrocytic histone deacetylase 2 facilitates delayed depression and memory impairment after subarachnoid hemorrhage by negatively regulating glutamate transporter-1.
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Interaction between Mesocortical and Mesothalamic Catecholaminergic Transmissions Associated with NMDA Receptor in the Locus Coeruleus.
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Opposing Ventral Striatal Medium Spiny Neuron Activities Shaped by Striatal Parvalbumin-Expressing Interneurons during Goal-Directed Behaviors.
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Dopaminergic loss of cyclin-dependent kinase-like 5 recapitulates methylphenidate-remediable hyperlocomotion in mouse model of CDKL5 deficiency disorder.
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GABA storage and release in the medial globus pallidus in L-DOPA-induced dyskinesia priming.
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The antagonistic activity profile of naloxone in μ-opioid receptor agonist-induced psychological dependence.
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Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels.
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Paraquat as an Environmental Risk Factor in Parkinson’s Disease Accelerates Age-Related Degeneration Via Rapid Influx of Extracellular Zn 2+ into Nigral Dopaminergic Neurons.
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Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior.
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Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice.
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Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight.
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Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis.
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Effect of Yokukansan on Nitric Oxide Production and Hydroxyl Radical Metabolism During Cerebral Ischemia and Reperfusion in Mice.
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Proteomic analysis and ATP assay reveal a positive effect of artificial cerebral spinal fluid perfusion following microdialysis sampling on repair of probe-induced brain damage.
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Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc−.
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Iso-α-acids, the bitter components of beer, improve hippocampus-dependent memory through vagus nerve activation.
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Brain Microdialysis Study of Vancomycin in the Cerebrospinal Fluid After Intracerebroventricular Administration in Mice.
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Somatostatin-somatostatin receptor 2 signaling mediates LH pulse suppression in lactating rats.
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Tropomyosin receptor kinase B receptor activation in the locus coeruleus restores impairment of endogenous analgesia at a late stage following nerve injury in rats.
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Noradrenaline reuptake inhibition increases control of impulsive action by activating D1-like receptors in the infralimbic cortex.
Sasamori, H., Ohmura, Y., Yoshida, T., & Yoshioka, M.
(2018) European Journal of Pharmacology.
Amyloid β 1–42-Induced Rapid Zn 2+ Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia.
Tamano, H., Suzuki, H., Murakami, T., Fujii, H., Adlard, P. A., Bush, A. I., & Takeda, A.
(2018) Molecular Neurobiology, 1-10.
In vivo neurochemical evidence that stimulation of accumbal GABAA and GABAB receptors each reduce acetylcholine efflux without affecting dopamine efflux in the nucleus accumbens of freely moving rats.
Aono, Y., Watanabe, Y., Ishikawa, M., Kuboyama, N., Waddington, J. L., & Saigusa, T.
(2018) Synapse.
Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission.
Fukuyama, K., Hasegawa, T., & Okada, M.
(2018) International Journal of Molecular Sciences, 19(11), 3645.
Pharmacological characterization of (3-(benzo [d][1, 3] dioxol-4-yloxy).
Xu, X., Wei, Y., Guo, Q., Zhao, S., Liu, Z., Xiao, T., … & Wang, K.
(2018) Neuropsychopharmacology, 25, 871-880.
Astrocyte‐neuron lactate shuttle sensitizes nociceptive transmission in the spinal cord.
Miyamoto, K., Ishikura, K. I., Kume, K., & Ohsawa, M.
(2018) Glia.
Enhanced AMPA receptor-mediated excitatory transmission in the rodent rostromedial tegmental nucleus following lesion of the nigrostriatal pathway.
Chang, Y., Du, C., Han, L., Lv, S., Zhang, J., Bian, G., … & Liu, J.
(2018) Neurochemistry International.
E rythropoietin reduces nerve demyelination, neuropathic pain behavior and microglial MAPK s activation through erythropoietin receptors on S chwann cells in a rat model of peripheral neuropathy.
Huang, C. T., Chen, S. H., Lin, S. C., Chen, W. T., Lue, J. H., & Tsai, Y. J
(2018) Glia.
Blockade of Rapid Influx of Extracellular Zn 2+ into Nigral Dopaminergic Neurons Overcomes Paraquat-Induced Parkinson’s Disease in Rats.
Tamano, H., Morioka, H., Nishio, R., Takeuchi, A., & Takeda, A.
(2018) Molecular Neurobiology, 1-10.
Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve.
Ayabe, T., Ohya, R., Taniguchi, Y., Shindo, K., Kondo, K., & Ano, Y.
(2018) Scientific Reports, 8(1), 15372.
In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes.
Yamada, K.
(2018). JoVE (Journal of Visualized Experiments), (139), e57869-e57869.
A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice.
Saitoh, A., Soda, A., Kayashima, S., Yoshizawa, K., Oka, J. I., Nagase, H., & Yamada, M.
(2018). Journal of Pharmacological Sciences.
An enzyme-modified capillary as a platform for simultaneous fluorometric detection of D-glucose and L-lactate.
Shoji, A., Takahashi, Y., Osato, S., & Sugawara, M.
(2018). Journal of Pharmaceutical and Biomedical Analysis.
Pregabalin increases food intake through dopaminergic systems in the hypothalamus.
Ikeda, H., Yonemochi, N., Ardianto, C., Yang, L., & Kamei, J.
(2018). Brain Research.
“SIALYLATION-INCREASING THERAPIES FOR DISEASES ASSOCIATED WITH OXIDATIVE STRESS.”
Huizing, M., Malicdan, M. C., & Carrillo, N.
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Mesolimbic Dopamine, Its Receptors and Social Learning
Matta, R.
(2018) (Doctoral dissertation, NOVA Science Publishers).
Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia.
Sobue, A., Kushima, I., Nagai, T., Shan, W., Kohno, T., Aleksic, B., … & Yamamoto, M.
(2018) Scientific Reports, 8(1), 13046.
Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity.
Lui, S., Torontali, Z., Tadjalli, A., & Peever, J.
(2018) Scientific Reports, 8(1), 12709.
A Smart and Sensitive Sensing Platform to Monitor the Extracellular of Hydrogen Peroxide in Rat Brain Microdialysate under Pathological Process based on Mesoporous Silica Nanoparticles.
Xu, G., Xie, Q., Chen, Z., Luo, F., Qiu, B., Guo, L., & Lin, Z.
(2018) Analytical Methods.
“METHODS OF TREATING PATIENTS SUFFERING FROM MOVEMENT DISORDERS.”
Kase, H., Mori, A., Waki, Y., Ohsawa, Y., Karasawa, A., & Kuwana, Y.
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“ANTI-SEMAPHORIN 3A ANTIBODY AND TREATMENT OF ALZHEIMER’S DISEASE AND INFLAMMATORY IMMUNE DISEASES USING SAME.”
Goshima, Y., Nakamura, F., Yamashita, N., Seo, H., Hashimoto, S., Murakami, K., … & Sasakura, Y.
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Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.
Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.
Stimulation of accumbal GABAB receptors inhibits delta1-and delta2-opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats.
Watanabe, Y., Aono, Y., Komiya, M., Waddington, J. L., & Saigusa, T.
(2018) European Journal of Pharmacology.
Translocator protein 18kDa antagonist ameliorates stress‐induced stool abnormality and abdominal pain in rodent stress models.
Kawahara, Y., Mitsui, K., Niwa, T., Morimoto, N., Kawaharada, S., & Katsumata, S.
(2018) Neurogastroenterology & Motility, e13425.
Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies.
Wang, J., Jin, W. S., Bu, X. L., Zeng, F., Huang, Z. L., Li, W. W., … & Zhu, J.
(2018) Acta Neuropathologica, 1-12.
Surgical Reinforcement Alters Collagen Alignment and Turnover in Healing Myocardial Infarcts.
Caggiano, L. R., Lee, J. J., & Holmes, J. W.
(2018) American Journal of Physiology-Heart and Circulatory Physiology.
Central apelin administration and restraint stress induce hypothalamic cholecystokinin release through APJ receptor.
Bülbül, M., Sinen, O., Abueid, L., Akkoyunlu, G., & Özsoy, Ö.
(2018) Journal of neuroendocrinology, e12635.
Acetaldehyde administration induces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice.
Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., … & Kinoshita, H.
(2018) Neuroscience Letters.
Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex.
Saiki, M., Matsui, T., Soya, M., Kashibe, T., Shima, T., Shimizu, T., … & Soya, H.
(2018) Scientific reports, 8(1), 10469.
Escitalopram Attenuates Fear Stress-Induced Increase in Amygdalar Dopamine Following Methamphetamine-induced Sensitisation: Implications of Fine-Tuning Action of Selective Serotonin Reuptake Inhibitors on Emotional Processing.
Muraoka, H., Oshibuchi, H., Kawano, M., Kawano, T., Tsutsumi, T., Yamada, M., … & Inada, K.
(2018) European Journal of Pharmacology.
Female Japanese quail visually differentiate testosterone-dependent male attractiveness for mating preferences.
Hiyama, G., Mizushima, S., Matsuzaki, M., Tobari, Y., Choi, J. H., Ono, T., … & Sugita, S.
(2018) Scientific Reports, 8(1), 10012.
A voxel-based analysis of neurobiological mechanisms in placebo analgesia in rats.
Zeng, Y., Hu, D., Yang, W., Hayashinaka, E., Wada, Y., Watanabe, Y., … & Cui, Y.
(2018) NeuroImage.
Rapid Intracellular Zn 2+ Dysregulation via Membrane Corticosteroid Receptor Activation Affects In Vivo CA1 LTP.
Suzuki, M., Sato, Y., Tamura, K., Tamano, H., & Takeda, A.
(2018) Molecular Neurobiology, 1-10.
Diazepam suppresses the stress-induced dopaminergic release in the amygdala of methamphetamine-sensitized rat.
Kawano, T., Oshibuchi, H., Kawano, M., Muraoka, H., Tsutsumi, T., Yamada, M., … & Inada, K.
(2018) European Journal of Pharmacology.
Involvement of NMDA receptors, nitric oxide and GABA in rostral ventrolateral medulla in acute ethanol‐induced cardiovascular responses in rats.
Lo, H., Lin, H. H., Chen, J. K., Situmorang, J. H., & Lai, C. C.
(2018) Alcoholism: Clinical and Experimental Research.
A single episode of binge alcohol drinking causes sleep disturbance, disrupts sleep homeostasis and downregulates equilibrative nucleoside transporter 1.
Sharma, R., Sahota, P., & Thakkar, M. M.
(2018) Journal of Neurochemistry.
Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer’s disease models.
Higaki, S., Muramatsu, M., Matsuda, A., Matsumoto, K., Satoh, J. I., Michikawa, M., & Niida, S.
(2018) PLOS ONE, 13(5), e0196929.
Extracellular Zn 2+ Influx into Nigral Dopaminergic Neurons Plays a Key Role for Pathogenesis of 6-Hydroxydopamine-Induced Parkinson’s Disease in Rats.
Tamano, H., Nishio, R., Morioka, H., & Takeda, A.
(2018) Molecular neurobiology, 1-9.
Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo
Yuan, X., Fei, F., Sun, H., Xiao, C., Zhao, X., Zhang, Y., & Zheng, X.
(2018) International journal of nanomedicine, 13, 2265.
Fear memory consolidation in sleep requires protein kinase A.
Cho, J., Sypniewski, K. A., Arai, S., Yamada, K., Ogawa, S., & Pavlides, C.
(2018) Learning & Memory, 25(5), 241-246.
Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity.
Kehr, J., Yoshitake, T., Ichinose, F., Yoshitake, S., Kiss, B., Gyertyán, I., & Adham, N.
(2018) Psychopharmacology, 1-15.
Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity.
Hayashida, K. I., Kimuram, M., & Eisenach, J. C.
(2018) Neuroscience Letters.
Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Igarashi, H., Ikeda, K., Onimaru, H., Kaneko, R., Koizumi, K., Beppu, K., … & Kobayashi, K.
(2018) Scientific Reports, 8(1), 5435.
Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with b-amyloid in rats.
Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences, 30, 1e6.
Age-related and function-dependent regional alterations of free L-and D-aspartate in postembryonic chick brain.
Zachar, G., Jakó, T., Vincze, I., Wagner, Z., Tábi, T., Bálint, E., … & Csillag, A.
(2018) Acta Biologica Hungarica, 69(1), 1-15.
Functional mechanism of ASP5736, a selective serotonin 5-HT 5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia.
Yamazaki, M., Yamamoto, N., Yarimizu, J., Okabe, M., Moriyama, A., Furutani, M., … & Harada, K.
(2018) European Neuropsychopharmacology.
Insular cortex inactivation generalizes fear-induced underestimation of interval timing in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.
Effects of mild perinatal hypothyroidism on cognitive function of adult male offspring.
Amano, I., Takatsuru, Y., Khairinisa, M. A., Kokubo, M., Haijima, A., & Koibuchi, N.
(2018) Endocrinology.
Effects of pregabalin and duloxetine on neurotransmitters in the dorsal horn of the spinal cord in a rat model of fibromyalgia.
Kiso, T., Moriyama, A., Furutani, M., Matsuda, R., & Funatsu, Y.
(2018) European Journal of Pharmacology.
Mass Spectrometric Analysis of Neurologically-Relevant Molecules.
Smith, C. L.
(2018) Doctoral dissertation, The University of Arizona.
Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition.
Wang, X., Ma, S., Wu, H., Shen, X., Xu, S., Guo, X., … & Wang, F.
(2018) Experimental & Molecular Medicine, 50(2), e445.
Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with β-amyloid in rats.
Egashira, N., Akiyoshi, Y., Iba, H., Arai, T., Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences.
Effects of Memantine on Nitric Oxide Production and Hydroxyl Radical Metabolism during Cerebral Ischemia and Reperfusion in Mice.
Tanaka, A., Ito, Y., Kawasaki, H., Kitabayashi, C., Nishioka, R., Yamazato, M., … & Yamamoto, T.
(2018) Journal of Stroke and Cerebrovascular Diseases.
Determination of the Target Temperature Required to Block Increases in Extracellular Glutamate Levels During Intraischemic Hypothermia.
Sato, S., Takeda, Y., Mizoue, R., Kawase, H., Fushimi, M., Shimizu, T., & Morimatsu, H.
(2018) Therapeutic Hypothermia and Temperature Management.
[EXPRESS] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer.
Watanabe, M., Narita, M., Hamada, Y., Yamashita, A., Tamura, H., Ikegami, D., … & Muto, A.
(2018) Molecular Pain, 1744806918756406.
Ketamine-induced prefrontal serotonin release is mediated by cholinergic neurons in the pedunculopontine tegmental nucleus.
Kinoshita, H., Nishitani, N., Nagai, Y., Andoh, C., Asaoka, N., Kawai, H., … & Kaneko, S.
(2018) International Journal of Neuropsychopharmacology.
Delayed administration of BQ788, an ETB antagonist, after experimental traumatic brain injury promotes recovery of blood–brain barrier function and reduction of cerebral edema in mice.
Michinaga, S., Kimura, A., Hatanaka, S., Minami, S., Asano, A., Ikushima, Y., … & Koyama, Y.
(2018) Journal of Neurotrauma, (ja)
[EXPRESS] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: analysis using a microdialysis/mass spectrometry integrated system.
Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., … & Narita, M.
(2018) Molecular Pain, 1744806918754934.
2017
“CNS hormonal and nutritional regulation of glucose and energy homeostasis.”
Abraham, M.
(2017) Doctoral dissertation
PKCδ-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity.
Dang, D. K., Shin, E. J., Kim, D. J., Tran, H. Q., Jeong, J. H., Jang, C. G., … & Kim, H. C.
(2017) Free Radical Biology and Medicine.
The Japanese Angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia.
Nogami-Hara, A., Nagao, M., Takasaki, K., Egashira, N., Fujikawa, R., Kubota, K., … & Iwasaki, K.
(2017) Journal of Ethnopharmacology.
δ-Subunit Containing GABA A Receptors Modulate Respiratory Networks.
Montandon, G., Wu, H., Liu, H., Vu, M. T., Orser, B. A., & Horner, R. L.
(2017) Scientific Reports, 7(1), 18105.
Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice.
Park, S. H., Eber, M. R., Tsuzuki, S., Booker, M. E., Sunil, A. G., Widner, D. B., … & Shiozawa, Y.
(2017) Scientific reports, 7(1), 17428.
Region‐specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice.
Sugimoto, J., Tanaka, M., Sugiyama, K., Ito, Y., Aizawa, H., Soma, M., … & Tanaka, K.
(2017) Glia.
Post-reexposure administration of riluzole attenuates the reconsolidation of conditioned fear memory in rats.
Akagi, K., Yamada, M., Saitoh, A., Oka, J. I., & Yamada, M
(2017) Neuropharmacology.
Hydroxyl radical production via NADPH oxidase in rat striatum due to carbon monoxide poisoning.
Hara, S., Kobayashi, M., Kuriiwa, F., Ikematsu, K., & Mizukami, H.
(2017) Toxicology.
Overexpression of transmembrane protein 168 in the mouse nucleus accumbens induces anxiety and sensorimotor gating deficit.
Fu, K., Miyamoto, Y., Sumi, K., Saika, E., Muramatsu, S. I., Uno, K., & Nitta, A.
(2017) PLoS One, 12(12), e0189006.
“METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS.”
Davidson, Beverly L., Bradley T. Hyman, and Eloise Hudry.
(2017) Patent 20,170,336,395, issued November 23, 2017.
Smaller effect of propofol than sevoflurane anesthesia on dopamine turnover induced by methamphetamine and nomifensine in the rat striatum: an in vivo microdialysis study.
TAHARABARU, S., SATOMOTO, M., TAMURA, T., & ADACHI, Y. U.
(2017) Experimental Animals, 17-0092.
Histamine N-methyltransferase regulates aggression and the sleep-wake cycle.
Kárpáti, A., Mogi, A., Yanai, A., Naganuma, F., Yanai, K., Okamura, N., … & Iida, T.
(2017) Scientific Reports, 7(1), 1.
β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system.
Ohara, K., Fukuda, T., Ishida, Y., Takahashi, C., Ohya, R., Katayama, M., … & Nagai, K.
(2017) Scientific Reports, 7(1), 15785.
Syntaxin1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.
Fujiwara, T., Kofuji, T., Mishima, T., & Akagawa, K.
(2017) European Journal of Neuroscience.
Moderate intensity, exercise-induced catecholamine release in the preoptic area and anterior hypothalamus in rats is enhanced in a warm environment.
Zheng, X., Takatsu, S., Ishikawa, R., & Hasegawa, H.
(2017) Journal of Thermal Biology.
Changes in thermoregulation and monoamine release in freely moving rats during cold exposure and inhibition of the ventromedial, dorsomedial, or posterior hypothalamus.
Ishiwata, T., & Greenwood, B. N.
(2017) Journal of Comparative Physiology B, 1-11.
Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23.
Deyama, S., Shimoda, K., Suzuki, H., Ishikawa, Y., Ishimura, K., Fukuda, H., … & Shuto, S.
(2017) Psychopharmacology, 1-8.
The Role of Cholecystokinin in Peripheral Taste Signaling in Mice.
Yoshida, R., Shin, M., Yasumatsu, K., Takai, S., Inoue, M., Shigemura, N., … & Ninomiya, Y.
(2017) Frontiers in Physiology, 8, 866.
Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior.
Li, Y., Yin, A., Sun, X., Zhang, M., Zhang, J., Wang, P., … & Wang, H.
(2017) The Journal of Clinical Investigation, 127(12)
Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice.
Gölöncsér, F., Baranyi, M., Balázsfi, D., Demeter, K., Haller, J., Freund, T. F., … & Sperlágh, B.
(2017) Frontiers in Molecular Neuroscience, 10, 325.
Involvement of neuronal and glial activities in control of the extracellular d-serine concentrations by the AMPA glutamate receptor in the mouse medial prefrontal cortex.
Ishiwata, S., Umino, A., & Nishikawa, T.
(2017) Neurochemistry International.
Subthalamic Nucleus and Globus Pallidus Interna Influence Firing of Tonically Active Neurons in the Primate Striatum through Different Mechanisms.
Nakajima, A., Shimo, Y., Uka, T., & Hattori, N.
(2017) European Journal of Neuroscience, 10.1111/ejn.13726.
The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain.
Du, J., Fang, J., Wen, C., Shao, X., Liang, Y., & Fang, J.
(2017) Neural Plasticity, 2017.
Stimulation of accumbal GABA A receptors inhibits delta2-, but not delta1-, opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats.
Aono, Y., Kiguchi, Y., Watanabe, Y., Waddington, J. L., & Saigusa, T.
(2017) European Journal of Pharmacology.
Striatal N-acetylaspartate synthetase Shati/Nat8l regulates depression-like behaviors via mGluR3-mediated serotonergic suppression in mice.
Miyamoto, Y., Iegaki, N., Fu, K., Ishikawa, Y., Sumi, K., Azuma, S., … & Nitta, A.
(2017) International Journal of Neuropsychopharmacology.
The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice.
Saitoh, A., Suzuki, S., Soda, A., Ohashi, M., Yamada, M., Oka, J. I., … & Yamada, M.
(2017) Behavioural Brain Research.
Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug.
Yamamoto, S., Ushio, S., Egashira, N., Kawashiri, T., Mitsuyasu, S., Higuchi, H., … & Masuda, S.
(2017) Scientific Reports, 7.
Perfusion with carbon monoxide does not affect extracellular glutamate in dialysates of the hippocampus of freely moving mice.
Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Miki, T., & Kinoshita, H.
(2017) Drug and Chemical Toxicology, 1-3.
Ginsenoside Re Protects Trimethyltin-Induced Neurotoxicity via Activation of IL-6-Mediated Phosphoinositol 3-Kinase/Akt Signaling in Mice.
Tu, T. H. T., Sharma, N., Shin, E. J., Tran, H. Q., Lee, Y. J., Jeong, J. H., … & Ko, S. K.
(2017) Neurochemical Research, 1-15.
Alpha-PVP induces the rewarding effect via activating dopaminergic neuron.
Hataoka, K., Kaizaki-Mitsumoto, A., & Numazawa, S.
(2017) The Journal of Toxicological Sciences, 42(5), 539-543
Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway.
Shimizu, S., Sogabe, S., Yanagisako, R., Inada, A., Yamanaka, M., Iha, H. A., & Ohno, Y.
(2017) International journal of molecular sciences, 18(7), 1416.
Characterization of CRF 1 receptor antagonists with differential peripheral vs central actions in CRF challenge in rats.
Tanaka, M., Tomimatsu, Y., Sakimura, K., Ootani, Y., Sako, Y., Kojima, T., … & Hirai, K
(2017) Peptides.
Evidence for Tonic Control by the GABAA Receptor of Extracellular D-Serine Concentrations in the Medial Prefrontal Cortex of Rodents.
Umino, A., Ishiwata, S., Iwama, H., & Nishikawa, T.
(2017) Frontiers in Molecular Neuroscience, 10, 240
The effect of electroacupuncture on PKMzeta in the ACC in regulating.
Du, J., Fang, J., Wen, C., Shao, X., Liang, Y., & Fang, J.
(2017)
A novel LRP1-binding peptide L57 that crosses the blood brain barrier.
Sakamoto, K., Shinohara, T., Adachi, Y., Asami, T., & Ohtaki, T.
(2017) Biochemistry and Biophysics Reports.
Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice.
Hara, Y., Ago, Y., Taruta, A., Hasebe, S., Kawase, H., Tanabe, W., … & Takuma, K.
(2017) Psychopharmacology, 1-12.
Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the.
Matsunami, S., Ogura, Y., Amita, H., Izumi, T., Yoshioka, M., & Matsushima, T.
(2017) Behavioural Brain Research, 233(2), 577-586.
Role of microglia in mechanical allodynia in the anterior cingulate cortex.
Miyamoto, K., Kume, K., & Ohsawa, M.
(2017) Journal of Pharmacological Sciences.
Rapid and sustained antidepressant effects of resolvin D1 and D2 in a chronic unpredictable stress model.
Ishikawa, Y., Deyama, S., Shimoda, K., Yoshikawa, K., Ide, S., Satoh, M., & Minami, M.
(2017) Behavioural Brain Research.
Involvement of serotonin in the ventral tegmental area in thermoregulation of freely moving rats.
Ishiwata, T., Hasegawa, H., & Greenwood, B. N
(2017) Neuroscience Letters.
Induction of hibernation-like hypothermia by central activation of the A1 adenosine receptor in a non-hibernator, the rat.
Shimaoka, H., Kawaguchi, T., Morikawa, K., Sano, Y., Naitou, K., Nakamori, H., … & Shimizu, Y.
(2017) Journal of Physiological Sciences, 1-6
Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation.
Shinozaki, Y., Shibata, K., Yoshida, K., Shigetomi, E., Gachet, C., Ikenaka, K., … & Koizumi, S.
(2017) Cell Reports, 19(6), 1151-1164.
Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential.
Sandweiss, A. J., McIntosh, M. I., Moutal, A., Davidson-Knapp, R., Hu, J., Giri, A. K., … & Vanderah, T. W.
(2017) Molecular Psychiatry.
The involvement of brain-derived neurotrophic factor in 3, 4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization.
Mouri, A., Noda, Y., Niwa, M., Matsumoto, Y., Mamiya, T., Nitta, A., … & Nabeshima, T.
(2017) Behavioural Brain Research.
A novel 5HT3 receptor–IGF1 mechanism distinct from SSRI-induced antidepressant effects.
Kondo, M., Koyama, Y., Nakamura, Y., & Shimada, S.
(2017) Molecular Psychiatry.
Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption.
Sharma, R., Sahota, P., & Thakkar, M. M.
(2017) Journal of Neurochemistry.
A novel device for continuous long-term electroencephalogram recording and drug administration in mice with a nice, powerful and sophisticated wired system.
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Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: differential responses to drug treatment.
Minami, S., Satoyoshi, H., Ide, S., Inoue, T., Yoshioka, M., & Minami, M.
(2017) Neuroscience Letters.
Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
Chen, M., Hoshino, H., Saito, S., Yang, Y., & Obata, H.
(2017) Neuroscience Letters.
Involvement of intracellular Zn2+ signaling in LTP at perforant pathway‐CA1 pyramidal cell synapse.
Tamano, H., Nishio, R., & Takeda, A.
(2017) Hippocampus.
Prenatal nicotine exposure decreases the release of dopamine in the medial frontal cortex and induces atomoxetine-responsive neurobehavioral deficits in mice.
Alkam, T., Mamiya, T., Kimura, N., Yoshida, A., Kihara, D., Tsunoda, Y., … & Nabeshima, T.
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Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Shimohata, A., Ishihara, K., Hattori, S., Miyamoto, H., Morishita, H., Ornthanalai, G., … & Sago, H.
(2017) Experimental Neurology.
Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer’s disease rat model.
Moriyama, H., Watanabe, T., Takasaki, K., Nagao, M., Kubota, K., Katsurabayashi, S., … & Iwasaki, K.
(2017) Traditional & Kampo Medicine.
Activation of the NMDA receptor–neuronal nitric oxide synthase pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain.
Deyama, S., Sugano, Y., Mori, S., Amano, T., Yoshioka, M., Kaneda, K., & Minami, M.
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A positive feedback loop between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage in human lens epithelial cells.
Nagai, N., Ito, Y., Shibata, T., Kubo, E., & Sasaki, H.
(2017) Toxicology.
In vitro and in vivo physiology of low nanomolar concentrations of Zn2+ in artificial cerebrospinal fluid.
Tamano, H., Nishio, R., Shakushi, Y., Sasaki, M., Osawa, M., & Takeda, A.
(2017) Scientific Reports, 7, 42897.
Differential requirements of hippocampal de novo protein and mRNA synthesis in two long-term spatial memory tests: Spontaneous place recognition and delay-interposed radial maze performance in rats.
Ozawa, T., Yamada, K., & Ichitani, Y.
(2017) PloS one, 12(2), e0171629.
Maintained LTP and Memory Are Lost by Zn2+ Influx into Dentate Granule Cells, but Not Ca2+ Influx.
Takeda, A., Tamano, H., Hisatsune, M., Murakami, T., Nakada, H., & Fujii, H.
(2017) Molecular Neurobiology, 1-11.
Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity.
Natsubori, A., Tsustui-Kimura, I., Nishida, H., Bouchekioua, Y., Sekiya, H., Uchigashima, M., … & Tanaka, K. F.
(2017) Journal of Neuroscience, 3377-16.
Oral administration of methylphenidate (Ritalin) differentially affects dopamine release between the prefrontal cortex and striatum-a microdialysis study in the monkey.
Kodama, T., Kojima, T., Honda, Y., Hosokawa, T., Tsutsui, K. I., & Watanabe, M.
(2017) Journal of Neuroscience, 2155-16.
Blockade of intracellular Zn 2+ signaling in the basolateral amygdala affects object recognition memory via attenuation of dentate gyrus LTP.
Fujise, Y., Kubota, M., Suzuki, M., Tamano, H., & Takeda, A.
(2017) Neurochemistry International.
Involvement of lateral habenula α1 subunit-containing GABA A receptor-mediated inhibitory transmission in the regulation of depression-related behaviors in experimental Parkinson’s disease.
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(2017) Neuropharmacology.
Pharmacological properties of SAK3, a novel T-type voltage-gated Ca 2+ channel enhancer.
Yabuki, Y., Matsuo, K., Izumi, H., Haga, H., Yoshida, T., Wakamori, M., … & Fukunaga, K.
(2017) Neuropharmacology.
Basic Study Correlation between colonic secretion and colonic motility in rats: Role of ghrelin
Huang, H. H., Chen, C. Y., Ting, C. H., Syu, Y. F., & Chang, S. C.
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Glutamatergic modulation of noradrenaline release in the rat median preoptic area.
Takahashi, M., Hayashi, Y., & Tanaka, J.
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2016
The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain.
Do Yun Kim, J. W. C., Lim, C. H., Heo, B. H., Park, K. S., Lee, H. G., Choi, J. I., … & Kim, W. M.
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Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice.
Tanaka, T., Ago, Y., Umehara, C., Imoto, E., Hasebe, S., Hashimoto, H., … & Matsuda, T.
(2016) International Journal of Neuropsychopharmacology, pyw115.
Exploring the mechanism by which accumbal deep brain stimulation attenuates morphine-induced reinstatement through manganese-enhanced MRI and pharmacological intervention.
Zhang, L., Cui, Y., Wang, Y. C., Yin, H., Zheng, J. M., Huang, L., … & Li, J.
(2016) Experimental Neurology.
Controlling the length of short electrospun polymer nanofibers via the addition of micro-spherical silica particles.
Yabuki, A., Motonobu, E., & Fathona, I. W.
Journal of Materials Science, 1-9.
Correlation between colonic secretion and colonic motility in rats: Role of ghrelin.
Huang, H. H., Ting, C. H., Syu, Y. F., Chang, S. C., & Chen, C. Y.
(2016) World J Gastroenterol, 22(46), 10140-10147.
Betaine attenuates memory impairment after water-immersion restraint stress and is regulated by the GABAergic neuronal system in the hippocampus.
Kunisawa, K., Kido, K., Nakashima, N., Matsukura, T., Nabeshima, T., & Hiramatsu, M.
(2016) European Journal of Pharmacology.
Noradrenaline receptor mechanisms modulate the angiotensin II-induced water intake in the subfornical organ in rats.
Takahashi, M., & Tanaka, J.
(2016) Experimental Brain Research, 1-7.
Induction of antinociceptive tolerance to the chronic intrathecal administration of apelin-13 in rat.
Abbasloo, E., Najafipour, H., & Esmaeili-Mahani, S.
(2016) Neuropeptides, 60, 7-12.
Opposite effects of central oxytocin and arginine vasopressin on changes in gastric motor function induced by chronic stress.
Bülbül, M., Sinen, O., Gemici, B., & İzgüt-Uysal, V. N.
(2016) Peptides, 87, 1-11.
Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.
Yue, J. T., Abraham, M. A., Bauer, P. V., LaPierre, M. P., Wang, P., Duca, F. A., … & Lam, T. K.
(2016) Nature Communications, 7, 13501
Neuropeptide EI-induced paradoxical sleep in rats.
Fujimoto, M., Fukuda, S., Sakamoto, H., Takata, J., & Sawamura, S.
(2016) Peptides.
Activation of mu-opioid receptors in the ventral pallidum decreases the negative hedonic evaluation of a conditioned aversive taste in rats.
Inui, T., & Shimura, T.
(2016) Behavioural Brain Research.
Opposite Effects of Central Oxytocin and Arginine Vasopressin on Changes in Gastric Motor Function Induced by Chronic Stress.
Bülbül, M., Sinen, O., Gemici, B., & İzgüt-Uysal, V. N.
(2016) Peptides.
Effect of p22phox depletion on sympathetic regulation of blood pressure in SHRSP: evaluation in a new congenic strain.
Zahid, H. M., Ferdaus, M. Z., Ohara, H., Isomura, M., & Nabika, T.
(2016) Scientific Reports, 6, 36739.
The role of inversely operating glutamate transporter in the paradoxical analgesia produced by glutamate transporter inhibitors.
Kim, W. M., Chae, J. W., Heo, B. H., Park, K. S., Kim, H. S., Lee, H. G., … & Yoon, M. H.
(2016) European Journal of Pharmacology
The Role of Adenosine in the Maturation of Sleep Homeostasis in Rats.
Gvilia, I., Suntsova, N., Kostin, A., Kalinchuk, A., McGinty, D., Basheer, R., & Szymusiak, R.
(2016) Journal of Neurophysiology, jn-00675
15-deoxy-Δ 12, 14-prostaglandin J 2 induced neurotoxicity via suppressing phosphoinositide 3-kinase.
Koma, H., Yamamoto, Y., Nishi, A., & Yagami, T.
(2016) Neuropharmacology.
Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropin releasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus.
Tokunaga, R., Shimoju, R., Shibata, H., & Kurosawa, M
(2016) The Journal of Physiological Sciences, 1-10.
PKCδ knockout mice are protected from para-methoxymethamphetamine-induced mitochondrial stress and associated neurotoxicity in the striatum of mice.
Shin, E. J., Dang, D. K., Tran, H. Q., Nam, Y., Jeong, J. H., Lee, Y. H., … & Nabeshima, T.
(2016) Neurochemistry International.
Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors.
Montandon, G., Liu, H., & Horner, R. L.
(2016) Scientific Reports, 6, 32707.
Mapping the influence of electrospinning parameters on the morphology transition of short and continuous nanofibers.
Fathona, I. W., & Yabuki, A.
(2016) Fibers and Polymers, 17(8), 1238-1244.
Equilibrative Nucleoside Transporter ENT1 as a Biomarker of Huntington Disease.
Guitart, X., Bonaventura, J., Rea, W., Orrú, M., Cellai, L., Dettori, I., … & Chang, C. P.
(2016) Neurobiology of Disease.
Suppressed GABAergic signaling in the zona incerta causes neuropathic pain in a thoracic hemisection spinal cord injury rat model.
Moon, H. C., Lee, Y. J., Cho, C. B., & Park, Y. S.
(2016) Neuroscience Letters.
Sex differences in abuse-related neurochemical and behavioral effects of 3, 4-methylenedioxymethamphetamine (MDMA) in rats.
Lazenka, M. F., Suyama, J. A., Bauer, C. T., Banks, M. L., & Negus, S. S.
(2016) Pharmacology Biochemistry and Behavior.
Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters.
Solis Jr, E., Suyama, J. A., Lazenka, M. F., DeFelice, L. J., Negus, S. S., Blough, B. E., & Banks, M. L.
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Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion.
Umezu, T., & Shibata, Y.
(2016) Toxicology Reports, 3, 552-562.
Wake-promoting effects of ONO-4127Na, a prostaglandin DP1 receptor antagonist, in hypocretin/orexin deficient narcoleptic mice.
Sagawa, Y., Sato, M., Sakai, N., Chikahisa, S., Chiba, S., Maruyama, T., … & Nishino, S.
(2016) Neuropharmacology.
Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats.
Yang, F., Zhou, L., Wang, D., Yang, L. L., Yuan, G. R., & Huang, Q. Y.
(2016) Scientific Reports, 6, 30168.
GABAergic Modulation of Serotonin Release in the Rat Subfornical Organ Area.
Takahashi, M., Nomura, M., & Tanaka, J.
(2016) Neuroscience Letters.
Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia.
Tamano, H., Ide, K., Adlard, P. A., Bush, A. I., & Takeda, A.
(2016) The Journal of Toxicological Sciences, 41(4), 449-457.
In vivo neurochemical evidence that delta1-, delta2-and mu2-opioid receptors, but not mu1-opioid receptors, inhibit acetylcholine efflux in the nucleus accumbens of freely moving rats.
Kiguchi, Y., Aono, Y., Watanabe, Y., Yamamoto, S., Shimizu, K., Shimizu, T., … & Saigusa, T.
(2016) European Journal of Pharmacology.
Neurochemical Substrates of Asymmetrical Sleep in the Fur Seal.
Lapierre, J. L.
(2016) Doctoral dissertation, University of Toronto.
The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain.
Kim, D. Y., Chae, J. W., Lim, C. H., Heo, B. H., Park, K. S., Lee, H. G., … & Kim, W. M.
(2016) The Korean Journal of Pain, 29(3), 164-171.
Involvement of GABAA.
Ago, Y., Hasebe, S., Hiramatsu, N., Mori, K., Watabe, Y., Onaka, Y., … & Matsuda, T.
(2016) Psychopharmacology, 1-10.
Pain relief induces dopamine release in the rat nucleus accumbens during the early but not late phase of neuropathic pain.
Kato, T., Ide, S., & Minami, M.
(2016) Neuroscience Letters.
Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion.
Umezu, T., & Shibata, Y.
(2016) Toxicology Reports.
Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission.
Tokudome, K., Okumura, T., Shimizu, S., Mashimo, T., Takizawa, A., Serikawa, T., … & Ohno, Y.
(2016) Scientific Reports, 6, 27420.
Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine.
Ip, J. Y., Sone, M., Nashiki, C., Pan, Q., Kitaichi, K., Yanaka, K., … & Nakagawa, S.
(2016) Scientific Reports, 6, 27204
Effects of propofol on the dopamine, metabolites and GABAA receptors in media prefrontal cortex in freely moving rats.
Wang, Y., Yu, T., Yuan, C., Yuan, J., Luo, Z., Pan, Y., … & Yu, B.
(2016) Am J Transl Res, 8(5), 2301-2308.
Motor Training Promotes Both Synaptic and Intrinsic Plasticity of Layer II/III Pyramidal Neurons in the Primary Motor Cortex.
Kida, H., Tsuda, Y., Ito, N., Yamamoto, Y., Owada, Y., Kamiya, Y., & Mitsushima, D.
(2016) Cerebral Cortex, bhw134.
Novel psychoactive benzofurans strongly increase extracellular serotonin level in mouse corpus striatum.
Fuwa, T., Suzuki, J., Tanaka, T., Inomata, A., Honda, Y., & Kodama, T.
(2016) The Journal of Toxicological Sciences, 41(3), 329-337.
“Acute and Chronic Effects of Inhalants in Intracranial Self-stimulation.”
Tracy, Matthew.
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GABA B receptors in the hippocampal dentate gyrus are involved in spatial learning and memory impairment in a rat model of vascular dementia.
Li, G., Lv, J., Wang, J., Wan, P., Li, Y., Jiang, H., & Jin, Q.
(2016) Brain Research Bulletin.
Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptors.
Miyazaki, Y., Sunaga, H., Hobo, S., Miyano, K., & Uezono, S.
(2016) Journal of Anesthesia, 1-6.
Mirtazapine exerts an anxiolytic-like effect through activation of the median raphe nucleus-dorsal hippocampal 5-HT pathway in contextual fear conditioning in rats.
An, Y., Chen, C., Inoue, T., Nakagawa, S., Kitaichi, Y., Wang, C., … & Kusumi, I.
(2016) Progress in Neuro-Psychopharmacology and Biological Psychiatry.
Serotonin release in the subfornical organ area induced by sodium and water intake in the rat.
Takahashi, M., & Tanaka, J.
(2016) Physiology & Behavior.
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.
Kim, S. K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., … & Bae, H.
(2016) The Journal of Clinical Investigation, 126(5).
Dopamine dynamics during emotional cognitive processing: implications of the specific actions of clozapine compared with haloperidol.
Kawano, M., Oshibuchi, H., Kawano, T., Muraoka, H., Tsutsumi, T., Yamada, M., … & Ishigooka, J.
(2016) European Journal of Pharmacology
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.
Kim, S. K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., … & Bae, H.
(2016) The Journal of Clinical Investigation, 126(5).
A Clock mutation enhances light-phase responsiveness to cocaine in locomotor activity and self-administration with impulsive-like responding in mice.
Meng, H., Murakami, G., Suenaga, T., Edamura, M., Doi, M., Ishida, Y., … & Nakahara, D.
(2016) Psychopharmacology, 1-8.
Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT.
Mori, T., Uzawa, N., Iwase, Y., Masukawa, D., Rahmadi, M., Hirayama, S., … & Suzuki, T.
(2016) Psychopharmacology, 1-11
Unusual social behavior in HPC‐1/syntaxin1A knockout mice is caused by disruption of the oxytocinergic neural system.
Fujiwara, T., Sanada, M., Kofuji, T., & Akagawa, K.
(2016) Journal of Neurochemistry.
Involvement of hippocampal NMDA receptors in retrieval of spontaneous object recognition memory in rats
Iwamura, E., Yamada, K., & Ichitani, Y.
(2016) Behavioural Brain Research.
Brain Site-and Transmitter-dependent Actions of Methamphetamine, Morphine and Antipsychotics.
Mori, T., Iwase, Y., Murata, A., Iwata, N., & Suzuki, T
(2016) Behavioural Brain Research.
5‐HT (1A) receptor antagonist improves behavior performance of delirium rats through inhibiting PI3K/Akt/mTOR activation‐induced NLRP3 activity.
Qiu, Y., Huang, X., Huang, L., Tang, L., Jiang, J., Chen, L., & Li, S.
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Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats.
Hazama, Y., Maekawa, T., Miki, R., Oshima, S., Egawa, Y., Morimoto, K., & Seki, T
(2016) Biological and Pharmaceutical Bulletin, 39(3), 343-352.
Non-invasive determination of glucose directly in raw fruits using a continuous flow system based on microdialysis sampling and amperometric detection at an integrated enzymatic biosensor.
Vargas, E., Ruiz, M. A., Campuzano, S., Reviejo, A. J., & Pingarrón, J. M
(2016) Analytica Chimica Acta.
Involvement of spinal glutamate in nociceptive behavior induced by intrathecal administration of hemokinin-1 in mice.
Watanabe, C., Mizoguchi, H., Bagetta, G., & Sakurada, S.
(2016) Neuroscience Letters.
Neuropeptide Y signaling in the dorsal raphe nucleus inhibits male sexual behavior in mice.
Inaba, A., Komori, Y., Muroi, Y., Kinoshita, K. I., & Ishii, T.
(2016) Neuroscience.
Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and gaba neurons.
Ardianto, C., Yonemochi, N., Yamamoto, S., Yang, L., Takenoya, F., Shioda, S., … & Kamei, J.
(2016) Neuroscience.
Opposing Roles of Cholinergic and GABAergic Activity in the Insular Cortex and Nucleus Basalis Magnocellularis during Novel Recognition and Familiar Taste Memory Retrieval.
Rodríguez-García, G., & Miranda, M. I.
(2016) The Journal of Neuroscience, 36(6), 1879-1889.
The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat.
Shahbazi-Gahrouei, D., Shiri, L., Alaei, H., & Naghdi, N.
(2016) Journal of Radiation Research, rrv093.
Differencial Activation of the Dopaminergic Systems in Rat Brain Basal Ganglia by Morphine and Methamphetamine.
Mori, T., Iwase, Y., Saeki, T., Iwata, N., Murata, A., Masukawa, D., & Suzuki, T.
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Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK.
Dang, D. K., Shin, E. J., Nam, Y., Ryoo, S., Jeong, J. H., Jang, C. G., … & Kim, H. C.
(2016) Journal of Neuroinflammation, 13(1), 12.
Causal Link between the Cortico-Rubral Pathway and Functional Recovery through Forced Impaired Limb Use in Rats with Stroke.
Ishida, A., Isa, K., Umeda, T., Kobayashi, K., Kobayashi, K., Hida, H., & Isa, T.
(2016) The Journal of Neuroscience, 36(2), 455-467.
Contributions of ADP and ATP to the increase in skeletal muscle blood flow after manual acupuncture stimulation in rats.
Nagaoka, S., Shinbara, H., Okubo, M., Kawakita, T., Hino, K., & Sumiya, E.
(2016) Acupuncture in Medicine, acupmed-2015.
2015
Elucidation of the central role of long-chain fatty acids in the palatability of dietary fat by neuroscientific and animal behavioral studies.
Adachi, S.
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“METHODS AND COMPOSITIONS USING 4-AMINO-2-(2, 6-DIOXO-PIPERIDINE-3-YL)-ISOINDOLINE-1, 3-DIONE FOR TREATMENT OF CANCERS.”
LI, Y., Palmisano, M., Zhou, S., Chen, N., & James, A. J.
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Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats.
Kawaura, K., Ogata, Y., Honda, S., Soeda, F., Shirasaki, T., & Takahama, K.
(2015) Behavioural Brain Research
Ethanol and Acetaldehyde Differentially Alter Extracellular Dopamine and Serotonin in Aldh2-Knockout Mouse Dorsal Striatum: A Reverse Microdialysis Study.
Jamal, M., Ameno, K., Miki, T., Tanaka, N., Ito, A., Ono, J., … & Kinoshita, H.
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Preventive Effect of 3, 5-dihydroxy-4-methoxybenzyl Alcohol (DHMBA) and Zinc, Components of the Pacific Oyster Crassostrea gigas, on Glutamatergic Neuron Activity in the Hippocampus.
Tamano, H., Shakushi, Y., Watanabe, M., Ohashi, K., Uematsu, C., Otsubo, T., … & Takeda, A.
(2015) The Biological Bulletin, 229(3), 282-288.
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
Bonaventure, P., Shelton, J., Yun, S., Nepomuceno, D., Sutton, S., Aluisio, L., … & Dugovic, C.
(2015) Journal of Pharmacology and Experimental Therapeutics, jpet-115.
Improvement of Cold Injury‐Induced Mouse Brain Edema by Endothelin ETB Antagonists is Accompanied with Decreases in Matrixmetalloproteinase 9 and Vascular Endothelial Growth Factor‐A.
Michinaga, S., Seno, N., Fuka, M., Yamamoto, Y., Minami, S., Kimura, A., … & Koyama, Y.
(2015) European Journal of Neuroscience.
Oxidative stress and lipid peroxidation are upstream of amyloid pathology.
Arimon, M., Takeda, S., Post, K. L., Svirsky, S., Hyman, B. T., & Berezovska, O.
(2015) Neurobiology of Disease.
Chewing, Stress-Related Diseases, and Brain Function.
Kubo, K. Y., Chen, H., Liu, J. H., Zhou, X., & Darbin, O.
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Changes in free amino acid and monoamine concentrations in the chick brain associated with feeding behavior.
Tran, P. V., Chowdhury, V. S., Nagasawa, M., & Furuse, M.
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Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex.
Ueda, S., Niwa, M., Hioki, H., Sohn, J., Kaneko, T., Sawa, A., & Sakurai, T.
(2015) Molecular Neuropsychiatry,1(2), 94-104.
Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain.
Navratilova, E., Xie, J. Y., Meske, D., Qu, C., Morimura, K., Okun, A., … & Porreca, F.
(2015) The Journal of Neuroscience,, 35(18), 7264-7271.
DSP‐1053, a novel serotonin reuptake inhibitor with 5‐HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats.
Kato, T., Matsumoto, Y., Yamamoto, M., Matsumoto, K., Baba, S., Nakamichi, K., … & Yabuuchi, K.
(2015) Pharmacology Research & Perspectives, 3(3).
2014
Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy.
Xie, J. Y., Qu, C., Patwardhan, A., Ossipov, M. H., Navratilova, E., Becerra, L., … & Porreca, F.
(2014) PAIN®, 155(8), 1659-1666.
A Food and Administration- approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer’s disease.
Hori Y, Takeda S, Cho H, Wegmann S, Shoup T, Takahashi K, Irima D, Elmaleh D, Hyman B, Hudry E.
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2013
Validation of an efficient LC-microdialysis method for gemifloxacin quantitation in lung, kidney and liver of rats.
Furness, A. M., Thomas, S., & Lunte, C. E. 10 de Araújo BV, Laureano JV, Grünspan LD, Dalla Costa T, Tasso L.
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Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis.
Yang, H., Thompson, A. B., McIntosh, B. J., Altieri, S. C., & Andrews, A. M.
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Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic γ-aminobutyric acid mechanisms.
Kimura M, Hayashida K, Eisenach J, Saito S, Obata H.
(2013) Anesthesiology 118;173-80
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry.
Navarailova E, Xie J, Okun A, Qu C, Eyde N, Ci S, Ossipov M, King T, Fields H, Porreca F.
(2013) PNAS 109; 50 2079-20713
2012
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve insury.
Hayashida K, Kimura M, Yoshizumi M, Hobo S, Obata H, J Eisenach.
(2012) Anesthesiology 117; 389-98
Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Yoshizumi M, Parker R, Esenach J, Hayashida K.
(2012) Anesthesiology 116; 1347-53
2011
Novel microdialysis method to assess meuropeptides and large molecules in free-moiving mouse.
Takeda S, Sato N, Ikimura K, Nishino H, Rkugi H, Morishita R.
(2011) Neuroscience; 186 110-119
2009
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
(2009) Brain Research 1260; 30-37
Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.
Yano K, Koda K, Ago Y, Kobayashi H, Kawasaki T, Takuma K, Matsuda T
(2009) British Journal of Pharmacology 156(1):173-180.
2008
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects.
Mitsushima D, Takase K, Funabashi T, Kimura F
(2008) Endocrinology;149(2):802-811. Epub 2007 Oct 25
Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats.
Deyama S, Katayama T, Ohno A, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M
(2008) Journal of Neuroscience; 28(31):7728-7736
Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure.
Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H.
(2008) Toxicology and applied pharmacology Jan 15;226(2):192-198
2007
Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats.
Takase K, Mitsushima D, Funabashi T, Kimura F.
(2007) Brain Research 1154:105-115. Epub 2007 Apr 5
Maternal attenuation of hypothalamic paraventricular nucleus norepinephrine switches avoidance learning to preference learning in preweanling rat pups.
Shionoya K, Moriceau S, Bradstock P, Sullivan RM.
(2007) Hormones and Behavior 52(3):391-400. Epub 2007 Jun 29
2006
Ascorbic acid concentration in rabbit vitreous measured by microdialysis with HPLC-electrochemical detection before and after vitreous surgery.
Koide K, Zhang XM, Ohishi K, Usami Y, Hotta Y, Hiramitsu T
(2006) Experimental Eye Research 82(5):868-873
Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Dong HL, Fukuda S, Murata E, Zhu Z, Higuchi T
(2006) Anesthesiology 104(5):1023-1032
Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats.
Sasaki M, Obata H, Kawahara K, Saito S, Goto F
(2006) Pain 122(1-2):130-136
Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.
Dong HL, Fukuda S, Murata E, Higuchi T
(2006) Anesthesiology 104(1):122-133
Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions.
De Leonibus E, Verheij MM, Mele A, Cools A
(2006) European Journal of Neuroscience 23(5):1332-1340
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T
(2006) Journal of Neuroscience 26(2):398-405
Epinephrine increases the extracellular lidocaine concentration in the brain: a possible mechanism for increased central nervous system toxicity.
Takahashi R, Oda Y, Tanaka K, Morishima HO, Inoue K, Asada A.
(2006) Anesthesiology 105(5):984-989
Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats.
Mitsushima D, Yamada K, Takase K, Funabashi T, Kimura F.
(2006) European Journal of Neuroscience 24(11):3245-3254
2005
Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex.Ago Y, Nakamura S, Baba A, Matsuda T
(2005) Neuropsychopharmacology 30: 43-51
Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats.
Jamal M, Ameno K, Wang W, Kumihashi M, Ameno S, Ikuo U, Shinji A, Ijiri I
(2005) Brain Research 1039(1-2):90-96
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F
(2005) Neuroscience 136: 593-599
Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats.
Masuda J, Mitsushima D, Funabashi T, Kimura F
(2005) Neuroscience 132: 537-542
Striatal dopamine level increases in the urinary storage phase in cats: an in vivo microdialysis study.
Yamamoto T, Sakakibara R, Hashimoto K, Nakazawa K, Uchiyama T, Liu Z, Ito T, Hattori T.
(2005) Neuroscience 135: 299-303
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.
Fusa K, Takahashi I, Watanabe S, Aono Y, Ikeda H, Saigusa T, Nagase H, Suzuki T, Koshikawa N, Cools AR
(2005) Neuroscience 130(3):745-755
Contribution of vesicular and cytosolic dopamine to the increased striatal dopamine efflux elicited by intrastriatal injection of dexamphetamine.
Watanabe S, Aono Y, Fusa K, Takada K, Saigusa T, Koshikawa N, Cools AR
(2005) Neuroscience 136(1):251-257
Effects of alpha-methyl-p-tyrosine on extracellular dopamine levels in the nucleus accumbens and the dorsal striatum of freely moving rats.
Watanabe S, Fusa K, Takada K, Aono Y, Saigusa T, Koshikawa N, Cools AR
(2005) Journal of Oral Science 47(4):185-190
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Narita M, Kishimoto Y, Ise Y, Yajima Y, Misawa K, Suzuki T
(2005) Neuropsychopharmacology 30(1):111-118
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M.
(2005) British Journal of Pharmacology 145(8):1035-1044
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F.
(2005) Neuroscience 136(2):593-9. Epub 2005 Oct 13
2004
Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats.
Yamato T, Misumi Y, Yamasaki S, Kino M, Aomine M
(2004) Diabetes, Nutrition & Metabolism 17: 128-136
Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.| Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, He J, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC, Nabeshima T
(2004) Journal of Neuroscience 24: 2212-2225
The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.
Nagai T, Yamada K, Yoshimura M, Ishikawa K, Miyamoto Y, Hashimoto K, Noda Y, Nitta A, Nabeshima T
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 3650-3655
Brain microdialysis study of the effects of hazardous chemicals on the central nervous system 2. Toluene exposure and cerebral acetylcholine.
Honma T, Suda M
(2004) Industrial Health 42(3):336-347
Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study.
Kino M, Yamato T, Aomine M
(2004) Neurochemistry International 44: 65-73
Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.
Okamura N, Hashimoto K, Shimizu E, Kumakiri C, Komatsu N, Iyo M
(2004) Neuropsychopharmacology 29: 544-550
Hypericum perforatum L (St John’s wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.
Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Muller WE, Ogren SO, Kehr J
(2004) British Journal of Pharmacology 142: 414-418
Determination of serotonin, noradrenaline, dopamine and their metabolites in rat brain extracts and microdialysis samples by column liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine.
Yoshitake T, Kehr J, Yoshitake S, Fujino K, Nohta H, Yamaguchi M
(2004) Journal of Chromatography B 807: 177-183
Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine.
Shioda K, Nisijima K, Yoshino T, Kato S
(2004) Progress in Neuro-Psychopharmacology & Biological Psychiatry 28: 633-640
Sexual dimorphism of GABA release in the medial preoptic area and luteinizing hormone release in gonadectomized estrogen-primed rats.
Tin-Tin-Win-Shwe, Mitsushima D, Shinohara K, Kimura F
(2004) Neuroscience 127(1):243-250
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Shen, H. W., Hagino, Y., Kobayashi, H., Shinohara-Tanaka, K., Ikeda, K., Yamamoto, H., … & Uhl, G. R.
(2004). Neuropsychopharmacology, 29(10), 1790-1799.
2003
Activation of cholinergic and adrenergic receptors increases the concentration of extracellular adenosine in the cerebral cortex of unanesthetized rat.
Bennett HJ, White TD, Semba K
(2003) Neuroscience 117: 119-127
Effects of repetitive transcranial magnetic stimulation on behavioral and neurochemical changes in rats during an elevated plus-maze test.
Kanno M, Matsumoto M, Togashi H, Yoshioka M, Mano Y
(2003) Journal of Neurological Sciences 211: 5-14
Implication of Rho-associated kinase in the elevation of extracellular dopamine levels and its related behaviors induced by methamphetamine in rats.
Narita M, Takagi M, Aoki K, Kuzumaki N, Suzuki T
(2003) Journal of Neurochemistry 86: 273-282
Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats.
John J, Wu MF, Kodama T, Siegel JM
(2003) The Journal of Physiology 548(Pt 2): 557-562
Increase of hippocampal acetylcholine release at the onset of dark phase is suppressed in a mutant mice model of evening-type individuals.
Sei H, Sano A, Oishi K, Fujihara H, Kobayashi H, Ishida N, Morita Y
(2003) Neuroscience 117: 785-789
In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis.
Jamal M, Ameno K, Kubota T, Ameno S, Zhang X, Kumihashi M, Ijiri I
(2003) Alcohol & Alcoholism 38: 197-201
Detection of 3-methoxy-4-hydroxyphenylglycol in rabbit skeletal muscle microdialysate
Tokunaga N, Yamazaki T, Akiyama T, Mori H
(2003) Journal of Chromatography B 798: 163-166
Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouse.
Nakahara D, Nakamura M, Iigo M, Okamura H
(2003) Proceedings of the National Academy of Sciences USA (PNAS) 100: 9584-9589
Simultaneous determination of norepinephrine, serotonin, and 5-hydroxyindole-3-acetic acid in microdialysis samples from rat brain by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine.
Yoshitake T, Fujino K, Kehr J, Ishida J, Nohta H, Yamaguchi M
(2003) Analytical Biochemistry 312: 125-33
Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.
Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M
(2003) Psychopharmacology (Berl) 170: 80-88
Sex differences in the stress-induced release of acetylcholine in the hippocampus and corticosterone from the adrenal cortex in rats.
Mitsushima D, Masuda J, Kimura F.
(2003) Neuroendocrinology 78(4):234-240
Sexual dimorphism in the GABAergic control of gonadotropin release in intact rats.
Mitsushima D, Tin-Tin-Win-Shwe, Kimura F
(2003) Neuroscience Research 46(4):399-405
Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release.
Mitsushima D, Funabashi T, Shinohara K, Kimura F
(2003) Psychoneuroendocrinology 28(4):574-583
2002
Expression of angiotensin II type 1 (AT1) receptor in the rostral ventrolateral medulla in rats.
Hu, L., Zhu, D. N., Yu, Z., Wang, J. Q., Sun, Z. J., & Yao, T.
(2002) Journal of Applied Physiology, 92(5), 2153-2161.
Suppression of the morphine-induced rewarding effect in the rat with neuropathic pain: implication of the reduction in mu-opioid receptor functions in the ventral tegmental area.
Ozaki S, Narita M, Narita M, Iino M, Sugita J, Matsumura Y, Suzuki T
(2002) Journal of Neurochemistry 82: 1192-1198
Effects of brief ischaemia on myocardial acetylcholine and noradrenaline levels in anaesthetized cats.
Kawada T, Yamazaki T, Akiyama T, Mori H, Inagaki M, Shishido T, Takaki H, Sugimachi M, Sunagawa K
(2002) Autonomic Neuroscience 95: 37-42
Effects of moderate hypothermia on in situ cardiac sympathetic nerve endings.
Kitagawa H, Akiyama T, Yamazaki T
(2002) Neurochemistry International 40: 235-242
Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors
Fujino K, Yoshitake T, Inoue O, Ibii N, Kehr J, Ishida J, Nohta H, Yamaguchi M
(2002) Neuroscience Letters 320: 91-95
Role of endothelin ET(B) receptors in the renal hemodynamic and excretory responses to big endothelin-1.
Konishi F, Okada Y, Takaoka M, Gariepy CE, Yanagisawa M, Matsumura Y
(2002) European Journal of Pharmacology 451: 177-184
Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359
Relationship between oxidation of glutathione and reactive nitrogen species during the early-reperfusion phase of cerebral ischemia.
Iijima T, Sakamoto H, Okada C, Iwao Y
(2002) Neurochemical Research 27: 497-500
Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems.
Matsuda Y, Hirano H, Watanabe Y
(2002) Brain Research 937: 58-65
Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359
GABA release in the medial preoptic area of cyclic female rats.|
Mitsushima D, Shwe TT, Funabashi T, Shinohara K, Kimura F
(2002) Neuroscience 113: 109-114
Profiles of in vivo gamma-aminobutyric acid release in the medial preoptic area of intact and castrated male rats.
Tin-Tin-Win-Shwe, Mitsushima D, Kimura F
(2002) Neuroendocrinology 76(5):290-296
2001
â-Phenylethlamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D2 receptor mechanism
Kato M, Ishida K, Chuma T, Abe K, Shigenaga T, Taguchi K, Miyake T
(2001) European Journal of Pharmacology 418: 65-71
Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca2+ – and K+ -evoked serotonin release
Kawata Y, Okada M, Murakami T, Kamata A, Zhu G, Kaneko S
(2001) British Jourmal of Pharmacology 133: 557-567
Determination of serotonin in microdialysis samples from rat brain by microbore column liquid chromatography with post-column derivatization and fluorescence detection
Yoshitake T, Iizuka R, Kehr J, Nohta H, Ishida J, Yamaguchi M
(2001) Journal of Neuroscience Methods 109: 91-96
Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine.
Hatip-Al-Khatib I, Mishima K, Iwasaki K, Fujiwara M
(2001) Brain Research 902: 108-118
Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study.
Hatip-Al-khati I, Bolukbasi F, Mishima K, Egashira N, Iwasaki K, Fujiwara M
(2001) Japanese Journal of Pharmacology 87: 277-287
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neuroscience Letters 306: 206-208
Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.
Yoshida Y, Fujiki N, Nakajima T, Ripley B, Matsumura H, Yoneda H, Mignot E, Nishino S
(2001) European Journal of Neuroscience 14: 1075-1081
Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.
Kishi T, Hirooka Y, Sakai K, Shigematsu H, Shimokawa H, Takeshita A
(2001) Hypertension 38: 896-901
Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo.
Matsuo I, Hirooka Y, Hironaga K, Eshima K, Shigematsu H, Shihara M, Sakai K, Takeshita A
The American Journal of Physiology – Regulatory, Integrative and (2001) Comparative Physiology 280: R1285-1291
Differential effects of psychological stress on activation of the 5-hydroxytryptamine- and dopamine-containing neurons in the brain of freely moving rats.
Funada M, Hara C.
(2001) Brain Research 901(1-2):247-251
Adenosine Receptor Subtypes Modulate Two Major Functional Pathways for Hippocampal Serotonin Release.
Okada M, Nutt DJ, Murakami T, Zhu G, Kamata A, Kawata Y, Kaneko S
(2001) The Journal of Neuroscience 21: 628-640
Monitering of extracellular dopamine levels in the dorsal striatum and the nucleus accumbens with 5-minute on-line microdialysis in freely movin rats.
Saigusa T, Fusa K, Okutsu H, Koshikawa N
(2001) Journal of Oral Science 43: 129-134
Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum.
Yamato H, Kannari K, Shen H, Suda T, Matsunaga M
(2001)Neuropharmacology and Neurotoxicology 12: 1123-1126
Activationof 5-HT1A but not 5-HT1B receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation.
Kannnari K, Yamato H, Shen H, Tomiyama M, Suda T, Matsunaga M
(2001) Journal of Neurochemistry 76: 1346-1353
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neurosci Letters 306: 206-208
In vivo assessment of acetylcholine-releasing function at cardiac vagal nerve terminals.
Kawada T, Yamazaki T, Akiyama T, Shishido T, Inagaki M, Uemura K, Miyamoto T, Sugimachi M, Takaki H, Sunagawa K
(2001) American Journal of Physiology – Heart and Circulatory Physiology 281: H139-H145
Effects of ketamine on in vivo cardiac sympathetic nerve endings.
Kitagawa H, Yamazaki T, Akiyama T, Mori H, Sunagawa K
(2001) Journal of Cardiovascular Pharmacology 38 (Suppl. 1): S39-S42
Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid.
Ueda Y, Doi T, Tokumaru J, Yokoyama H, Nakajima A, Mitsuyama Y, Ohya-Nishiguchi H, Kamada H, Willmore LJ
(2001) Journal of Neurochemistry 76: 892-900
Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia.
Anzawa N, Kushikata T, Ohkawa H, Yoshida H, Kubota T, Matsuki A
(2001) Canadian Journal of Anaesthesia 48: 462-465
Xenon inhalation increases norepinephrine release from the anterior and posterior hypothalamus in rats.
Yoshida H, Kushikata T, Kubota T, Hirota K, Ishihara H, Matsuki A.
(2001) Canadian Journal of Anesthesia 48:651-655
2000
Nitric oxide formation in the dog sphincter of Oddi from nitric oxide donors as measured with in vivo microdialysis.
Yamamoto I, Fujiwara M, Kuhara N, Kumano K, Yamada T, Yamamoto H, Fujiwara M
(2000) Alimentary Pharmacology & Therapeutics 14: 1095-1101
静脈麻酔薬がラット背側海馬の一酸化窒素産生に与える影響 (The Influence of Intravenous Anethetics on Nitric Oxide Production in the Rat Dorsal Hippocampus).
白石直之、大井久美子
(2000) 日本歯科麻酔学会雑誌 28: 27-35
Reserpine Pretreatment Prevents Increase in Extracellular Striatal Dopamine Following L-DOPA Administration in Rats with Nigrostriatal Denervation.
Kannari K, Tanaka H, Maeda T, Tomiyama M, Suda T, Matsunaga M
(2000) Journal of Neurochemistry 74: 263-269
Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarnic M1 receptor stimulation.
Murakami Y, Ikenoya M, Matsumoto K, Li H, Watanabe H
(2000) Behavioural Brain Research 109: 83-90
Preferable Monosodium Glutamate and Sodium Chloride Solutions do not Affect Diurnal Norepinephrine Release in the Rat Lateral Hypothalamus.
Smriga M, Torii K
(2000) Nutritional Neuroscience 3: 367-372
Presynaptic L-type Ca2+ channels on excessive dopamine release from rat caudate putamen.
Okita M, Watanabe Y, Taya K, Utsumi H, Hayashi T
(2000) Physiology & Behavior 68: 641-649
抹消組織での無麻酔・無拘束マイクロダイアリシス法
倉田知光
(2000) 日薬理誌 116: 181-187
Chronic adriamycin treatment impairs myocardial interstitial neuronal release of norepinephrine and epinephrine.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Sunagawa K
(2000) Journal of Cardiovascular Pharmacology 36 (Suppl. 2): S31-S34
Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Takaki H, Sugimachi M, Sunagawa K
(2000) Journal of Molecular and Cellular Cardiology 32: 405-414
Vasopressin regulation of noradrenaline release within the supraoptic nucleus.
Ludwig M, Onaka T, Yagi K
(2000) Journal of Neuroendocrinology 12: 477-479
The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral hippocampus in rats.
Mishima K, Iwasaki K, Tsukikawa H, Matsumoto Y, Egashira N, Abe K, Egawa T, Fujiwara M.
(2000) Japanese Journal of Pharmacology 84: 163-173
Activation of peripheral NMDA-nitric oxide cascade in formalin test.
Omote K, Kawamata T, Kawamata M, Nakayama Y, Hazama K, Namiki A.
(2000) Anesthesiology 93(1):173-178
1999
Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia.
Ohtani N, Sugano T, Ohta M
(1999) Brain Research 842: 6-14
Effect of selegiline on dopamine concentration in the striatum of a primate.
Kaseda S, Nomoto M, Iwata S
(1999) Brain Research 815: 44-50
セフジトレンピボキシルの脳内移行について
山崎由香子、今井恵子、奈良圭之輔、岩井信市、徳永 晋、小口勝司
(1999) 昭和医学会雑誌 59: 629-634
Serotonin-mediated increases in the extracellular levels of beta-endorphin in the arcuate nucleus and nucleus accumbens: a microdialysis study.
Zangen A, Nakash R, Yadid G
(1999) Journal of Neurochemistry 73: 2569-2574
1998
Enhanced glutamate release during REM sleep in the rostromedial medulla as measured by in vivo microdialysis.
Kodama T, Lai YY, Siegel JM
(1998) Brain Research 780: 178-181
Pharmacokinetics of Topical â-Adrenergic Antagonists in Rabbit Aqueous Humor Evaluated with the Microdialysis Method.
Ohtori R, Sato H, Fukuda S, Ueda T, Koide R, Kanda Y, Kiuchi Y, Oguchi K
(1998) Experimental Eye Research 66: 487-494
Liquid chromatographic determination of myocardial interstitial epinephrine.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Inagaki M, Alexander J, Sunagawa K
(1998) Journal of chromatography B 714: 375-378
Effect of the nitric oxide level in the medial preoptic area on male copulatory behavior in rats.
Sato Y, Horita H, Kurohata T, Adachi H, Tsukamoto T.
(1998) American Journal of Physiology 274(1 Pt 2):R243-R247
1997
Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats.
Murakami Y, Matsumoto K, Watanabe H
(1997) Biological & Pharmaceutical Bulletin 20: 88-90
New antioxidant mixture for long term stability of serotonin, dopamine and their metabolites in automated microbore liquid chromatography with dual electrochemical detection.
Thorré K, Pravda M, Sarre S, Ebinger G, Michotte Y
(1997) Journal of Chromatography B, 694: 297-303
High-performance liquid chromatographic determination of myocardial interstitial dihidroxyphenylglycol.
Takauchi Y, Kitagawa H, Kaeada T, Akiyama T, Yamazaki T
(1997) Journal of Chromatography B 693: 218-221
1995
Routine high-performance liquid chromatographic determination of myocardial interstitial norepinephrine.
Yamazaki T, Akiyama T, Shindo T
(1995) Journal of Chromatography B 670: 328-331
Changes of hepatic microsomal oxidative drug metabolizing enzymes in chronic renal failure (CRF) rats by partial nephrectomy.
Uchida N, Kurata N, Shimada K, Nishimura Y, Yasuda K, Hashimoto M, Uchida E, Yasuhara H.
(1995) Japanese Journal of Pharmacology 68(4):431-439
1993
Effects of repeated cerebral ischemia on extracellular amino acid concentrations measured with intracerebral microdialysis in the gerbil hippocampus.
Nakata, N., Kato, H., & Kogure, K.
(1993) Stroke, 24(3), 458-463.
Increase in serotonin levels in the dog ileum and blood by cisplatin as measured by microdialysis.
Fukui H, Yamamoto M, Ando T, Sasaki S, Sato S.
(1993) Neuropharmacology 32(10):959-968
1991
Pineal microdialysis in freely moving rats.
Azekawa T, Sano A, Sei H, Yamamoto A, Aoi K, Morita Y
(1991) Brain Research Bulletin 26(3):413-417
1990
Concurrent on-line sampling of melatonin in pineal microdialysates from conscious rat and its analysis by high-performance liquid chromatography with electrochemical detection.
Azekawa T, Sano A, Aoi K, Sei H, Morita Y
(1990) Journal of Chromatography 530(1):47-55
Microdialysis Probes, Instruments and Accessories
2023
Mesolimbic dopamine release precedes actively sought aversive stimuli in mice.
Yawata, Y., Shikano, Y., Ogasawara, J., Makino, K., Kashima, T., Ihara, K., … & Ikegaya, Y.
(2023). Nature Communications, 14(1), 2433.
Acute and chronic actions of methylphenidate mediated through the L-DOPA receptor GPR143.
Uchimura, H., Kanai, K., Arai, M., Inoue, M., Hishimoto, A., Masukawa, D., & Goshima, Y.
(2023). Journal of Pharmacological Sciences.
Toxicity manifestations and sex differences due to MARTA olanzapine.
Hattori-Usami, N., Kaizaki-Mitsumoto, A., Ashino, T., Yamamoto, M., & Numazawa, S.
(2023). The Journal of Toxicological Sciences, 48(4), 191-202.
Rat model of attention-deficit hyperactivity disorder exhibits delayed recovery from acute incisional pain due to impaired descending noradrenergic inhibition.
Suto, T., Kato, D., Koibuchi, I., Arai, Y., Ohta, J., Hiroki, T., … & Saito, S.
(2023). Scientific Reports, 13(1), 5526.
A Candidate Gliotransmitter, L-β-Aminoisobutyrate, Contributes to Weight Gain and Metabolic Complication Induced by Atypical Antipsychotics
Fukuyama, K., Motomura, E., & Okada, M.
(2023). . Nutrients, 15(7), 1621.
Changes in Acupuncture-Induced Specific Acupoint Neurotransmitters are Possibly Related to Their Physiological Functions in Rats.
Nguyen, H. T. M., Lee, D. Y., Liu, C. H., & Hsieh, C. L.
(2023). Evidence-Based Complementary and Alternative Medicine, 2023.
Electrochemical activities of Fe2O3-modified microelectrode for dopamine detection using fast-scan cyclic voltammetry.
Sato, N., Ohta, Y., Haruta, M., Takehara, H., Tashiro, H., Sasagawa, K., … & Ohta, J.
(2023). AIP Advances, 13(2), 025026.
Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain.
Fukuyama, K., Motomura, E., & Okada, M.
(2023). Schizophrenia, 9(1), 8.
Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice.
Tanaka, K., Kondo, T., Narita, M., Muta, T., Yoshida, S., Sato, D., … & Narita, M.
(2023). Molecular Brain, 16(1), 1-11.
Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus.
Yoshida, S., Hamada, Y., Narita, M., Sato, D., Tanaka, K., Mori, T., … & Narita, M.
(2023). Molecular Brain, 16(1), 1-11.
Highly selective transgene expression through the flip-excision switch system by using a unilateral spacer sequence.
Matsushita, N., Kato, S., Nishizawa, K., Sugawara, M., Takeuchi, K., Miyasaka, Y., … & Kobayashi, K.
(2023). Cell Reports Methods, 100393.
Modulation of trigeminal neuropathic pain by optogenetic inhibition of posterior hypothalamus in CCI-ION rat.
Islam, J., Kc, E., So, K. H., Kim, S., Kim, H. K., Park, Y. Y., & Park, Y. S.
(2023). Scientific Reports, 13(1), 1-14.
Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle.
Natsubori, A., Hirai, S., Kwon, S., Ono, D., Deng, F., Wan, J., … & Honda, M.
(2023). iScience, 105830.
Altered Pharmacological Efficacy of Phenobarbital with the Treatment of 7, 8-Dihydroxyflavone, an Agonist of Tropomyosin Receptor Kinase B, in Rats.
Suzuki, K., Matsumoto, K., Takenaka, M., & Aiba, T.
(2023). Biological and Pharmaceutical Bulletin, 46(1), 86-94.
2022
Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion.
Kawai, H., Bouchekioua, Y., Nishitani, N., Niitani, K., Izumi, S., Morishita, H., … & Kaneko, S.
(2022). Nature Communications, 13(1), 1-22.
Kamishoyosan Alleviates Anxiety-like Behavior in a Premenstrual Syndrome Rat Model.
Iba-Tanaka, H., Watanabe, T., Harada, K., Kubota, K., Katsurabayashi, S., & Iwasaki, K.
(2022). Evidence-Based Complementary and Alternative Medicine, 2022.
Pro-cognitive effects of the GlyT1 inhibitor Bitopertin in rodents.
Deiana, S., Hauber, W., Munster, A., Sommer, S., Ferger, B., Marti, A., … & Rosenbrock, H.
(2022). European Journal of Pharmacology, 175306.
Rubiscolin‑6 rapidly suppresses the postprandial motility of the gastric antrum and subsequently increases food intake via δ‑opioid receptors in mice.
Ataka, K., Asakawa, A., & Kato, I.
(2022). Molecular Medicine Reports, 26(5), 1-6.
Differential pharmacological and sex-specific effects of antimuscarinic agents at the hypoglossal motor nucleus in vivo in rats.
Niakani, S., Liu, H., Liu, W. Y., & Horner, R. L.
(2022). Scientific Reports, 12(1), 1-25.
High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain.
Hisaoka-Nakashima, K., Ohata, K., Yoshimoto, N., Tokuda, S., Yoshii, N., Nakamura, Y., … & Morioka, N.
(2022). Experimental Neurology, 114146.
TMEM16A blockers T16Ainh‐A01 and benzbromarone do not modulate the regulation of sweating and cutaneous vasodilatation in humans in vivo.
Fujii, N., Amano, T., Kenny, G. P., Mündel, T., Lei, T. H., Honda, Y., … & Nishiyasu, T.
(2022). Experimental Physiology.
Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy.
Hashimoto, Y., Kuniishi, H., Sakai, K., Fukushima, Y., Du, X., Yamashiro, K., … & Aoki, Y.
(2022). Progress in Neurobiology, 102288.
Effects of Lisdexamfetamine, a Prodrug of D-Amphetamine, on Locomotion, Spatial Cognitive Processing and Neurochemical Profiles in Rats: A Comparison With Immediate-Release Amphetamine.
Jian-Min, C., Zhi-Yuan, W., Shi-Xuan, W., Rui, S., Ning, W., & Jin, L.
(2022). Frontiers in Psychiatry, 13.
Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia.
Hasegawa, T., Chiken, S., Kobayashi, K., & Nambu, A.
(2022). Nature Communications, 13(1), 1-15.
Depolarization time and extracellular glutamate levels aggravate ultra-early brain injury after subarachnoid hemorrhage.
Murai, S., Hishikawa, T., Takeda, Y., Okura, Y., Fushimi, M., Kawase, H., … & Date, I.
(2022). Research Square In Review Scientific Reports
Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.
Niu, M., Kasai, A., Tanuma, M., Seiriki, K., Igarashi, H., Kuwaki, T., … & Hashimoto, H.
(2022). Science Advances, 8(11), eabi6375.
Toxicokinetic evaluation during intoxication of psychotropic drugs using brain microdialysis in mice.
Inoue, Y., Kaizaki-Mitsumoto, A., & Numazawa, S.
(2022). The Journal of Toxicological Sciences, 47(3), 99-108.
Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice.
Kawaminami, A., Yamada, D., Yanagisawa, S., Shirakata, M., Iio, K., Nagase, H., & Saitoh, A.
(2022). Frontiers in Behavioral Neuroscience.
Glucose infusion suppresses acute restraint stress-induced peripheral and central sympathetic responses in rats.
Yamaguchi, N., Kakinuma, Y., Yakura, T., Naito, M., & Okada, S.
(2022). Autonomic Neuroscience, 102957.
The efficacy of duloxetine depends on spinal cholinergic plasticity in neuropathic pain model rats.
Kato, D., Suto, T., Obata, H., & Saito, S.
(2022). IBRO Neuroscience Reports.
Phasic firing of dopaminergic neurons in the ventral tegmental area triggers peripheral immune responses.
Kayama, T., Ikegaya, Y., & Sasaki, T.
(2022). Scientific Reports, 12(1), 1-9.
Investigating the Influence of GABA Neurons on Dopamine Neurons in the Ventral Tegmental Area Using Optogenetic Techniques.
Ohta, Y., Murakami, T. E., Kawahara, M., Haruta, M., Takehara, H., Tashiro, H., … & Akay, Y. M.
(2022). International Journal of Molecular Sciences, 23(3), 1114.
Oral acetaminophen-induced spinal 5-hydroxytriyptamine release produces analgesic effects in the rat formalin test.
Nakamura, S., Nonaka, T., Komatsu, S., Yamada, T., & Yamamoto, T.
(2022). Biomedicine & Pharmacotherapy, 146, 112578.
Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson’s disease.
Sato, F., Nakamura, Y., Ma, S., Kochi, T., Hisaoka-Nakashima, K., Wang, D., … & Morioka, N.
(2022). Biomedicine & Pharmacotherapy, 145, 112479.
2021
Optogenetic stimulus-triggered acquisition of seizure resistance
Shimoda, Y., Beppu, K., Ikoma, Y., Morizawa, Y. M., Zuguchi, S., Hino, U., … & Matsui, K.
(2021). . Neurobiology of Disease, 105602.
The abuse potential of prolintane in rodents: Behavioral pharmacology approaches.
Lee, W., Lee, J. W., Kim, J. M., Hong, Y. K., Kim, M. S., Choi, S. O., & Kang, M. S.
(2021). Neuropharmacology, 108917.
Characterization and Relative Efficacy of Muscarinic Receptor Antagonism at the Hypoglossal Motor Nucleus to Block Inhibition of Tongue Motor Activity.
Niakani, S.
(2021). (Doctoral dissertation)
Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine.
Hashimoto, K., Yamawaki, Y., Yamaoka, K., Yoshida, T., Okada, K., Tan, W., … & Yamawaki, S.
(2021). Brain Communications.
Isoproterenol injected into the basolateral amygdala rescues amyloid β1-42-induced conditioned fear memory deficit via reducing intracellular Zn2+ toxicity.
Ishikawa, Y., Itoh, R., Tsujimoto, R., Tamano, H., & Takeda, A.
(2021). Neuroscience Letters, 136353.
Reduction of acetylcholine in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
Kondo-Takuma, Y., Mizuno, M., Tsuda, Y., Madokoro, Y., Suzuki, K., Sato, T., … & Matsukawa, N.
(2021). Scientific Reports, 11(1), 1-9.
Effect of P-glycoprotein Inhibition on the Penetration of Ceftriaxone Across the Blood–Brain Barrier.
Shan, Y., Cen, Y., Zhang, Y., Tan, R., Zhao, J., Nie, Z., … & Yu, S.
(2021). Neurochemical Research, 1-10.
Pharmacogenetic excitation of the median raphe region affects social and depressive-like behavior and core body temperature in male mice.
Fazekas, C. L., Bellardie, M., Török, B., Sipos, E., Tóth, B., Baranyi, M., … & Zelena, D.
(2021). Life Sciences, 120037.
Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats.
WAKABAYASHI, Y., OKAMURA, H., & YAMAMURA, T.
(2021). Journal of Reproduction and Development.
Participation of the descending noradrenergic inhibitory system in the anti-hyperalgesic effect of acetaminophen in a rat model of inflammation.
Juri, T., Fujimoto, Y., Suehiro, K., Nishikawa, K., & Mori, T.
(2021). Life Sciences, 120030.
Paraquat-induced intracellular Zn2+ dysregulation causes dopaminergic degeneration in the substantia nigra, but not in the striatum.Tamura, H., Nishio, R., Saeki, N., Katahira, M., Morioka, H., Tamano, H., & Takeda, A.
2021). Research Square
Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss.
Zhu, Y., Wang, R., Fan, Z., Luo, D., Cai, G., Li, X., … & Wu, S.
(2021). Research Square.
FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice.
Sadamura, Y., Thapa, S., Mizunuma, R., Kambe, Y., Hirasawa, A., Nakamoto, K., … & Kurihara, T.
(2021). Front. Pharmacol. 12: 699026. doi: 10.3389/fphar. 2021.699026. Frontiers in Pharmacology| www. frontiersin. org, 12.
Methods for Intratumoral Microdialysis Probe Targeting and Validation in Murine Brain Tumor Models.
Rajani, K., Olson, I., Jacobs, J. J., Riviere-cazaux, C., Burns, K., Carlstrom, L., … & Burns, T. C.
(2021). Journal of Neuroscience Methods, 109321.
Specific gene expression in unmyelinated dorsal root ganglion neurons in nonhuman primates by intra-nerve injection of adeno-associated virus 6 vector.
Kudo, M., Wupuer, S., Fujiwara, M., Saito, Y., Kubota, S., Inoue, K. I., … & Seki, K.
(2021). Molecular Therapy-Methods & Clinical Development.
Regulation of maternal care by corticotropin-releasing factor receptors in the dorsal raphe nucleus in mice.
Kijima, T., Muroi, Y., & Ishii, T.
(2021). Behavioral Neuroscience, 135(3), 359.
Preventive effect of Ninjin-yoei-to, a Kampo medicine, on amyloid β1-42-induced neurodegeneration via intracellular Zn2+ toxicity in the dentate gyrus.
TAMANO, H., TOKORO, H., MURAKAMI, D., FURUHATA, R., NAKAJIMA, S., SAEKI, N., … & TAKEDA, A.
(2021). Experimental Animals, 21-0044.
Intracellular Hydrogen Peroxide Produced by 6-Hydroxydopamine is a Trigger for Nigral Dopaminergic Degeneration Via Rapid Influx of Extracellular Zn2+.
Nishio, R., Morioka, H., Takeuchi, A., Saeki, N., Furuhata, R., Chinenn, T., … & Takeda, A.
(2021).
Deep Brain Stimulation Using Animal Models of Parkinson’s Disease. In Experimental Models of Parkinson’s Disease (pp. 151-160).
Nakajima, A., & Shimo, Y.
(2021). Humana, New York, NY.
Astrocytes in the rostral ventromedial medulla contribute to the maintenance of orofacial hyperalgesia induced by late removal of dental occlusal interference.
Mo, S. Y., Bai, S. S., Xu, X. X., Liu, Y., Fu, K. Y., Sessle, B. J., … & Xie, Q. F.
(2021). Journal of Oral Rehabilitation.
Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model.
Elina, K. C., Oh, B. H., Islam, J., Kim, S., & Park, Y. S.
(2021). The Journal of Headache and Pain, 22(1), 1-14.
Lesions of the lateral habenula produce anxiolytic effects in a rat model of Parkinson’s disease.
Du, C. X., Guo, Y., & Liu, J.
(2021). Neurological Research, 1-8.
A Novel Chronic Dural Port Platform for Continuous Collection of Large Volumes of Cerebrospinal Fluid and Intrathecal Drug Delivery in Free-Moving Mice.
Nakajima, T., Takeda, S., Ito, Y., Oyama, A., Takami, Y., Takeya, Y., … & Morishita, R.
(2021).
β-adrenergic Receptor Activity in the Hippocampal Dentate Gyrus Participates in Spatial Learning and Memory Impairment in Sleep-deprived Rats.
Lu, H. J.
(2021). Experimental Neurobiology, 30(2), 144-154.
Period1 gene expression in the olfactory bulb and liver of freely moving streptozotocin-treated diabetic mouse.
Kanou, H., Nagasawa, K., Ishii, Y., Chishima, A., Hayashi, J., Haga, S., … & Hamada, T.
(2021). Biochemical and Biophysical Research Communications, 560, 14-20.
Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment.
Toriumi, K., Miyashita, M., Suzuki, K., Yamasaki, N., Yasumura, M., Horiuchi, Y., … & Arai, M.
(2021). Translational Psychiatry, 11(1), 1-11.
Effects of Inhaled Linalool on Anxiety Related Behaviors and Frontal Cortical Serotonin Levels in Mice.
KAWAGUCHI, T., GOTOH, L., TAGUCHI, M., OGUSHI, Y., HATANAKA, A., IIDA, H., & KAWASAKI, H.
(2021). Med. Bull. Fukuoka Univ: 48 (1), 31-38
Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia.
Sotoyama, H., Namba, H., Kobayashi, Y., Hasegawa, T., Watanabe, D., Nakatsukasa, E., … & Nawa, H.
(2021). Translational Psychiatry, 11(1), 1-11.
In Vivo Monitoring of Acetylcholine Release from Nerve Endings in Salivary Gland.
Yoshikawa, M., & Kawaguchi, M.
(2021). Biology, 10(5), 351
Striatal TRPV1 activation by acetaminophen ameliorates dopamine D 2 receptor antagonists-induced orofacial dyskinesia.
Nagaoka, K., Nagashima, T., Asaoka, N., Yamamoto, H., Toda, C., Kayanuma, G., … & Kaneko, S.
(2021). JCI insight.
Monitoring Neuronal Dynamics in the Ventral Tegmental Area Using an Implantable Microimaging Device With Microdialysis System.
Sunaga, Y., Ohta, Y., Murakami, T. E., Akay, Y. M., Ohta, J., & Akay, M.
(2021). IEEE Access, 9, 55871-55878.
Ferulic acid alleviates abnormal behaviors in isolation-reared mice via 5-HT 1A receptor partial agonist activity.
Araki, R., Yasubuchi, A., Ikegaya, M., Hojo, C., Tachioka, H., Kawai, K., … & Yabe, T.
(2021). Psychopharmacology, 1-8.
Dehydroeffusol Pprevents Amyloid β 1-42-mediated Hippocampal Neurodegeneration via Reducing Intracellular Zn 2+ Toxicity.
Tamano, H., Takiguchi, M., Saeki, N., Katahira, M., Shioya, A., Tanaka, Y., … & Takeda, A.
(2021). Molecular Neurobiology, 1-11.
Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target.
Okada, T., Kato, D., Nomura, Y., Obata, N., Quan, X., Morinaga, A., … & Wake, H.
(2021). Science Advances, 7(12), eabd8261.
Mitochondrial toxins potentiate hydroxyl radical production in rat striatum during carbon monoxide poisoning.
Kuriiwa, F., Kobayashi, M., Mizukami, H., & Hara, S.
(2021). Journal of Pharmacological Sciences.
Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression.
Kinoshita, C., Kikuchi-Utsumi, K., Aoyama, K., Suzuki, R., Okamoto, Y., Matsumura, N., … & Nakaki, T.
(2021). Communications Biology, 4(1), 1-12.
Dual actions of 5‐MeO‐DIPT at the serotonin transporter and serotonin 5‐HT1A receptor in the mouse striatum and prefrontal cortex.
Hagino, Y., Hall, F. S., Uhl, G. R., Sora, I., & Ikeda, K.
(2021). Neuropsychopharmacology Reports.
Effects of Subchronic Administrations of Vortioxetine, Lurasidone, and Escitalopram on Thalamocortical Glutamatergic Transmission Associated with Serotonin 5-HT7 Receptor.
Okada, M., Matsumoto, R., Yamamoto, Y., & Fukuyama, K.
(2021). International Journal of Molecular Sciences, 22(3), 1351.
Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis.
Chang, H. Y., Wu, S., Li, Y., Zhang, W., Burrell, M., Webster, C. I., & Shah, D. K.
(2021, January). In mAbs (Vol. 13, No. 1, p. 1874121). Taylor & Francis.
Antagonism for NPY signaling reverses cognitive behavior defects induced by activity-based anorexia in mice.
Rokot, N. T., Ataka, K., Iwai, H., Suzuki, H., Tachibe, H., Kairupan, T. S., … & Asakawa, A.
(2021). Psychoneuroendocrinology, 105133.
Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors.
Matsuo, T., Isosaka, T., Tang, L., Soga, T., Kobayakawa, R., & Kobayakawa, K.
(2021). Communications Biology, 4(1), 1-17.
Toxicokinetic characteristics and effects of diphenylarsinic acid on dopamine in the striatum of free-moving mice.
Umezu, T., & Shibata, Y.
(2021). NeuroToxicology.
Age-related vulnerability to nigral dopaminergic degeneration in rats via Zn2+-permeable GluR2-lacking AMPA receptor activation.
Nakajima, S., Saeki, N., Tamano, H., Nishio, R., Katahira, M., Takeuchi, A., & Takeda, A.
(2021). NeuroToxicology.
A potential defense mechanism against amyloid deposition in cerebellum.
Shahnur, A., Nakano, M., Ishihara, S., Kakuda, N., Miyasaka, T., Uchiyama, H., … & Nishimura, M.
(2021). Biochemical and Biophysical Research Communications, 535, 25-32.
2020
Role of Oral Sensory and Serotonergic Neurons in Dopamine-induced Tongue Movement in Rat.
HARADA, T., IIDA, S., INADA, Y., TANAKA, S., HAMADA, Y., & KOGO, M.
(2020). Nano Biomedicine, 12(2), 53-60.
A potential defense mechanism against amyloid deposition in cerebellum.
Shahnur, A., Nakano, M., Ishihara, S., Kakuda, N., Miyasaka, T., Uchiyama, H., … & Nishimura, M. Biochemical and Biophysical Research Communications, 535, 25-32.
Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques.
Hashimoto, T., Fujii, D., Naka, Y., Kashiwagi-Hakozaki, M., Matsuo, Y., Matsuura, Y., … & Iwatsubo, T.
(2020). Acta Neuropathologica Communications, 8(1), 1-18.
Increased penetration of diphenhydramine in brain via proton-coupled organic cation antiporter in rats with lipopolysaccharide-induced inflammation.
Kawase, A., Chuma, T., Irie, K., Kazaoka, A., Kakuno, A., Matsuda, N., … & Iwaki, M.
(2020). Brain, Behavior, & Immunity-Health, 100188.
Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway.
Lin, Y. H., Yamahashi, Y., Kuroda, K., Faruk, M. O., Zhang, X., Yamada, K., … & Kaibuchi, K.
(2020). Neurochemistry International, 104935.
Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction.
Kellis, D. M., Kaigler, K. F., Witherspoon, E., Fadel, J. R., & Wilson, M. A.
(2020). Neurobiology of Stress, 100279.
G-protein Signaling Regulating Opioid-induced Respiratory Rate Depression (Doctoral dissertation).
Danaf, J. (2020).
Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards.
Miyazaki, K., Miyazaki, K. W., Sivori, G., Yamanaka, A., Tanaka, K. F., & Doya, K.
(2020). Science Advances, 6(48), eabc7246.
Gαq protein signaling in the bed nucleus of the stria terminalis regulate the lipopolysaccharide-induced despair-like behavior in mice.
Fukuwada, N., Kanno, M., Yoshida, S., & Seki, K.
(2020). AIMS Neuroscience, 7(4): 438–458.
Simultaneous blood and brain microdialysis in a free-moving mouse to test blood-brain barrier permeability of chemicals.
Umezu, T., Sano, T., Hayashi, J., & Shibata, Y.
(2020). Toxicology Reports.
Mice Carrying a Schizophrenia-associated Mutation of the Arhgap10 Gene Are Vulnerable to the Effects of Methamphetamine Treatment on Cognitive Function: Association With Morphological Abnormalities in Striatal Neurons.
Hada, K., Wulaer, B., Nagai, T., Itoh, N., Sawahata, M., Sobue, A., … & Ozaki, N.
(2020).
Glutathione Peroxidase-1 Knockout Facilitates Memory Impairment Induced by β-Amyloid (1–42) in Mice via Inhibition of PKC βII-Mediated ERK Signaling; Application with Glutathione Peroxidase-1 Gene-Encoded Adenovirus Vector.
Shin, E. J., Chung, Y. H., Sharma, N., Nguyen, B. T., Lee, S. H., Kang, S. W., … & Kim, H. C.
(2020). Neurochemical Research, 1-12.
α2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline.
Kawashita, E., Ishihara, K., Miyaji, H., Tanishima, Y., Kiriyama, A., Matsuo, O., & Akiba, S.
(2020). Molecular Brain, 13(1), 1-14.
Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice.
Kawaguchi, C., Shintani, N., Hayata-Takano, A., Hatanaka, M., Kuromi, A., Nakamura, R., … & Sugimoto, Y.
(2020). Communications Biology, 3(1), 1-13.
Dissecting the tectal output channels for orienting and defense responses.
Isa, K., Sooksawate, T., Kobayashi, K., Kobayashi, K., Redgrave, P., & Isa, T.
(2020). eNeuro.
Noradrenaline enhances the excitatory effects of dopamine on medial prefrontal cortex pyramidal neurons in rats.
Shinohara, F., Arakaki, S., Amano, T., Minami, M., & Kaneda, K.
(2020). Neuropsychopharmacology Reports.
Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure.
Yamaguchi, T., Sumida, T. S., Nomura, S., Satoh, M., Higo, T., Ito, M., … & Yoshimi, K.
(2020). Nature Communications, 11(1), 1-8.
Effects of the Endocannabinoid Anandamide on the Efficiency of Noradrenergic Neurotransmission in the Amygdaloid Body in Acute Stress in Mice.
Anderzhanova, E. E., Kudrin, V. S., & Wotjak, S. T.
(2020). Neuroscience and Behavioral Physiology, 1-6.
Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice.
Sakayori, N., Katakura, M., Hamazaki, K., Higuchi, O., Fujii, K., Fukabori, R., … & Arita, M.
(2020). Communications Biology, 3(1), 1-13.
Immobility-reducing Effects of Ketamine during the Forced Swim Test on 5-HT1A Receptor Activity in the Medial Prefrontal Cortex in an Intractable Depression Model.
Takahashi, K., Kitamura, Y., Ushio, S., & Sendo, T.
(2020). Acta Medica Okayama, 74(4), 301-306.
Absence of methamphetamine‐induced conditioned place preference in weaver mutant mice.
Ikekubo, Y., Ide, S., Hagino, Y., & Ikeda, K.
(2020). Neuropsychopharmacology Reports.
Modulation of TASK-1/3 Channels at the Hypoglossal Motoneuron Pool and Effects on Tongue Motor Output and Responses to Excitatory Inputs In-Vivo: Implications for Strategies for Obstructive Sleep Apnea Pharmacotherapy.
Gurges, P., Liu, H., & Horner, R. L.
(2020). Sleep.
Enhancement of the rewarding effects of 3, 4-methylenedioxymethamphetamine in orexin knockout mice.
Mori, T., Uzawa, N., Masukawa, D., Hirayama, S., Iwase, Y., Hokazono, M., … & Suzuki, T.
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(2019) Pharmacology Research & Perspectives, 7(1), e00457.
Iso-α-acids, the bitter components of beer, improve hippocampus-dependent memory through vagus nerve activation.
Ano, Y., Hoshi, A., Ayabe, T., Ohya, R., Uchida, S., Yamada, K., … & Furuyashiki, T.
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Brain Microdialysis Study of Vancomycin in the Cerebrospinal Fluid After Intracerebroventricular Administration in Mice.
Miura, Y., Fuchigami, Y., Nomura, S., Nishimura, K., Hagimori, M., & Kawakami, S.
(2019) AAPS PharmSciTech, 20(1), 5.
Theanine attenuates memory impairments induced by klotho gene depletion in mice.
Nguyen, B. T., Sharma, N., Shin, E. J., Jeong, J. H., Lee, S. H., Jang, C. G., … & Kim, H. C.
(2018) Food & Function.
2018
“Soluble high molecular weight (hmw) tau species and applications thereof.”
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T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.
Wang, S., Yabuki, Y., Matsuo, K., Xu, J., Izumi, H., Sakimura, K., … & Fukunaga, K.
(2018) PLOS ONE, 13(12), e0206986.
Somatostatin-somatostatin receptor 2 signaling mediates LH pulse suppression in lactating rats.
Sugimoto, A., Tsuchida, H., Ieda, N., Ikegami, K., Inoue, N., Uenoyama, Y., & Tsukamura, H.
(2018) Endocrinology.
Tropomyosin receptor kinase B receptor activation in the locus coeruleus restores impairment of endogenous analgesia at a late stage following nerve injury in rats.
Suto, T., Kato, D., Obata, H., & Saito, S.
(2018) The Journal of Pain.
Dopamine in the hippocampal dentate gyrus modulates spatial learning via D1-like receptors.
Wang, F., Wan, P., Wang, W., Xiao, B., Jin, H., & Jin, Q.
(2018) Brain research bulletin.
Propranolol prevents cerebral blood flow changes and pain-related behaviors in migraine model mice.
Kurauchi, Y., Haruta, M., Tanaka, R., Sasagawa, K., Ohta, J., Hisatsune, A., … & Katsuki, H.
(2018) Biochemical and Biophysical Research Communications.
Noradrenaline reuptake inhibition increases control of impulsive action by activating D1-like receptors in the infralimbic cortex.
Sasamori, H., Ohmura, Y., Yoshida, T., & Yoshioka, M.
(2018) European Journal of Pharmacology.
Amyloid β 1–42-Induced Rapid Zn 2+ Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia.
Tamano, H., Suzuki, H., Murakami, T., Fujii, H., Adlard, P. A., Bush, A. I., & Takeda, A.
(2018) Molecular Neurobiology, 1-10.
In vivo neurochemical evidence that stimulation of accumbal GABAA and GABAB receptors each reduce acetylcholine efflux without affecting dopamine efflux in the nucleus accumbens of freely moving rats.
Aono, Y., Watanabe, Y., Ishikawa, M., Kuboyama, N., Waddington, J. L., & Saigusa, T.
(2018) Synapse.
Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission.
Fukuyama, K., Hasegawa, T., & Okada, M.
(2018) International Journal of Molecular Sciences, 19(11), 3645.
Pharmacological characterization of (3-(benzo [d][1, 3] dioxol-4-yloxy).
Xu, X., Wei, Y., Guo, Q., Zhao, S., Liu, Z., Xiao, T., … & Wang, K.
(2018) Neuropsychopharmacology, 25, 871-880.
Astrocyte‐neuron lactate shuttle sensitizes nociceptive transmission in the spinal cord.
Miyamoto, K., Ishikura, K. I., Kume, K., & Ohsawa, M.
(2018) Glia.
Enhanced AMPA receptor-mediated excitatory transmission in the rodent rostromedial tegmental nucleus following lesion of the nigrostriatal pathway.
Chang, Y., Du, C., Han, L., Lv, S., Zhang, J., Bian, G., … & Liu, J.
(2018) Neurochemistry International.
E rythropoietin reduces nerve demyelination, neuropathic pain behavior and microglial MAPK s activation through erythropoietin receptors on S chwann cells in a rat model of peripheral neuropathy.
Huang, C. T., Chen, S. H., Lin, S. C., Chen, W. T., Lue, J. H., & Tsai, Y. J
(2018) Glia.
Blockade of Rapid Influx of Extracellular Zn 2+ into Nigral Dopaminergic Neurons Overcomes Paraquat-Induced Parkinson’s Disease in Rats.
Tamano, H., Morioka, H., Nishio, R., Takeuchi, A., & Takeda, A.
(2018) Molecular Neurobiology, 1-10.
Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve.
Ayabe, T., Ohya, R., Taniguchi, Y., Shindo, K., Kondo, K., & Ano, Y.
(2018) Scientific Reports, 8(1), 15372.
In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes.
Yamada, K.
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A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice.
Saitoh, A., Soda, A., Kayashima, S., Yoshizawa, K., Oka, J. I., Nagase, H., & Yamada, M.
(2018). Journal of Pharmacological Sciences.
An enzyme-modified capillary as a platform for simultaneous fluorometric detection of D-glucose and L-lactate.
Shoji, A., Takahashi, Y., Osato, S., & Sugawara, M.
(2018). Journal of Pharmaceutical and Biomedical Analysis.
Pregabalin increases food intake through dopaminergic systems in the hypothalamus.
Ikeda, H., Yonemochi, N., Ardianto, C., Yang, L., & Kamei, J.
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“SIALYLATION-INCREASING THERAPIES FOR DISEASES ASSOCIATED WITH OXIDATIVE STRESS.”
Huizing, M., Malicdan, M. C., & Carrillo, N.
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Mesolimbic Dopamine, Its Receptors and Social Learning
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Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia.
Sobue, A., Kushima, I., Nagai, T., Shan, W., Kohno, T., Aleksic, B., … & Yamamoto, M.
(2018) Scientific Reports, 8(1), 13046.
Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity.
Lui, S., Torontali, Z., Tadjalli, A., & Peever, J.
(2018) Scientific Reports, 8(1), 12709.
A Smart and Sensitive Sensing Platform to Monitor the Extracellular of Hydrogen Peroxide in Rat Brain Microdialysate under Pathological Process based on Mesoporous Silica Nanoparticles.
Xu, G., Xie, Q., Chen, Z., Luo, F., Qiu, B., Guo, L., & Lin, Z.
(2018) Analytical Methods.
“METHODS OF TREATING PATIENTS SUFFERING FROM MOVEMENT DISORDERS.”
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“ANTI-SEMAPHORIN 3A ANTIBODY AND TREATMENT OF ALZHEIMER’S DISEASE AND INFLAMMATORY IMMUNE DISEASES USING SAME.”
Goshima, Y., Nakamura, F., Yamashita, N., Seo, H., Hashimoto, S., Murakami, K., … & Sasakura, Y.
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Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.
Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.
Stimulation of accumbal GABAB receptors inhibits delta1-and delta2-opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats.
Watanabe, Y., Aono, Y., Komiya, M., Waddington, J. L., & Saigusa, T.
(2018) European Journal of Pharmacology.
Translocator protein 18kDa antagonist ameliorates stress‐induced stool abnormality and abdominal pain in rodent stress models.
Kawahara, Y., Mitsui, K., Niwa, T., Morimoto, N., Kawaharada, S., & Katsumata, S.
(2018) Neurogastroenterology & Motility, e13425.
Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies.
Wang, J., Jin, W. S., Bu, X. L., Zeng, F., Huang, Z. L., Li, W. W., … & Zhu, J.
(2018) Acta Neuropathologica, 1-12.
Surgical Reinforcement Alters Collagen Alignment and Turnover in Healing Myocardial Infarcts.
Caggiano, L. R., Lee, J. J., & Holmes, J. W.
(2018) American Journal of Physiology-Heart and Circulatory Physiology.
Central apelin administration and restraint stress induce hypothalamic cholecystokinin release through APJ receptor.
Bülbül, M., Sinen, O., Abueid, L., Akkoyunlu, G., & Özsoy, Ö.
(2018) Journal of neuroendocrinology, e12635.
Acetaldehyde administration induces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice.
Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., … & Kinoshita, H.
(2018) Neuroscience Letters.
Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex.
Saiki, M., Matsui, T., Soya, M., Kashibe, T., Shima, T., Shimizu, T., … & Soya, H.
(2018) Scientific reports, 8(1), 10469.
Escitalopram Attenuates Fear Stress-Induced Increase in Amygdalar Dopamine Following Methamphetamine-induced Sensitisation: Implications of Fine-Tuning Action of Selective Serotonin Reuptake Inhibitors on Emotional Processing.
Muraoka, H., Oshibuchi, H., Kawano, M., Kawano, T., Tsutsumi, T., Yamada, M., … & Inada, K.
(2018) European Journal of Pharmacology.
Female Japanese quail visually differentiate testosterone-dependent male attractiveness for mating preferences.
Hiyama, G., Mizushima, S., Matsuzaki, M., Tobari, Y., Choi, J. H., Ono, T., … & Sugita, S.
(2018) Scientific Reports, 8(1), 10012.
A voxel-based analysis of neurobiological mechanisms in placebo analgesia in rats.
Zeng, Y., Hu, D., Yang, W., Hayashinaka, E., Wada, Y., Watanabe, Y., … & Cui, Y.
(2018) NeuroImage.
Rapid Intracellular Zn 2+ Dysregulation via Membrane Corticosteroid Receptor Activation Affects In Vivo CA1 LTP.
Suzuki, M., Sato, Y., Tamura, K., Tamano, H., & Takeda, A.
(2018) Molecular Neurobiology, 1-10.
Diazepam suppresses the stress-induced dopaminergic release in the amygdala of methamphetamine-sensitized rat.
Kawano, T., Oshibuchi, H., Kawano, M., Muraoka, H., Tsutsumi, T., Yamada, M., … & Inada, K.
(2018) European Journal of Pharmacology.
Involvement of NMDA receptors, nitric oxide and GABA in rostral ventrolateral medulla in acute ethanol‐induced cardiovascular responses in rats.
Lo, H., Lin, H. H., Chen, J. K., Situmorang, J. H., & Lai, C. C.
(2018) Alcoholism: Clinical and Experimental Research.
A single episode of binge alcohol drinking causes sleep disturbance, disrupts sleep homeostasis and downregulates equilibrative nucleoside transporter 1.
Sharma, R., Sahota, P., & Thakkar, M. M.
(2018) Journal of Neurochemistry.
Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer’s disease models.
Higaki, S., Muramatsu, M., Matsuda, A., Matsumoto, K., Satoh, J. I., Michikawa, M., & Niida, S.
(2018) PLOS ONE, 13(5), e0196929.
Extracellular Zn 2+ Influx into Nigral Dopaminergic Neurons Plays a Key Role for Pathogenesis of 6-Hydroxydopamine-Induced Parkinson’s Disease in Rats.
Tamano, H., Nishio, R., Morioka, H., & Takeda, A.
(2018) Molecular neurobiology, 1-9.
Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo
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(2018) International journal of nanomedicine, 13, 2265.
Fear memory consolidation in sleep requires protein kinase A.
Cho, J., Sypniewski, K. A., Arai, S., Yamada, K., Ogawa, S., & Pavlides, C.
(2018) Learning & Memory, 25(5), 241-246.
Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity.
Kehr, J., Yoshitake, T., Ichinose, F., Yoshitake, S., Kiss, B., Gyertyán, I., & Adham, N.
(2018) Psychopharmacology, 1-15.
Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity.
Hayashida, K. I., Kimuram, M., & Eisenach, J. C.
(2018) Neuroscience Letters.
Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Igarashi, H., Ikeda, K., Onimaru, H., Kaneko, R., Koizumi, K., Beppu, K., … & Kobayashi, K.
(2018) Scientific Reports, 8(1), 5435.
Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with b-amyloid in rats.
Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences, 30, 1e6.
Age-related and function-dependent regional alterations of free L-and D-aspartate in postembryonic chick brain.
Zachar, G., Jakó, T., Vincze, I., Wagner, Z., Tábi, T., Bálint, E., … & Csillag, A.
(2018) Acta Biologica Hungarica, 69(1), 1-15.
Functional mechanism of ASP5736, a selective serotonin 5-HT 5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia.
Yamazaki, M., Yamamoto, N., Yarimizu, J., Okabe, M., Moriyama, A., Furutani, M., … & Harada, K.
(2018) European Neuropsychopharmacology.
Insular cortex inactivation generalizes fear-induced underestimation of interval timing in a temporal bisection task.
Kamada, T., & Hata, T.
(2018) Behavioural Brain Research.
Effects of mild perinatal hypothyroidism on cognitive function of adult male offspring.
Amano, I., Takatsuru, Y., Khairinisa, M. A., Kokubo, M., Haijima, A., & Koibuchi, N.
(2018) Endocrinology.
Effects of pregabalin and duloxetine on neurotransmitters in the dorsal horn of the spinal cord in a rat model of fibromyalgia.
Kiso, T., Moriyama, A., Furutani, M., Matsuda, R., & Funatsu, Y.
(2018) European Journal of Pharmacology.
Mass Spectrometric Analysis of Neurologically-Relevant Molecules.
Smith, C. L.
(2018) Doctoral dissertation, The University of Arizona.
Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition.
Wang, X., Ma, S., Wu, H., Shen, X., Xu, S., Guo, X., … & Wang, F.
(2018) Experimental & Molecular Medicine, 50(2), e445.
Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with β-amyloid in rats.
Egashira, N., Akiyoshi, Y., Iba, H., Arai, T., Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences.
Effects of Memantine on Nitric Oxide Production and Hydroxyl Radical Metabolism during Cerebral Ischemia and Reperfusion in Mice.
Tanaka, A., Ito, Y., Kawasaki, H., Kitabayashi, C., Nishioka, R., Yamazato, M., … & Yamamoto, T.
(2018) Journal of Stroke and Cerebrovascular Diseases.
Determination of the Target Temperature Required to Block Increases in Extracellular Glutamate Levels During Intraischemic Hypothermia.
Sato, S., Takeda, Y., Mizoue, R., Kawase, H., Fushimi, M., Shimizu, T., & Morimatsu, H.
(2018) Therapeutic Hypothermia and Temperature Management.
[EXPRESS] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer.
Watanabe, M., Narita, M., Hamada, Y., Yamashita, A., Tamura, H., Ikegami, D., … & Muto, A.
(2018) Molecular Pain, 1744806918756406.
Ketamine-induced prefrontal serotonin release is mediated by cholinergic neurons in the pedunculopontine tegmental nucleus.
Kinoshita, H., Nishitani, N., Nagai, Y., Andoh, C., Asaoka, N., Kawai, H., … & Kaneko, S.
(2018) International Journal of Neuropsychopharmacology.
Delayed administration of BQ788, an ETB antagonist, after experimental traumatic brain injury promotes recovery of blood–brain barrier function and reduction of cerebral edema in mice.
Michinaga, S., Kimura, A., Hatanaka, S., Minami, S., Asano, A., Ikushima, Y., … & Koyama, Y.
(2018) Journal of Neurotrauma, (ja)
[EXPRESS] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: analysis using a microdialysis/mass spectrometry integrated system.
Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., … & Narita, M.
(2018) Molecular Pain, 1744806918754934.
2017
“CNS hormonal and nutritional regulation of glucose and energy homeostasis.”
Abraham, M.
(2017) Doctoral dissertation
PKCδ-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity.
Dang, D. K., Shin, E. J., Kim, D. J., Tran, H. Q., Jeong, J. H., Jang, C. G., … & Kim, H. C.
(2017) Free Radical Biology and Medicine.
The Japanese Angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia.
Nogami-Hara, A., Nagao, M., Takasaki, K., Egashira, N., Fujikawa, R., Kubota, K., … & Iwasaki, K.
(2017) Journal of Ethnopharmacology.
δ-Subunit Containing GABA A Receptors Modulate Respiratory Networks.
Montandon, G., Wu, H., Liu, H., Vu, M. T., Orser, B. A., & Horner, R. L.
(2017) Scientific Reports, 7(1), 18105.
Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice.
Park, S. H., Eber, M. R., Tsuzuki, S., Booker, M. E., Sunil, A. G., Widner, D. B., … & Shiozawa, Y.
(2017) Scientific reports, 7(1), 17428.
Region‐specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice.
Sugimoto, J., Tanaka, M., Sugiyama, K., Ito, Y., Aizawa, H., Soma, M., … & Tanaka, K.
(2017) Glia.
Post-reexposure administration of riluzole attenuates the reconsolidation of conditioned fear memory in rats.
Akagi, K., Yamada, M., Saitoh, A., Oka, J. I., & Yamada, M
(2017) Neuropharmacology.
Hydroxyl radical production via NADPH oxidase in rat striatum due to carbon monoxide poisoning.
Hara, S., Kobayashi, M., Kuriiwa, F., Ikematsu, K., & Mizukami, H.
(2017) Toxicology.
Overexpression of transmembrane protein 168 in the mouse nucleus accumbens induces anxiety and sensorimotor gating deficit.
Fu, K., Miyamoto, Y., Sumi, K., Saika, E., Muramatsu, S. I., Uno, K., & Nitta, A.
(2017) PLoS One, 12(12), e0189006.
“METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS.”
Davidson, Beverly L., Bradley T. Hyman, and Eloise Hudry.
(2017) Patent 20,170,336,395, issued November 23, 2017.
Smaller effect of propofol than sevoflurane anesthesia on dopamine turnover induced by methamphetamine and nomifensine in the rat striatum: an in vivo microdialysis study.
TAHARABARU, S., SATOMOTO, M., TAMURA, T., & ADACHI, Y. U.
(2017) Experimental Animals, 17-0092.
Histamine N-methyltransferase regulates aggression and the sleep-wake cycle.
Kárpáti, A., Mogi, A., Yanai, A., Naganuma, F., Yanai, K., Okamura, N., … & Iida, T.
(2017) Scientific Reports, 7(1), 1.
β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system.
Ohara, K., Fukuda, T., Ishida, Y., Takahashi, C., Ohya, R., Katayama, M., … & Nagai, K.
(2017) Scientific Reports, 7(1), 15785.
Syntaxin1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.
Fujiwara, T., Kofuji, T., Mishima, T., & Akagawa, K.
(2017) European Journal of Neuroscience.
Moderate intensity, exercise-induced catecholamine release in the preoptic area and anterior hypothalamus in rats is enhanced in a warm environment.
Zheng, X., Takatsu, S., Ishikawa, R., & Hasegawa, H.
(2017) Journal of Thermal Biology.
Changes in thermoregulation and monoamine release in freely moving rats during cold exposure and inhibition of the ventromedial, dorsomedial, or posterior hypothalamus.
Ishiwata, T., & Greenwood, B. N.
(2017) Journal of Comparative Physiology B, 1-11.
Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23.
Deyama, S., Shimoda, K., Suzuki, H., Ishikawa, Y., Ishimura, K., Fukuda, H., … & Shuto, S.
(2017) Psychopharmacology, 1-8.
The Role of Cholecystokinin in Peripheral Taste Signaling in Mice.
Yoshida, R., Shin, M., Yasumatsu, K., Takai, S., Inoue, M., Shigemura, N., … & Ninomiya, Y.
(2017) Frontiers in Physiology, 8, 866.
Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior.
Li, Y., Yin, A., Sun, X., Zhang, M., Zhang, J., Wang, P., … & Wang, H.
(2017) The Journal of Clinical Investigation, 127(12)
Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice.
Gölöncsér, F., Baranyi, M., Balázsfi, D., Demeter, K., Haller, J., Freund, T. F., … & Sperlágh, B.
(2017) Frontiers in Molecular Neuroscience, 10, 325.
Involvement of neuronal and glial activities in control of the extracellular d-serine concentrations by the AMPA glutamate receptor in the mouse medial prefrontal cortex.
Ishiwata, S., Umino, A., & Nishikawa, T.
(2017) Neurochemistry International.
Subthalamic Nucleus and Globus Pallidus Interna Influence Firing of Tonically Active Neurons in the Primate Striatum through Different Mechanisms.
Nakajima, A., Shimo, Y., Uka, T., & Hattori, N.
(2017) European Journal of Neuroscience, 10.1111/ejn.13726.
The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain.
Du, J., Fang, J., Wen, C., Shao, X., Liang, Y., & Fang, J.
(2017) Neural Plasticity, 2017.
Stimulation of accumbal GABA A receptors inhibits delta2-, but not delta1-, opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats.
Aono, Y., Kiguchi, Y., Watanabe, Y., Waddington, J. L., & Saigusa, T.
(2017) European Journal of Pharmacology.
Striatal N-acetylaspartate synthetase Shati/Nat8l regulates depression-like behaviors via mGluR3-mediated serotonergic suppression in mice.
Miyamoto, Y., Iegaki, N., Fu, K., Ishikawa, Y., Sumi, K., Azuma, S., … & Nitta, A.
(2017) International Journal of Neuropsychopharmacology.
The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice.
Saitoh, A., Suzuki, S., Soda, A., Ohashi, M., Yamada, M., Oka, J. I., … & Yamada, M.
(2017) Behavioural Brain Research.
Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug.
Yamamoto, S., Ushio, S., Egashira, N., Kawashiri, T., Mitsuyasu, S., Higuchi, H., … & Masuda, S.
(2017) Scientific Reports, 7.
Perfusion with carbon monoxide does not affect extracellular glutamate in dialysates of the hippocampus of freely moving mice.
Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Miki, T., & Kinoshita, H.
(2017) Drug and Chemical Toxicology, 1-3.
Ginsenoside Re Protects Trimethyltin-Induced Neurotoxicity via Activation of IL-6-Mediated Phosphoinositol 3-Kinase/Akt Signaling in Mice.
Tu, T. H. T., Sharma, N., Shin, E. J., Tran, H. Q., Lee, Y. J., Jeong, J. H., … & Ko, S. K.
(2017) Neurochemical Research, 1-15.
Alpha-PVP induces the rewarding effect via activating dopaminergic neuron.
Hataoka, K., Kaizaki-Mitsumoto, A., & Numazawa, S.
(2017) The Journal of Toxicological Sciences, 42(5), 539-543
Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway.
Shimizu, S., Sogabe, S., Yanagisako, R., Inada, A., Yamanaka, M., Iha, H. A., & Ohno, Y.
(2017) International journal of molecular sciences, 18(7), 1416.
Characterization of CRF 1 receptor antagonists with differential peripheral vs central actions in CRF challenge in rats.
Tanaka, M., Tomimatsu, Y., Sakimura, K., Ootani, Y., Sako, Y., Kojima, T., … & Hirai, K
(2017) Peptides.
Evidence for Tonic Control by the GABAA Receptor of Extracellular D-Serine Concentrations in the Medial Prefrontal Cortex of Rodents.
Umino, A., Ishiwata, S., Iwama, H., & Nishikawa, T.
(2017) Frontiers in Molecular Neuroscience, 10, 240
The effect of electroacupuncture on PKMzeta in the ACC in regulating.
Du, J., Fang, J., Wen, C., Shao, X., Liang, Y., & Fang, J.
(2017)
A novel LRP1-binding peptide L57 that crosses the blood brain barrier.
Sakamoto, K., Shinohara, T., Adachi, Y., Asami, T., & Ohtaki, T.
(2017) Biochemistry and Biophysics Reports.
Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice.
Hara, Y., Ago, Y., Taruta, A., Hasebe, S., Kawase, H., Tanabe, W., … & Takuma, K.
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Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the.
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Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation.
Shinozaki, Y., Shibata, K., Yoshida, K., Shigetomi, E., Gachet, C., Ikenaka, K., … & Koizumi, S.
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Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential.
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Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer’s disease rat model.
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A positive feedback loop between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage in human lens epithelial cells.
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In vitro and in vivo physiology of low nanomolar concentrations of Zn2+ in artificial cerebrospinal fluid.
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Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity.
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Blockade of intracellular Zn 2+ signaling in the basolateral amygdala affects object recognition memory via attenuation of dentate gyrus LTP.
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Involvement of lateral habenula α1 subunit-containing GABA A receptor-mediated inhibitory transmission in the regulation of depression-related behaviors in experimental Parkinson’s disease.
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Exploring the mechanism by which accumbal deep brain stimulation attenuates morphine-induced reinstatement through manganese-enhanced MRI and pharmacological intervention.
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Controlling the length of short electrospun polymer nanofibers via the addition of micro-spherical silica particles.
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Correlation between colonic secretion and colonic motility in rats: Role of ghrelin.
Huang, H. H., Ting, C. H., Syu, Y. F., Chang, S. C., & Chen, C. Y.
(2016) World J Gastroenterol, 22(46), 10140-10147.
Betaine attenuates memory impairment after water-immersion restraint stress and is regulated by the GABAergic neuronal system in the hippocampus.
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(2016) European Journal of Pharmacology.
Noradrenaline receptor mechanisms modulate the angiotensin II-induced water intake in the subfornical organ in rats.
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Induction of antinociceptive tolerance to the chronic intrathecal administration of apelin-13 in rat.
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Opposite effects of central oxytocin and arginine vasopressin on changes in gastric motor function induced by chronic stress.
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Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.
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Neuropeptide EI-induced paradoxical sleep in rats.
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Opposite Effects of Central Oxytocin and Arginine Vasopressin on Changes in Gastric Motor Function Induced by Chronic Stress.
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Effect of p22phox depletion on sympathetic regulation of blood pressure in SHRSP: evaluation in a new congenic strain.
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The role of inversely operating glutamate transporter in the paradoxical analgesia produced by glutamate transporter inhibitors.
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The Role of Adenosine in the Maturation of Sleep Homeostasis in Rats.
Gvilia, I., Suntsova, N., Kostin, A., Kalinchuk, A., McGinty, D., Basheer, R., & Szymusiak, R.
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15-deoxy-Δ 12, 14-prostaglandin J 2 induced neurotoxicity via suppressing phosphoinositide 3-kinase.
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Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropin releasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus.
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PKCδ knockout mice are protected from para-methoxymethamphetamine-induced mitochondrial stress and associated neurotoxicity in the striatum of mice.
Shin, E. J., Dang, D. K., Tran, H. Q., Nam, Y., Jeong, J. H., Lee, Y. H., … & Nabeshima, T.
(2016) Neurochemistry International.
Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors.
Montandon, G., Liu, H., & Horner, R. L.
(2016) Scientific Reports, 6, 32707.
Mapping the influence of electrospinning parameters on the morphology transition of short and continuous nanofibers.
Fathona, I. W., & Yabuki, A.
(2016) Fibers and Polymers, 17(8), 1238-1244.
Equilibrative Nucleoside Transporter ENT1 as a Biomarker of Huntington Disease.
Guitart, X., Bonaventura, J., Rea, W., Orrú, M., Cellai, L., Dettori, I., … & Chang, C. P.
(2016) Neurobiology of Disease.
Suppressed GABAergic signaling in the zona incerta causes neuropathic pain in a thoracic hemisection spinal cord injury rat model.
Moon, H. C., Lee, Y. J., Cho, C. B., & Park, Y. S.
(2016) Neuroscience Letters.
Sex differences in abuse-related neurochemical and behavioral effects of 3, 4-methylenedioxymethamphetamine (MDMA) in rats.
Lazenka, M. F., Suyama, J. A., Bauer, C. T., Banks, M. L., & Negus, S. S.
(2016) Pharmacology Biochemistry and Behavior.
Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters.
Solis Jr, E., Suyama, J. A., Lazenka, M. F., DeFelice, L. J., Negus, S. S., Blough, B. E., & Banks, M. L.
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Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion.
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Wake-promoting effects of ONO-4127Na, a prostaglandin DP1 receptor antagonist, in hypocretin/orexin deficient narcoleptic mice.
Sagawa, Y., Sato, M., Sakai, N., Chikahisa, S., Chiba, S., Maruyama, T., … & Nishino, S.
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Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats.
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GABAergic Modulation of Serotonin Release in the Rat Subfornical Organ Area.
Takahashi, M., Nomura, M., & Tanaka, J.
(2016) Neuroscience Letters.
Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia.
Tamano, H., Ide, K., Adlard, P. A., Bush, A. I., & Takeda, A.
(2016) The Journal of Toxicological Sciences, 41(4), 449-457.
In vivo neurochemical evidence that delta1-, delta2-and mu2-opioid receptors, but not mu1-opioid receptors, inhibit acetylcholine efflux in the nucleus accumbens of freely moving rats.
Kiguchi, Y., Aono, Y., Watanabe, Y., Yamamoto, S., Shimizu, K., Shimizu, T., … & Saigusa, T.
(2016) European Journal of Pharmacology.
Neurochemical Substrates of Asymmetrical Sleep in the Fur Seal.
Lapierre, J. L.
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The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain.
Kim, D. Y., Chae, J. W., Lim, C. H., Heo, B. H., Park, K. S., Lee, H. G., … & Kim, W. M.
(2016) The Korean Journal of Pain, 29(3), 164-171.
Involvement of GABAA.
Ago, Y., Hasebe, S., Hiramatsu, N., Mori, K., Watabe, Y., Onaka, Y., … & Matsuda, T.
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Pain relief induces dopamine release in the rat nucleus accumbens during the early but not late phase of neuropathic pain.
Kato, T., Ide, S., & Minami, M.
(2016) Neuroscience Letters.
Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion.
Umezu, T., & Shibata, Y.
(2016) Toxicology Reports.
Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission.
Tokudome, K., Okumura, T., Shimizu, S., Mashimo, T., Takizawa, A., Serikawa, T., … & Ohno, Y.
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Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine.
Ip, J. Y., Sone, M., Nashiki, C., Pan, Q., Kitaichi, K., Yanaka, K., … & Nakagawa, S.
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Effects of propofol on the dopamine, metabolites and GABAA receptors in media prefrontal cortex in freely moving rats.
Wang, Y., Yu, T., Yuan, C., Yuan, J., Luo, Z., Pan, Y., … & Yu, B.
(2016) Am J Transl Res, 8(5), 2301-2308.
Motor Training Promotes Both Synaptic and Intrinsic Plasticity of Layer II/III Pyramidal Neurons in the Primary Motor Cortex.
Kida, H., Tsuda, Y., Ito, N., Yamamoto, Y., Owada, Y., Kamiya, Y., & Mitsushima, D.
(2016) Cerebral Cortex, bhw134.
Novel psychoactive benzofurans strongly increase extracellular serotonin level in mouse corpus striatum.
Fuwa, T., Suzuki, J., Tanaka, T., Inomata, A., Honda, Y., & Kodama, T.
(2016) The Journal of Toxicological Sciences, 41(3), 329-337.
“Acute and Chronic Effects of Inhalants in Intracranial Self-stimulation.”
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GABA B receptors in the hippocampal dentate gyrus are involved in spatial learning and memory impairment in a rat model of vascular dementia.
Li, G., Lv, J., Wang, J., Wan, P., Li, Y., Jiang, H., & Jin, Q.
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Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptors.
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Mirtazapine exerts an anxiolytic-like effect through activation of the median raphe nucleus-dorsal hippocampal 5-HT pathway in contextual fear conditioning in rats.
An, Y., Chen, C., Inoue, T., Nakagawa, S., Kitaichi, Y., Wang, C., … & Kusumi, I.
(2016) Progress in Neuro-Psychopharmacology and Biological Psychiatry.
Serotonin release in the subfornical organ area induced by sodium and water intake in the rat.
Takahashi, M., & Tanaka, J.
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Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.
Kim, S. K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., … & Bae, H.
(2016) The Journal of Clinical Investigation, 126(5).
Dopamine dynamics during emotional cognitive processing: implications of the specific actions of clozapine compared with haloperidol.
Kawano, M., Oshibuchi, H., Kawano, T., Muraoka, H., Tsutsumi, T., Yamada, M., … & Ishigooka, J.
(2016) European Journal of Pharmacology
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.
Kim, S. K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., … & Bae, H.
(2016) The Journal of Clinical Investigation, 126(5).
A Clock mutation enhances light-phase responsiveness to cocaine in locomotor activity and self-administration with impulsive-like responding in mice.
Meng, H., Murakami, G., Suenaga, T., Edamura, M., Doi, M., Ishida, Y., … & Nakahara, D.
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Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT.
Mori, T., Uzawa, N., Iwase, Y., Masukawa, D., Rahmadi, M., Hirayama, S., … & Suzuki, T.
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Unusual social behavior in HPC‐1/syntaxin1A knockout mice is caused by disruption of the oxytocinergic neural system.
Fujiwara, T., Sanada, M., Kofuji, T., & Akagawa, K.
(2016) Journal of Neurochemistry.
Involvement of hippocampal NMDA receptors in retrieval of spontaneous object recognition memory in rats
Iwamura, E., Yamada, K., & Ichitani, Y.
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Brain Site-and Transmitter-dependent Actions of Methamphetamine, Morphine and Antipsychotics.
Mori, T., Iwase, Y., Murata, A., Iwata, N., & Suzuki, T
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5‐HT (1A) receptor antagonist improves behavior performance of delirium rats through inhibiting PI3K/Akt/mTOR activation‐induced NLRP3 activity.
Qiu, Y., Huang, X., Huang, L., Tang, L., Jiang, J., Chen, L., & Li, S.
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Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats.
Hazama, Y., Maekawa, T., Miki, R., Oshima, S., Egawa, Y., Morimoto, K., & Seki, T
(2016) Biological and Pharmaceutical Bulletin, 39(3), 343-352.
Non-invasive determination of glucose directly in raw fruits using a continuous flow system based on microdialysis sampling and amperometric detection at an integrated enzymatic biosensor.
Vargas, E., Ruiz, M. A., Campuzano, S., Reviejo, A. J., & Pingarrón, J. M
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Involvement of spinal glutamate in nociceptive behavior induced by intrathecal administration of hemokinin-1 in mice.
Watanabe, C., Mizoguchi, H., Bagetta, G., & Sakurada, S.
(2016) Neuroscience Letters.
Neuropeptide Y signaling in the dorsal raphe nucleus inhibits male sexual behavior in mice.
Inaba, A., Komori, Y., Muroi, Y., Kinoshita, K. I., & Ishii, T.
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Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and gaba neurons.
Ardianto, C., Yonemochi, N., Yamamoto, S., Yang, L., Takenoya, F., Shioda, S., … & Kamei, J.
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Opposing Roles of Cholinergic and GABAergic Activity in the Insular Cortex and Nucleus Basalis Magnocellularis during Novel Recognition and Familiar Taste Memory Retrieval.
Rodríguez-García, G., & Miranda, M. I.
(2016) The Journal of Neuroscience, 36(6), 1879-1889.
The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat.
Shahbazi-Gahrouei, D., Shiri, L., Alaei, H., & Naghdi, N.
(2016) Journal of Radiation Research, rrv093.
Differencial Activation of the Dopaminergic Systems in Rat Brain Basal Ganglia by Morphine and Methamphetamine.
Mori, T., Iwase, Y., Saeki, T., Iwata, N., Murata, A., Masukawa, D., & Suzuki, T.
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Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK.
Dang, D. K., Shin, E. J., Nam, Y., Ryoo, S., Jeong, J. H., Jang, C. G., … & Kim, H. C.
(2016) Journal of Neuroinflammation, 13(1), 12.
Causal Link between the Cortico-Rubral Pathway and Functional Recovery through Forced Impaired Limb Use in Rats with Stroke.
Ishida, A., Isa, K., Umeda, T., Kobayashi, K., Kobayashi, K., Hida, H., & Isa, T.
(2016) The Journal of Neuroscience, 36(2), 455-467.
Contributions of ADP and ATP to the increase in skeletal muscle blood flow after manual acupuncture stimulation in rats.
Nagaoka, S., Shinbara, H., Okubo, M., Kawakita, T., Hino, K., & Sumiya, E.
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Elucidation of the central role of long-chain fatty acids in the palatability of dietary fat by neuroscientific and animal behavioral studies.
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“METHODS AND COMPOSITIONS USING 4-AMINO-2-(2, 6-DIOXO-PIPERIDINE-3-YL)-ISOINDOLINE-1, 3-DIONE FOR TREATMENT OF CANCERS.”
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Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats.
Kawaura, K., Ogata, Y., Honda, S., Soeda, F., Shirasaki, T., & Takahama, K.
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Ethanol and Acetaldehyde Differentially Alter Extracellular Dopamine and Serotonin in Aldh2-Knockout Mouse Dorsal Striatum: A Reverse Microdialysis Study.
Jamal, M., Ameno, K., Miki, T., Tanaka, N., Ito, A., Ono, J., … & Kinoshita, H.
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Preventive Effect of 3, 5-dihydroxy-4-methoxybenzyl Alcohol (DHMBA) and Zinc, Components of the Pacific Oyster Crassostrea gigas, on Glutamatergic Neuron Activity in the Hippocampus.
Tamano, H., Shakushi, Y., Watanabe, M., Ohashi, K., Uematsu, C., Otsubo, T., … & Takeda, A.
(2015) The Biological Bulletin, 229(3), 282-288.
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
Bonaventure, P., Shelton, J., Yun, S., Nepomuceno, D., Sutton, S., Aluisio, L., … & Dugovic, C.
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Improvement of Cold Injury‐Induced Mouse Brain Edema by Endothelin ETB Antagonists is Accompanied with Decreases in Matrixmetalloproteinase 9 and Vascular Endothelial Growth Factor‐A.
Michinaga, S., Seno, N., Fuka, M., Yamamoto, Y., Minami, S., Kimura, A., … & Koyama, Y.
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Oxidative stress and lipid peroxidation are upstream of amyloid pathology.
Arimon, M., Takeda, S., Post, K. L., Svirsky, S., Hyman, B. T., & Berezovska, O.
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Chewing, Stress-Related Diseases, and Brain Function.
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Changes in free amino acid and monoamine concentrations in the chick brain associated with feeding behavior.
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Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex.
Ueda, S., Niwa, M., Hioki, H., Sohn, J., Kaneko, T., Sawa, A., & Sakurai, T.
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Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain.
Navratilova, E., Xie, J. Y., Meske, D., Qu, C., Morimura, K., Okun, A., … & Porreca, F.
(2015) The Journal of Neuroscience,, 35(18), 7264-7271.
DSP‐1053, a novel serotonin reuptake inhibitor with 5‐HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats.
Kato, T., Matsumoto, Y., Yamamoto, M., Matsumoto, K., Baba, S., Nakamichi, K., … & Yabuuchi, K.
(2015) Pharmacology Research & Perspectives, 3(3).
2014
Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy.
Xie, J. Y., Qu, C., Patwardhan, A., Ossipov, M. H., Navratilova, E., Becerra, L., … & Porreca, F.
(2014) PAIN®, 155(8), 1659-1666.
A Food and Administration- approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer’s disease.
Hori Y, Takeda S, Cho H, Wegmann S, Shoup T, Takahashi K, Irima D, Elmaleh D, Hyman B, Hudry E.
(2014) J Biol Chem; 23 1966-78
2013
Validation of an efficient LC-microdialysis method for gemifloxacin quantitation in lung, kidney and liver of rats.
Furness, A. M., Thomas, S., & Lunte, C. E. 10 de Araújo BV, Laureano JV, Grünspan LD, Dalla Costa T, Tasso L.
(3). J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 919–920 (0), 62–66 (2013).
Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis.
Yang, H., Thompson, A. B., McIntosh, B. J., Altieri, S. C., & Andrews, A. M.
(2013). ACS chemical neuroscience, 4(5), 790-798.
Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic γ-aminobutyric acid mechanisms.
Kimura M, Hayashida K, Eisenach J, Saito S, Obata H.
(2013) Anesthesiology 118;173-80
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry.
Navarailova E, Xie J, Okun A, Qu C, Eyde N, Ci S, Ossipov M, King T, Fields H, Porreca F.
(2013) PNAS 109; 50 2079-20713
2012
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve insury.
Hayashida K, Kimura M, Yoshizumi M, Hobo S, Obata H, J Eisenach.
(2012) Anesthesiology 117; 389-98
Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Yoshizumi M, Parker R, Esenach J, Hayashida K.
(2012) Anesthesiology 116; 1347-53
2011
Novel microdialysis method to assess meuropeptides and large molecules in free-moiving mouse.
Takeda S, Sato N, Ikimura K, Nishino H, Rkugi H, Morishita R.
(2011) Neuroscience; 186 110-119
2009
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
(2009) Brain Research 1260; 30-37
Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.
Yano K, Koda K, Ago Y, Kobayashi H, Kawasaki T, Takuma K, Matsuda T
(2009) British Journal of Pharmacology 156(1):173-180.
2008
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects.
Mitsushima D, Takase K, Funabashi T, Kimura F
(2008) Endocrinology;149(2):802-811. Epub 2007 Oct 25
Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats.
Deyama S, Katayama T, Ohno A, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M
(2008) Journal of Neuroscience; 28(31):7728-7736
Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure.
Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H.
(2008) Toxicology and applied pharmacology Jan 15;226(2):192-198
2007
Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats.
Takase K, Mitsushima D, Funabashi T, Kimura F.
(2007) Brain Research 1154:105-115. Epub 2007 Apr 5
Maternal attenuation of hypothalamic paraventricular nucleus norepinephrine switches avoidance learning to preference learning in preweanling rat pups.
Shionoya K, Moriceau S, Bradstock P, Sullivan RM.
(2007) Hormones and Behavior 52(3):391-400. Epub 2007 Jun 29
2006
Ascorbic acid concentration in rabbit vitreous measured by microdialysis with HPLC-electrochemical detection before and after vitreous surgery.
Koide K, Zhang XM, Ohishi K, Usami Y, Hotta Y, Hiramitsu T
(2006) Experimental Eye Research 82(5):868-873
Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Dong HL, Fukuda S, Murata E, Zhu Z, Higuchi T
(2006) Anesthesiology 104(5):1023-1032
Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats.
Sasaki M, Obata H, Kawahara K, Saito S, Goto F
(2006) Pain 122(1-2):130-136
Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.
Dong HL, Fukuda S, Murata E, Higuchi T
(2006) Anesthesiology 104(1):122-133
Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions.
De Leonibus E, Verheij MM, Mele A, Cools A
(2006) European Journal of Neuroscience 23(5):1332-1340
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T
(2006) Journal of Neuroscience 26(2):398-405
Epinephrine increases the extracellular lidocaine concentration in the brain: a possible mechanism for increased central nervous system toxicity.
Takahashi R, Oda Y, Tanaka K, Morishima HO, Inoue K, Asada A.
(2006) Anesthesiology 105(5):984-989
Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats.
Mitsushima D, Yamada K, Takase K, Funabashi T, Kimura F.
(2006) European Journal of Neuroscience 24(11):3245-3254
2005
Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex.Ago Y, Nakamura S, Baba A, Matsuda T
(2005) Neuropsychopharmacology 30: 43-51
Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats.
Jamal M, Ameno K, Wang W, Kumihashi M, Ameno S, Ikuo U, Shinji A, Ijiri I
(2005) Brain Research 1039(1-2):90-96
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F
(2005) Neuroscience 136: 593-599
Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats.
Masuda J, Mitsushima D, Funabashi T, Kimura F
(2005) Neuroscience 132: 537-542
Striatal dopamine level increases in the urinary storage phase in cats: an in vivo microdialysis study.
Yamamoto T, Sakakibara R, Hashimoto K, Nakazawa K, Uchiyama T, Liu Z, Ito T, Hattori T.
(2005) Neuroscience 135: 299-303
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.
Fusa K, Takahashi I, Watanabe S, Aono Y, Ikeda H, Saigusa T, Nagase H, Suzuki T, Koshikawa N, Cools AR
(2005) Neuroscience 130(3):745-755
Contribution of vesicular and cytosolic dopamine to the increased striatal dopamine efflux elicited by intrastriatal injection of dexamphetamine.
Watanabe S, Aono Y, Fusa K, Takada K, Saigusa T, Koshikawa N, Cools AR
(2005) Neuroscience 136(1):251-257
Effects of alpha-methyl-p-tyrosine on extracellular dopamine levels in the nucleus accumbens and the dorsal striatum of freely moving rats.
Watanabe S, Fusa K, Takada K, Aono Y, Saigusa T, Koshikawa N, Cools AR
(2005) Journal of Oral Science 47(4):185-190
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Narita M, Kishimoto Y, Ise Y, Yajima Y, Misawa K, Suzuki T
(2005) Neuropsychopharmacology 30(1):111-118
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M.
(2005) British Journal of Pharmacology 145(8):1035-1044
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F.
(2005) Neuroscience 136(2):593-9. Epub 2005 Oct 13
2004
Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats.
Yamato T, Misumi Y, Yamasaki S, Kino M, Aomine M
(2004) Diabetes, Nutrition & Metabolism 17: 128-136
Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.| Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, He J, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC, Nabeshima T
(2004) Journal of Neuroscience 24: 2212-2225
The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.
Nagai T, Yamada K, Yoshimura M, Ishikawa K, Miyamoto Y, Hashimoto K, Noda Y, Nitta A, Nabeshima T
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 3650-3655
Brain microdialysis study of the effects of hazardous chemicals on the central nervous system 2. Toluene exposure and cerebral acetylcholine.
Honma T, Suda M
(2004) Industrial Health 42(3):336-347
Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study.
Kino M, Yamato T, Aomine M
(2004) Neurochemistry International 44: 65-73
Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.
Okamura N, Hashimoto K, Shimizu E, Kumakiri C, Komatsu N, Iyo M
(2004) Neuropsychopharmacology 29: 544-550
Hypericum perforatum L (St John’s wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.
Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Muller WE, Ogren SO, Kehr J
(2004) British Journal of Pharmacology 142: 414-418
Determination of serotonin, noradrenaline, dopamine and their metabolites in rat brain extracts and microdialysis samples by column liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine.
Yoshitake T, Kehr J, Yoshitake S, Fujino K, Nohta H, Yamaguchi M
(2004) Journal of Chromatography B 807: 177-183
Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine.
Shioda K, Nisijima K, Yoshino T, Kato S
(2004) Progress in Neuro-Psychopharmacology & Biological Psychiatry 28: 633-640
Sexual dimorphism of GABA release in the medial preoptic area and luteinizing hormone release in gonadectomized estrogen-primed rats.
Tin-Tin-Win-Shwe, Mitsushima D, Shinohara K, Kimura F
(2004) Neuroscience 127(1):243-250
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Shen, H. W., Hagino, Y., Kobayashi, H., Shinohara-Tanaka, K., Ikeda, K., Yamamoto, H., … & Uhl, G. R.
(2004). Neuropsychopharmacology, 29(10), 1790-1799.
2003
Activation of cholinergic and adrenergic receptors increases the concentration of extracellular adenosine in the cerebral cortex of unanesthetized rat.
Bennett HJ, White TD, Semba K
(2003) Neuroscience 117: 119-127
Effects of repetitive transcranial magnetic stimulation on behavioral and neurochemical changes in rats during an elevated plus-maze test.
Kanno M, Matsumoto M, Togashi H, Yoshioka M, Mano Y
(2003) Journal of Neurological Sciences 211: 5-14
Implication of Rho-associated kinase in the elevation of extracellular dopamine levels and its related behaviors induced by methamphetamine in rats.
Narita M, Takagi M, Aoki K, Kuzumaki N, Suzuki T
(2003) Journal of Neurochemistry 86: 273-282
Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats.
John J, Wu MF, Kodama T, Siegel JM
(2003) The Journal of Physiology 548(Pt 2): 557-562
Increase of hippocampal acetylcholine release at the onset of dark phase is suppressed in a mutant mice model of evening-type individuals.
Sei H, Sano A, Oishi K, Fujihara H, Kobayashi H, Ishida N, Morita Y
(2003) Neuroscience 117: 785-789
In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis.
Jamal M, Ameno K, Kubota T, Ameno S, Zhang X, Kumihashi M, Ijiri I
(2003) Alcohol & Alcoholism 38: 197-201
Detection of 3-methoxy-4-hydroxyphenylglycol in rabbit skeletal muscle microdialysate
Tokunaga N, Yamazaki T, Akiyama T, Mori H
(2003) Journal of Chromatography B 798: 163-166
Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouse.
Nakahara D, Nakamura M, Iigo M, Okamura H
(2003) Proceedings of the National Academy of Sciences USA (PNAS) 100: 9584-9589
Simultaneous determination of norepinephrine, serotonin, and 5-hydroxyindole-3-acetic acid in microdialysis samples from rat brain by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine.
Yoshitake T, Fujino K, Kehr J, Ishida J, Nohta H, Yamaguchi M
(2003) Analytical Biochemistry 312: 125-33
Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.
Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M
(2003) Psychopharmacology (Berl) 170: 80-88
Sex differences in the stress-induced release of acetylcholine in the hippocampus and corticosterone from the adrenal cortex in rats.
Mitsushima D, Masuda J, Kimura F.
(2003) Neuroendocrinology 78(4):234-240
Sexual dimorphism in the GABAergic control of gonadotropin release in intact rats.
Mitsushima D, Tin-Tin-Win-Shwe, Kimura F
(2003) Neuroscience Research 46(4):399-405
Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release.
Mitsushima D, Funabashi T, Shinohara K, Kimura F
(2003) Psychoneuroendocrinology 28(4):574-583
2002
Expression of angiotensin II type 1 (AT1) receptor in the rostral ventrolateral medulla in rats.
Hu, L., Zhu, D. N., Yu, Z., Wang, J. Q., Sun, Z. J., & Yao, T.
(2002) Journal of Applied Physiology, 92(5), 2153-2161.
Suppression of the morphine-induced rewarding effect in the rat with neuropathic pain: implication of the reduction in mu-opioid receptor functions in the ventral tegmental area.
Ozaki S, Narita M, Narita M, Iino M, Sugita J, Matsumura Y, Suzuki T
(2002) Journal of Neurochemistry 82: 1192-1198
Effects of brief ischaemia on myocardial acetylcholine and noradrenaline levels in anaesthetized cats.
Kawada T, Yamazaki T, Akiyama T, Mori H, Inagaki M, Shishido T, Takaki H, Sugimachi M, Sunagawa K
(2002) Autonomic Neuroscience 95: 37-42
Effects of moderate hypothermia on in situ cardiac sympathetic nerve endings.
Kitagawa H, Akiyama T, Yamazaki T
(2002) Neurochemistry International 40: 235-242
Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors
Fujino K, Yoshitake T, Inoue O, Ibii N, Kehr J, Ishida J, Nohta H, Yamaguchi M
(2002) Neuroscience Letters 320: 91-95
Role of endothelin ET(B) receptors in the renal hemodynamic and excretory responses to big endothelin-1.
Konishi F, Okada Y, Takaoka M, Gariepy CE, Yanagisawa M, Matsumura Y
(2002) European Journal of Pharmacology 451: 177-184
Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359
Relationship between oxidation of glutathione and reactive nitrogen species during the early-reperfusion phase of cerebral ischemia.
Iijima T, Sakamoto H, Okada C, Iwao Y
(2002) Neurochemical Research 27: 497-500
Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems.
Matsuda Y, Hirano H, Watanabe Y
(2002) Brain Research 937: 58-65
Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359
GABA release in the medial preoptic area of cyclic female rats.|
Mitsushima D, Shwe TT, Funabashi T, Shinohara K, Kimura F
(2002) Neuroscience 113: 109-114
Profiles of in vivo gamma-aminobutyric acid release in the medial preoptic area of intact and castrated male rats.
Tin-Tin-Win-Shwe, Mitsushima D, Kimura F
(2002) Neuroendocrinology 76(5):290-296
2001
â-Phenylethlamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D2 receptor mechanism
Kato M, Ishida K, Chuma T, Abe K, Shigenaga T, Taguchi K, Miyake T
(2001) European Journal of Pharmacology 418: 65-71
Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca2+ – and K+ -evoked serotonin release
Kawata Y, Okada M, Murakami T, Kamata A, Zhu G, Kaneko S
(2001) British Jourmal of Pharmacology 133: 557-567
Determination of serotonin in microdialysis samples from rat brain by microbore column liquid chromatography with post-column derivatization and fluorescence detection
Yoshitake T, Iizuka R, Kehr J, Nohta H, Ishida J, Yamaguchi M
(2001) Journal of Neuroscience Methods 109: 91-96
Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine.
Hatip-Al-Khatib I, Mishima K, Iwasaki K, Fujiwara M
(2001) Brain Research 902: 108-118
Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study.
Hatip-Al-khati I, Bolukbasi F, Mishima K, Egashira N, Iwasaki K, Fujiwara M
(2001) Japanese Journal of Pharmacology 87: 277-287
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neuroscience Letters 306: 206-208
Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.
Yoshida Y, Fujiki N, Nakajima T, Ripley B, Matsumura H, Yoneda H, Mignot E, Nishino S
(2001) European Journal of Neuroscience 14: 1075-1081
Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.
Kishi T, Hirooka Y, Sakai K, Shigematsu H, Shimokawa H, Takeshita A
(2001) Hypertension 38: 896-901
Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo.
Matsuo I, Hirooka Y, Hironaga K, Eshima K, Shigematsu H, Shihara M, Sakai K, Takeshita A
The American Journal of Physiology – Regulatory, Integrative and (2001) Comparative Physiology 280: R1285-1291
Differential effects of psychological stress on activation of the 5-hydroxytryptamine- and dopamine-containing neurons in the brain of freely moving rats.
Funada M, Hara C.
(2001) Brain Research 901(1-2):247-251
Adenosine Receptor Subtypes Modulate Two Major Functional Pathways for Hippocampal Serotonin Release.
Okada M, Nutt DJ, Murakami T, Zhu G, Kamata A, Kawata Y, Kaneko S
(2001) The Journal of Neuroscience 21: 628-640
Monitering of extracellular dopamine levels in the dorsal striatum and the nucleus accumbens with 5-minute on-line microdialysis in freely movin rats.
Saigusa T, Fusa K, Okutsu H, Koshikawa N
(2001) Journal of Oral Science 43: 129-134
Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum.
Yamato H, Kannari K, Shen H, Suda T, Matsunaga M
(2001)Neuropharmacology and Neurotoxicology 12: 1123-1126
Activationof 5-HT1A but not 5-HT1B receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation.
Kannnari K, Yamato H, Shen H, Tomiyama M, Suda T, Matsunaga M
(2001) Journal of Neurochemistry 76: 1346-1353
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neurosci Letters 306: 206-208
In vivo assessment of acetylcholine-releasing function at cardiac vagal nerve terminals.
Kawada T, Yamazaki T, Akiyama T, Shishido T, Inagaki M, Uemura K, Miyamoto T, Sugimachi M, Takaki H, Sunagawa K
(2001) American Journal of Physiology – Heart and Circulatory Physiology 281: H139-H145
Effects of ketamine on in vivo cardiac sympathetic nerve endings.
Kitagawa H, Yamazaki T, Akiyama T, Mori H, Sunagawa K
(2001) Journal of Cardiovascular Pharmacology 38 (Suppl. 1): S39-S42
Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid.
Ueda Y, Doi T, Tokumaru J, Yokoyama H, Nakajima A, Mitsuyama Y, Ohya-Nishiguchi H, Kamada H, Willmore LJ
(2001) Journal of Neurochemistry 76: 892-900
Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia.
Anzawa N, Kushikata T, Ohkawa H, Yoshida H, Kubota T, Matsuki A
(2001) Canadian Journal of Anaesthesia 48: 462-465
Xenon inhalation increases norepinephrine release from the anterior and posterior hypothalamus in rats.
Yoshida H, Kushikata T, Kubota T, Hirota K, Ishihara H, Matsuki A.
(2001) Canadian Journal of Anesthesia 48:651-655
2000
Nitric oxide formation in the dog sphincter of Oddi from nitric oxide donors as measured with in vivo microdialysis.
Yamamoto I, Fujiwara M, Kuhara N, Kumano K, Yamada T, Yamamoto H, Fujiwara M
(2000) Alimentary Pharmacology & Therapeutics 14: 1095-1101
静脈麻酔薬がラット背側海馬の一酸化窒素産生に与える影響 (The Influence of Intravenous Anethetics on Nitric Oxide Production in the Rat Dorsal Hippocampus).
白石直之、大井久美子
(2000) 日本歯科麻酔学会雑誌 28: 27-35
Reserpine Pretreatment Prevents Increase in Extracellular Striatal Dopamine Following L-DOPA Administration in Rats with Nigrostriatal Denervation.
Kannari K, Tanaka H, Maeda T, Tomiyama M, Suda T, Matsunaga M
(2000) Journal of Neurochemistry 74: 263-269
Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarnic M1 receptor stimulation.
Murakami Y, Ikenoya M, Matsumoto K, Li H, Watanabe H
(2000) Behavioural Brain Research 109: 83-90
Preferable Monosodium Glutamate and Sodium Chloride Solutions do not Affect Diurnal Norepinephrine Release in the Rat Lateral Hypothalamus.
Smriga M, Torii K
(2000) Nutritional Neuroscience 3: 367-372
Presynaptic L-type Ca2+ channels on excessive dopamine release from rat caudate putamen.
Okita M, Watanabe Y, Taya K, Utsumi H, Hayashi T
(2000) Physiology & Behavior 68: 641-649
抹消組織での無麻酔・無拘束マイクロダイアリシス法
倉田知光
(2000) 日薬理誌 116: 181-187
Chronic adriamycin treatment impairs myocardial interstitial neuronal release of norepinephrine and epinephrine.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Sunagawa K
(2000) Journal of Cardiovascular Pharmacology 36 (Suppl. 2): S31-S34
Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Takaki H, Sugimachi M, Sunagawa K
(2000) Journal of Molecular and Cellular Cardiology 32: 405-414
Vasopressin regulation of noradrenaline release within the supraoptic nucleus.
Ludwig M, Onaka T, Yagi K
(2000) Journal of Neuroendocrinology 12: 477-479
The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral hippocampus in rats.
Mishima K, Iwasaki K, Tsukikawa H, Matsumoto Y, Egashira N, Abe K, Egawa T, Fujiwara M.
(2000) Japanese Journal of Pharmacology 84: 163-173
Activation of peripheral NMDA-nitric oxide cascade in formalin test.
Omote K, Kawamata T, Kawamata M, Nakayama Y, Hazama K, Namiki A.
(2000) Anesthesiology 93(1):173-178
1999
Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia.
Ohtani N, Sugano T, Ohta M
(1999) Brain Research 842: 6-14
Effect of selegiline on dopamine concentration in the striatum of a primate.
Kaseda S, Nomoto M, Iwata S
(1999) Brain Research 815: 44-50
セフジトレンピボキシルの脳内移行について
山崎由香子、今井恵子、奈良圭之輔、岩井信市、徳永 晋、小口勝司
(1999) 昭和医学会雑誌 59: 629-634
Serotonin-mediated increases in the extracellular levels of beta-endorphin in the arcuate nucleus and nucleus accumbens: a microdialysis study.
Zangen A, Nakash R, Yadid G
(1999) Journal of Neurochemistry 73: 2569-2574
1998
Enhanced glutamate release during REM sleep in the rostromedial medulla as measured by in vivo microdialysis.
Kodama T, Lai YY, Siegel JM
(1998) Brain Research 780: 178-181
Pharmacokinetics of Topical â-Adrenergic Antagonists in Rabbit Aqueous Humor Evaluated with the Microdialysis Method.
Ohtori R, Sato H, Fukuda S, Ueda T, Koide R, Kanda Y, Kiuchi Y, Oguchi K
(1998) Experimental Eye Research 66: 487-494
Liquid chromatographic determination of myocardial interstitial epinephrine.
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Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats.
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High-performance liquid chromatographic determination of myocardial interstitial dihidroxyphenylglycol.
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1995
Routine high-performance liquid chromatographic determination of myocardial interstitial norepinephrine.
Yamazaki T, Akiyama T, Shindo T
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Changes of hepatic microsomal oxidative drug metabolizing enzymes in chronic renal failure (CRF) rats by partial nephrectomy.
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Effects of repeated cerebral ischemia on extracellular amino acid concentrations measured with intracerebral microdialysis in the gerbil hippocampus.
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Increase in serotonin levels in the dog ileum and blood by cisplatin as measured by microdialysis.
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1991
Pineal microdialysis in freely moving rats.
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1990
Concurrent on-line sampling of melatonin in pineal microdialysates from conscious rat and its analysis by high-performance liquid chromatography with electrochemical detection.
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AtmosLM™ for In Vivo Protein and Peptide Microdialysis
2023
Novel method for collecting hippocampal interstitial fluid extracellular vesicles (EV-ISF) reveals sex-dependent changes in microglial EV proteome in response to Aβ pathology.
Pait, M. C., Kaye, S. D., Su, Y., Kumar, A., Singh, S., Gironda, S. C., … & Macauley, S. L.
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2022
PBPK model for antibody disposition in mouse brain: validation using large-pore microdialysis data.
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Measurement of α-Synuclein Dynamics In Vivo Using Microdialysis with a Novel Homogeneous Immunoassay.
Kim, Y., Geng, L., Lenhart, A. E., Li, J., Dauer, W. T., & Kennedy, R. T.
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IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine.
Deyama, S., Kondo, M., Shimada, S., & Kaneda, K.
(2022). Translational Psychiatry, 12(1), 1-10.
Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid.
Custers, M. L., Nestor, L., De Bundel, D., Van Eeckhaut, A., & Smolders, I.
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A novel chronic dural port platform for continuous collection of cerebrospinal fluid and intrathecal drug delivery in free-moving mice.
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2021
Sexual dimorphism in maternally separated rats: effects of repeated homotypic stress on gastrointestinal motor functions.
Bülbül, M., & Sinen, O.
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Kamikihito, a traditional Japanese Kampo medicine, increases the secretion of oxytocin in rats with acute stress.
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Effect of Size on Brain Disposition of Protein Therapeutics Determined Using Microdialysis.
Shah, D. K.
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Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.a
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(2021). Journal of Alzheimer’s Disease, (Preprint), 1-16.
2020
Assessment of neuroinflammation in the aging hippocampus using large-molecule microdialysis: sex differences and role of purinergic receptors.
Perkins, A. E., Piazza, M. K., Vore, A. S., Deak, M. M., Varlinskaya, E. I., & Deak, T.
(2020). Brain, Behavior, and Immunity.
Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model.
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(2020). Acta Neuropathologica Communications, 8(1), 1-15.
“RARE PHOSPHORYLATED HIGH MOLECULAR WEIGHT (HMW) TAU SPECIES THAT ARE INVOLVED IN NEURONAL UPTAKE AND PROPAGATION AND APPLICATIONS THEREOF.”
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Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning.
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2019
Antibody pharmacokinetics in rat brain determined using microdialysis. Amuza blogpost: PK modeling using AtmosLM data
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In vivo measurement of enhanced agouti-related peptide release in the paraventricular nucleus of the hypothalamus through Gs activation of agouti-related peptide neurons.
Cui, Z., & Smith, A. S.
(2019). Journal of Biological Methods, 6(3), e116.
Frequency-dependent exacerbation of Alzheimer’s disease neuropathophysiology.
Kastanenka, K. V., Calvo-Rodriguez, M., Hou, S. S., Zhou, H., Takeda, S., Arbel-Ornath, M., … & Logan, R.
(2019) Scientific Reports, 9(1), 8964.
Late aging-associated increases in L-DOPA-induced dyskinesia are accompanied by heightened neuroinflammation in the hemi-parkinsonian rat.
Lanza, K., Perkins, A. E., Deak, T., & Bishop, C.
(2019) Neurobiology of Aging.
Differential effects of diet-and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease.
Wakabayashi, T., Yamaguchi, K., Matsui, K., Sano, T., Kubota, T., Hashimoto, T., … & Kadowaki, T.
(2019) Molecular Neurodegeneration, 14(1), 15.
Difference in ability for extracellular Zn2+ influx between human and rat amyloid β1-42 and its significance.
Tamano, H., Suzuki, H., Kobuchi, S., Adlard, P. A., Bush, A. I., & Takeda, A.
(2019) NeuroToxicology.
2018
“Soluble high molecular weight (hmw) tau species and applications thereof.”
Hyman, B., & Takeda, S.
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In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes.
Yamada, K.
(2018). JoVE (Journal of Visualized Experiments), (139), e57869-e57869.
Extracellular α-synuclein levels are regulated by neuronal activity.
Yamada, K., & Iwatsubo, T.
(2018) Molecular neurodegeneration, 13(1), 9.
2017
Tissue distribution of a therapeutic monoclonal antibody determined by large pore microdialysis.
Jadhav, S. B., Khaowroongrueng, V., Fueth, M., Otteneder, M. B., Richter, W., & Derendorf, H.
(2017) Journal of pharmaceutical sciences, 106(9), 2853-2859.
“METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS.”
Davidson, Beverly L., Bradley T. Hyman, and Eloise Hudry.
(2017) Patent 20,170,336,395, issued November 23, 2017.
2016
Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.
Kang, S. S., Kurti, A., Baker, K. E., Liu, C. C., Colonna, M., Ulrich, J. D., … & Fryer, J. D.
(2016) Human Molecular Genetics, ddx366.
Extracellular Zn 2+ Is Essential for Amyloid β 1–42-Induced Cognitive Decline in the Normal Brain and Its Rescue.
Takeda, A., Tamano, H., Tempaku, M., Sasaki, M., Uematsu, C., Sato, S., … & Bush, A. I.
(2016) Journal of Neuroscience, 37(30), 7253-7262.
Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers.
Xu, H., Gelyana, E., Rajsombath, M., Yang, T., Li, S., & Selkoe, D.
(2016) The Journal of Neuroscience, 36(35), 9041-9056.
2015
Analysis of in vivo turnover of tau in a mouse model of tauopathy.
Yamada, K., Patel, T. K., Hochgräfe, K., Mahan, T. E., Jiang, H., Stewart, F. R., … & Holtzman, D. M.
(2015) Molecular neurodegeneration, 10(1), 1.
A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.
Hori, Y., Takeda, S., Cho, H., Wegmann, S., Shoup, T. M., Takahashi, K., … & Hudry, E.
(2015) Journal of Biological Chemistry, 290(4), 1966-1978.
Oxidative stress and lipid peroxidation are upstream of amyloid pathology.
Arimon, M., Takeda, S., Post, K. L., Svirsky, S., Hyman, B. T., & Berezovska, O.
(2015) Neurobiology of disease, 84, 109-119.
2014
Intravenously injected human apolipoprotein AI rapidly enters the central nervous system via the choroid plexus.
Cirrito, J. R.
(2014)
Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus.
Stukas, S., Robert, J., Lee, M., Kulic, I., Carr, M., Tourigny, K., … & Chan, J.
(2014) Journal of the American Heart Association, 3(6), e001156.
Neuronal activity regulates extracellular tau in vivo.
Yamada, K., Holth, J. K., Liao, F., Stewart, F. R., Mahan, T. E., Jiang, H., … & Holtzman, D. M.
(2014) The Journal of experimental medicine, 211(3), 387-393.
Improvement of memory deficits and amyloid-β clearance in aged APP23 mice treated with a combination of anti-amyloid-β antibody and LXR agonist.
Fitz, N. F., Castranio, E. L., Carter, A. Y., Kodali, R., Lefterov, I., & Koldamova, R.
(2014) Journal of Alzheimer’s Disease, 41(2), 535-549.
2013
Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567.
Bhattacharya, A., Wang, Q., Ao, H., Shoblock, J. R., Lord, B., Aluisio, L., … & Lovenberg, T. W.
(2013) British journal of pharmacology, 170(3), 624-640
Antisense reduction of tau in adult mice protects against seizures.
DeVos, S. L., Goncharoff, D. K., Chen, G., Kebodeaux, C. S., Yamada, K., Stewart, F. R., … & Bennett, C. F.
(2013) The Journal of Neuroscience, 33(31), 12887-12897.
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis.
Ulrich, J. D., Burchett, J. M., Restivo, J. L., Schuler, D. R., Verghese, P. B., Mahan, T. E., … & Holtzman, D. M.
(2013) Molecular neurodegeneration, 8(1), 1.
Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats.
Ide, S., Hara, T., Ohno, A., Tamano, R., Koseki, K., Naka, T., … & Minami, M.
(2013) The Journal of Neuroscience, 33(14), 5881-5894.
Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer’s disease.
Takeda, S., Hashimoto, T., Roe, A. D., Hori, Y., Spires-Jones, T. L., & Hyman, B. T.
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2012
Selective P2X7 receptor antagonists inhibit Bz-ATP induced IL-1β release in the rat brain.
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(2012) Monitoring Molecules in Neuroscience.
Neurochemical Analysis
HPLC-ECD (Electrochemical Detection)
2023
Striatal serotonin transporter gain-of-function in L-DOPA-treated, hemi-parkinsonian rats.
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A COMPARATIVE ANALYSIS OF MONOAMINE OXIDASE ENZYMES AND CANNABINOID RECEPTOR 1 AMONG PRIMATES
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(2023). (Doctoral dissertation, Kent State University).
Low-dose nafamostat mesilate ameliorates tissue injury and inhibits 5-hydroxytryptamine synthesis in the rat intestine after methotrexate administration.
Yamamoto, T., Machida, T., Tanno, C., Hasebe, S., Tamura, M., Kobayashi, N., … & Iizuka, K.
(2023). Journal of Pharmacological Sciences.
Rat model of attention-deficit hyperactivity disorder exhibits delayed recovery from acute incisional pain due to impaired descending noradrenergic inhibition.
Suto, T., Kato, D., Koibuchi, I., Arai, Y., Ohta, J., Hiroki, T., … & Saito, S.
(2023). Scientific Reports, 13(1), 5526.
Differing Patterns of Diurnal Variation and Impact of Antacids on Levodopa Pharmacokinetics in Patients with Parkinson’s Disease.
NAGAI, M., TADA, S., YAMANISHI, Y., MIYAUE, N., & ANDO, R.
(2023). Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 54(1), 3-8.
Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys.
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Broad Serotonergic Actions of Vortioxetine as a Promising Avenue for the Treatment of L-DOPA-Induced Dyskinesia.
Budrow, C., Elder, K., Coyle, M., Centner, A., Lipari, N., Cohen, S., … & Bishop, C.
(2023). Cells, 12(6), 837.
Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State.
Sinenko, S. A., Kuzmin, A. A., Skvortsova, E. V., Ponomartsev, S. V., Efimova, E. V., Bader, M., … & Tomilin, A. N.
(2023). International Journal of Molecular Sciences, 24(5), 4862.
Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain.
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(2023). Schizophrenia, 9(1), 8.
Prenatal ketamine exposure impairs prepulse inhibition via arginine vasopressin receptor 1A-mediated GABAergic neuronal dysfunction in the striatum.
Kim, A., Gu, S. M., Lee, H., Kim, D. E., Hong, J. T., Yun, J., & Cha, H. J.
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Rescuing Cortical Acetylcholine Tone and Behaviors Following Adolescent Alcohol Exposure
Fecik, M.
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Caste-specific storage of dopamine-related substances in the brains of four Polistes paper wasp species.
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Overexpression of tyrosine hydroxylase in dopaminergic neurons increased sensitivity to methamphetamine.
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Quantification of catecholamine neurotransmitters released from cutaneous vasoconstrictor nerve endings in men with cervical spinal cord injury.
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(2023). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.
Modulation of Notch Signaling at Early Stages of Differentiation of Human Induced Pluripotent Stem Cells to Dopaminergic Neurons.
Katolikova, N. V., Khudiakov, A. A., Shafranskaya, D. D., Prjibelski, A. D., Masharskiy, A. E., Mor, M. S., … & Malashicheva, A. B.
(2023). International Journal of Molecular Sciences, 24(2), 1429.
Intrastriatal injection of Parkinson’s disease intestine and vagus lysates initiates α-synucleinopathy in rat brain.
Yang, Z., Wang, Y., Wei, M., Li, S., Jia, C., Cheng, C., … & Le, W.
(2023). Cell Death & Disease, 14(1), 1-11.
Inhibition of PDE10A in a New Rat Model of Severe Dopamine Depletion Suggests New Approach to Non-Dopamine Parkinson’s Disease Therapy.
Sukhanov, I., Dorotenko, A., Fesenko, Z., Savchenko, A., Efimova, E. V., Mor, M. S., … & Gainetdinov, R. R.
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2022
Analytical Techniques to Investigate the Neurochemical Basis of Behavior
Perrotta, K.
(2022). (Doctoral dissertation, UCLA).
Behavioral roles of biogenic amines in bumble bee males.
Watanabe, T., & Sasaki, K.
(2022). Scientific Reports, 12(1), 1-11.
Oxidative DNA damage by N4-hydroxycytidine, a metabolite of the SARS-CoV-2 antiviral molnupiravir.
Kobayashi, H., Mori, Y., Ahmed, S., Hirao, Y., Kato, S., Kawanishi, S., … & Oikawa, S.
(2022). The Journal of Infectious Diseases.
Short-Term Combined Intake of Vitamin B2 and Vitamin E Decreases Plasma Homocysteine Concentrations in Female Track Athletes.
Shinagawa, A., Serizawa, N., Yamazaki, T., Minematsu, A., Miyakoshi, Y., Yano, T., & Ota, M.
(2022). Dietetics, 1(3), 216-226.
Transporter-dependent uptake and metabolism of myocardial interstitial serotonin in the rat heart.
Sonobe, T., Akiyama, T., & Pearson, J. T.
(2022). The Journal of Physiological Sciences, 72(1), 1-10.
Kamishoyosan Alleviates Anxiety-like Behavior in a Premenstrual Syndrome Rat Model.
Iba-Tanaka, H., Watanabe, T., Harada, K., Kubota, K., Katsurabayashi, S., & Iwasaki, K.
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Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane.
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Deficiency of the circadian clock gene Rev-erbα induces mood disorder-like behaviours and dysregulation of the serotonergic system in mice.
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SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex.
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Cannabinoid Type 1 Receptors in the Basolateral Amygdala Regulate ACPA-Induced Place Preference and Anxiolytic-Like Behaviors.
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Tryptophan Challenge in Healthy Controls and People with Schizophrenia: Acute Effects on Plasma Levels of Kynurenine, Kynurenic Acid and 5-Hydroxyindoleacetic Acid.
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Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson’s disease mouse model.
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Knockdown of Piccolo in the Nucleus Accumbens Suppresses Methamphetamine-Induced Hyperlocomotion and Conditioned Place Preference in Mice.
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Humanin derivative, HNG, enhances neurotransmitter release.
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Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice.
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Separation and detection of D-/L-serine by conventional HPLC.
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Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery.
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Cerebro-cerebellar interactions in non-human primates examined by optogenetic functional magnetic resonance imaging.
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Ethanol concentration induces production of 3, 4-dihydroxyphenylacetic acid and homovanillic acid in mouse brain through activation of monoamine oxidase pathway.
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Excessive folic acid intake combined with undernutrition during gestation alters offspring behavior and brain monoamine profiles.
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Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein Sorting in the Striatal Projection System and Its Deficiency Causes Disturbances in Motor Responses and Monoamine Dynamics.
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Developmental, neurochemical, and behavioral analyses of ErbB4 Cyt‐1 knockout mice.
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The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.
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Pyridostigmine bromide elicits progressive and chronic impairments in the cholinergic anti-inflammatory pathway in the prefrontal cortex and hippocampus of male rats.
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Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring.
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Trace Amine-Associated Receptor 2 Is Expressed in the Limbic Brain Areas and Is Involved in Dopamine Regulation and Adult Neurogenesis.
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Neferine, an Alkaloid from Lotus Seed Embryos, Exerts Antiseizure and Neuroprotective Effects in a Kainic Acid-Induced Seizure Model in Rats.
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Peroxiredoxin 6 Overexpression Induces Anxiolytic and Depression-Like Behaviors by Regulating the Serotonergic Pathway in Mice.
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Optogenetic Stimulation of Midbrain Dopamine Neurons Produces Striatal Serotonin Release.
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Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA.
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A role for foregut tyrosine metabolism in glucose tolerance.
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The effect of tamoxifen on opening ATP-sensitive K+ channels enhances hydroxyl radical generation in rat striatum.
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Tryptophan-Tyrosine Dipeptide, the Core Sequence of β-Lactolin, Improves Memory by Modulating the Dopamine System.
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Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons.
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Sophora Tomentosa Extract Prevents MPTP-Induced Parkinsonism in C57BL/6 Mice Via the Inhibition of GSK-3β Phosphorylation and Oxidative Stress.
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Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation.
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Differentiation of human mesenchymal stem cells (MSC) to dopaminergic neurons: A comparison between Wharton’s Jelly and olfactory mucosa as sources of MSCs.
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(2019). Journal of Chemical Neuroanatomy.
Iso-α-acids, the bitter components of beer, improve hippocampus-dependent memory through vagus nerve activation.
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Human olfactory stem cells: As a promising source of dopaminergic neuron-like cells for treatment of Parkinson’s disease.
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Brain hyperserotonemia causes autism-relevant social deficits in mice.
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Optically active iodohelicene derivatives exhibit histamine N-methyl transferase inhibitory activity.
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(2018) The Journal of Antibiotics, 1.
In vivo neurochemical evidence that stimulation of accumbal GABAA and GABAB receptors each reduce acetylcholine efflux without affecting dopamine efflux in the nucleus accumbens of freely moving rats.
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(2018) Synapse.
Anxiolytic effects of γ-oryzanol in chronically-stressed mice are related to monoamine levels in the brain.
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(2018) Life Sciences.
Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson’s disease.
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(2018) Neurobiology of disease.
The α2A‐adrenoceptor subtype plays a key role in the analgesic and sedative effects of xylazine.
Kitano, T., Kobayashi, T., Yamaguchi, S., & Otsuguro, K. I.
(2018) Veterinary Pharmacology and Therapeutics.
Behavioral tests predicting striatal dopamine level in a rat hemi-Parkinson’s disease model.
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(2018) Neurochemistry International.
Selegiline ameliorates depression-like behaviors in rodents and modulates hippocampal dopaminergic transmission and synaptic plasticity.
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(2018) Behavioural Brain Research.
Comparison of the Effect of Soy and Casein-Derived Peptide Administration on Tyrosine and Catecholamine Metabolism in the Mouse Brain.
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(2018) Journal of nutritional science and vitaminology, 64(5), 329-334.
Night eating model shows time-specific depression-like behavior in the forced swimming test.
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Exposure to hot and cold environments increases noradrenaline release in the bed nucleus of the stria terminalis in rats.
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(2018) Neuropsychopharmacology Reports.
Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats.
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Enhancement of fear learning in PPARα knockout mice.
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(2018) Behavioural brain research.
phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol‐preferring from genetically heterogenous rats.
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(2018) Addiction biology.
Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve.
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(2018) Scientific Reports, 8(1), 15372.
Cardiac Glutathione Levels Increase in Response to Glucose in Diabetic Rats.
Thorwald, M. A., Godoy-Lugo, J. A., Rodriguez, G. J., Rodriguez, M. A., Jamal, M., Kinoshita, H., … & Ortiz, R. M.
(2018) Free Radical Biology and Medicine.
A Neural Circuit for Gut-Induced Reward.
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Ropivacaine Protects against Memory Impairment and Hippocampal Damage in a Rat Neurodegeneration Model.
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(2018) Pharmacology, 102(5-6), 307-315.
Roles of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis in bidirectional brain‐intestine interactions.
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(2018) Neuropsychopharmacology Reports.
Increased cholinergic response in α-synuclein transgenic mice (h-α-synL62).
König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., … & Klein, J.
(2018) ACS Chemical Neuroscience.
Prenatal metformin treatment improves ovarian function in offspring of obese rats.
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(2018) Journal of Endocrinology, 1(aop).
“SIALYLATION-INCREASING THERAPIES FOR DISEASES ASSOCIATED WITH OXIDATIVE STRESS.”
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Mesolimbic Dopamine, Its Receptors and Social Learning
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Central activation of cardiac vagal nerve by α2-adrenergic stimulation is impaired in streptozotocin-induced type 1 diabetic rats.
Kawada, T., Akiyama, T., Sonobe, T., Shimizu, S., Hayama, Y., Pearson, J. T., … & Sugimachi, M.
(2018) Autonomic Neuroscience: Basic and Clinical.
Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia.
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(2018) Scientific Reports, 8(1), 13046.
6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
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Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin.
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(2018) Scientific Reports, 8(1), 12056.
Novel lacto-peptides in fermented dairy products improve memory function and cognitive decline.
Ano, Y., Ayabe, T., Kutsukake, T., Ohya, R., Takaichi, Y., Uchida, S., … & Nakayama, H.
(2018) Neurobiology of Aging.
“Examining the Associative Learning and Accumbal Dopaminergic Mechanisms of Caffeine Reinforcement.”
Bradley, Curtis
(2018) Electronic Theses and Dissertations. Paper 3457. https://dc.etsu.edu/etd/3457
Nausea-Induced 5-HT Release in the Interoceptive Insular Cortex and Regulation by Monoacylglycerol Lipase (MAGL) Inhibition and Cannabidiol.
Limebeer, C. L., Rock, E. M., Sharkey, K. A., & Parker, L. A.
(2018) eNeuro, ENEURO-0256.
“Neurochemistry, Physiology, and Behavior in a Model of Gulf War Illness”
Macht, V. A.
(2018) Doctoral dissertation, University of South Carolina
“Effort-Related Motivational Dysfunctions: Behavioral and Neurochemical Studies of the Wistar-Kyoto Rat Model of Depression.”
Abbott, Brendan
(2018) Masters Theses. 625.
Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex.
Saiki, M., Matsui, T., Soya, M., Kashibe, T., Shima, T., Shimizu, T., … & Soya, H.
(2018) Scientific reports, 8(1), 10469.
Monoamine system disruption induces functional somatic syndromes associated symptomatology in mice.
Nagakura, Y., Ohsaka, N., Azuma, R., Takahashi, S., Takebayashi, Y., Kawasaki, S., … & Saito, H.
(2018) Physiology & Behavior.
Molecular vibration as a novel explanatory mechanism for the expression of animal colouration.
Galván, I., Cerezo, J., Jorge, A., & Wakamatsu, K.
(2018) Integrative Biology.
Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder.
Kato, T. M., Kubota-Sakashita, M., Fujimori-Tonou, N., Saitow, F., Fuke, S., Masuda, A., … & Kato, T.
(2018) Molecular Psychiatry, 1.
Comparison of brain monoamine content in three populations of Lymnaea that correlates with taste-aversive learning ability.
Aonuma, H., Totani, Y., Sakakibara, M., Lukowiak, K., & Ito, E.
(2018) Biophysics and Physicobiology, 15, 129-135.
Cisplatin increases the number of enterochromaffin cells containing substance P in rat intestine.
Obara, Y., Machida, T., Takano, Y., Shiga, S., Suzuki, A., Hamaue, N., … & Hirafuji, M.
(2018) Naunyn-Schmiedeberg’s archives of pharmacology, 1-12.
Sound‐induced monoaminergic turnover in the auditory forebrain depends on endocrine state in a seasonally‐breeding songbird.
Rodríguez‐Saltos, C. A., Lyons, S. M., Sockman, K. W., & Maney, D. L.
(2018) Journal of Neuroendocrinology.
The Effects of Chronic Amitriptyline on Zebrafish Behavior and Monoamine Neurochemistry.
Meshalkina, D. A., Kysil, E. V., Antonova, K. A., Demin, K. A., Kolesnikova, T. O., Khatsko, S. L., … & Kalueff, A. V.
(2018) Neurochemical Research, 1-9.
Sex Differences in Hippocampal Memory and Kynurenic Acid Formation Following Acute Sleep Deprivation in Rats.
Baratta, A. M., Buck, S. A., Buchla, A. D., Fabian, C. B., Chen, S., Mong, J. A., & Pocivavsek, A.
(2018) Scientific Reports, 8(1), 6963.
TLR4 Inhibits Spinal Gabaergic Activities via Microglial Activation in Chronic Constriction Injury Mice.
Kong, E. L., Wu, X. Z., He, Y., Wang, H. Q., Zhang, Y., Zhang, J. M., … & Wu, F.
(2018) Neuropsychiatry (London), 8(2), 761-771.
Development of a hematocrit-insensitive device to collect accurate volumes of dried blood spots without specialized skills for measuring clozapine and its metabolites as model analytes.
Nakahara, T., Otani, N., Ueno, T., & Hashimoto, K.
(2018) Journal of Chromatography B.
Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity.
Kehr, J., Yoshitake, T., Ichinose, F., Yoshitake, S., Kiss, B., Gyertyán, I., & Adham, N.
(2018) Psychopharmacology, 1-15.
Uptake of plant-derived specific alkaloids allows males of a butterfly to copulate.
Honda, K., Matsumoto, J., Sasaki, K., Tsuruta, Y., & Honda, Y.
(2018) Scientific Reports, 8(1), 5516.
Measurement of 8-hydroxyguanine as an oxidative stress biomarker in saliva by HPLC-ECD.
Kawai, K., Kasai, H., Li, Y. S., Kawasaki, Y., Watanabe, S., Ohta, M., … & Yamato, H.
(2018) Genes and Environment, 40(1), 5.
Mechanisms of the pH-and Oxygen-Dependent Oxidation Activities of Artesunate.
Tsuda, K., Miyamoto, L., Hamano, S., Morimoto, Y., Kangawa, Y., Fukue, C., … & Tamaki, T.
(2018) Biological and Pharmaceutical Bulletin, 41(4), 555-563.
Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with b-amyloid in rats.
Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences, 30, 1e6.
The Effects of Housing Density on Social Interactions and Their Correlations with Serotonin in Rodents and Primates.
Lee, Y. A., Obora, T., Bondonny, L., Toniolo, A., Mivielle, J., Yamaguchi, Y., … & Goto, Y.
(2018) Scientific reports, 8(1), 3497.
Astaxanthin protects against kainic acid-induced seizures and pathological consequences.
Chang, Y., Lu, C. W., Chen, Y. J., Lin, T. Y., Huang, S. K., & Wang, S. J.
(2018) Neurochemistry international.
NF‐κB/p53‐activated inflammatory response involves in diquat‐induced mitochondrial dysfunction and apoptosis.
Choi, S. E., Park, Y. S., & Koh, H. C.
(2018) Environmental Toxicology.
Tyraminergic modulation of agonistic outcomes in crayfish.
Momohara, Y., Aonuma, H., & Nagayama, T.
(2018) Journal of Comparative Physiology A, 1-9.
Peptide YY Causes Apathy-Like Behavior via the Dopamine D2 Receptor in Repeated Water-Immersed Mice.
Yamada, C., Mogami, S., Kanno, H., & Hattori, T.
(2018) Molecular Neurobiology, 1-12.
Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with β-amyloid in rats.
Egashira, N., Akiyoshi, Y., Iba, H., Arai, T., Hatip-Al-Khatib, I., Mishima, K., & Iwasaki, K.
(2018) Journal of Pharmacological Sciences.
Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI), Milnacipran, in Rats.
Kawai, H., Machida, M., Ishibashi, T., Kudo, N., Kawashima, Y., & Mitsumoto, A.
(2018) Biological and Pharmaceutical Bulletin, 41(2), 213-219
Negatively-charged aerosol improves burn wound healing by promoting eNOS-dependent angiogenesis.
Zhao, J., Zhou, F., Chen, L., Shu, B., Zhai, Q., Wu, J., … & Xu, Y.
(2018) Am J Transl Res, 10(1), 246-255.
Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus.
Kolata, S. M., Nakao, K., Jeevakumar, V., Farmer-Alroth, E. L., Fujita, Y., Bartley, A. F., … & Martinowich, K.
(2018) Neuropsychopharmacology.
The influence of cellular senescence on intracellular vitamin C transport, accumulation, and function.
Saitoh, Y., Nakawa, A., Tanabe, T., & Akiyama, T.
(2018) Molecular and Cellular Biochemistry, 1-11.
Effects of intravenous tryptophan infusion on thermoregulation in steers exposed to acute heat stress.
Sutoh, M., Kasuya, E., & Yayou, K. I.
(2018) Animal Science Journal.
Malaria infectivity of xanthurenic acid-deficient anopheline mosquitoes produced by TALEN-mediated targeted mutagenesis.
Yamamoto, D. S., Sumitani, M., Hatakeyama, M., & Matsuoka, H.
(2018) Transgenic Research, 1-10.
Night eating model shows time-specific depression-like behavior in the forced swimming test.
Haraguchi, A., Fukuzawa, M., Iwami, S., Nishimura, Y., Motohashi, H., Tahara, Y., & Shibata, S.
(2018) Scientific Reports, 8(1), 1081.
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ADVANCED MICRODIALYSIS APPROACHES RESOLVE DIFFERENCES IN SEROTONIN HOMEOSTASIS AND SIGNALING.
Sampson, M. M., Yang, H., & Andrews, A. M.
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Effects of 5-HT and insulin on learning and memory formation in food-deprived snails.
Aonuma, H., Totani, Y., Kaneda, M., Nakamura, R., Watanabe, T., Hatakeyama, D., … & Ito, E.
(2017) Neurobiology of Learning and Memory.
Sexual odor preference and dopamine release in the nucleus accumbens by estrous olfactory cues in sexually naïve and experienced male rats.
Fujiwara, M., & Chiba, A.
(2017) Physiology & Behavior.
“The role of serotonergic dysfunction in the etiology of affective disorder in a Huntington’s disease translational mouse model.”
Alselehdar, S. K.
(2017) Doctoral dissertation, Rutgers University-Graduate School-Newark
Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice.
Yu, H., Li, M., Zhou, D., Lv, D., Liao, Q., Lou, Z., … & Zhang, Y.
(2017) Neuropharmacology.
Generation of dopamine-secreting cells from human adipose tissue-derived stem cells in vitro.
Soheilifar, M. H., Javeri, A., Amini, H., & Taha, M. F.
(2017) Rejuvenation Research, (ja).
Targeting Hypersensitive Corticostriatal Terminals in Restless Legs Syndrome.
Yepes, G., Guitart, X., Rea, W., Newman, A. H., Allen, R. P., Earley, C. J., … & Ferré,
(2017) Annals of Neurology.
Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models.
Misu, H., Nakayama, K., Sotani, K., Inagaki, K., Ikegawa, M., Iwasaki, M., … & Takamura, T.
(2017) Nature Communications, 8(1), 1658.
Aroclor 1254 and BDE-47 inhibit dopaminergic function manifesting as changes in locomotion behaviors in zebrafish embryos.
Tanaka, Y., Fujiwara, M., Shindo, A., Yin, G., Kitazawa, T., & Teraoka, H.
(2017) Chemosphere.
5-Hydroxytryptamine-independent antidepressant actions of (R)-ketamine in a chronic social defeat stress model.
Zhang, K., Dong, C., Fujita, Y., Fujita, A., & Hashimoto, K.
(2017) International Journal of Neuropsychopharmacology.
Syntaxin1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.
Fujiwara, T., Kofuji, T., Mishima, T., & Akagawa, K.
(2017) European Journal of Neuroscience.
Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid.
Goeden, N., Notarangelo, F. M., Pocivavsek, A., Beggiato, S., Bonnin, A., & Schwarcz, R.
(2017) Developmental Neuroscience.
Caste differences in the association between dopamine and reproduction in the bumble bee Bombus ignitus.
Sasaki, K., Matsuyama, H., Morita, N., & Ono, M.
(2017) Journal of Insect Physiology.
Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson’s disease: Involvement of neuroinflammation and neurotrophins.
Goes, A. T., Jesse, C. R., Antunes, M. S., Ladd, F. V. L., Ladd, A. A. B. L., Luchese, C., … & Boeira, S. P.
(2017) Chemico-Biological Interactions.
Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects.
Sathyasaikumar, K. V., Tararina, M., Wu, H. Q., Neale, S. A., Weisz, F., Salt, T. E., & Schwarcz, R.
(2017) Neuroscience.
Exercise Enhances Medial Septal Cholinergic Function: The Role of Neurotrophins on the Maintenance and Enhancement of the Cholinergic Neuronal Phenotypes
Hall, J. M.
(2017) Doctoral dissertation, State University of New York at Binghamton
L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.
Masukawa, D., Koga, M., Sezaki, A., Nakao, Y., Kamikubo, Y., Hashimoto, T., … & Wakui, H.
(2017) JCI Insight, 2(18).
Striatal N-acetylaspartate synthetase Shati/Nat8l regulates depression-like behaviors via mGluR3-mediated serotonergic suppression in mice.
Miyamoto, Y., Iegaki, N., Fu, K., Ishikawa, Y., Sumi, K., Azuma, S., … & Nitta, A.
(2017) International Journal of Neuropsychopharmacology.
Microglia may compensate for dopaminergic neuron loss in experimental Parkinsonism through selective elimination of glutamatergic synapses from the subthalamic nucleus
Aono, H., Choudhury, M. E., Higaki, H., Miyanishi, K., Kigami, Y., Fujita, K., … & Nishikawa, N.
(2017) Glia.
Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine‐induced dopamine release in the mouse nucleus accumbens.
Pavon, F. J., Serrano, A., Sidhpura, N., Polis, I., Stouffer, D., Fonseca, F. R., … & Parsons, L. H.
(2017) Addiction Biology.
Cyclic AMP‐regulated opposing and parallel effects of serotonin and dopamine on phototaxis in the Marmorkrebs (marbled crayfish).
Shiratori, C., Suzuki, N., Momohara, Y., Shiraishi, K., Aonuma, H., & Nagayama, T.
(2017) European Journal of Neuroscience.
Noradrenergic modulation of gonadotropin‐inhibitory hormone gene expression in the brain of Japanese quail.
Tobari, Y., Kansaku, N., & Tsutsui, K.
(2017) Journal of Neuroendocrinology.
Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study.
Takiguchi, K., Uezato, A., Itasaka, M., Atsuta, H., Narushima, K., Yamamoto, N., … & Tamaru, M.
(2017) BMC psychiatry, 17(1), 249.
Individual differences are consistent across changes in mating status and mediated by biogenic amines.
DiRienzo, N., & Aonuma, H.
(2017) Behavioral Ecology and Sociobiology, 71(8), 118.
Differential effects of neonatal SSRI treatments on hypoxia-induced behavioral changes in male and female offspring.
Nagano, R., Nagano, M., Nakai, A., Takeshita, T., & Suzuki, H.
(2017) Neuroscience.
In Vitro Differentiation of Adipose Derived Stem Cells Into Functional Dopaminergic Neurons.
Rad, A. A., Heidari, M. H., Aliaghaei, A., Broujeni, M. E., Shojaei, A., & Abbaszadeh, H. A.
(2017) Biomedical and Pharmacology Journal, 10(2), 595-605
Metformin increases norepinephrine transporter expression in placenta of patients with polycystic ovary syndrome.
Medina, G., Maliqueo, M., Crisosto, N., Echiburú, B., Sir-Petermann, T., & Lara, H. E.
(2017) Eur Rev Med Pharmacol Sci, 21(15), 3482-3489
Adolescent Binge Ethanol Exposure Alters Specific Forebrain Cholinergic Cell Populations and Leads to Selective Functional Deficits in the Prefrontal Cortex.
Fernandez, G. M., & Savage, L. M.
(2017) Neuroscience.
Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice.
Nakai, N., Nagano, M., Saitow, F., Watanabe, Y., Kawamura, Y., Kawamoto, A., … & Monai, H.
(2017) Science Advances, 3(6), e1603001
Genistein alleviates anxiety-like behaviors in post-traumatic stress disorder model through enhancing serotonergic transmission in the amygdala.
Zhong-Min, W. U., Gui-Lian, N. I., Ai-Min, S. H. A. O., & Rong, C. U. I.
(2017) Psychiatry Research.
Echinacoside ameliorates memory impairment and cholinergic deficit induced by amyloid beta peptide via inhibiting amyloid deposition and toxicology.
Shiao, Y. J., Su, M. H., Lin, H. C., & Wu, C. R.
(2017) Food & Function
LPA1 receptor involvement in fibromyalgia-like pain induced by intermittent psychological stress, empathy.
Ueda, H., & Neyama, H.
(2017) Neurobiology of Pain, 1, 16-25
Effect of basal forebrain stimulation on extracellular acetylcholine release and blood flow in the olfactory bulb.
Uchida, S., & Kagitani, F.
(2017) The Journal of Physiological Sciences, 1-9.
Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism
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Differences in activity levels as well as in brain amino acid levels and monoamine metabolisms, that exist between the Djungarian hamster (P. sungorus) and the Roborovskii hamster (P. roborovskii) are scarcely influenced by social isolation.
Ikeda, H., Yamaguchi, T., Kodaira, M., Bahry, M. A., Chowdhury, V. S., & Furuse, M.
(2017) Journal of Pet Animal Nutrition, 20(1), 47-58.
Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo.
Shiao, Y. J., Su, M. H., Lin, H. C., & Wu, C. R.
(2017) International Journal of Molecular Sciences, 18(4), 895.
Weak involvement of octopamine in aversive taste learning in a snail.
Aonuma, H., Kaneda, M., Hatakeyama, D., Watanabe, T., Lukowiak, K., & Ito, E.
(2017) Neurobiology of Learning and Memory.
Manipulation of dopamine metabolism contributes to attenuating innate high locomotor activity in ICR mice.
Yamaguchi, T., Nagasawa, M., Ikeda, H., Kodaira, M., Minaminaka, K., Chowdhury, V. S., … & Furuse, M.
(2017) Behavioural Brain Research SreeTestContent1.
Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice.
Fujikawa, R., Higuchi, S., Ikedo, T., Nagata, M., Hayashi, K., Yang, T., … & Minami, M.
(2017) Biochemical and Biophysical Research Communications.
“FOOD ADDITIVE FOR PRODUCING FOOD FOR PREVENTING CRANIAL NERVE DISEASE AND/OR IMPROVING BRAIN FUNCTION.”
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Effects of endogenous nitric oxide on adrenergic nerve-mediated vasoconstriction and calcitonin gene-related peptide-containing nerve-mediated vasodilation in pithed rats.
Yamawaki, K., Zamami, Y., Kawasaki, H., & Takatori, S.
(2017) European Journal of Pharmacology.
Immunohistochemical and biochemical evidence for the presence of serotonin-containing neurons and nerve fibers in the octopus arm.
Bellier, J. P., Xie, Y., Farouk, S. M., Sakaue, Y., Tooyama, I., & Kimura, H.
(2017) Brain Structure and Function, 1-19.
Idiopathic Parkinson’s disease patient‐derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains.
Kikuchi, T., Morizane, A., Okita, K., Nakagawa, M., Yamakado, H., Inoue, H., … & Takahashi, J.
(2017) Journal of Neuroscience Research
Oxidative stress inactivates ecto-5′-nucleotidase by inhibiting protein kinase C in rat hearts in vivo.
Obata, T., & Nakashima, M.
(2017) European Journal of Pharmacology
CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.
Hirose, M., Hasegawa, A., Mochida, K., Matoba, S., Hatanaka, Y., Inoue, K., … & Abe, K.
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Restraint Stress during Pregnancy Rapidly Raises Kynurenic Acid Levels in Mouse Placenta and Fetal Brain.
Notarangelo, F. M., & Schwarcz, R.
(2017) Developmental Neuroscience.
Desipramine increases cardiac parasympathetic activity via α 2-adrenergic mechanism in rats.
Kawada, T., Akiyama, T., Shimizu, S., Fukumitsu, M., Kamiya, A., & Sugimachi, M.
(2017) Autonomic Neuroscience.
Investigation of 5-HT 3 receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of PYY-containing endocrine cell.
Kojima, S. I., Kojima, K., & Fujita, T.
(2017) European Journal of Pharmacology.
Effects of the 5-HT 6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex.
Mørk, A., Russell, R. V., de Jong, I. E., & Smagin, G.
(2017) European Journal of Pharmacology.
Involvement of host defense mechanisms against Toxoplasma gondii infection in anhedonic and despair-like behaviors in mice.
Mahmoud, M. E., Fereig, R., & Nishikawa, Y.
(2017) Infection and Immunity, IAI-00007.
Key role of the dopamine D4 receptor in the modulation of corticostriatal glutamatergic neurotransmission.
Bonaventura, J., Quiroz, C., Cai, N. S., Rubinstein, M., Tanda, G., & Ferré, S.
(2017) Science Advances, 3(1), e1601631.
Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation.
Tahara, Y., Takatsu, Y., Shiraishi, T., Kikuchi, Y., Yamazaki, M., Motohashi, H., … & Nakamura, T. J.
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Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy.
Saidan, D., Jianjing, Y., Xueli, H., Leping, L., Jiangnan, H., Zhu, X., & Qichuan, Z.
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2016
The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain.
Do Yun Kim, J. W. C., Lim, C. H., Heo, B. H., Park, K. S., Lee, H. G., Choi, J. I., … & Kim, W. M.
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Correlated responses in death-feigning behavior, activity, and brain biogenic amine expression in red flour beetle Tribolium castaneum strains selected for walking distance.
Matsumura, K., Sasaki, K., & Miyatake, T.
(2016) Journal of ethology, 34(2), 97-105
Enhanced alcohol-drinking behavior associated with active ghrelinergic and serotoninergic neurons in the lateral hypothalamus and amygdala.
Yoshimoto, K., Nagao, M., Watanabe, Y., Yamaguchi, T., Ueda, S., Kitamura, Y., … & Murakami, K.
(2016) Pharmacology Biochemistry and Behavior.
Discovery of piperonal-converting oxidase involved in the metabolism of a botanical aromatic aldehyde.
Doi, S., Hashimoto, Y., Tomita, C., Kumano, T., & Kobayashi, M.
(2016) Scientific Reports, 6, 38021.
Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice.
Kubo, H., Hoshi, M., Mouri, A., Tashita, C., Yamamoto, Y., Nabeshima, T., & Saito, K.
(2016) Immunology Letters.
Vitamin C impacts anxiety-like behavior and stress-induced anorexia relative to social environment in SMP30/GNL knockout mice.
Koizumi, M., Kondo, Y., Isaka, A., Ishigami, A., & Suzuki, E.
(2016) Nutrition Research.
Identification of 1-Methyl-N-(propan-2-yl)-N-({2-[4-(trifluoromethoxy) phenyl] pyridin-4-yl} methyl)-1H-imidazole-4-carboxamide as a Potent and Orally Available Glycine Transporter 1 Inhibitor.
Yamamoto, S., Ohta, H., Abe, K., Kambe, D., Tsukiyama, N., Kawakita, Y., … & Yasuhara, A.
(2016) Chemical and Pharmaceutical Bulletin, 64(11), 1630-1640
Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion.
Du, C. K., Zhan, D. Y., Akiyama, T., Inagaki, T., Shishido, T., Shirai, M., & Pearson, J. T.
(2016) American Journal of Physiology-Heart and Circulatory Physiology, ajpheart-00471.
Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.
Ishikawa, T., Imamura, K., Kondo, T., Koshiba, Y., Hara, S., Ichinose, H., … & Takahashi, R.
(2016) Human Molecular Genetics, ddw339.
Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1.
Samata, B., Doi, D., Nishimura, K., Kikuchi, T., Watanabe, A., Sakamoto, Y., … & Takahashi, J.
(2016) Nature Communications, 7, 13097.
Long-Term Citalopram Treatment Alters the Stress Responses of the Cortical Dopamine and Noradrenaline Systems: the Role of Cortical 5-HT.
Hanada, Y., Yamada, M., Kakuma, T., Kawahara, H., & Nishi, A.
(2016) International Journal of Neuropsychopharmacology, 19(8), 1-12.
Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.
Tashiro, T., Murakami, Y., Mouri, A., Imamura, Y., Nabeshima, T., Yamamoto, Y., & Saito, K.
(2016) Behavioural Brain Research SreeTestContent1.
In utero exposure to diesel exhaust particles induces anxiogenic effects on male offspring via chronic activation of serotonergic neuron in dorsal raphe nucleus.
Yokota, S., Oshio, S., & Takeda, K.
(2016) The Journal of Toxicological Sciences, 41(5), 583-593.
Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3K/Akt/GSK3β Pathway.
Zhang, W., He, H., Song, H., Zhao, J., Li, T., Wu, L., … & Chen, J.
(2016) Parkinson’s Disease, 2016.
Esterification of 24 (S)-hydroxycholesterol induces formation of atypical lipid droplet-like structures, leading to neuronal cell death.
Takabe, W., Urano, Y., Vo, D. K. H., Shibuya, K., Tanno, M., Kitagishi, H., … & Noguchi, N.
(2016) Journal of Lipid Research, jlr-M068775.
The Anti-Inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD).
Ebenezer, P. J., Wilson, C. B., Wilson, L. D., Nair, A. R., & Francis, J.
(2016) PloS one, 11(9), e0160923.
Role of rho-mediated ROCK-Semaphorin3A signaling pathway in the pathogenesis of Parkinson’s disease in a mouse model.
Qi, L., Tang, Y. G., Wang, L., He, W., Pan, H. H., Nie, R. R., & Can, Y.
(2016) Journal of the Neurological Sciences.
Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice.
Ishizu, N., Yui, D., Hebisawa, A., Aizawa, H., Cui, W., Fujita, Y., … & Watase, K.
(2016) Human Molecular Genetics, ddw279.
“PHARMACOLOGICAL IMPLICATIONS OF ADENOSINE 2A RECEPTOR-DOPAMINE TYPE 2 RECEPTOR HETEROMERIZATION.”
Compass, V. S.
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Dopaminergic abnormalities in Hdac6-deficient mice.
Fukada, M., Nakayama, A., Mamiya, T., Yao, T. P., & Kawaguchi, Y.
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“Color measurement of the animal integument predicts the content of specific melanin forms.”
Galván, Ismael, and Kazumasa Wakamatsu.
(2016) RSC Advances
“Neuroprotective Effects of Salidroside in the MPTP mouse model of Parkinson’s.”
Zhang, X., & Chen, J.
Acute arterial baroreflex‐mediated changes in plasma catecholamine concentrations in a chronic rat model of myocardial infarction.
Kawada, T., Akiyama, T., Li, M., Zheng, C., Turner, M. J., Shirai, M., & Sugimachi, M.
(2016) Physiological Reports, 4(15), e12880.
Toxoplasma gondii Infection in Mice Impairs Long-Term Fear Memory Consolidation Through Dysfunction of the Cortex and Amygdala.
Ihara, F., Nishimura, M., Muroi, Y., Mahmoud, M. E., Yokoyama, N., Nagamune, K., & Nishikawa, Y.
(2016) Infection and Immunity, IAI-00217.
3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of l-DOPA.
Asanuma, M., & Miyazaki, I.
(2016) BMC Neuroscience, 17(1), 1.
Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2, 3-dioxygenase 1.
Murakami, Y., Ishibashi, T., Tomita, E., Imamura, Y., Tashiro, T., Watcharanurak, K., … & Fujigaki, H.
(2016) Scientific Reports, 6, 29920.
In vivo neurochemical evidence that delta1-, delta2-and mu2-opioid receptors, but not mu1-opioid receptors, inhibit acetylcholine efflux in the nucleus accumbens of freely moving rats.
Kiguchi, Y., Aono, Y., Watanabe, Y., Yamamoto, S., Shimizu, K., Shimizu, T., … & Saigusa, T.
(2016) European Journal of Pharmacology.
Neurochemical Substrates of Asymmetrical Sleep in the Fur Seal.
Lapierre, J. L.
(2016) Doctoral dissertation, University of Toronto.
Carbonyl stress-induced 5-hydroxytriptamine secretion from RIN-14B, rat pancreatic islet tumor cells, via the activation of transient receptor potential ankyrin 1.
Suzawa, S., Takahashi, K., Shimada, T., & Ohta, T.
(2016) Brain Research Bulletin.
“METHOD FOR PRODUCING DOPAMINERGIC NEURONS.”
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Involvement of glutamatergic N-Methyl-D-Aspartate receptors in the expression of increased head-dipping behaviors in the hole-board tests of olfactory bulbectomized mice.
Hirose, N., Saitoh, A., & Kamei, J.
(2016) Brain Research.
Dopamine level in the stratium exhibits circadian rhythms in the rat model of Tourette syndrome.
Ji, X., Wu, M., & Zhang, X.
(2016) Int J Clin Exp Med, 9(6), 9015-9020.
Progressive loss of nigrostriatal dopaminergic neurons induced by inflammatory responses to fipronil.
Park, J. H., Park, Y. S., & Koh, H. C.
(2016) Toxicology Letters.
Maternal Inflammation Disrupts Fetal Neurodevelopment via Increased Placental Output of Serotonin to the Fetal Brain.
Goeden, N., Velasquez, J., Arnold, K. A., Chan, Y., Lund, B. T., Anderson, G. M., & Bonnin, A.
(2016) The Journal of Neuroscience, 36(22), 6041-6049.
Octopaminergic system in the central nervous system of the terrestrial slug Limax.
Matsuo, R., Tanaka, M., Fukata, R., Kobayashi, S., Aonuma, H., & Matsuo, Y.
(2016) Journal of Comparative Neurology.
New Insights on Different Response of MDMA-Elicited Serotonin Syndrome to Systemic and Intracranial Administrations in the Rat Brain.
Shokry, I. M., Callanan, J. J., Sousa, J., & Tao, R.
(2016) PloS one, 11(5), e0155551.
Tyraminergic and Octopaminergic Modulation of Defensive Behavior in Termite Soldier.
Ishikawa, Y., Aonuma, H., Sasaki, K., & Miura, T.
(2016) PloS one, 11(5), e0154230.
“Acute and Chronic Effects of Inhalants in Intracranial Self-stimulation.”
Tracy, Matthew.
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Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats.
Lin, T. Y., Lu, C. W., & Wang, S. J.
(2016) NeuroToxicology.
The Rapidly-Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits.
Witkin, J. M., Monn, J. A., Schoepp, D. D., Li, X., Overshiner, C. D., Mitchell, S. N., … & Rorick-Kehn, L. M.
(2016) Journal of Pharmacology and Experimental Therapeutics, jpet-116.
“Original Research Article Effects of intravenous cariporide on norepinephrine and myoglobin releases during myocardial ischemia/reperfusion in rabbits.”
Shigeru Sakurai, M. D., Kuroko, Y., Kawada, T., Sugimachi, M., & Shuji Shimizu, M. D.
Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase.
Otsuki, N., Homma, T., Fujiwara, H., Kaneko, K., Hozumi, Y., Shichiri, M., … & Yoshida, Y.
(2016) Regulatory Toxicology and Pharmacology.
Vitamin D3: a role in dopamine circuit regulation, diet-induced obesity, and drug consumption.
Trinko, J. R., Land, B. B., Solecki, W. B., Wickham, R. J., Tellez, L. A., Maldonado-Aviles, J., … & DiLeone, R. J.
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Stability of Adrenaline in Irrigating Solution for Intraocular Surgery.
Shibata, Y., Kimura, Y., Taogoshi, T., Matsuo, H., & Kihira, K.
(2016) Biological and Pharmaceutical Bulletin, 39(5), 879-882.
Environmental Estrogen-like Substances Enhances 1-Methyl-4-Phenylpyridinium Ion-Induced Hydroxyl Radical Generation in Rat Striatum.
Obata, T.
(2016) MJ Anest, 1(1), 001.
Prenatal phencyclidine treatment induces behavioral deficits through impairment of GABAergic interneurons in the prefrontal cortex.
Toriumi, K., Oki, M., Muto, E., Tanaka, J., Mouri, A., Mamiya, T., … & Nabeshima, T.
(2016) Psychopharmacology, 1-9.
Synthesis of 24 (S)-hydroxycholesterol esters responsible for the induction of neuronal cell death.
Shibuya, K., Watanabe, T., Urano, Y., Takabe, W., Noguchi, N., & Kitagishi, H.
(2016) Bioorganic & Medicinal Chemistry.
Opening of ATP-sensitive K+(K ATP) channels enhance hydroxyl radical generation induced by MPP+ in rat striatum.
Obata, T., & Nakashima, M.
(2016) Journal of the Neurological Sciences.
Differences in neurotransmitter systems of ventrolateral periaqueductal gray between the micturition reflex and nociceptive regulation: An in vivo microdialysis study.
Kitta, T., Mitsui, T., Kanno, Y., Chiba, H., Moriya, K., Yoshioka, M., & Shinohara, N.
(2016) International Journal of Urology.
Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse.
Wu, H. H., Choi, S., & Levitt, P.
(2016) Placenta.
Changes of brain monoamine levels and physiological indexes during heat acclimation in rats.
Nakagawa, H., Matsumura, T., Suzuki, K., Ninomiya, C., & Ishiwata, T.
(2016) Journal of Thermal Biology.
Changes in neurotransmitter levels and expression of immediate early genes in brain of mice infected with Neospora caninum.
Ihara, F., Nishimura, M., Muroi, Y., Furuoka, H., Yokoyama, N., & Nishikawa, Y.
(2016) Scientific Reports, 6.
Monoamine oxidase-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia–reperfusion in rats.
Inagaki, T., Akiyama, T., Du, C. K., Zhan, D. Y., Yoshimoto, M., & Shirai, M.
(2016) Free Radical Research, (just-accepted), 1-32.
Artificially reared mice exhibit anxiety-like behavior in adulthood.
YASUDA, H., HARAUMA, A., KATO, M., OOTOMO, Y., HATANAKA, E., & MORIGUCHI, T.
(2016) Experimental Animals, (0).
Social Isolation-Induced Territorial Aggression in Male Offspring Is Enhanced by Exposure to Diesel Exhaust during Pregnancy.
Yokota, S., Oshio, S., Moriya, N., & Takeda, K.
(2016) PLOS ONE, 11(2), e0149737.
The influence of n-3 fatty acids on maternal behavior and brain monoamines in the perinatal period.
Harauma, A., Sagisaka, T., Horii, T., Watanabe, Y., & Moriguchi, T.
(2016) Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA).
Dopamine regulates termite soldier differentiation through trophallactic behaviours.
Yaguchi, H., Inoue, T., Sasaki, K., & Maekawa, K
(2016) Royal Society Open Science, 3(2), 150574.
The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem.
Moriyasu, K., Ichinose, T., Nakahata, A., Tanaka, M., Matsui, T., & Furuya, S.
(2016) International Journal of Peptides, 2016.
“Exercise leads to the re-emergence of the cholinergic/nestin neuronal phenotype within the medial septum/diagonal band and subsequent rescue of both hippocampal ACh efflux and spatial behavior.”
Hall, J. M., & Savage, L. M.
(2016) Experimental Neurology.
“Research Article The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem.”
Moriyasu, K., Ichinose, T., Nakahata, A., Tanaka, M., Matsui, T., & Furuya
Effect of spinal monoaminergic neuronal system dysfunction on pain threshold in rats, and the analgesic effect of serotonin and norepinephrine reuptake inhibitors
Tamano, R., Ishida, M., Asaki, T., Hasegawa, M., & Shinohara, S.
(2016) Neuroscience Letters.
Effects of soybean ingestion on pharmacokinetics of levodopa and motor symptoms of Parkinson’s disease—In relation to the effects of Mucuna pruriens.
Nagashima, Y., Kondo, T., Sakata, M., Koh, J., & Ito, H.
(2016) Journal of the Neurological Sciences.
Yokukansan, a Traditional Japanese Medicine, Enhances the L-DOPA-Induced Rotational Response in 6-Hydroxydopamine-Lesioned Rats: Possible Inhibition of COMT.
Ishida, Y., Ebihara, K., Tabuchi, M., Imamura, S., Sekiguchi, K., Mizoguchi, K., … & Ikarashi, Y.
(2016) Biological and Pharmaceutical Bulletin, 39(1), 104-113.
A Stress-related Peptide Bombesin Centrally Induces Frequent Urination through Brain Bombesin Receptor Types 1 and 2 in the Rat.
Shimizu, T., Shimizu, S., Higashi, Y., Nakamura, K., Yoshimura, N., & Saito, M.
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2015
Perinatal vs genetic programming of serotonin states associated with anxiety.
Altieri, S. C., Yang, H., O’brien, H. J., Redwine, H. M., Senturk, D., Hensler, J. G., & Andrews, A. M.
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Studies on Natural Low Molecular Mass Organic Compounds with Catalytic Activity.
触媒活性を有する低分子天然有機化合物に関する研究
(2015) Doctoral dissertation, School of Life and Environmental Sciences, University of Tsukuba.
“ANTI-SEMAPHORIN 3A ANTIBODY AND TREATMENT OF ALZHEIMER’S DISEASE AND INFLAMMATORY IMMUNE DISEASES USING SAME.”
Goshima, Y., Nakamura, F., Yamashita, N., Seo, H., Hashimoto, S., Murakami, K., … & Sasakura, Y.
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A 5‐HT2A/2C receptor agonist, 1‐(2, 5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane, mitigates developmental neurotoxicity of ethanol to serotonergic neurons.
Ishiguro, T., Sakata‐Haga, H., & Fukui, Y.
(2015) Congenital anomalies.
“MARKER FOR DEPRESSION, ASSAY METHOD, METHOD FOR DETERMINING DEPRESSION, SCREENING METHOD FOR ANTIDEPRESSANTS, AND KIT.”
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Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium.
Obata, T., & Nakashima, M.
(2015) European Journal of Pharmacology.
Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress.
Kato-Kataoka, A., Nishida, K., Takada, M., Suda, K., Kawai, M., Shimizu, K., … & Miyazaki, K.
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Sex-and SERT-Mediated Differences in Stimulated Serotonin Revealed by Fast Microdialysis.
Yang, H., Sampson, M. M., Senturk, D., & Andrews, A. M.
(2015) ACS Chemical Neuroscience.
Insular neural system controls decision-making in healthy and methamphetamine-treated rats.
Mizoguchi, H., Katahira, K., Inutsuka, A., Fukumoto, K., Nakamura, A., Wang, T., … & Yamada, K.
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Rab3 interacting molecule 3 mutations associated with autism alter regulation of voltage-dependent Ca 2+ channels.
Takada, Y., Hirano, M., Kiyonaka, S., Ueda, Y., Yamaguchi, K., Nakahara, K., … & Mori, Y.
(2015) Cell Calcium.
Chewing, Stress-Related Diseases, and Brain Function.
Kubo, K. Y., Chen, H., Liu, J. H., Zhou, X., & Darbin, O.
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Changes in free amino acid and monoamine concentrations in the chick brain associated with feeding behavior.
Tran, P. V., Chowdhury, V. S., Nagasawa, M., & Furuse, M.
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Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex.
Ueda, S., Niwa, M., Hioki, H., Sohn, J., Kaneko, T., Sawa, A., & Sakurai, T.
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GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.
Herman, M. A., Sidhu, H., Stouffer, D. G., Kreifeldt, M., Le, D., Cates-Gatto, C., … & Contet, C.
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Nicotinic receptor-dependent and-independent effects of galantamine, an acetylcholinesterase inhibitor, on the non-neuronal acetylcholine system in C2C12 cells.
Oikawa, S., Mano, A., Iketani, M., & Kakinuma, Y.
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Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice.
Hwa, L. S., Nathanson, A. J., Shimamoto, A., Tayeh, J. K., Wilens, A. R., Holly, E. N., … & Miczek, K. A.
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Reded prefrontal dopaminergic activity in valproic acid-treated mouse autism model.
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2013
Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis.
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Relief of hypersensivitity after nerve injury from systemic donepezil involves spinal cholinergic γ-aminobutyric acid mechanisms.
Kimura M, Hayashida K, Eisenach J, Saito S, Obata H.
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2012
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve insury.
Hayashida K, Kimura M, Yoshizumi M, Hobo S, Obata H, J Eisenach
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Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
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The roles of vesicular GABA transporter during embryonic development.
斉藤憲史, & サイトウ,ケンジ.
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2009
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
(2009) Brain Research 1260; 30-37
2008
Dopamine Release in the Ventromedial Hypothalamus of Growing Chickens Decreases when They are Fed a Lysine Devoid Diet
Ichijo A, Hayashi N, Fukuoka C, Hu JJ, Yoshizawa F, Sugahara K
(2008) The Journal of Poultry Science 45(4);281-286
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects.
Mitsushima D, Takase K, Funabashi T, Kimura F
(2008) Endocrinology;149(2):802-811. Epub 2007 Oct 25
Identification of glutamic acid decarboxylase gene and distribution of GABAergic nervous system in the planarian Dugesia japonica.
Nishimura K, Kitamura Y, Umesono Y, Takeuchi K, Takata K, Taniguchi T, Agata K
Neuroscience; 153(4):1103-1114. Epub 2008 Mar 22.
Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats.
Deyama S, Katayama T, Ohno A, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M
(2008) Journal of Neuroscience; 28(31):7728-7736
Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure.
Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H.
(2008) Toxicology and applied pharmacology Jan 15;226(2):192-198
2007
Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats.
Takase K, Mitsushima D, Funabashi T, Kimura F
(2007) Brain Research 1154:105-115. Epub 2007 Apr 5
Protein S-guanylation by the biological signal 8-nitroguanosine 3’,5’-cyclic monophosphate.
Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T
(2007) Nature Chemical Biology. Nov;3(11):727-735. Epub 2007 Sep 30.
Kynurenic acid leads, dopamine follows: a new case of volume transmission in the brain?
Wu HQ, Rassoulpour A, Schwarcz R
(2007) Journal of Neural Transmission 114(1):33-41. Epub 2006 Aug 24.
Disposition of protein-bound 3-nitrotyrosine in rat plasma analysed by a novel protocol for HPLC-ECD.
Hitomi YH, Okuda J, Nishino H, Kambayashi Y, Hibino Y, Takemoto K, Takigawa T, Ohno H, Taniguchi N, Ogino K
(2007) Journal of Biochemistry (Tokyo) 141(4):495-502. Epub 2007 Jan 29
Effect of lipid-hydroperoxide-induced oxidative stress on vitamin E, ascorbate and glutathione in the rabbit retina.
Kamegawa M, Nakanishi-Ueda T, Iwai S, Ueda T, Kosuge S, Ogura H, Sasuga K, Inagaki M, Watanabe M, Oguchi K, Yasuhara H, Armstrong D, Koide R
(2007) Ophthalmic Research 39(1):49-54. Epub 2006 Dec 11
Antidepressant administration modulates neural stem cell survival and serotoninergic differentiation through bcl-2.
Chen SJ, Kao CL, Chang YL, Yen CJ, Shui JW, Chien CS, Chen IL, Tsai TH, Ku HH, Chiou SH
(2007) Current Neurovascular Research; 4(1):19-29
Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers.
Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M
(2007) Regulatory Toxicology and Pharmacology; 47(1):19-28. Epub 2006 Aug 21.
Fluvastatin alters platelet aggregability in patients with hypercholesterolemia: possible improvement of intraplatelet redox imbalance via HMG-CoA reductase.
Haramaki N, Ikeda H, Takenaka K, Katoh A, Sugano R, Yamagishi S, Matsuoka H, Imaizumi T
(2007) Arteriosclerosis, Thrombosis, and Vascular Biology 27(6):1471-147.
2006
Ascorbic acid concentration in rabbit vitreous measured by microdialysis with HPLC-electrochemical detection before and after vitreous surgery.
Koide K, Zhang XM, Ohishi K, Usami Y, Hotta Y, Hiramitsu T
(2006) Experimental Eye Research 82(5):868-873
Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Dong HL, Fukuda S, Murata E, Zhu Z, Higuchi T
(2006) Anesthesiology 104(5):1023-1032
Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats.
Sasaki M, Obata H, Kawahara K, Saito S, Goto F
(2006) Pain 122(1-2):130-136
Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum.
Kawasaki T, Ishihara K, Ago Y, Nakamura S, Itoh S, Baba A, Matsuda T
(2006) European Journal of Pharmacology 542(1-3):92-99. Epub 2006 May 17
Up-regulation of microglial CD11b expression by nitric oxide.
Roy A, Fung YK, Liu X, Pahan K
(2006) The Journal of Biological Chemistry 281(21):14971-1480. Epub 2006 Mar 20
Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.
Dong HL, Fukuda S, Murata E, Higuchi T
(2006) Anesthesiology 104(1):122-133
Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions.
De Leonibus E, Verheij MM, Mele A, Cools A
(2006) European Journal of Neuroscience 23(5):1332-1340
The effects of blood feeding and exogenous supply of tryptophan on the quantities of xanthurenic acid in the salivary glands of Anopheles stephensi (Diptera: Culicidae).
Okech B, Arai M, Matsuoka H
(2006) Biochemical and Biophysical Research Communication 341(4):1113-1118
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T
(2006) Journal of Neuroscience 26(2):398-405
Epinephrine increases the extracellular lidocaine concentration in the brain: a possible mechanism for increased central nervous system toxicity.
Takahashi R, Oda Y, Tanaka K, Morishima HO, Inoue K, Asada A
(2006) Anesthesiology 105(5):984-989
Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats.
Mitsushima D, Yamada K, Takase K, Funabashi T, Kimura F|
(2006) European Journal of Neuroscience 24(11):3245-3254
Detection of Genotoxic Nucleosides, 8-Hydroxydeoxyguanosine, 8-Hydroxyguanosine and Free Base 8-Hydroxyguanine, in Fish Food Products.
Kawai K, Svoboda P, Kasai H
(2006) Genes and Environment 28(3) 120-122
2005
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice.
Morishima Y, Miyakawa T, Furuyashiki T, Tanaka Y, Mizuma H, Nakanishi S
(2005) Proceedings of the National Academy of Sciences USA (PNAS) 102: 4170-4175
Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats.
Jamal M, Ameno K, Wang W, Kumihashi M, Ameno S, Ikuo U, Shinji A, Ijiri I
(2005) Brain Research 1039(1-2):90-96
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.
Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, Iida H, Itoh N, Nakatsuji N, Sasai Y, Hashimoto N
(2005) The Journal of Clinical Investigation 115: 102-109
Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers.
Morita H, Ikeda H, Haramaki N, Eguchi H, Imaizumi T
(2005) Journal of the American College of Cardiology 45: 589-594
A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats.
Kamiya Y, Ohta Y, Imai Y, Arisawa T, Nakano H
(2005) World Journal of Gastroenterology 11: 1324-1332
Expression of acetylcholine (ACh) and ACh-synthesizing activity in Archaea.
Yamada T, Fujii T, Kanai T, Amo T, Imanaka T, Nishimasu H, Wakagi T, Shoun H, Kamekura M, Kamagata Y, Kato T, Kawashima K
(2005) Life Sciences 77: 1935-1944
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F
(2005) Neuroscience 136: 593-599
Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats.
Masuda J, Mitsushima D, Funabashi T, Kimura F
(2005) Neuroscience 132: 537-542
Striatal dopamine level increases in the urinary storage phase in cats: an in vivo microdialysis study.
Yamamoto T, Sakakibara R, Hashimoto K, Nakazawa K, Uchiyama T, Liu Z, Ito T, Hattori T.
(2005) Neuroscience 135: 299-303
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M
(2005) British Journal of Pharmacology 145(8):1035-1044
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F
(2005) Neuroscience 136(2):593-9. Epub 2005 Oct 13
2004
Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats.
Yamato T, Misumi Y, Yamasaki S, Kino M, Aomine M
(2004) Diabetes, Nutrition & Metabolism 17: 128-136
Brain microdialysis study of the effects of hazardous chemicals on the central nervous system 2. Toluene exposure and cerebral acetylcholine.
Honma T, Suda M
(2004) Industrial Health 42(3):336-347
Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study.
Kino M, Yamato T, Aomine M
(2004) Neurochemistry International 44: 65-73
Serotonin modifies the sensitivity of the male silkmoth to pheromone.
Gatellier L, Nagao T, Kanzaki R
(2004) The Journal of Experimental Biology. 207: 2487-2496
Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL.
Shim JW, Koh HC, Chang MY, Roh E, Choi CY, Oh YJ, Son H, Lee YS, Studer L, Lee SH
(2004) Journal of Neuroscience 24: 843-852
Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.
Okamura N, Hashimoto K, Shimizu E, Kumakiri C, Komatsu N, Iyo M
(2004) Neuropsychopharmacology 29: 544-550
7Alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.
Matsunaga M, Ukena K, Baulieu EE, Tsutsui K
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 17282-17287
Hypericum perforatum L (St John’s wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.
Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Muller WE, Ogren SO, Kehr J
(2004)British Journal of Pharmacology 142: 414-418
Sexual dimorphism of GABA release in the medial preoptic area and luteinizing hormone release in gonadectomized estrogen-primed rats.
Tin-Tin-Win-Shwe, Mitsushima D, Shinohara K, Kimura F
(2004) Neuroscience 127(1):243-250
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Shen, H. W., Hagino, Y., Kobayashi, H., Shinohara-Tanaka, K., Ikeda, K., Yamamoto, H., … & Uhl, G. R.
(2004). Neuropsychopharmacology, 29(10), 1790-1799.
2003
Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion.
Narita M, Mizuo K, Mizoguchi H, Sakata M, Narita M, Tseng LF, Suzuki T
(2003) Journal of Neuroscience 23: 1006-1012
Reversible suppression of glutamatergic neurotransmission of cerebellar granule cells in vivo by genetically manipulated expression of tetanus neurotoxin light chain.
Yamamoto M, Wada N, Kitabatake Y, Watanabe D, Anzai M, Yokoyama M, Teranishi Y, Nakanishi S
(2003) Journal of Neuroscience 23: 6759-6767
A flow injection biosensor system for highly sensitive detection of 2,4,6-trichlorophenol based on preoxidation by ceric sulfate.
Yao T, Kotegawa K.
(2003) Analytical Sciences Jun;19(6):829-833.
Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion.
Narita M, Mizuo K, Mizoguchi H, Sakata M, Narita M, Tseng LF, Suzuki T
(2003) Journal of Neuroscience 23: 1006-1012
In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis.
Jamal M, Ameno K, Kubota T, Ameno S, Zhang X, Kumihashi M, Ijiri I
(2003) Alcohol & Alcoholism 38: 197-201
Improvement by repeated administration of 6R-tetrahydrobiopterin of 5,7-dihydroxytryptamine-induced abnormal behaviors in immature rats.
Mizuma H, Mizutani M, Nozaki S, Iizuka H, Tohyama H, Nishimura N, Watanabe Y, Kohashi R
(2003) Biochemical and Biophysical Research Communications 302: 156-161
Detection of 3-methoxy-4-hydroxyphenylglycol in rabbit skeletal muscle microdialysate.
Tokunaga N, Yamazaki T, Akiyama T, Mori H
(2003) Journal of Chromatography B 798: 163-166
Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures.
Koizumi S, Fujishita K, Tsuda M, Shigemoto-Mogami Y, Inoue K
(2003) Proceedings of the National Academy of Sciences USA (PNAS) 100: 11023-11028
Ascorbate enhances iNOS activity by increasing tetrahydrobiopterin in RAW 264.7 cells.
Nakai K, Urushihara M, Kubota Y, Kosaka H
(2003) Free Radical Biology & Medicine 35: 929-937
Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.
Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M
(2003) Psychopharmacology (Berl) 170: 80-88
An immnosuppressive drug, cyclosporine-A acts like anti-depressant for rats under unpredictable chronic stress.
Fujisaki C, Utsuyama M, Kuroda Y, Watanabe A, Seidler H, Watanabe S, Kitagawa M, Hirokawa K
(2003) Journal of Medical and Dental Sciences 50: 93-100
Sex differences in the stress-induced release of acetylcholine in the hippocampus and corticosterone from the adrenal cortex in rats.
Mitsushima D, Masuda J, Kimura F.
(2003) Neuroendocrinology 78(4):234-240
2002
Roles of brain prostaglandin E2 and thromboxane A2 in the activation of the central sympatho-adrenomedullary outflow in rats.
Murakami Y, Okada S, Nishihara M, Yokotani K
(2002) European Journal of Pharmacology 452: 289-294
Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level: comparison with a spectroscopic assay.
Hiraku Y, Murata M, Kawanishi S
(2002) Biochimica et Biophysica Acta 1570: 47-52
Relationship between oxidation of glutathione and reactive nitrogen species during the early-reperfusion phase of cerebral ischemia.
Iijima T, Sakamoto H, Okada C, Iwao Y
(2002) Neurochemical Research 27: 497-500
Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems.
Matsuda Y, Hirano H, Watanabe Y
(2002) Brain Research 937: 58-65
Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide.
Mizutani H, Tada-Oikawa S, Hiraku Y, Oikawa S, Kojima M, Kawanishi S
(2002) Journal of Biological Chemistry 277: 30684-30689
Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate).
Tottori K, Nakai M, Uwahodo Y, Miwa T, Yamada S, Oshiro Y, Kikuchi T, Altar CA
(2002) The Journal of Pharmacology and Experimental Therapeutics 301: 249-257
Cliniconeuropathologic findings of familial frontal lobe epilepsy in Shetland sheepdogs.
Morita T, Shimada A, Takeuchi T, Hikasa Y, Sawada M, Ohiwa S, Takahashi M, Kubo N, Shibahara T, Miyata H, Ohama E
(2002) The Canadian Journal of Veterinary Research 66: 35-41
GABA release in the medial preoptic area of cyclic female rats.
Mitsushima D, Shwe TT, Funabashi T, Shinohara K, Kimura F
(2002) Neuroscience 113: 109-114
Profiles of in vivo gamma-aminobutyric acid release in the medial preoptic area of intact and castrated male rats.
Tin-Tin-Win-Shwe, Mitsushima D, Kimura F.
(2002) Neuroendocrinology 76(5):290-296
2001
beta-Phenylethlamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D2 receptor mechanism.
Kato M, Ishida K, Chuma T, Abe K, Shigenaga T, Taguchi K, Miyake T
(2001) European Journal of Pharmacology 418: 65-71
Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca2+ – and K+ -evoked serotonin release.
Kawata Y, Okada M, Murakami T, Kamata A, Zhu G, Kaneko S
(2001) British Jourmal of Pharmacology 133: 557-567
Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine.
Hatip-Al-Khatib I, Mishima K, Iwasaki K, Fujiwara M
(2001) Brain Research 902: 108-118
Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study.
Hatip-Al-khati I, Bolukbasi F, Mishima K, Egashira N, Iwasaki K, Fujiwara
(2001) Japanese Journal of Pharmacology 87: 277-287
Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats.
Suzuki S, Yamatoya H, Sakai M, Kataoka A, Furushiro M, Kudo S
(2001) Journal of Nutrition 131:2951-2956
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neuroscience Letters 306: 206-208
Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.
Kishi T, Hirooka Y, Sakai K, Shigematsu H, Shimokawa H, Takeshita A
(2001) Hypertension 38: 896-901
Normalization of elevated hepatic 8-hydroxy-2’-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet.
Kato J, Kobune M, Nakamura T, Kuroiwa G, Takada K, Takimoto R, Sato Y, Fujikawa K, Takahashi M, Takayama T, Ikeda T, Niitsu Y
(2001) Cancer Research 61: 8697-8702
Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo.
Matsuo I, Hirooka Y, Hironaga K, Eshima K, Shigematsu H, Shihara M, Sakai K, Takeshita A
(2001) The American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 280: R1285-1291
Adenosine Receptor Subtypes Modulate Two Major Functional Pathways for Hippocampal Serotonin Release.
Okada M, Nutt DJ, Murakami T, Zhu G, Kamata A, Kawata Y, Kaneko S
(2001) The Journal of Neuroscience 21: 628-640
Monitoring of extracellular dopamine levels in the dorsal striatum and the nucleus accumbens with 5-minute on-line microdialysis in freely moving rats.
Saigusa T, Fusa K, Okutsu H, Koshikawa N
(2001) Journal of Oral Science 43: 129-134
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Negishi H, Ikeda K, Nara Y, Yamori Y
(2001) Neurosci Letters 306: 206-208
Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs.
Yamasaki T, Tamai I, Matsumura Y
(2001) American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 280: R1450-R1456
Effects of bradykinin on renal nerve stimulation-induced antidiuresis and norepinephrine overflow in anesthetized dogs.
Tadano K, Yamasaki T, Matsumura Y
(2001) Jounal of Cardiovascular Pharmacology 37: 461-470
Role of brain arachidonic acid cascade on central CRF1 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
Yokotani K, Murakami Y, Okada S, Hirata M
(2001) European Journal of Pharmacology 419: 183-189
Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia.
Anzawa N, Kushikata T, Ohkawa H, Yoshida H, Kubota T, Matsuki A
(2001) Canadian Journal of Anaesthesia 48: 462-465
Long-term smoking causes nitroglycerin resistance in platelets by depletion of intraplatelet glutathione.
Haramaki N, Ikeda H, Takajo Y, Katoh A, Kanaya S, Shintani S, Haramaki R, Murohara T, Imaizumi T
(2001) Arteriosclerosis, Thrombosis, and Vascular Biology 21: 1852-1856
2000
Reserpine Pretreatment Prevents Increase in Extracellular Striatal Dopamine Following L-DOPA Administration in Rats with Nigrostriatal Denervation.
Kannari K, Tanaka H, Maeda T, Tomiyama M, Suda T, Matsunaga M
(2000) Journal of Neurochemistry 74: 263-269
Preferable Monosodium Glutamate and Sodium Chloride Solutions do not Affect Diurnal Norepinephrine Release in the Rat Lateral Hypothalamus.
Smriga M, Torii K
(2000) Nutritional Neuroscience 3: 367-372
Presynaptic L-type Ca2+ channels on excessive dopamine release from rat caudate putamen.
Okita M, Watanabe Y, Taya K, Utsumi H, Hayashi T
(2000) Physiology & Behavior 68: 641-649
Fatal Severe Vasospasm Due to Rewarming Following Hypothermia -Case Report-
Jimbo H, Dohi K, Nakamura Y, Izumiyama H, Ikeda Y, Matsumoto K, Kushima M, Takaki A
(2000) Neurologia medico-chirurgica 40: 463-466
Interleukin-4-dependent induction of preproenkephalin in antigen-specific T helper-type 2 (Th2) cells.
Yahata T, Yahata C, Ohta A, Sekimoto M, Kitamura H, Iwakabe K, Habu S, Azuma S, Nakui M, Sato M, Koda T, Nishimura T
(2000) Journal of Neuroimmunology 105: 103-108
Brain phospholipase A(2)-arachidonic acid cascade is involved in the activation of central sympatho-adrenomedullary outflow in rats.
Yokotani K, Wang M, Murakami Y, Okada S, Hirata M
(2000) European Journal of Pharmacology 398: 341-347
Vasopressin regulation of noradrenaline release within the supraoptic nucleus.
Ludwig M, Onaka T, Yagi K
(2000) Journal of Neuroendocrinology 12: 477-479
1999
Nitric Oxide Synthase Inhibitors Induce Motor Abnormality in Mice.
Mizutani, H., Araki, T., Matsubara, M., Imai, Y., Mizugaki, M., & Itoyama, Y.
(1999)
Neuroprotective Effects of Monoamine Oxidase Inhibitor and Glutamate Receptor Inhibitor on MPTP-induced Dopamine and DOPAC Depletion in Mice
Kumagai, T., Kosaka, R., Ido, T., Araki, T., Imai, Y., Mizugaki, M., & Itoyama, Y.
(1999)
Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia.
Ohtani N, Sugano T, Ohta M
(1999) Brain Research 842: 6-14
Effect of selegiline on dopamine concentration in the striatum of a primate.
Kaseda S, Nomoto M, Iwata S
(1999) Brain Research 815: 44-50
Modification of acetylcholine release by nociceptin in conscious rat striatum.
Itoh K, Konya H, Takai E, Masuda H, Nagai K
(1999) Brain Research 845: 242-245
1998
Liquid chromatographic determination of myocardial interstitial epinephrine.
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Inagaki M, Alexander J, Sunagawa K
Journal of chromatography B 714: 375-378 (1998)
1997
Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats.
Murakami Y, Matsumoto K, Watanabe H
(1997) Biological & Pharmaceutical Bulletin 20: 88-90
High-performance liquid chromatographic determination of myocardial interstitial dihidroxyphenylglycol.
Takauchi Y, Kitagawa H, Kaeada T, Akiyama T, Yamazaki T
(1997) Journal of Chromatography B 693: 218-221
1995
Routine high-performance liquid chromatographic determination of myocardial interstitial norepinephrine.
Yamazaki T, Akiyama T, Shindo T
(1995) Journal of Chromatography B 670: 328-331
Elevation of plasma noradrenaline levels in urethane-anaesthetized rats by activation of central prostanoid EP3 receptors.
Yokotani K, Nishihara M, Murakami Y, Hasegawa T, Okuma Y, Osumi Y
(1995) British Journal of Pharmacology 115: 672-676
1991
Pineal microdialysis in freely moving rats.
Azekawa T, Sano A, Sei H, Yamamoto A, Aoi K, Morita Y
(1991) Brain Research Bulletin 26(3):413-417
1990
Concurrent on-line sampling of melatonin in pineal microdialysates from conscious rat and its analysis by high-performance liquid chromatography with electrochemical detection.
Azekawa T, Sano A, Aoi K, Sei H, Morita Y
(1990) Journal of Chromatography 530(1):47-55
Acethylcholine Analysis
Reduction of acetylcholine in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
Kondo-Takuma, Y., Mizuno, M., Tsuda, Y., Madokoro, Y., Suzuki, K., Sato, T., … & Matsukawa, N.
(2021). Scientific Reports, 11(1), 1-9.
Substantial acetylcholine reduction in multiple brain regions of Mecp 2-deficient female rats and associated behavioral abnormalities. Murasawa, H., Kobayashi, H., Imai, J., Nagase, T., Soumiya, H., & Fukumitsu, H.
(2021). PLOS ONE, 16(10), e0258830.
Improvement of analytical results quality in neuroscience–Good Methodology Practice in the acetylcholine determination.
Świt, P., Herian, M., & Gołembiowska, K.
(2021). Microchemical Journal, 106404.
Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications.
Saw, E. L., Pearson, J. T., Schwenke, D. O., Munasinghe, P. E., Tsuchimochi, H., Rawal, S., … & Katare, R.
(2021). Cardiovascular Diabetology, 20(1), 1-16.
Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction.
Kellis, D. M., Kaigler, K. F., Witherspoon, E., Fadel, J. R., & Wilson, M. A.
(2020). Neurobiology of Stress, 100279.
Effects of Intranasal Orexin-A (Hypocretin-1) Administration on Neuronal Activation, Neurochemistry, and Attention in Aged Rats.
Calva, C. B., Fayyaz, H., & Fadel, J. R.
(2020). Frontiers in Aging Neuroscience, 11, 362.
Increased cholinergic response in α-synuclein transgenic mice (h-α-synL62).
König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., … & Klein, J.
(2018) ACS Chemical Neuroscience.
Nicotinic receptor-dependent and-independent effects of galantamine, an acetylcholinesterase inhibitor, on the non-neuronal acetylcholine system in C2C12 cells.
Oikawa, S., Mano, A., Iketani, M., & Kakinuma, Y.
(2015) International Immunopharmacology.
Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic γ-aminobutyric acid mechanisms.
Kimura M, Hayashida K, Eisenach J, Saito S, Obata H.
(2013) Anesthesiology 118;173-80
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve insury.
Hayashida K, Kimura M, Yoshizumi M, Hobo S, Obata H, J Eisenach.
Anesthesiology, 117;389-98 (2012)
Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.
Yano K, Koda K, Ago Y, Kobayashi H, Kawasaki T, Takuma K, Matsuda T
(2009) British Journal of Pharmacology 156(1):173-180.
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects.
Mitsushima D, Takase K, Funabashi T, Kimura F
(2008) Endocrinology;149(2):802-811. Epub 2007 Oct 25
Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Dong HL, Fukuda S, Murata E, Zhu Z, Higuchi T
(2006) Anesthesiology 104(5):1023-1032
Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.
Dong HL, Fukuda S, Murata E, Higuchi T
(2006) Anesthesiology 104(1):122-133
Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats.
Jamal M, Ameno K, Wang W, Kumihashi M, Ameno S, Ikuo U, Shinji A, Ijiri I
(2005) Brain Research 1039(1-2):90-96
Expression of acetylcholine (ACh) and ACh-synthesizing activity in Archaea.
Yamada T, Fujii T, Kanai T, Amo T, Imanaka T, Nishimasu H, Wakagi T, Shoun H, Kamekura M, Kamagata Y, Kato T, Kawashima K
(2005) Life Sciences 77: 1935-1944
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F
(2005) Neuroscience 136: 593-599
Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats.
Masuda J, Mitsushima D, Funabashi T, Kimura F
(2005) Neuroscience 132: 537-542
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M.
(2005) British Journal of Pharmacology 145(8):1035-1044
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats.
Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F.
(2005) Neuroscience 136(2):593-9. Epub 2005 Oct 13
Brain microdialysis study of the effects of hazardous chemicals on the central nervous system 2. Toluene exposure and cerebral acetylcholine.
Honma T, Suda M
(2004) Industrial Health 42(3):336-347
Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.
Okamura N, Hashimoto K, Shimizu E, Kumakiri C, Komatsu N, Iyo M
(2004) Neuropsychopharmacology 29: 544-550
Increase of hippocampal acetylcholine release at the onset of dark phase is suppressed in a mutant mice model of evening-type individuals.
Sei H, Sano A, Oishi K, Fujihara H, Kobayashi H, Ishida N, Morita Y
(2003) Neuroscience 117: 785-789
Sex differences in the stress-induced release of acetylcholine in the hippocampus and corticosterone from the adrenal cortex in rats.
Mitsushima D, Masuda J, Kimura F.
(2003) Neuroendocrinology 78(4):234-240
Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release.
Mitsushima D, Funabashi T, Shinohara K, Kimura F
(2003) Psychoneuroendocrinology 28(4):574-583
Effects of brief ischaemia on myocardial acetylcholine and noradrenaline levels in anaesthetized cats
Kawada T, Yamazaki T, Akiyama T, Mori H, Inagaki M, Shishido T, Takaki H, Sugimachi M, Sunagawa K
(2002) Autonomic Neuroscience 95: 37-42
Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems.
Matsuda Y, Hirano H, Watanabe Y
(2002) Brain Research 937: 58-65
Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate).
Tottori K, Nakai M, Uwahodo Y, Miwa T, Yamada S, Oshiro Y, Kikuchi T, Altar CA
(2002) The Journal of Pharmacology and Experimental Therapeutics 301: 249-257
â-Phenylethlamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D2 receptor mechanism
Kato M, Ishida K, Chuma T, Abe K, Shigenaga T, Taguchi K, Miyake T
(2001) European Journal of Pharmacology 418: 65-71
Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats.
Suzuki S, Yamatoya H, Sakai M, Kataoka A, Furushiro M, Kudo S
(2001) Journal of Nutrition 131:2951-2956
Vagosympathetic interactions in ischemia-induced myocardial norepinephrine and acetylcholine release.
Kawada T, Yamazaki T, Akiyama T, Inagaki M, Shishido T, Zheng C, Yanagiya Y, Sugimachi M, Sunagawa K
(2001) American Journal of Physiology – Heart and Circulatory Physiology 280: H216-H221
In vivo assessment of acetylcholine-releasing function at cardiac vagal nerve terminals.
Kawada T, Yamazaki T, Akiyama T, Shishido T, Inagaki M, Uemura K, Miyamoto T, Sugimachi M, Takaki H, Sunagawa K
(2001) American Journal of Physiology – Heart and Circulatory Physiology 281: H139-H145
Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarnic M1 receptor stimulation
Murakami Y, Ikenoya M, Matsumoto K, Li H, Watanabe H
(2000) Behavioural Brain Research 109: 83-90
Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Takaki H, Sugimachi M, Sunagawa K
(2000) Journal of Molecular and Cellular Cardiology 32: 405-414
The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral hippocampus in rats.
Mishima K, Iwasaki K, Tsukikawa H, Matsumoto Y, Egashira N, Abe K, Egawa T, Fujiwara M.
(2000) Japanese Journal of Pharmacology 84: 163-173
Modification of acetylcholine release by nociceptin in conscious rat striatum
Itoh K, Konya H, Takai E, Masuda H, Nagai K
(1999) Brain Research 845: 242-245
Restriction of environmental space attenuates locomotor activity and hippocampal acetylcholine release in male rats.
Mitsushima D, Yamanoi C, Kimura F
(1998) Brain Research 805: 207-212
Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats
Murakami Y, Matsumoto K, Watanabe H
(1997) Biological & Pharmaceutical Bulletin 20: 88-90
Monoamine (NE, DA and/or 5-HT) Analysis
Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys.
Hori, Y., Mimura, K., Nagai, Y., Hori, Y., Kumata, K., Zhang, M. R., … & Minamimoto, T.
(2023). bioRxiv, 2023-02.
Caste-specific storage of dopamine-related substances in the brains of four Polistes paper wasp species.
Sasaki, K., Yoshimura, H., & Nishimura, M.
(2023). Plos one, 18(1), e0280881.
Trace Amine-Associated Receptor 2 Is Expressed in the Limbic Brain Areas and Is Involved in Dopamine Regulation and Adult Neurogenesis.
Efimova, E. V., Kuvarzin, S. R., Mor, M. S., Katolikova, N. V., Shemiakova, T. S., Razenkova, V., … & Gainetdinov, R. R.
(2022). Frontiers in Behavioral Neuroscience.
Optogenetic Stimulation of Midbrain Dopamine Neurons Produces Striatal Serotonin Release.
Dagher, M., Perrotta, K. A., Erwin, S. A., Hachisuka, A., Iyer, R., Masmanidis, S. C., … & Andrews, A. M.
(2022). ACS Chemical Neuroscience.
The dual role of dopamine in the modulation of information processing in the prefrontal cortex underlying social behavior.
Sotoyama, H., Inaba, H., Iwakura, Y., Namba, H., Takei, N., Sasaoka, T., & Nawa, H.
(2022). The FASEB Journal, 36(2), e22160.
Levels of dopamine, 5-hydroxytryptamine and their metabolites in the striatum of rats of various strains receiving a high-calorie diet.
Apryatin, S., Efimova, E., Fesenko, Z., Shumakova, A., & Gmoshinski, I.
(2021). Biological Communications, 66(4), 326-332.
Simultaneous serotonin and dopamine monitoring across timescales by rapid pulse voltammetry with partial least squares regression.5-HT2B Receptors-triggered Serotonin Release from Guinea-pig Isolated Colonic Mucosa: a Role of Endogenous Peptide YY.
Kojima, K., Kojima, S. I., & Fujita, T.
(2021). Dokkyo Journal of Medical Sciences, 48(2), 81-86.
Ninjin’yoeito, a traditional Japanese medicine, increases dopamine content in PC12 cells.
Miyazaki, S., Omiya, Y., & Mizoguchi, K.
(2021). Bioscience, Biotechnology, and Biochemistry.
Monitoring Neuronal Dynamics in the Ventral Tegmental Area Using an Implantable Microimaging Device With Microdialysis System.
Sunaga, Y., Ohta, Y., Murakami, T. E., Akay, Y. M., Ohta, J., & Akay, M.
(2021). IEEE Access, 9, 55871-55878.
Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons.
Yamane, M., Takaoka, N., Obara, K., Shirai, K., Aki, R., Hamada, Y., … & Amoh, Y.
(2021). Cells, 10(4), 864.
Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain.
Sasaki, K., Yokoi, K., & Toga, K.
(2021). Scientific Reports, 11(1), 1-14.
Intracranial mast cells contribute to the control of social behavior in male mice.
Tanioka, D., Chikahisa, S., Shimizu, N., Shiuchi, T., Sakai, N., Nishino, S., & Séi, H.
(2021). Behavioural Brain Research, 113143
Reduction of dopamine and glycogen synthase kinase-3 signaling in rat striatum after repeated administration of haloperidol.
Kimura, M., Oda, Y., Kimura, H., Nangaku, M., Hirose, Y., Niitsu, T., … & Iyo, M.
(2021). Pharmacology Biochemistry and Behavior, 173114.
Beta-blockade Prevents Coronary Macro and Microvascular Dysfunction Induced by a High Salt Diet and Insulin Resistance in the Goto-Kakizaki Rat.
Pearson, J., Thambyah, H. P., Waddingham, M. T., Inagaki, T., Sukumaran, V., Ngo, J. P., … & Shirai, M.
(2021). Clinical Science.
Difference in the brain serotonin and its metabolite level and anxiety-like behavior between forced and voluntary exercise conditions in rats.
Matsunaga, D., Nakagawa, H., & Ishiwata, T.
(2020). Neuroscience Letters, 135556.
Dopamine production in the brain is associated with caste-specific morphology and behavior in an artificial intermediate honey bee caste.
Sasaki, K., & Harada, M.
(2020). PloS one, 15(12), e0244140.
Increased dopamine transmission and adult neurogenesis in trace amine-associated receptor 5 (TAAR5) knockout mice.
Efimova, E. V., Kozlova, A. A., Razenkova, V., Katolikova, N. V., Antonova, K. A., Sotnikova, T. D., … & Musienko, P. E.
(2020). Neuropharmacology, 108373.
Comparison of neurotransmitter levels, physiological conditions, and emotional behavior between isolation‐housed rats with group‐housed rats.
Kaneda, Y., Kawata, A., Suzuki, K., Matsunaga, D., Yasumatsu, M., & Ishiwata, T.
(2020). Developmental Psychobiology.
Frontal Cortical Monoamine Release, Attention, and Working Memory in a Perinatal Nicotine Exposure Mouse Model Following Kappa Opioid Receptor Antagonism.
Zhang, L., McCarthy, D. M., Eskow Jaunarajs, K. L., Biederman, J., Spencer, T. J., & Bhide, P. G.
(2020). Cerebral Cortex.
Monoamine and genome-wide DNA methylation investigation in behavioral addiction.
Asaoka, Y., Won, M., Morita, T., Ishikawa, E., Lee, Y. A., & Goto, Y.
(2020). Scientific Reports, 10(1), 1-11.
Synaptotagmin-1 is the Ca 2+ sensor for fast striatal dopamine release.
Aditi, B., Lee, J., Changliang, L., & Kaeser, P. S.
(2020). eLife, 9.
The antagonistic activity profile of naloxone in μ-opioid receptor agonist-induced psychological dependence.
Nakamura, A., Yasufuku, K., Shimada, S., Aritomi, H., Furue, Y., Chiba, H., … & Shimada, T.
(2020). Neuroscience Letters, 135177.
Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats.
Steece-Collier, K., Collier, T. J., Lipton, J. W., Stancati, J. A., Winn, M. E., Cole-Strauss, A., … & Sortwell, C. E.
(2020). Experimental Neurology, 113327.
Depression‐related disturbances in rat maternal behaviour are associated with altered monoamine levels within mesocorticolimbic structures.
Winokur, S. B., Lopes, K. L., Moparthi, Y., & Pereira, M.
(2019). Journal of neuroendocrinology, 31(9), e12766.
5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism.
Ago, Y., Tanabe, W., Higuchi, M., Tsukada, S., Tanaka, T., Yamaguchi, T., … & Nakazawa, T.
(2019). International Journal of Neuropsychopharmacology, 22(10), 665-674.
Effect of Yokukansan and Yokukansankachimpihange on Aggressive Behavior, 5-HT Receptors and Arginine Vasopressin Expression in Social Isolation-Reared Mice.
Iba, H., Watanabe, T., Matsuzawa, K., Saimiya, M., Tanaka, M., Nagao, M., … & Iwasaki, K.
(2019). Biological and Pharmaceutical Bulletin, 42(12), 2009-2015.
Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia‐reperfusion in the rat heart in vivo.
Sonobe, T., Akiyama, T., Du, C. K., & Pearson, J. T.
(2019). Physiological Reports, 7(22).
Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats.
Takeshita, N., Kawade, N., Suzuki, W., Hara, S., Horio, F., & Ichinose, H.
(2019). Neuroscience Letters, 134656.
Pharmacological Discrimination of Effects of MK801 on Thalamocortical, Mesothalamic, and Mesocortical Transmissions.
Okada, M., Fukuyama, K., Nakano, T., & Ueda, Y.
(2019). Biomolecules, 9(11), 746.
Monoamine oxidase polymorphisms in rhesus and Japanese macaques (Macaca mulatta and M. fuscata).
Jones, D. N., Ruiz, C., Raghanti, M. A., Tosi, A. J., Tanaka, H., & Goto, Y.
(2019). Journal of Chemical Neuroanatomy, 101726.
Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus.
Okada, M., Fukuyama, K., Okubo, R., Shiroyama, T., & Ueda, Y.
(2019). Pharmaceuticals, 12(4), 149.
Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy.
Li, R., & Chen, J.
(2019). Oxidative Medicine and Cellular Longevity, 2019.
Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats.
Shokry, I. M., Shields, C. J., Callanan, J. J., Ma, Z., & Tao, R.
(2019). BMC Pharmacology and Toxicology, 20(1), 1-13.
Putative Trace-Amine Associated Receptor 5 (TAAR5) Agonist α-NETA Increases Electrocorticogram Gamma-Rhythm in Freely Moving Rats.
Belov, D. R., Efimova, E. V., Fesenko, Z. S., Antonova, K. A., Kolodyazhny, S. F., Lakstygal, A. M., & Gainetdinov, R. R.
(2019). Cellular and Molecular Neurobiology, 1-11.
Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons.
Wang, H. L., Zhang, S., Qi, J., Wang, H., Cachope, R., Mejias-Aponte, C. A., … & Cheer, J. F.
(2019). Cell Reports, 26(5), 1128-1142.
Dopamine in the hippocampal dentate gyrus modulates spatial learning via D1-like receptors.
Wang, F., Wan, P., Wang, W., Xiao, B., Jin, H., & Jin, Q.
(2018) Brain research bulletin.
Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve.
Ayabe, T., Ohya, R., Taniguchi, Y., Shindo, K., Kondo, K., & Ano, Y.
(2018) Scientific Reports, 8(1), 15372.
A Neural Circuit for Gut-Induced Reward.
Han, W., Tellez, L. A., Perkins, M. H., Perez, I. O., Qu, T., Ferreira, J., … & Kaelberer, M. M.
(2018) Cell.
Mesolimbic Dopamine, Its Receptors and Social Learning
Matta, R.
(2018) (Doctoral dissertation, NOVA Science Publishers).
Novel lacto-peptides in fermented dairy products improve memory function and cognitive decline.
Ano, Y., Ayabe, T., Kutsukake, T., Ohya, R., Takaichi, Y., Uchida, S., … & Nakayama, H.
(2018) Neurobiology of Aging.
Manipulation of dopamine metabolism contributes to attenuating innate high locomotor activity in ICR mice.
Yamaguchi, T., Nagasawa, M., Ikeda, H., Kodaira, M., Minaminaka, K., Chowdhury, V. S., … & Furuse, M.
(2017) Behavioural Brain Research SreeTestContent1.
CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.
Hirose, M., Hasegawa, A., Mochida, K., Matoba, S., Hatanaka, Y., Inoue, K., … & Abe, K.
(2017) Scientific Reports, 7, 42476.
Effects of the 5-HT 6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex.
Mørk, A., Russell, R. V., de Jong, I. E., & Smagin, G.
(2017) European Journal of Pharmacology.
Effect of spinal monoaminergic neuronal system dysfunction on pain threshold in rats, and the analgesic effect of serotonin and norepinephrine reuptake inhibitors
Tamano, R., Ishida, M., Asaki, T., Hasegawa, M., & Shinohara, S.
(2016) Neuroscience Letters.
Chewing, Stress-Related Diseases, and Brain Function.
Kubo, K. Y., Chen, H., Liu, J. H., Zhou, X., & Darbin, O.
(2015) BioMed Research International, 2015.
Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain.
Navratilova, E., Xie, J. Y., Meske, D., Qu, C., Morimura, K., Okun, A., … & Porreca, F.
(2015). The Journal of Neuroscience,, 35(18), 7264-7271.
DSP‐1053, a novel serotonin reuptake inhibitor with 5‐HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats.
Kato, T., Matsumoto, Y., Yamamoto, M., Matsumoto, K., Baba, S., Nakamichi, K., … & Yabuuchi, K.
(2015). Pharmacology Research & Perspectives, 3(3).
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
(2009) Brain Research 1260; 30-37
Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.
Yano K, Koda K, Ago Y, Kobayashi H, Kawasaki T, Takuma K, Matsuda T
(2009) British Journal of Pharmacology 156(1):173-180.
Dopamine Release in the Ventromedial Hypothalamus of Growing Chickens Decreases when They are Fed a Lysine Devoid Diet.
Ichijo A, Hayashi N, Fukuoka C, Hu JJ, Yoshizawa F, Sugahara K
(2008) The Journal of Poultry Science 45(4);281-286
Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats.
Deyama S, Katayama T, Ohno A, Nakagawa T, Kaneko S, Yamaguchi T, Yoshioka M, Minami M
(2008) Journal of Neuroscience; 28(31):7728-7736
Maternal attenuation of hypothalamic paraventricular nucleus norepinephrine switches avoidance learning to preference learning in preweanling rat pups.
Shionoya K, Moriceau S, Bradstock P, Sullivan RM.
(2007) Hormones and Behavior 52(3):391-400. Epub 2007 Jun 29
Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats.
Sasaki M, Obata H, Kawahara K, Saito S, Goto F
(2006) Pain 122(1-2):130-136
Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum.
Kawasaki T, Ishihara K, Ago Y, Nakamura S, Itoh S, Baba A, Matsuda T.
(2006) European Journal of Pharmacology 542(1-3):92-99. Epub 2006 May 17
Up-regulation of microglial CD11b expression by nitric oxide.
Roy A, Fung YK, Liu X, Pahan K.
(2006) The Journal of Biological Chemistry 281(21):14971-1480. Epub 2006 Mar 20
Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions.
De Leonibus E, Verheij MM, Mele A, Cools A
(2006) European Journal of Neuroscience 23(5):1332-1340
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T
(2006) Journal of Neuroscience 26(2):398-405
Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats.
Mitsushima D, Yamada K, Takase K, Funabashi T, Kimura F.
(2006) European Journal of Neuroscience 24(11):3245-3254
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice.
Morishima Y, Miyakawa T, Furuyashiki T, Tanaka Y, Mizuma H, Nakanishi S
(2005) Proceedings of the National Academy of Sciences USA (PNAS) 102: 4170-4175
Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex.
Ago Y, Nakamura S, Baba A, Matsuda T
(2005) Neuropsychopharmacology 30: 43-51
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.
Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, Iida H, Itoh N, Nakatsuji N, Sasai Y, Hashimoto N
(2005) The Journal of Clinical Investigation 115: 102-109
Striatal dopamine level increases in the urinary storage phase in cats: an in vivo microdialysis study.
Yamamoto T, Sakakibara R, Hashimoto K, Nakazawa K, Uchiyama T, Liu Z, Ito T, Hattori T.
(2005) Neuroscience 135: 299-303
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.
Fusa K, Takahashi I, Watanabe S, Aono Y, Ikeda H, Saigusa T, Nagase H, Suzuki T, Koshikawa N, Cools AR
(2005) Neuroscience 130(3):745-755
Contribution of vesicular and cytosolic dopamine to the increased striatal dopamine efflux elicited by intrastriatal injection of dexamphetamine.
Watanabe S, Aono Y, Fusa K, Takada K, Saigusa T, Koshikawa N, Cools AR
(2005) Neuroscience 136(1):251-257
Effects of alpha-methyl-p-tyrosine on extracellular dopamine levels in the nucleus accumbens and the dorsal striatum of freely moving rats.
Watanabe S, Fusa K, Takada K, Aono Y, Saigusa T, Koshikawa N, Cools AR
(2005) Journal of Oral Science 47(4):185-190
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Narita M, Kishimoto Y, Ise Y, Yajima Y, Misawa K, Suzuki T
(2005) Neuropsychopharmacology 30(1):111-118
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M.
(2005) British Journal of Pharmacology 145(8):1035-1044
Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats.
Yamato T, Misumi Y, Yamasaki S, Kino M, Aomine M
(2004) Diabetes, Nutrition & Metabolism 17: 128-136
Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.
Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, He J, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC, Nabeshima T
(2004) Journal of Neuroscience 24: 2212-2225
The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.
Nagai T, Yamada K, Yoshimura M, Ishikawa K, Miyamoto Y, Hashimoto K, Noda Y, Nitta A, Nabeshima T
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 3650-3655
Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study.
Kino M, Yamato T, Aomine M
(2004) Neurochemistry International 44: 65-73
Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson’s disease.
Kurosaki R, Muramatsu Y, Kato H, Araki T
(2004) Pharmacology, Biochemistry and Behavior 78: 143-153
Serotonin modifies the sensitivity of the male silkmoth to pheromone.
Gatellier L, Nagao T, Kanzaki R
(2004) The Journal of Experimental Biology. 207: 2487-2496
Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL.
Shim JW, Koh HC, Chang MY, Roh E, Choi CY, Oh YJ, Son H, Lee YS, Studer L, Lee SH
(2004) Journal of Neuroscience 24: 843-852
7alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.
Matsunaga M, Ukena K, Baulieu EE, Tsutsui K
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 17282-17287
Hypericum perforatum L (St John’s wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.
Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Muller WE, Ogren SO, Kehr J
(2004) British Journal of Pharmacology 142: 414-418
Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine.
Shioda K, Nisijima K, Yoshino T, Kato S
(2004) Progress in Neuro-Psychopharmacology & Biological Psychiatry 28: 633-640
Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation.
Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y, Tajima N, Yamada H, Sawada H, Ishikawa H, Mimura T, Kitada M, Suzuki Y, Ide C.
(2004) The Journal of Clinical Investigation 113(12):1701-1710
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Shen HW, Hagino Y, Kobayashi H, Shinohara-Tanaka K, Ikeda K, Yamamoto H, Yamamoto T, Lesch KP, Murphy DL, Hall FS, Uhl GR, Sora I.
(2004) Neuropsychopharmacology 29(10):1790-1799
Effects of repetitive transcranial magnetic stimulation on behavioral and neurochemical changes in rats during an elevated plus-maze test.
Kanno M, Matsumoto M, Togashi H, Yoshioka M, Mano Y
(2003) Journal of Neurological Sciences 211: 5-14
Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion.
Narita M, Mizuo K, Mizoguchi H, Sakata M, Narita M, Tseng LF, Suzuki T
(2003) Journal of Neuroscience 23: 1006-1012
Implication of Rho-associated kinase in the elevation of extracellular dopamine levels and its related behaviors induced by methamphetamine in rats.
Narita M, Takagi M, Aoki K, Kuzumaki N, Suzuki T
(2003) Journal of Neurochemistry 86: 273-282
Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion.
Narita M, Mizuo K, Mizoguchi H, Sakata M, Narita M, Tseng LF, Suzuki T
(2003) Journal of Neuroscience 23: 1006-1012
An immnosuppressive drug, cyclosporine-A acts like anti-depressant for rats under unpredictable chronic stress.
Fujisaki C, Utsuyama M, Kuroda Y, Watanabe A, Seidler H, Watanabe S, Kitagawa M, Hirokawa K
(2003) Journal of Medical and Dental Sciences 50: 93-100
Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex.
Maeda J, Suhara T, Okauchi T, Semba J
(2003) Neuroscience Letters 336: 171-174
In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis.
Jamal M, Ameno K, Kubota T, Ameno S, Zhang X, Kumihashi M, Ijiri I
(2003) Alcohol & Alcoholism 38: 197-201
Improvement by repeated administration of 6R-tetrahydrobiopterin of 5,7-dihydroxytryptamine-induced abnormal behaviors in immature rats.
Mizuma H, Mizutani M, Nozaki S, Iizuka H, Tohyama H, Nishimura N, Watanabe Y, Kohashi R
(2003) Biochemical and Biophysical Research Communications 302: 156-161
Cerebral alterations in a MPTP-mouse model of Parkinson’s disease–an immunocytochemical study.
Muramatsu Y, Kurosaki R, Watanabe H, Michimata M, Matsubara M, Imai Y, Araki T
(2003) Journal of Neural Transmission 110: 1129-1144
Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.
Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M
(2003) Psychopharmacology (Berl) 170: 80-88
An immnosuppressive drug, cyclosporine-A acts like anti-depressant for rats under unpredictable chronic stress.
Fujisaki C, Utsuyama M, Kuroda Y, Watanabe A, Seidler H, Watanabe S, Kitagawa M, Hirokawa K
(2003) Journal of Medical and Dental Sciences 50: 93-100
Suppression of the morphine-induced rewarding effect in the rat with neuropathic pain: implication of the reduction in mu-opioid receptor functions in the ventral tegmental area.
Ozaki S, Narita M, Narita M, Iino M, Sugita J, Matsumura Y, Suzuki T
(2002) Journal of Neurochemistry 82: 1192-1198
Differential roles between dopaminergic and serotonergic systems on motor deficits in mice.
Mizutani H, Muramatsu Y, Araki T
(2002) Brain Pharmacology 1: 253-266
Effects of brief ischaemia on myocardial acetylcholine and noradrenaline levels in anaesthetized cats
Kawada T, Yamazaki T, Akiyama T, Mori H, Inagaki M, Shishido T, Takaki H, Sugimachi M, Sunagawa K
(2002) Autonomic Neuroscience 95: 37-42
Effects of moderate hypothermia on in situ cardiac sympathetic nerve endings
Kitagawa H, Akiyama T, Yamazaki T
(2002) Neurochemistry International 40: 235-242
Roles of brain prostaglandin E2 and thromboxane A2 in the activation of the central sympatho-adrenomedullary outflow in rats.
Murakami Y, Okada S, Nishihara M, Yokotani K
(2002) European Journal of Pharmacology 452: 289-294
Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359
Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice.
Ago Y, Sakaue M, Baba A, Matsuda T
(2002) Journal of Neurochemistry 83: 353-359
Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca2+ – and K+ -evoked serotonin release
Kawata Y, Okada M, Murakami T, Kamata A, Zhu G, Kaneko S
(2001) British Jourmal of Pharmacology 133: 557-567
Determination of serotonin in microdialysis samples from rat brain by microbore column liquid chromatography with post-column derivatization and fluorescence detection
Yoshitake T, Iizuka R, Kehr J, Nohta H, Ishida J, Yamaguchi M
(2001) Journal of Neuroscience Methods 109: 91-96
Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine.
Hatip-Al-Khatib I, Mishima K, Iwasaki K, Fujiwara M
(2001) Brain Research 902: 108-118
Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study.
Hatip-Al-khati I, Bolukbasi F, Mishima K, Egashira N, Iwasaki K, Fujiwara M
(2001) Japanese Journal of Pharmacology 87: 277-287
Differential effects of psychological stress on activation of the 5-hydroxytryptamine- and dopamine-containing neurons in the brain of freely moving rats.
Funada M, Hara C.
(2001) Brain Research 901(1-2):247-251
Adenosine Receptor Subtypes Modulate Two Major Functional Pathways for Hippocampal Serotonin Release.
Okada M, Nutt DJ, Murakami T, Zhu G, Kamata A, Kawata Y, Kaneko S
(2001) The Journal of Neuroscience 21: 628-640
Monitering of extracellular dopamine levels in the dorsal striatum and the nucleus accumbens with 5-minute on-line microdialysis in freely movin rats.
Saigusa T, Fusa K, Okutsu H, Koshikawa N
(2001) Journal of Oral Science 43: 129-134
Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum
Yamato H, Kannari K, Shen H, Suda T, Matsunaga M
(2001) Neuropharmacology and Neurotoxicology 12: 1123-1126
Activationof 5-HT1A but not 5-HT1B receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation
Kannnari K, Yamato H, Shen H, Tomiyama M, Suda T, Matsunaga M
(2001) Journal of Neurochemistry 76: 1346-1353
Myocardial interstitial norepinephrine and dihydroxyphenylglycol levels during ischemia and reperfusion
Akiyama T, Yamazaki T
(2001) Cardiovasclar Research 49: 78-85
Vagosympathetic interactions in ischemia-induced myocardial norepinephrine and acetylcholine release
Kawada T, Yamazaki T, Akiyama T, Inagaki M, Shishido T, Zheng C, Yanagiya Y, Sugimachi M, Sunagawa K
(2001) American Journal of Physiology – Heart and Circulatory Physiology 280: H216-H221
Effects of ketamine on in vivo cardiac sympathetic nerve endings
Kitagawa H, Yamazaki T, Akiyama T, Mori H, Sunagawa K
(2001) Journal of Cardiovascular Pharmacology 38 (Suppl. 1): S39-S42
Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs
Yamasaki T, Tamai I, Matsumura Y
American Journal of Physiology – Regulatory, Integrative and Comparative (2001) Physiology 280: R1450-R1456
Effects of bradykinin on renal nerve stimulation-induced antidiuresis and norepinephrine overflow in anesthetized dogs
Tadano K, Yamasaki T, Matsumura Y
(2001) Jounal of Cardiovascular Pharmacology 37: 461-470
Role of brain arachidonic acid cascade on central CRF1 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
Yokotani K, Murakami Y, Okada S, Hirata M
(2001) European Journal of Pharmacology 419: 183-189
Riluzole protects against MPTP-induced dopamine and DOPAC depletion in mice.
Kumagai T, Ido T, Araki T, Matsubara m, Imai Y
(2001) Biogenic Amines 16: 157-172
Neuroprotective effect of riluzole in MPTP-treated mice.
Araki T, Kumagai T, Tanaka K, Matsubara M, Kato H, Itoyama Y, Imai Y
(2001) Brain Research 918: 176-181
Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia.
Anzawa N, Kushikata T, Ohkawa H, Yoshida H, Kubota T, Matsuki A
(2001) Canadian Journal of Anaesthesia 48: 462-465
Xenon inhalation increases norepinephrine release from the anterior and posterior hypothalamus in rats.
Yoshida H, Kushikata T, Kubota T, Hirota K, Ishihara H, Matsuki A.
(2001) Canadian Journal of Anesthesia 48:651-655
Reserpine Pretreatment Prevents Increase in Extracellular Striatal Dopamine Following L-DOPA Administration in Rats with Nigrostriatal Denervation
Kannari K, Tanaka H, Maeda T, Tomiyama M, Suda T, Matsunaga M
(2000) Journal of Neurochemistry 74: 263-269
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.
Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, Nakanishi S, Nishikawa SI, Sasai Y
(2000) Neuron 28: 31-40
Preferable Monosodium Glutamate and Sodium Chloride Solutions do not Affect Diurnal Norepinephrine Release in the Rat Lateral Hypothalamus
Smriga M, Torii K
(2000) Nutritional Neuroscience 3: 367-372
Presynaptic L-type Ca2+ channels on excessive dopamine release from rat caudate putamen
Okita M, Watanabe Y, Taya K, Utsumi H, Hayashi T
(2000) Physiology & Behavior 68: 641-649
Selective Corticotropin-Releasing Factor Type 1 Receptor Antagonist Blocks Conditioned Fear-Induced Release of Noradrenaline in the Hypothalamic Paraventricular Nucleus of Rats
Otagiri A, Wakabayashi I, Shibasaki T
(2000) Journal of Neuroendocrinology 12: 1022-1026
Chronic adriamycin treatment impairs myocardial interstitial neuronal release of norepinephrine and epinephrine
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Sunagawa K
(2000) Journal of Cardiovascular Pharmacology 36 (Suppl. 2): S31-S34
Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Takaki H, Sugimachi M, Sunagawa K
(2000) Journal of Molecular and Cellular Cardiology 32: 405-414
Brain phospholipase A(2)-arachidonic acid cascade is involved in the activation of central sympatho-adrenomedullary outflow in rats.
Yokotani K, Wang M, Murakami Y, Okada S, Hirata M
(2000) European Journal of Pharmacology 398: 341-347
Vasopressin regulation of noradrenaline release within the supraoptic nucleus.
Ludwig M, Onaka T, Yagi K
(2000) Journal of Neuroendocrinology 12: 477-479
Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia
Ohtani N, Sugano T, Ohta M
(1999) Brain Research 842: 6-14
Effect of selegiline on dopamine concentration in the striatum of a primate
Kaseda S, Nomoto M, Iwata S
(1999) Brain Research 815: 44-50
Serotonin-mediated increases in the extracellular levels of beta-endorphin in the arcuate nucleus and nucleus accumbens: a microdialysis study.
Zangen A, Nakash R, Yadid G
(1999) Journal of Neurochemistry 73: 2569-2574
New antioxidant mixture for long term stability of serotonin, dopamine and their metabolites in automated microbore liquid chromatography with dual electrochemical detection
Thorré K, Pravda M, Sarre S, Ebinger G, Michotte Y
(1997) Journal of Chromatography B, 694: 297-303
Routine high-performance liquid chromatographic determination of myocardial interstitial norepinephrine
Yamazaki T, Akiyama T, Shindo T
(1995) Journal of Chromatography B 670: 328-331
Elevation of plasma noradrenaline levels in urethane-anaesthetized rats by activation of central prostanoid EP3 receptors.
Yokotani K, Nishihara M, Murakami Y, Hasegawa T, Okuma Y, Osumi Y
(1995) British Journal of Pharmacology 115: 672-676
Amino Acids
Relief of hypersensivitity after nerve injury from systemic donepezil involves spinal cholinergic γ-aminobutyric acid mechanisms.
Kimura M, Hayashida K, Eisenach J, Saito S, Obata H.
(2013) Anesthesiology 118;173-80
Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Yoshizumi M, Parker R, Esenach J, Hayashida K.
(2012) Anesthesiology 116:1347-53
Glutamate Enzymatic Assay
Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction.
Kellis, D. M., Kaigler, K. F., Witherspoon, E., Fadel, J. R., & Wilson, M. A.
(2020). Neurobiology of Stress, 100279.
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice.
Morishima Y, Miyakawa T, Furuyashiki T, Tanaka Y, Mizuma H, Nakanishi S
(2005) Proceedings of the National Academy of Sciences USA (PNAS) 102: 4170-4175
Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine.
Shioda K, Nisijima K, Yoshino T, Kato S
(2004) Progress in Neuro-Psychopharmacology & Biological Psychiatry 28: 633-640
Reversible suppression of glutamatergic neurotransmission of cerebellar granule cells in vivo by genetically manipulated expression of tetanus neurotoxin light chain.
Yamamoto M, Wada N, Kitabatake Y, Watanabe D, Anzai M, Yokoyama M, Teranishi Y, Nakanishi S
(2003) Journal of Neuroscience 23: 6759-6767
Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures.
Koizumi S, Fujishita K, Tsuda M, Shigemoto-Mogami Y, Inoue K
(2003) Proceedings of the National Academy of Sciences USA (PNAS) 100: 11023-11028
Glutathione
Fluvastatin alters platelet aggregability in patients with hypercholesterolemia: possible improvement of intraplatelet redox imbalance via HMG-CoA reductase.
Haramaki N, Ikeda H, Takenaka K, Katoh A, Sugano R, Yamagishi S, Matsuoka H, Imaizumi T
(2007) Arteriosclerosis, Thrombosis, and Vascular Biology 27(6):1471-147.
Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers.
Morita H, Ikeda H, Haramaki N, Eguchi H, Imaizumi T
(2005)Journal of the American College of Cardiology 45: 589-594
Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level: comparison with a spectroscopic assay.
Hiraku Y, Murata M, Kawanishi S
(2002) Biochimica et Biophysica Acta 1570: 47-52
Relationship between oxidation of glutathione and reactive nitrogen species during the early-reperfusion phase of cerebral ischemia.
Iijima T, Sakamoto H, Okada C, Iwao Y
(2002) Neurochemical Research 27: 497-500
Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide.
Mizutani H, Tada-Oikawa S, Hiraku Y, Oikawa S, Kojima M, Kawanishi S
(2002) Journal of Biological Chemistry 277: 30684-30689
Long-term smoking causes nitroglycerin resistance in platelets by depletion of intraplatelet glutathione.
Haramaki N, Ikeda H, Takajo Y, Katoh A, Kanaya S, Shintani S, Haramaki R, Murohara T, Imaizumi T
(2001) Arteriosclerosis, Thrombosis, and Vascular Biology 21: 1852-1856
8-OH-dG Analysis
Normalization of elevated hepatic 8-hydroxy-2′-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet.
Kato J, Kobune M, Nakamura T, Kuroiwa G, Takada K, Takimoto R, Sato Y, Fujikawa K, Takahashi M, Takayama T, Ikeda T, Niitsu Y
(2001) Cancer Research 61: 8697-8702
Fatal Severe Vasospasm Due to Rewarming Following Hypothermia -Case Report-
Jimbo H, Dohi K, Nakamura Y, Izumiyama H, Ikeda Y, Matsumoto K, Kushima M, Takaki A
(2000) Neurologia medico-chirurgica 40: 463-466
3-Nitrotyrosine
Wireless Neuroscience
EEG Logger
Fiber Photometry
2022
Locus Coeruleus-Noradrenergic Neurons Regulate Stress Coping During Subchronic Exposure to Social Threats: A Characteristic Feature in Postpartum Female Mice.
Nakamura, A., Muroi, Y., & Ishii, T.
(2022). Cellular and Molecular Neurobiology, 1-18.
Deconstruction of a hypothalamic astrocyte-white adipocyte sympathetic axis that regulates lipolysis in mice.
Chen, D., Qi, Y., Zhang, J., & Yang, Y.
(2022). Nature Communications, 13(1), 1-16.
A possible mechanism for development of working memory impairment in male mice subjected to inflammatory pain.
Papadogiannis, A., & Dimitrov, E.
(2022). Neuroscience.
Enhanced motor cortex output and disinhibition in asymptomatic female mice with C9orf72 genetic expansion.
Amalyan, S., Tamboli, S., Lazarevich, I., Topolnik, D., Bouman, L. H., & Topolnik, L.
(2022). Cell Reports, 40(1), 111043.
2021
Activation of septal OXTr neurons induces anxiety-but not depressive-like behaviors.
Huang, T., Guan, F., Licinio, J., Wong, M. L., & Yang, Y.
(2021). Molecular Psychiatry, 1-10.
The role of medial prefrontal cortex projections to locus ceruleus in mediating the sex differences in behavior in mice with inflammatory pain.
Cardenas, A., Papadogiannis, A., & Dimitrov, E.
(2021). The FASEB Journal, 35(7), e21747.
In-vivo Optogenetics
In-vitro Optogenetics
2023
n cellulo light‐induced dynamics in a BODIPY‐perylene dyad.
Yang, T., Arellano-Reyes, R. A., Curley, R. C., Jha, K. K., Chettri, A., Keyes, T. E., & Dietzek-Ivansic, B.
(2023). I Chemistry–A European Journal, e202300224.
Visible-Light-Controlled Histone Deacetylase Inhibitors for Targeted Cancer Therapy.
Josa-Culleré, L., & Llebaria, A.
(2023). Journal of medicinal chemistry.
2022
Caged-carvedilol as a new tool for visible-light photopharmacology of β-adrenoceptors in native tissues.
Duran-Corbera, A., Font, J., Faria, M., Prats, E., Consegal, M., Catena, J., … & Rovira, X.
(2022). iScience, 105128.
Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors.
Rifaie-Graham, O., Yeow, J., Najer, A., Wang, R., Sun, R., Zhou, K., … & Stevens, M.
(2022). Research Square
2021
Single-pixel imaging: An overview of different methods to be used for 3D space reconstruction in harsh environments.
Osorio Quero, C. A., Durini, D., Rangel-Magdaleno, J., & Martinez-Carranza, J.
(2021). Review of Scientific Instruments, 92(11), 111501.
Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations.
Nasrallah, C., Cannone, G., Briot, J., Rottier, K., Berizzi, A. E., Huang, C. Y., … & Lebon, G.
(2021). Cell Reports, 36(9), 109648.
Sunitinib with photoirradiation-mediated reactive oxygen species generation induces apoptosis of renal cell carcinoma cells.
Yamamoto, S., Nakayama, T., Seki, H., Kawada, C., Fukuhara, H., Karashima, T., … & Inoue, K.
(2021). Photodiagnosis and Photodynamic Therapy, 102427.
Chromatin mechanics dictates subdiffusion and coarsening dynamics of embedded condensates.
Lee, D. S., Wingreen, N. S., & Brangwynne, C. P.
(2021). Nature Physics, 17(4), 531-538.
2020
Light-Activated Antifungal Properties of Imidazolium-Functionalized Cationic Conjugated Polymers.
Jagadesan, P., Yu, Z., Barboza-Ramos, I., Lara, H. H., Vazquez-Munoz, R., López-Ribot, J. L., & Schanze, K. S.
(2020). Chemistry of Materials, 32(14), 6186-6196.
Photoswitchable antagonists for a precise spatiotemporal control of β2-adrenoceptors.
Duran Corbera, A., Catena, J., Otero Viñas, M., Llebaria, A., & Rovira, X.
(2020). Journal of Medicinal Chemistry.
Controlling the material properties and rRNA processing function of the nucleolus using light.
Zhu, L., Richardson, T. M., Wacheul, L., Wei, M. T., Feric, M., Whitney, G., … & Brangwynne, C. P.
(2019). Proceedings of the National Academy of Sciences, 116(35), 17330-17335.
Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress.
Westergard, T., McAvoy, K., Russell, K., Wen, X., Pang, Y., Morris, B., … & Haeusler, A.
(2019). EMBO molecular medicine, 11(2), e9423.
Nitrite and Nitrate Detection
NOx Analyzer, Model ENO-20/ENO-30
2023
Short-term beetroot juice supplementation improves muscle speed and power but does not reduce blood pressure or oxidative stress in 65–79 y old men and women.
Zoughaib, W. S., Hoffman, R. L., Yates, B. A., Moorthi, R. N., Lim, K., & Coggan, A. R.
(2023). Nitric Oxide.
Acute beetroot juice reduces blood pressure in young Black and White males but not females.
Grosicki, G. J., Flatt, A. A., Cross, B. L., Vondrasek, J. D., Blumenburg, W. T., Lincoln, Z. R., … & Robinson, A. T.
(2023). Redox Biology, 102718.
The influence of acute dietary nitrate supplementation on skeletal muscle fatigue and recovery in older women.
Zoughaib, W. S., Hoffman, R. L., Yates, B. A., Moorthi, R. N., Lim, K. L., & Coggan, A. R.
(2023). TmedRxiv, 2023-02.
Training-induced impairment of endothelial function in track and field female athletes.
Grandys, M., Majerczak, J., Frolow, M., Chlopicki, S., & Zoladz, J. A.
(2023). Scientific Reports, 13(1), 3502.
Perioperative water and electrolyte balance and water homeostasis regulation in children with acute surgery.
Roberts, D. N., Vallén, P., Cronhjort, M., Alfvén, T., Sandblom, G., Tönroth-Horsefield, S., … & Krmar, R. T.
(2023). Pediatric Research, 1-7.
Ginkgolide B caused the activation of the Akt/eNOS pathway through the antioxidant effect of SOD1 in the diabetic aorta.
Taguchi, K., Okudaira, K., Matsumoto, T., & Kobayashi, T.
(2023). Pflügers Archiv-European Journal of Physiology, 1-11.
2022
Clustering patients with gout based on comorbidities and biomarkers: A cross-sectional study.
Alduraibi, F., Saleem, M., Ricart, K., Patel, R. P., Szalai, A. J., & Singh, J. A.
(2022). The Journal of Rheumatology.
Ameliorative Effects of Beetroot Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats.
Tawa, M., Nagano, J., Kitama, J., Abe, S., Fujita, A., Nakagawa, K., & Ohkita, M.
(2022). Future Pharmacology, 2(4), 547-557.
Efficacy and Variability in Plasma Nitrite Levels during Long-Term Supplementation with Nitrate Containing Beetroot Juice.
Miller, G. D., Collins, S., Ives, J., Williams, A., Basu, S., Kim-Shapiro, D. B., & Berry, M. J.
(2022). Journal of Dietary Supplements, 1-26.
The Molecular Mechanism of Exercise for Treatment of Patients with Major Depression: A Preliminary Report on the Dynamics of Metabolites of Nitric Oxide and Catecholamines.
Ikenouchi, A., Okamoto, N., Igata, R., Natsuyama, T., & Yoshimura, R.
(2022). Journal of Integrative Neuroscience, 21(4), 123.
Alpha7 Nicotinic Acetylcholine Receptor Mediates Chronic Nicotine Inhalation-Induced Cardiopulmonary Dysfunction.
Whitehead, A. K., Fried, N. D., Li, Z., Neelamegam, K., Pearson, C. S., LaPenna, K. B., … & Yue, X.
(2022). Clinical Science.
On the origin of nitrosylated hemoglobin in COVID-19: Endothelial NO capture or redox conversion of nitrite? Experimental results and a cautionary note on challenges in translational research.
Nogueira, R. C., Minnion, M., Clark, A. D., Dyson, A., Tanus-Santos, J. E., & Feelisch, M.
(2022). Redox Biology, 102362.
Nitric oxide and long-term outcomes after kidney transplantation: Results of the TransplantLines cohort study.
Maassen, H., Said, M. Y., Frenay, A. R. S., Koning, A., Post, A., Riphagen, I. J., … & van Goor, H.
(2022). Nitric Oxide.
Beneficial Effects of Dietary Nitrite on a Model of Nonalcoholic Steatohepatitis Induced by High-Fat/High-Cholesterol Diets in SHRSP5/Dmcr Rats: A Preliminary Study.
Sonoda, K., Kono, Y., Kitamori, K., Ohtake, K., Shiba, S., Kasono, K., & Kobayashi, J.
(2022). International Journal of Molecular Sciences, 23(6), 2931.
Inorganic nitrate supplementation and blood flow restricted exercise tolerance in post-menopausal women.
Proctor, D. N., Neely, K. A., Mookerjee, S., Tucker, J., Somani, Y. B., Flanagan, M., … & Kim, D. J. K.
(2022). Nitric Oxide.
Tri-iodide and vanadium chloride based chemiluminescent methods for quantification of nitrogen oxides.
Basu, S., Ricart, K., Gladwin, M. T., Patel, R. P., & Kim-Shapiro, D. B.
(2022). Nitric Oxide.
Effect of fat reformulated dairy food consumption on postprandial flow-mediated dilatation and cardiometabolic risk biomarkers compared with conventional dairy: a randomized, controlled trial.
Markey, O., Vasilopoulou, D., Kliem, K. E., Fagan, C. C., Grandison, A. S., Sutton, R., … & Lovegrove, J. A.
(2022). The American Journal of Clinical Nutrition.
Influence of antidepressants on plasma levels of nitric oxide metabolites in patients with major depressive disorder.
Ikenouchi, A., Okamoto, N., Konno, Y., Fujii, R., Fujino, Y., & Yoshimura, R.
(2022). BJPsych Open, 8(1).
2021
The role of systemic endothelial dysfunction in an experimental model of aortic valve stenosis
Gyamfi Poku, I.
(2021). (Doctoral dissertation).
Dietary nitrate supplementation to enhance exercise capacity in hypoxic COPD: EDEN-OX, a double-blind, placebo-controlled, randomised cross-over study.
Pavitt, M. J., Lewis, A., Buttery, S. C., Fernandez, B. O., Mikus-Lelinska, M., Banya, W. A., … & Hopkinson, N. S.
(2021). Thorax.
Dietary nitrate supplementation to enhance exercise capacity in hypoxic COPD: EDEN-OX, a double-blind, placebo-controlled, randomised cross-over study.
Pavitt, M. J., Lewis, A., Buttery, S. C., Fernandez, B. O., Mikus-Lelinska, M., Banya, W. A., … & Hopkinson, N. S.
(2021). Thorax.
Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms.
Kato, K., Tsutsui, M., Noguchi, S., Iha, Y., Naito, K., Ogoshi, T., … & Yatera, K.
(2021). Scientific Reports, 11(1), 1-13.
Temporal relationship between systemic endothelial dysfunction and alterations in erythrocyte function in a murine model of chronic heart failure.
Mohaissen, T., Proniewski, B., Targosz‐Korecka, M., Bar, A., Kij, A., Bulat, K., … & Chlopicki, S.
(2021). Cardiovascular Research.
Oral administration of l-citrulline alters the vascular delivery of substances to rat skeletal muscles.
Miyatake, S., Hino, K., Ebisu, G., & Fujita, S.
(2021). Biochemistry and Biophysics Reports, 28, 101149.
Supplemental nitrite increases choroidal neovascularization in mice.
Qi, X., Ricart, K., Ahmed, K. A., Patel, R. P., & Boulton, M. E.
(2021). Nitric Oxide.
Balance of Drug Residence and Diffusion in Lacrimal Fluid Determine Ocular Bioavailability in In Situ Gels Incorporating Tranilast Nanoparticles.
Minami, M., Otake, H., Nakazawa, Y., Okamoto, N., Yamamoto, N., Sasaki, H., & Nagai, N.
(2021). Pharmaceutics, 13(9), 1425.
THE EFFECTS OF OXIDATIVE STRESS ON THE EYES OF SPRAGUE–DAWLEY RATS.
Pai, C. L., Chen, J. R., Lin, H. J., & Lin, S. L.
(2021). Taiwan Veterinary Journal, 1-12.
The effect of chlorhexidine mouthwash vs propolis mouthwash on the nitrate-reducing activity of oral bacteria and vascular control in healthy individuals.
Ellis, S.
(2021). The Plymouth Student Scientist – Volume 14 – 2021
Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure.
Leo, F., Suvorava, T., Heuser, S. K., Li, J., LoBue, A., Barbarino, F., … & Cortese-Krott, M. M.
(2021). Circulation.
Effects of vitamin D-induced supernatant of placental explants from preeclamptic women on oxidative stress and nitric oxide bioavailability in human umbilical vein endothelial cells.
Nunes, P. R., Gomes, V. J., Sandrim, V. C., Peraçoli, J. C., Peraçoli, M. T. S., & Carlström, M.
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Direct comparison of inorganic nitrite and nitrate on vascular dysfunction and oxidative damage in experimental arterial hypertension.
Stamm, P., Oelze, M., Steven, S., Kröller-Schön, S., Kvandova, M., Kalinovic, S., … & Münzel, T.
(2021). Nitric Oxide.
Liver circadian clock disruption alters perivascular adipose tissue gene expression and aortic function in mice.
Pati, P., Valcin, J. A., Zhang, D., Neder, T. H., Millender-Swain, T., Allan, J. M., … & Pollock, J. S.
(2021). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.
Preventive effects of nitrate-rich beetroot juice supplementation on monocrotaline-induced pulmonary hypertension in rats.
Tawa, M., Nagata, R., Sumi, Y., Nakagawa, K., Sawano, T., Ohkita, M., & Matsumura, Y.
(2021). Plos one, 16(4), e0249816.
Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO2) and nitroalkene (RNO2) substituents.
Fazzari, M., Woodcock, S. R., Rowart, P., Ricart, K., Lancaster Jr, J. R., Patel, R., … & Schopfer, F. J.
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Hydroxyurea Improves Nitric Oxide Bioavailability in Humanized Sickle Cell Mice.
Taylor, C. M., Kasztan, M., Sedaka, R. S., Molina, P. A., Dunaway, L. S., Pollock, J. S., & Pollock, D. M.
(2021). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.
Monocytes from preeclamptic women previously treated with silibinin attenuate oxidative stress in human endothelial cells.
Gomes, V. J., Rezeck Nunes, P., Haworth, S. M., Sandrim, V. C., Peraçoli, J. C., Peraçoli, M. T. S., & Carlström, M.
(2021). Hypertension in Pregnancy, 1-9.
2020
High salt intake induces collecting duct HDAC1-dependent NO signaling.
Sedaka, R. S., Hyndman, K. A., Mironova, E., Stockand, J. D., & Pollock, J. S.
(2020). American Journal of Physiology-Renal Physiology.
Potential role for age as a modulator of oral nitrate reductase activity.
Ahmed, K. A., Kim, K., Ricart, K., Van Der Pol, W., Qi, X., Bamman, M. M., … & O’Neal, P. V.
(2020). Nitric Oxide.
Simultaneous Pharmacokinetic Analysis of Nitrate and its Reduced Metabolite, Nitrite, Following Ingestion of Inorganic Nitrate in a Mixed Patient Population.
Coggan, A. R., Racette, S. B., Thies, D., Peterson, L. R., & Stratford, R. E.
(2020). Pharmaceutical Research, 37(12), 1-12.
Acute beetroot juice supplementation improves exercise tolerance and cycling efficiency in adults with obesity.
Behrens Jr, C. E., Ahmed, K., Ricart, K., Linder, B., Fernández, J., Bertrand, B., … & Fisher, G.
(2020). Physiological Reports, 8(19), e14574.
Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
Harper, S. A., Bassler, J. R., Peramsetty, S., Yang, Y., Roberts, L. M., Drummer, D., … & Bamman, M. M.
(2020). Experimental Gerontology, 111111.
Efficacy of resuscitative infusion with haemoglobin vesicles for severe postpartum haemorrhage in pregnant rabbits: An animal research study.
Ishibashi, H., Hagisawa, K., Kinoshita, M., Yuki, Y., Miyamoto, M., Sakai, H., … & Takano, M.
(2020). Authorea Preprints.
Leg heat therapy improves perceived physical function but does not enhance walking capacity or vascular function in patients with peripheral artery disease.
Monroe, J. C., Lin, C., Perkins, S. M., Han, Y., Wong, B. J., Motaganahalli, R. L., & Roseguini, B. T.
(2020). Journal of Applied Physiology.
Endothelial Cell Cystathionine γ‐Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury.
Xia, H., Li, Z., Sharp III, T. E., Polhemus, D. J., Carnal, J., Moles, K. H., … & Lefer, D. J.
(2020). Journal of the American Heart Association, e017544.
The nitric oxide dependence of cutaneous microvascular function to independent and combined hypoxic cold exposure.
Arnold, J. T., Lloyd, A. B., Bailey, S. J., Fujimoto, T., Matsukate, R., Takayanagi, M., … & Fujii, N.
(2020). Journal of Applied Physiology.
Plant polyphenols Morin and Quercetin rescue nitric oxide production in diabetic mouse aorta through distinct pathways.
Taguchi, K., Tano, I., Kaneko, N., Matsumoto, T., & Kobayashi, T.
(2020). Biomedicine & Pharmacotherapy, 129, 110463.
A randomized controlled trial of nitrate supplementation in well-trained middle and older-aged adults.
Berry, M. J., Miller, G. D., Kim-Shapiro, D. B., Fletcher, M. S., Jones, C. G., Gauthier, Z. D., … & Heinrich, T. M.
(2020). PloS one, 15(6), e0235047.
Anaemia is associated with severe RBC dysfunction and a reduced circulating NO pool: vascular and cardiac eNOS are crucial for the adaptation to anaemia.
Wischmann, P., Kuhn, V., Suvorava, T., Muessig, J. M., Fischer, J. W., Isakson, B. E., … & Cortese-Krott, M. M.
(2020). Basic Research in Cardiology, 115(4), 1-21.
Beetroot juice lowers blood pressure and improves endothelial function in pregnant eNOS−/− mice: importance of nitrate‐independent effects.
Tropea, T., Renshall, L. J., Nihlen, C., Weitzberg, E., Lundberg, J. O., David, A. L., … & Sibley, C. P.
(2020). The Journal of Physiology.
Unexpected effects of long-term treatment with acetylsalicylic acid on late phase of pulmonary metastasis in murine model of orthotopic breast cancer.
Smeda, M., Kij, A., Proniewski, B., Matyjaszczyk-Gwarda, K., Przyborowski, K., Jasztal, A., … & Sternak, M.
(2020). PLOS ONE, 15(4), e0230520.
“The role of dietary nitrate in regulation of blood pressure and metabolism.”
Sundqvist, M.
(2020). Doctoral Dissertation
Removal of nitrate and nitrite by hemodialysis in end-stage renal disease and by sustained low-efficiency dialysis in acute kidney injury.
Martinez, A. H., Diez, G. R., Ferraris, V., Coccia, P. A., Ferraris, J. R., Checa, A., … & Krmar, R. T.
(2020). Nitric Oxide.
A randomized clinical trial of the effects of leafy green vegetables and inorganic nitrate on blood pressure.
Sundqvist, M. L., Larsen, F. J., Carlström, M., Bottai, M., Pernow, J., Hellénius, M. L., … & Lundberg, J. O.
(2020). The American Journal of Clinical Nutrition.
“COMPOSITIONS AND METHODS FOR PROMOTING NITRIC OXIDE PRODUCTION THROUGH AN ORAL DELIVERY SYSTEM.”
Bryan, N. S.
(2020). U.S. Patent Application No. 16/598,649.
Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism.
Kline, J. A., Puskarich, M. A., Pike, J., Zagorski, J., & Alves, N. J.
(2020). Nitric Oxide.
Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice.
Zhang, D., Jin, C., Obi, I. E., Rhoads, M. K., Soliman, R. H., Sedaka, R. S., … & Pollock, D. M.
(2020). American Journal of Physiology-Renal Physiology.
Grape Extract from Chardonnay Seeds Restores Deoxycorticosterone Acetate–Salt-Induced Endothelial Dysfunction and Hypertension in Rats.
Sato, A., Nishioka, S., Kiuchi, M., Imada, Y., Makino, K., Nakagawa, K., … & Ohkita, M.
(2020). Biological and Pharmaceutical Bulletin, 43(1), 59-67.
2019
Anti- inflammatory effects of vitamin K in murine macrophages.
Kieronska, A., Tworzydlo, A., Chlopicki, S. (2019).
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“Beet-ing Muscle Dysfunction and Exercise Intolerance in Pulmonary Hypertension”
Long, G. M.
(2019). (Doctoral dissertation).
Glucagon-like peptide-1 increased the vascular relaxation response via AMPK/Akt signaling in diabetic mice aortas.
Taguchi, K., Bessho, N., Kaneko, N., Okudaira, K., Matsumoto, T., & Kobayashi, T.
(2019). European Journal of Pharmacology, 172776.
Preventive Effects of Grape Extract on Ischemia/Reperfusion-Induced Acute Kidney Injury in Mice.
Ohkita, M., Hayashi, H., Ito, K., Shigematsu, N., Tanaka, R., Tsutsui, H., & Matsumura, Y.
(2019). Biological and Pharmaceutical Bulletin, 42(11), 1883-1890.
Effects of dietary nitrate supplementation on microvascular physiology at 4559 m altitude–A randomised controlled trial (Xtreme Alps).
Cumpstey, A. F., Hennis, P. J., Gilbert-Kawai, E. T., Fernandez, B. O., Grant, D., Jenner, W., … & Meale, P.
(2019). Nitric Oxide.
Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans.
Ntessalen, M., Procter, N. E., Schwarz, K., Loudon, B. L., Minnion, M., Fernandez, B. O., … & Horowitz, J. D.
(2019). The American journal of clinical nutrition.
Frequency of Tongue Cleaning Impacts the Human Tongue Microbiome Composition and Enterosalivary Circulation of Nitrate.
Tribble, G. D., Angelov, N., Weltman, R., Wang, B. Y., Eswaran, S. V., Gay, I. C., … & Sharina, I. G.
(2019). Frontiers in Cellular and Infection Microbiology, 9, 39.
Impact of the Apolipoprotein E (epsilon) Genotype on Cardiometabolic Risk Markers and Responsiveness to Acute and Chronic Dietary Fat Manipulation.
Rathnayake, K. M., Weech, M., Jackson, K. G., & Lovegrove, J. A.
(2019). Nutrients, 11(9), 2044.
Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells.
Kopacz, A., Kloska, D., Proniewski, B., Cysewski, D., Personnic, N., Piechota-Polanczyk, A., … & Jozkowicz, A.
(2019). Redox Biology, 101304.
Effects of inorganic nitrate in a rat model of monocrotaline‐induced pulmonary arterial hypertension.
Malikova, E., Carlström, M., Kmecova, Z., Marusakova, M., Zsigmondova, B., Krenek, P., … & Henrohn, D.
(2019). Basic & Clinical Pharmacology & Toxicology.
Evaluation of a rat model of functional urinary bladder outlet obstruction produced by chronic inhibition of nitric oxide synthase.
Noguchi, K., Sugaya, K., Nishijima, S., Sakanashi, M., Kadekawa, K., Ashitomi, K., … & Yamamoto, H.
(2019). Life Sciences, 116772.
Mechanisms underlying the effects of propiverine on bladder activity in rats with pelvic venous congestion and urinary frequency.
NISHIJIMA, S., SUGAYA, K., KADEKAWA, K., ASHITOMI, K., UEDA, T., & YAMAMOTO, H.
(2019). Biomedical Research, 40(4), 145-152.
Troponin-T, NT-proBNP, and Serum Creatinine at Presentation Predict Outcomes in Patients with Cardiac Sarcoidosis.
Kolluri, N., Rosenbaum, A., Schmidt, T., Elwazir, M. Y., Cooper, L. T., Kapa, S., & Blauwet, L.
(2019). Journal of Cardiac Failure, 25(8), S22-S23.
Difference in Serological Marker Profile of Fontan Patients with Decompensated Heart Failure.
Nguyen, V., Li, S., & Buber, Y.
(2019). Journal of Cardiac Failure, 25(8), S23.
FGF-23 and Cardio-Renal Interactions in Heart Failure.
Stewart, B., Gomez, N., Barnett, J., Thomas, A., Wycallis, E., Pattoli, M., … & Mahoney, D.
(2019). Journal of Cardiac Failure, 25(8), S23-S24.
Plasma Cystine and Nitrite Levels are Synergistic Determinants of Arterial Stiffness and Mortality in Heart Failure.
Nayak, A., Dong, T., Steinberg, R., Udeshi, E., Lefer, D., Jones, D. P., … & Morris, A. A.
(2019). Journal of Cardiac Failure, 25(8), S23.
Post-exercise hypotension and skeletal muscle oxygenation is regulated by nitrate-reducing activity of oral bacteria.
Cutler, C., Kiernan, M., Willis, J. R., Gallardo-Alfaro, L., Casas-Agustench, P., White, D., … & Bescos, R.
(2019). Free Radical Biology and Medicine.
A single dose of dietary nitrate increases maximal knee extensor angular velocity and power in healthy older men and women.
Coggan, A. R., Hoffman, R. L., Gray, D. A., Moorthi, R. N., Thomas, D. P., Leibowitz, J. L., … & Peterson, L. R.
(2019) The Journals of Gerontology: Series A.
Effect of Spironolactone for One Year on Endothelial Function and Vascular Inflammation Biomarkers in Renal Transplant Recipients.
Mortensen, L. A., Bistrup, C., Stubbe, J., Carlström, M., Checa, A., Wheelock, C. E., … & Jensen, B. L.
(2019) American Journal of Physiology-Renal Physiology.
Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country.
Waheed, S., Kalsekar, A. G., Kamal, A. K., Bryan, N., & Mian, A. I.
(2019) Emergency Medicine International, 2019.
Biophysical regulation of thermodynamic effects on type 2 diabetes.
Belfield, L. T., Jeffers, A. B., Davis, A. T., Kavanagh, K., & Presley, T. D.
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“COMPOSITIONS AND METHODS FOR TREATING CARDIAC INJURY.”
Lefer, D. J., & Polhemus, D. J.
(2019) U.S. Patent Application No. 16/265,067.
Comparison of the effect of curing ingredients derived from purified and natural sources on inhibition of Clostridium perfringens outgrowth during cooling of deli-style turkey breast.
King, A. M., Glass, K. A., Milkowski, A. L., & Sindelar, J. J.
(2019) Journal of food protection, 78(8), 1527-1535.
Multiorgan Development of Oxidative and Nitrosative Stress in LPS-Induced Endotoxemia in C57Bl/6 Mice: DHE-Based In Vivo Approach.
Proniewski, B., Kij, A., Sitek, B., Kelley, E. E., & Chlopicki, S.
(2019) Oxidative Medicine and Cellular Longevity, 2019.
Hypothalamic impairment underlying heat intolerance in pregnant mice.
Lin, C. H., Chen, S. H., Chang, C. P., & Lin, K. C.
(2019) Molecular and Cellular Endocrinology.
Acute study of dose-dependent effects of (-)-epicatechin on vascular function in healthy male volunteers: a randomised controlled trial.
Alañón, M. E., Castle, S. M., Serra, G., Lévèques, A., Poquet, L., Actis-Goretta, L., & Spencer, J. P. E.
(2019) Clinical Nutrition.
The oral nitrate-reducing capacity correlates with peak power output and peak oxygen uptake in healthy humans.
Thomas, B., Smallwood, S., Cutler, C., & Bescos, R.
(2019) Nitric Oxide.
Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia.
Bos, M., Schoots, M. H., Fernandez, B. O., Mikus-Lelinska, M., Lau, L. C., Eikmans, M., … & Hoorn, M. L. P.
(2019) International Journal of Molecular Sciences, 20(5), 1150.
A combination of oral l-citrulline and l-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial.
Suzuki, I., Sakuraba, K., Horiike, T., Kishi, T., Yabe, J., Suzuki, T., … & Suzuki, Y.
(2019) European Journal of Applied Physiology, 1-10.
Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion.
Nishijima, S., Sugaya, K., Kadekawa, K., Ashitomi, K., Ueda, T., & Yamamoto, H.
(2019) International Journal of Urology.
Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia.
Rushing, A. M., Donnarumma, E., Polhemus, D. J., Au, K. R., Victoria, S. E., Schumacher, J. D., … & Goodchild, T. T.
(2019) Journal of Vascular Surgery.
Regulation and role of endoglin in cholesterol-induced endothelial and vascular dysfunction in vivo and in vitro.
Vicen, M., Vitverova, B., Havelek, R., Blazickova, K., Machacek, M., Rathouska, J., … & Bernabeu, C.
(2019) The FASEB Journal, fj-201802245R.
Proteomic characterization of early lung response to breast cancer metastasis in mice.
Kurpińska, A., Suraj, J., Bonar, E., Zakrzewska, A., Stojak, M., Sternak, M., … & Walczak, M.
(2019) Experimental and Molecular Pathology.
Pushing Arterial-Venous Plasma Biomarkers to New Heights: A Model for Personalised Redox Metabolomics?
Cumpstey, A. F., Minnion, M., Fernandez, B. O., Mikus-Lelinska, M., Mitchell, K., Martin, D. S., … & Xtreme Alps research group.
(2019) Redox Biology, 101113.
Effects of acute dietary nitrate supplementation on aortic blood pressures and pulse wave characteristics in post-menopausal women.
Kim, D. J. K., Roe, C. A., Somani, Y., Moore, D. J., Barrett, M. A., Flanagan, M., … & Proctor, D. N.
(2019) Nitric Oxide.
Inhaled nitric oxide to treat intermediate risk pulmonary embolism: A multicenter randomized controlled trial.
Kline, J. A., Puskarich, M. A., Jones, A. E., Mastouri, R. A., Hall, C. L., Perkins, A., … & Lahm, T.
(2019) Nitric Oxide.
2018
Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model.
Sonoda, K., Ohtake, K., Tagiri, M., Hirata, M., Tamada, H., Uchida, H., … & Kobayashi, J.
(2018) Biological and Pharmaceutical Bulletin, 41(12), 1818-1823.
HSP-70-Mediated Hyperbaric Oxygen Reduces Brain and Pulmonary Edema and Cognitive Deficits in Rats in a Simulated High-Altitude Exposure.
Wu, H. H., Niu, K. C., Lin, C. H., Lin, H. J., Chang, C. P., & Wang, C. T.
(2018) BioMed Research International, 2018.
What’s in Your Beet Juice? Nitrate and Nitrite Content of Beet Juice Products Marketed to Athletes.
Gallardo, E. J., & Coggan, A. R.
(2018) International journal of sport nutrition and exercise metabolism, 1-17.
Effects of Beet Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats.
Troutman, A. D., Gallardo, E. J., Brown, M. B., & Coggan, A. R.Ishima, Y., Watanabe, K., Chuang, V. T., Takeda, I., Tawa, M., Yano, Y., Yamanaka, M., Sawano, T., Iesaki, K., Murata, Y., … & Matsumura, Y.
(2018) American Journal of Hypertension.
S‐Nitrosated alpha‐1‐acid glycoprotein exhibits antibacterial activity against multidrug‐resistant bacteria strains and synergistically enhances the effect of antibiotics.
Troutman, A. D., Gallardo, E. J., Brown, M. B., & Coggan, A. R.Ishima, Y., Watanabe, K., Chuang, V. T., Takeda, I., Kuroda, T., Ogawa, W., … & Maruyama, T.
(2018) FASEB BioAdvances.
Measurement of nitrate and nitrite in biopsy-sized muscle samples using HPLC.
Troutman, A. D., Gallardo, E. J., Brown, M. B., & Coggan, A. R.
(2018) Journal of Applied Physiology.
Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: A randomised, double-blind, placebo-controlled feasibility trial.
Ormesher, L., Myers, J. E., Chmiel, C., Wareing, M., Greenwood, S. L., Tropea, T., … & Johnstone, E. D.
(2018) Nitric Oxide.
Platelet inhibitory effects of the Phase 3 anticancer and normal tissue cytoprotective agent, RR x‐001.
Oronsky, B., Oronsky, N., & Cabrales, P.
(2018) Journal of cellular and molecular medicine.
Nitric oxide alters hyaluronan deposition by airway smooth muscle cells.
Majors, A. K., Chakravarti, R., Ruple, L. M., Leahy, R., Stuehr, D. J., Lauer, M., … & Aronica, M. A.
(2018) PloS one, 13(7), e0200074.
Pulmonary Hypertension and the Nitric Oxide System.
HENROHN, D.
(2018) Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1461. 83
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Dual antiplatelet therapy with clopidogrel and aspirin increases mortality in 4T1 metastatic breast cancer-bearing mice by inducing vascular mimicry in primary tumour.
Buczek, C. W., Wietrzyk, J., & Chlopicki, S.
(2018) Oncotarget, 2018, Vol. 9, (No. 25), pp: 17810-17824
Spontaneously hypertensive rats exhibit higher sensitivity to ethanol-induced hypotensive effects: role of NMDA receptors and nitric oxide in rostral ventrolateral medulla.
Lin, H. H., Cheng, T. T., Lin, Y. C., & Lai, C. C.
(2018) Alcohol.
Hydroxyhydroquinone impairs fat utilization in mice by reducing nitric oxide availability.
Ishida, K., Misawa, K., Yamamoto, M., & Shimotoyodome, A.
(2018) The Journal of Physiological Sciences, 1-10.
Disruption of the pacemaker activity of interstitial cells of Cajal via nitric oxide contributes to postoperative ileus.
Kaji, N., Nakayama, S., Horiguchi, K., Iino, S., Ozaki, H., & Hori, M.
(2018) Neurogastroenterology & Motility.
“Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection.”
Erkens, R., Suvorava, T., Sutton, T. R., Fernandez, B. O., Mikus-Lelinska, M., Barbarino, F., … & Cortese-Krott, M. M.
Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes.
Taguchi, K., Bessho, N., Hasegawa, M., Narimatsu, H., Matsumoto, T., & Kobayashi, T.
(2018) Hypertension Research, 1.
Protective Role of Myelocytic Nitric Oxide Synthases Against Hypoxic Pulmonary Hypertension in Mice.
Ogoshi, T., Tsutsui, M., Kido, T., Sakanashi, M., Naito, K., Oda, K., … & Izumi, H.
(2018) American Journal of Respiratory and Critical Care Medicine, (ja).
Organ uptake and release of inorganic nitrate and nitrite in the pig.
Eriksson, K. E., Yang, T., Carlström, M., & Weitzberg, E.
(2018) Nitric Oxide.
Effects of Memantine on Nitric Oxide Production and Hydroxyl Radical Metabolism during Cerebral Ischemia and Reperfusion in Mice.
Tanaka, A., Ito, Y., Kawasaki, H., Kitabayashi, C., Nishioka, R., Yamazato, M., … & Yamamoto, T.
(2018) Journal of Stroke and Cerebrovascular Diseases.
Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.
Shimizu, Y., Polavarapu, R., Eskla, K. L., Nicholson, C. K., Koczor, C. A., Wang, R., … & Calvert, J. W.
(2018) Journal of Molecular and Cellular Cardiology, 116, 29-40
Negatively-charged aerosol improves burn wound healing by promoting eNOS-dependent angiogenesis.
Zhao, J., Zhou, F., Chen, L., Shu, B., Zhai, Q., Wu, J., … & Xu, Y.
(2018) Am J Transl Res, 10(1), 246-255.
Dietary nitrate‐induced increases in human muscle power: high versus low responders.
Coggan, A. R., Broadstreet, S. R., Mikhalkova, D., Bole, I., Leibowitz, J. L., Kadkhodayan, A., … & Peterson, L. R.
(2018). Physiological Reports, 6(2), e13575.
Angiotensin-(1-7)-induced Mas receptor activation attenuates atherosclerosis through a nitric oxide-dependent mechanism in apolipoproteinE-KO mice.
Yang, G., Istas, G., Höges, S., Yakoub, M., Hendgen-Cotta, U., Rassaf, T., … & Rump, L. C.
(2018). Pflügers Archiv-European Journal of Physiology, 1-7.
2017
Low-dose nitric oxide as targeted anti-biofilm adjunctive therapy to treat chronic Pseudomonas aeruginosa infection in cystic fibrosis.
Howlin, R. P., Cathie, K., Hall-Stoodley, L., Cornelius, V., Duignan, C., Allan, R. N., … & Kelso, M.
(2017). Molecular Therapy, 25(9), 2104-2116.
“Changes in arterial pressure and markers of nitric oxide homeostasis and oxidative stress following surgical correction of hydronephrosis in children.”
Al-Mashhadi, A., Checa, A., Wåhlin, N., Neveus, T., Fossum, M., Wheelock, C. E., … & Carlstrom, M.
(2017). Pediatric Nephrology, 1-11.
AFM-based detection of glycocalyx degradation and endothelial stiffening in the db/db mouse model of diabetes.
Zakrzewska, A., Gregorius, A., Sitek, B., Malek-Zietek, K. E., Jaglarz, M., Szymonski, M., … & Rajfur, Z.
(2017). Scientific Reports, 7(1), 15951.
“Clinical Trial Protocol A randomized double-blind placebo controlled cross-over trial of sodium nitrate in patients with stable angina. Inorganic Nitrate in Angina Study (INAS).”
Schwarz, K., Singh, S., Parasuraman, S. K., Bruce, M., Shepstone, L., Feelisch, M., … & Frenneaux, M.
(2017).
“Effect of Ammonium Chloride on the Methane-Oxidizing Bacterial Community 2.”
Kim, I. T., Ahn, K., Yoo, Y. S., & Kim, K. S.
(2017). Preprints
Development, validation and application of a micro–liquid chromatography–tandem mass spectrometry based method for simultaneous quantification of selected protein biomarkers of endothelial dysfunction in murine plasma.
Suraj, J., Kurpińska, A., Olkowicz, M., Niedzielska-Andres, E., Smolik, M., Zakrzewska, A., … & Walczak, M.
(2017). Journal of Pharmaceutical and Biomedical Analysis.
Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney.
Polhemus, D. J., Trivedi, R. K., Gao, J., Li, Z., Scarborough, A. L., Goodchild, T. T., … & Lefer, D. J.
(2017). Journal of the American College of Cardiology, 70(17), 2139-2153.
Breast cancer pulmonary metastasis is increased in mice undertaking spontaneous physical training in the running wheel; a call for revising beneficial effects of exercise on cancer progression.
Smeda, M., Przyborowski, K., Proniewski, B., Zakrzewska, A., Kaczor, D., Stojak, M., … & Chlopicki, S.
(2017). American Journal of Cancer Research, 7(9), 1926.
Protective effects of oral glutathione on fasting-induced intestinal atrophy through oxidative stress.
Uchida, H., Nakajima, Y., Ohtake, K., Ito, J., Morita, M., Kamimura, A., & Kobayashi, J.
(2017). World Journal of Gastroenterology, 23(36), 6650-6664.
25-Hydroxycholecalciferol–Fortified Dairy Drink Is More Effective at Raising a Marker of Postprandial Vitamin D Status than Cholecalciferol in Men with Suboptimal Vitamin D Status.
Guo, J., Jackson, K. G., Li, Y., Givens, D. I., & Lovegrove, J. A.
(2017). The Journal of Nutrition, jn254789.
Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats.
Murata, I., Abe, Y., Yaginuma, Y., Yodo, K., Kamakari, Y., Miyazaki, Y., … & Kobayashi, J.
(2017). Annals of Intensive Care, 7(1), 90
Intravenous superoxide dismutase as a protective agent to prevent impairment of lung function induced by high tidal volume ventilation.
Wu, N. C., Liao, F. T., Cheng, H. M., Sung, S. H., Yang, Y. C., & Wang, J. J.
(2017). BMC Pulmonary Medicine, 17(1), 105.
Co-administration of Magnesium Ion Prevents Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced Arthritis Rats.
Nagai, N., Ueno, A., Tanino, T., Oka, M., & Ito, Y.
(2017). Biological and Pharmaceutical Bulletin, 40(6), 910-915.
Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction.
Shaltout, H. A., Eggebeen, J., Marsh, A. P., Brubaker, P. H., Laurienti, P. J., Burdette, J. H., … & Morgan, T. M.
(2017). Nitric Oxide.
Synthesis and Characterization of a Novel Organic Nitrate NDHP: Role of Xanthine Oxidoreductase-Mediated Nitric Oxide Formation.
Zhuge, Z., Paulo, L. L., Jahandideh, A., Brandão, M. C., Athayde-Filho, P. F., Lundberg, J. O., … & Montenegro, M. F.
(2017). Redox Biology
Potential therapeutic action of nitrite in Sickle Cell Disease.
Wajih, N., Basu, S., Jailwala, A., Kim, H. W., Ostrowski, D., Perlegas, A., … & Rahbar, E.
(2017). Redox Biology
“Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition.”
Wandrag, Liesl, Mario Siervo, Heather L. Riley, Maryam Khosravi, Bernadette O. Fernandez, Carl A. Leckstrom, Daniel S. Martin et al.
(2017). Redox Biology
Dietary nitrite supplementation attenuates cardiac remodeling in l-NAME-induced hypertensive rats.
Sonoda, K., Ohtake, K., Uchida, H., Ito, J., Uchida, M., Natsume, H., … & Kobayashi, J.
(2017). Nitric Oxide.
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall.
Liu, X., El-Mahdy, M. A., Boslett, J., Varadharaj, S., Hemann, C., Abdelghany, T. M., … & Zweier, J. L.
(2017). Nature Communications, 8, 14807
“METHODS AND COMPOSITIONS FOR TREATING NITRIC OXIDE DEFICIENCY DISORDERS AND RELATED CONDITIONS.”
Giordano, A., & Lefer, D. J.
(2017). U.S. Patent No. 20,170,087,180. Washington, DC: U.S. Patent and Trademark Office.
Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.
Kina-Tanada, M., Sakanashi, M., Tanimoto, A., Kaname, T., Matsuzaki, T., Noguchi, K., … & Kubota, H.
(2017). Diabetologia, 1-14.
“Agent for preventing or ameliorating vascular endothelial malfunction.”
Morita, M., Komatsu, M., Hara, T.
(2017). United States Patent Application 20170042962
Inducible and neuronal nitric oxide synthases exert contrasting effects during rat intestinal recovery following fasting.
Ito, J., Uchida, H., Machida, N., Ohtake, K., Saito, Y., & Kobayashi, J.
(2017). Experimental Biology and Medicine, 1535370217694434.
Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1.
Lee, E. S., Boldo, L. S., Fernandez, B. O., Feelisch, M., & Harmsen, M. C.
(2017). Scientific Reports, 7, 42487.
Effects of nitrate supplementation in trained and untrained muscle is modest with initial high plasma nitrite levels.
Christensen, P. M., Petersen, N. K., Friis, S. N., Weitzberg, E., & Nybo, L.
(2017). Scandinavian Journal of Medicine & Science in Sports.
Validation of two point-of-care tests against standard lab measures of NO in saliva and in serum.
Modi, A., Morou-Bermudez, E., Vergara, J., Patel, R., Nichols, A., & Joshipura, K.
(2017). Nitric Oxide.
Acute improvement of endothelial functions after oral ingestion of isohumulones, bitter components of beer.
Tomita, J., Mochizuki, S., Fujimoto, S., Kashihara, N., Akasaka, T., Tanimoto, M., & Yoshida, K.
(2017). Biochemical and Biophysical Research Communications
2016
van der Graaf, A. M.
(2016)
Beetroot juice versus chard gel: A pharmacokinetic and pharmacodynamic comparison of nitrate bioavailability.
McIlvenna, L. C., Monaghan, C., Liddle, L., Fernandez, B. O., Feelisch, M., Muggeridge, D. J., & Easton, C.
(2016). Nitric Oxide.
Effects of chronic nitric oxide synthase inhibition on V’O2max and exercise capacity in mice.
Wojewoda, M., Przyborowski, K., Sitek, B., Zakrzewska, A., Mateuszuk, L., Zoladz, J. A., & Chlopicki, S.
(2016). Naunyn-Schmiedeberg’s Archives of Pharmacology, 1-10.
Genetic Overexpression of the Hydrogen Sulfide Producing Enzyme Cystathionine gama-Lyase in Endothelial Cells Enhances Hydrogen Sulfide and Nitric Oxide Signaling.
Li, Z., Polhemus, D. J., Organ, C. L., Elrod, J. W., & Lefer, D. J.
(2016). Circulation, 134(Suppl 1), A17911-A17911.
Single and Combined Effects of Beetroot Crystals and Sodium Bicarbonate on 4-km Cycling Time Trial Performance.
Callahan, M. J., Parr, E. B., Hawley, J. A., & Burke, L. M.
(2016). International Journal of Sport Nutrition and Exercise Metabolism.
Profound differences between humans and rodents in the ability to concentrate salivary nitrate: Implications for translational research.
Montenegro, M. F., Sundqvist, M. L., Nihlén, C., Hezel, M., Carlström, M., Weitzberg, E., & Lundberg, J. O.
(2016). Redox Biology.
Effects of antiseptic mouthwash on resting metabolic rate: A randomized, double-blind, crossover study.
Sundqvist, M. L., Lundberg, J. O., & Weitzberg, E.
(2016). Nitric Oxide.
A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS.
Schwarz, K., Singh, S., Parasuraman, S. K., Bruce, M., Shepstone, L., Feelisch, M., … & Frenneaux, M. P.
(2016). Future Cardiology, (0).
Short-term treatment with nitrate is not sufficient to induce in vivo antithrombotic effects in rats and mice.
Kramkowski, K., Leszczynska, A., Przyborowski, K., Proniewski, B., Marcinczyk, N., Rykaczewska, U., … & Chlopicki, S.
(2016). Naunyn-Schmiedeberg’s Archives of Pharmacology, 1-10.
Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner.
Gao, Y., Stuart, D., Pollock, J. S., Takahashi, T., & Kohan, D. E.
(2016). American Journal of Physiology-Renal Physiology, ajprenal-00494.
Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ.
Li, M., Tejada, T., Lambert, J. P., Nicholson, C. K., Yahiro, E., Ambai, V. T., … & Calvert, J. W.
(2016). American Journal of Cardiovascular Disease, 6(3), 118.
Consumption of a flavonoid-rich açai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men.
Alqurashi, R. M., Galante, L. A., Rowland, I. R., Spencer, J. P., & Commane, D. M.
(2016). The American Journal of Clinical Nutrition, ajcn128728.
Effects of methylphenidate on the impairment of spontaneous alternation behavior in mice intermittently deprived of REM sleep.
Niijima-Yaoita, F., Nagasawa, Y., Tsuchiya, M., Arai, Y., Tadano, T., & Tan-No, K.
(2016). Neurochemistry International.
Tunicamycin-Induced Alterations in the Vasorelaxant Response in Organ-Cultured Superior Mesenteric Arteries of Rats.
Matsumoto, T., Ando, M., Watanabe, S., Iguchi, M., Nagata, M., Kobayashi, S., … & Kobayashi, T.
(2016). Biological and Pharmaceutical Bulletin, 39(9), 1475-1481.
Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous congestion.
SUGAYA, K., NISHIJIMA, S., KADEKAWA, K., ASHITOMI, K., UEDA, T., & YAMAMOTO, H.
(2016). Biomedical Research, 37(4), 221-226
Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure.
Donnarumma, E., Bhushan, S., Bradley, J. M., Otsuka, H., Donnelly, E. L., Lefer, D. J., & Islam, K. N.
(2016). Journal of the American Heart Association, 5(8), e003551.
Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation.
Hezel, M., Peleli, M., Liu, M., Zollbrecht, C., Jensen, B. L., Checa, A., … & Carlström, M.
(2016). Free Radical Biology and Medicine.
In situ eNOS/NO up-regulation—a simple and effective therapeutic strategy for diabetic skin ulcer.
Yang, Y., Yin, D., Wang, F., Hou, Z., & Fang, Z.
(2016). Scientific Reports, 6, 30326.
Effects of silodosin on bladder activity in rats with frequent urination induced by pelvic venous congestion.
Sugaya, K., Nishijima, S., Kadekawa, K., Ashitomi, K., Ueda, T., & Yamamoto, H.
(2016). International Journal of Urology.
Simultaneous quantification of PGI 2 and TXA 2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method.
Kij, A., Mateuszuk, L., Sitek, B., Przyborowski, K., Zakrzewska, A., Wandzel, K., … & Chlopicki, S.
(2016). Journal of Pharmaceutical and Biomedical Analysis.
“COMPOSITIONS AND METHODS FOR PROMOTING NITRIC OXIDE PRODUCTION THROUGH AN ORAL DELIVERY SYSTEM.”
Bryan, N. S.
(2016). U.S. Patent 20,160,151,428, issued June 2, 2016.
Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling.
Polhemus, D. J., Gao, J., Scarborough, A., Trivedi, R. K., McDonough, K. H., Goodchild, T. T., … & Lefer, D. J.
(2016). Circulation Research, CIRCRESAHA-115.
High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via up-regulated ETB receptor expression.
Hyndman, K. A., Dugas, C., Arguello, A. M., Goodchild, T. T., Buckley, K. M., Burch, M., … & Pollock, J. S.
(2016). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, ajpregu-00016.
Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia.
Carlström, M., Cananau, C., Checa, A., Wide, K., Sartz, L., Svensson, A., … & Lundberg, J. O.
(2016). Nitric Oxide.
Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II‐mediated hypertension.
Porpino, S. K., Zollbrecht, C., Peleli, M., Montenegro, M. F., Brandão, M. C., Athayde‐Filho, P. F., … & Persson, E. G.
(2016). British Journal of Pharmacology.
Identification of Differential ER-Alpha versus ER-Beta Mediated Activation of eNOS In Uterine Artery Endothelial Cells.
Pastore, M. B., Talwar, S., Conley, M. R., & Magness, R. R.
(2016). Biology of Reproduction, biolreprod-115.
Impaired sodium dependent adaptation of arterial stiffness in formerly preeclamptic women: The RETAP-vascular study.
van der Graaf, A. M., Paauw, N. D., Toering, T. J., Feelisch, M., Faas, M. M., Sutton, T. R., … & Navis, G.
(2016). American Journal of Physiology-Heart and Circulatory Physiology, ajpheart-00010.
Attenuating spinal cord injury by conditioned medium from human umbilical cord blood-derived CD34+ cells in rats.
Yeng, C. H., Chen, P. J., Chang, H. K., Lo, W. Y., Wu, C. C., Chang, C. Y., … & Chen, S. H.
(2016). Taiwanese Journal of Obstetrics and Gynecology, 55(1), 85-93.
Pitavastatin Exhibits Protective Effects on Podocytes Accompanied by BMP-7 Up-Regulation and Rho Suppression.
Ohigashi, M., Imai, N., Toba, H., Kobara, M., & Nakata, T.
(2016). Pharmacology, 97(5-6), 265-276.
One Week of Daily Dosing With Beetroot Juice Improves Submaximal Endurance and Blood Pressure in Older Patients With Heart Failure and Preserved Ejection Fraction.
Eggebeen, J., Kim-Shapiro, D. B., Haykowsky, M., Morgan, T. M., Basu, S., Brubaker, P., … & Kitzman, D. W.
(2016). JACC: Heart Failure.
Modeling the Impact of Ingoing Sodium Nitrite, Sodium Ascorbate, and Residual Nitrite Concentrations on Growth Parameters of Listeria monocytogenes in Cooked, Cured Pork Sausage.
King, A. M., Glass, K. A., Milkowski, A. L., Seman, D. L., & Sindelar, J. J.
(2016). Journal of Food Protection®, 79(2), 184-193.
Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein E/Low-Density Lipoprotein Receptor–Deficient Mice: A Comparison with Nicotinic Acid.
Mateuszuk, L., Jasztal, A., Maslak, E., Gasior-Glogowska, M., Baranska, M., Sitek, B., … & Chlopicki, S.
(2016). Journal of Pharmacology and Experimental Therapeutics, 356(2), 514-524.
Examination of neurological prognostic markers in patients with respiratory syncytial virus-associated encephalopathy.
Morichi, S., Morishita, N., Ishida, Y., Oana, S., Yamanaka, G., Kashiwagi, Y., & Kawashima, H.
(2016). International Journal of Neuroscience, (just-accepted), 1-23.
2015
Activation of regulatory T cells by endothelial cells in inflammatory skin disease
Lim, W. C.
(2015). (Doctoral dissertation, University of Southampton)
“AGENT FOR ELEVATING NITRIC OXIDE CONCENTRATION.”
Morita, M., & Kamimura, A.
(2015). U.S. Patent No. 20,150,352,067. Washington, DC: U.S. Patent and Trademark Office.
Acute Dietary Nitrate Supplementation and Exercise Performance in COPD: A Double-Blind, Placebo-Controlled, Randomised Controlled Pilot Study.
Curtis, K. J., O’Brien, K. A., Tanner, R. J., Polkey, J. I., Minnion, M., Feelisch, M., … & Hopkinson, N. S.
(2015). PLoS One, 10(12).
DL-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats.
Oosterhuis, N. R., Frenay, A. R. S., Wesseling, S., Snijder, P. M., Slaats, G. G., Yazdani, S., … & van Goor, H.
(2015). Nitric Oxide.
P2Y 2 and G q/G 11 control blood pressure by mediating endothelial mechanotransduction.
Wang, S., Iring, A., Strilic, B., Juárez, J. A., Kaur, H., Troidl, K., … & Offermanns, S.
(2015). The Journal of Clinical Investigation, 125(125 (8)), 0-0.
Physiological recycling of endogenous nitrate by oral bacteria regulates gastric mucus thickness.
El-Ferzli, G. T., Andukuri, A., Alexander, G., Scopel, M., Ambalavanan, N., Patel, R. P., & Jun, H. W.
(2015). Free Radical Biology and Medicine.
A nitric oxide releasing self-assembled peptide amphiphile nanomatrix for improving the biocompatibility of microporous hollow fibers.
Petersson, J., Jädert, C., Phillipson, M., Borniquel, S., Lundberg, J. O., & Holm, L.
(2015).ASAIO Journal.
Effects of long-term dietary nitrate supplementation in mice
Hezel, M. P., Liu, M., Schiffer, T. A., Larsen, F. J., Checa, A., Wheelock, C. E., … & Weitzberg, E.
(2015). Redox Biology.
Impact of Clean-Label Antimicrobials and Nitrite Derived from Natural Sources on the Outgrowth of Clostridium perfringens during Cooling of Deli-Style Turkey Breast.
King, A. M., Glass, K. A., Milkowski, A. L., & Sindelar, J. J.
(2015). Journal of Food Protection®, 78(5), 946-953.
1H-NMR-Based Metabolomic Analysis of Cerebrospinal Fluid From Adult Bilateral Moyamoya Disease: Comparison With Unilateral Moyamoya Disease and Atherosclerotic Stenosis.
Polhemus, D. J., Li, Z., Pattillo, C. B., Goodchild, T. T., Gojon, G., Giordano, T., & Krum, H.
(2015) Medicine, 94(17), e629.
A Novel Hydrogen Sulfide Prodrug, SG1002, Promotes Hydrogen Sulfide and Nitric Oxide Bioavailability in Heart Failure Patients.
Jeon, J. P., Yun, T., Jin, X., Cho, W. S., Son, Y. J., Bang, J. S., … & Park, S.
(2015) Nitric Oxide.
The relationship between plasma and salivary NO x.
Clodfelter, W. H., Basu, S., Bolden, C., Dos Santos, P. C., King, S. B., & Kim-Shapiro, D. B.
(2015) Cardiovascular Therapeutics.
2014
Histone deacetylas 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3.
Hyndman, K. A., Ho, D. H., Sega, M. F., & Pollock, J. S.
(2014) American Journal of Physiology-Heart and Circulatory Physiology, 307(5), H803-H809
2013
Renal collecting duct Nos1 maintains fluid-electrolyte homeostasis and blood pressure novelty and significance.
Hyndman K, Boesen E, Elmarakby A, Brands M, Huang P, Kohan D, Pollock D, Pollock J.
(2013) Hypertension; 62, 91-98
Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats.
Hyndman, K. A., Xue, J., MacDonell, A., Speed, J. S., Jin, C., & Pollock, J. S.
(2013) Clinical and experimental Pharmacology and Physiology, 40(3), 233-239.
2012
Extracellular signal-regulated kinases1/2 signaling pathways are not involved in endothelin regulation of mouse inner medullary collecting duct nitric oxide production.
Hyndman K, MacDonell A, Pollock J.
(2012) Life Science 91; 578-582
2008
Quantifying nanomolar levels of nitrite in biological samples by HPLC-Griess method: special reference to arterio-venous difference in vivo.
Ishibashi T, Miwa T, Shinkawa I, Nishizawa N, Nomura M, Yoshida J, Kawada T, Nishio M
(2008) Tohoku Journal of Experimental Medicine; 215(1):1-11
2007
Methods to detect nitric oxide and its metabolites in biological samples.
Bryan NS, Grisham MB
(2007) Free Radical Biology & Medicine. 43(5):645-657. Epub 2007 Apr 29.
2005
Effects of two formulations for overcoming oketsu on vascular function and expression patterns of plasma proteins in spontaneously diabetic rats.
Li, M., Tejada, T., Lambert, J. P., Nicholson, C. K., Yahiro, E., Ambai, V. T., … & Calvert, J. W.
(2005). Journal of Traditional Medicines, 22(4), 237-243.
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues.
Bryan NS, Fernandez BO, Bauer SM, Garcia-Saura MF, Milsom AB, Rassaf T, Maloney RE, Bharti A, Rodriguez J, Feelisch M
(2005) Nature Chemical Biology 1: 290-297
Development of polyethylene glycol-conjugated poly-S-nitrosated serum albumin, a novel S-Nitrosothiol for prolonged delivery of nitric oxide in the blood circulation in vivo.
Katsumi H, Nishikawa M, Yamashita F, Hashida M
(2005) The Journal of Pharmacology and Experimental Therapeutics 314: 1117-1124
2004
Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep.
Okawa T, Honda S, Sanpei M, Ishida T, Fujimori K, Sato A
(2004) Journal of Perinatal Medicine 32: 495-499
Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study.
Kino M, Yamato T, Aomine M
(2004) Neurochemistry International 44: 65-73
Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo.
Bryan NS, Rassaf T, Maloney RE, Rodriquez CM, Saijo F, Rodriguez JR, Feelisch M
(2004) Proceedings of the National Academy of Sciences USA (PNAS) 101: 4308-4313
2003
Chemical nature of nitric oxide storage forms in rat vascular tissue.
Rodriguez J, Maloney RE, Rassaf T, Bryan NS, Feelisch M
(2003) Proceeding of the National Academy of Sciences of the United States of America (PNAS) 100: 336-341. Epub 2002 Dec 26
Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model.
Namba T, Koike H, Murakami K, Aoki M, Makino H, Hashiya N, Ogihara T, Kaneda Y, Kohno M, Morishita R
(2003) Circulation 108: 2250-2257
Aspirin inhibits Chlamydia pneumoniae-induced NF-kappa B activation, cyclo-oxygenase-2 expression and prostaglandin E2 synthesis and attenuates chlamydial growth.
Yoneda H, Miura K, Matsushima H, Sugi K, Murakami T, Ouchi K, Yamashita K, Itoh H, Nakazawa T, Suzuki M, Shirai M
(2003) Journal of Medical Microbiology 52: 409-415
Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release.
Mochizuki S, Vink H, Hiramatsu O, Kajita T, Shigeto F, Spaan JA, Kajiya F.
(2003) American Journal of Physiology – Heart and Circulatory Physiology 285: H722-726
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.
Kleinbongard P, Dejam A, Lauer T, Rassaf T, Schindler A, Picker O, Scheeren T, Godecke A, Schrader J, Schulz R, Heusch G, Schaub GA, Bryan NS, Feelisch M, Kelm M.
(2003) Free Radical Biology & Medicine 35: 790-796
2002
Concomitant presence of N-nitroso and S-nitroso proteins in human plasma.
Rassaf T, Bryan NS, Kelm M, Feelisch M.
(2002) Free Radical Biology & Medicine 33: 1590-1596. Erratum in: Free Radical Biology & Medicine 2003 34: 283.\
Role of endothelin ET(B) receptors in the renal hemodynamic and excretory responses to big endothelin-1.
Konishi F, Okada Y, Takaoka M, Gariepy CE, Yanagisawa M, Matsumura Y.
(2002) European Journal of Pharmacology 451(2):177-184.
Smoking a single cigarette rapidly reduces combined concentrations of nitrate and nitrite and concentrations of antioxidants in plasma.
Tsuchiya M, Asada A, Kasahara E, Sato EF, Shindo M, Inoue M.
(2002) Circulation 105: 1155-1157
Relationship between oxidation of glutathione and reactive nitrogen species during the early-reperfusion phase of cerebral ischemia.
Iijima T, Sakamoto H, Okada C, Iwao Y.
(2002) Neurochemical Research 27: 497-500
2001
Cerebrospinal fluid nitric oxide metabolites are novel predictors of pain relief degenerative lumbar diseases.
Kimura S, Watanabe K, Yajiri Y, Uchiyama S, Hasegawa K, Shibuki K, Endo N.
(2001) Pain 92: 363-371
2000
Nitric oxide formation in the dog sphincter of Oddi from nitric oxide donors as measured with in vivo micro-dialysis.
Yamamoto I, Fujiwara M, Kuhara N, Kumano K, Yamada T, Yamamoto H, Fujiwara M
(2000) Alimentary Pharmacology & Therapeutics 14: 1095-1101
Potentiation of penile tumescence by T-1032, a new potent and specific phosphodiesterase type V inhibitor, in dogs.
Noto T, Inoue H, Ikeo T, Kikkawa K
(2000) The Journal of Pharmacology and Experimantal Therapeutics 294: 870-875
Mechanisms for Regulation of Fluid Shear Stress Response in Circulation Leukocytes.
Fukuda S, Yasu T, Predescu DN, Schmid-Schönbein GW
(2000) Circulation Research 86: e13-e18
1999
Psychological stress-induced enhancement of brain lipid peroxidation via nitric oxide systems and its modulation by anxiolytis and anxiogenic drugs in mice.
Matsumoto K, Yobimoto K, Huong NTT, Abdel-Fattah M, Van Hien T, Watanabe H
(1999) Brain Research 839: 74-84
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